DK1626974T3 - Substituerede benzopyraner som selektive östrogenreceptor-beta-agonister - Google Patents

Substituerede benzopyraner som selektive östrogenreceptor-beta-agonister

Info

Publication number: DK1626974T3
Authority: DK; Denmark
Prior art keywords: estrogen receptor; receptor beta; beta agonists; selective estrogen; substituted benzopyrans
Prior art date: 2003-04-21

Application number

DK04759767T

Other languages

Danish (da)

English (en)

Inventor

Gregory Lee Durst

Bryan Hurst Norman

Lance Allen Pfeifer

Timothy Ivo Richardson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-21

Filing date

2004-04-08

Publication date

2008-11-17

2004-04-08 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2008-11-17 Application granted granted Critical

2008-11-17 Publication of DK1626974T3 publication Critical patent/DK1626974T3/da

Links

150000001562 benzopyrans Chemical class 0.000 title abstract 2
239000000900 selective estrogen receptor beta agonist Substances 0.000 title 1
102000000509 Estrogen Receptor beta Human genes 0.000 abstract 2
108010041356 Estrogen Receptor beta Proteins 0.000 abstract 2
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
229940125388 beta agonist Drugs 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK04759767T 2003-04-21 2004-04-08 Substituerede benzopyraner som selektive östrogenreceptor-beta-agonister DK1626974T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US46440403P	2003-04-21	2003-04-21
PCT/US2004/009272 WO2004094400A2 (en)	2003-04-21	2004-04-08	Substituted benzopyrans as selective estrogen receptor-beta agonists

Publications (1)

Publication Number	Publication Date
DK1626974T3 true DK1626974T3 (da)	2008-11-17

Family

ID=33310882

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04759767T DK1626974T3 (da)	2003-04-21	2004-04-08	Substituerede benzopyraner som selektive östrogenreceptor-beta-agonister

Country Status (17)

Country	Link
US (3)	US7442812B2 (de)
EP (1)	EP1626974B1 (de)
JP (1)	JP4481300B2 (de)
CN (1)	CN100374444C (de)
AT (1)	ATE406373T1 (de)
AU (1)	AU2004232798B2 (de)
BR (1)	BRPI0409588A (de)
CA (1)	CA2518819A1 (de)
CY (1)	CY1110443T1 (de)
DE (1)	DE602004016150D1 (de)
DK (1)	DK1626974T3 (de)
ES (1)	ES2311838T3 (de)
MX (1)	MXPA05011243A (de)
PL (1)	PL1626974T3 (de)
PT (1)	PT1626974E (de)
SI (1)	SI1626974T1 (de)
WO (1)	WO2004094400A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101023085A (zh) *	2004-07-19	2007-08-22	詹森药业有限公司	用作雌激素受体调节剂的螺－苯并[c]色烯衍生物
CN101052641A (zh)	2004-09-07	2007-10-10	惠氏公司	6H－[1]苯并吡喃并[4,3－b]喹啉及其作为雌激素药物的用途
CA2578300A1 (en) *	2004-10-18	2006-04-27	Eli Lilly And Company	Substituted benzopyrans as selective estrogen receptor-beta agonists
WO2006088716A1 (en)	2005-02-15	2006-08-24	Eli Lilly And Company	Substituted tetralins as selective estrogen receptor-beta agonists
JP2006232727A (ja) *	2005-02-24	2006-09-07	Chisso Corp	クマリン誘導体、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子
EA026578B1 (ru)	2007-01-22	2017-04-28	ДЖиТиЭкс, ИНК.	Вещества, связывающие ядерные рецепторы
US9623021B2 (en)	2007-01-22	2017-04-18	Gtx, Inc.	Nuclear receptor binding agents
US9604931B2 (en)	2007-01-22	2017-03-28	Gtx, Inc.	Nuclear receptor binding agents
WO2011014516A1 (en)	2009-07-28	2011-02-03	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Estrogen antagonists as treatments for sclerosing disorders
CN109134493A (zh) *	2018-09-19	2019-01-04	浙江师范大学	一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用
CN109400564B (zh) *	2018-09-25	2021-03-12	信阳师范学院	一种含三氟甲基的苯并二氢吡喃-4-酮类化合物及其制备方法
CN110128393B (zh) *	2019-06-21	2022-09-30	华侨大学	一种取代异香豆素衍生物的制备方法
CN112898263B (zh) *	2021-01-28	2022-03-08	江西中医药大学	一种从佛手中分离的香豆素骈木脂素化合物及其保肝用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100263137B1 (ko)	1995-09-08	2000-08-01	오테스코그 페르	오판 수용체
AU8102398A (en)	1997-07-09	1999-02-08	Central Drug Research Institute	(dl)-2,3-diaryl-2h-1-benzopyrans
US6593322B1 (en) *	1999-03-17	2003-07-15	Signal Pharmaceuticals, Inc.	Compounds and methods for modulation of estrogen receptors
AU766648B2 (en) *	1999-03-17	2003-10-23	Axys Pharmaceuticals, Inc.	Compounds and methods for modulation of estrogen receptors
JP2002542187A (ja) *	1999-04-16	2002-12-10	アストラゼネカ・アクチエボラーグ	エストロゲン−β受容体リガンド
IL150463A0 (en)	1999-12-30	2002-12-01	Signal Pharm Inc	Compounds and methods for modulation of estrogen receptors
AU2001256164A1 (en) *	2000-03-01	2001-09-12	Akzo Nobel N.V.	Chroman derivatives as estrogenic compounds
JP2003528858A (ja)	2000-03-27	2003-09-30	アクゾ・ノベル・エヌ・ベー	エストロゲン関連治療用のノンステロイド系四環式化合物
GB2361642A (en)	2000-10-24	2001-10-31	Karobio Ab	Estrogen receptor beta (ERbeta) agonists for use in cancer treatment
US7147876B2 (en)	2001-08-13	2006-12-12	Michael Hargreaves Riley	Compositions for removal of toxins
WO2003044006A1 (en) *	2001-11-19	2003-05-30	Eli Lilly And Company	Substituted benzopyrans as selective estrogen receptor-beta agonists
UA83620C2 (ru) *	2001-12-05	2008-08-11	Уайт	Замещенные бензоксазолы и их аналоги как эстрогенные агенты
US6914074B2 (en)	2001-12-13	2005-07-05	Wyeth	Substituted phenyl naphthalenes as estrogenic agents
US6630508B1 (en) *	2002-02-11	2003-10-07	Eli Lilly And Company	Substituted benzopyrans as selective estrogen receptor β agonists
DE602004025460D1 (de)	2003-04-21	2010-03-25	Lilly Co Eli	Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta
CA2578300A1 (en)	2004-10-18	2006-04-27	Eli Lilly And Company	Substituted benzopyrans as selective estrogen receptor-beta agonists
WO2006088716A1 (en)	2005-02-15	2006-08-24	Eli Lilly And Company	Substituted tetralins as selective estrogen receptor-beta agonists

2004
- 2004-04-08 AT AT04759767T patent/ATE406373T1/de not_active IP Right Cessation
- 2004-04-08 MX MXPA05011243A patent/MXPA05011243A/es active IP Right Grant
- 2004-04-08 AU AU2004232798A patent/AU2004232798B2/en not_active Ceased
- 2004-04-08 PL PL04759767T patent/PL1626974T3/pl unknown
- 2004-04-08 ES ES04759767T patent/ES2311838T3/es not_active Expired - Lifetime
- 2004-04-08 CA CA002518819A patent/CA2518819A1/en not_active Abandoned
- 2004-04-08 WO PCT/US2004/009272 patent/WO2004094400A2/en not_active Ceased
- 2004-04-08 CN CNB2004800108171A patent/CN100374444C/zh not_active Expired - Fee Related
- 2004-04-08 PT PT04759767T patent/PT1626974E/pt unknown
- 2004-04-08 BR BRPI0409588-0A patent/BRPI0409588A/pt not_active IP Right Cessation
- 2004-04-08 DE DE602004016150T patent/DE602004016150D1/de not_active Expired - Lifetime
- 2004-04-08 EP EP04759767A patent/EP1626974B1/de not_active Expired - Lifetime
- 2004-04-08 DK DK04759767T patent/DK1626974T3/da active
- 2004-04-08 SI SI200430916T patent/SI1626974T1/sl unknown
- 2004-04-08 US US10/552,504 patent/US7442812B2/en not_active Expired - Fee Related
- 2004-04-08 JP JP2006509332A patent/JP4481300B2/ja not_active Expired - Lifetime
2008
- 2008-08-01 US US12/184,507 patent/US7585985B2/en not_active Expired - Fee Related
- 2008-10-23 CY CY20081101190T patent/CY1110443T1/el unknown
2009
- 2009-07-31 US US12/533,220 patent/US7842822B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN100374444C (zh)	2008-03-12
US7842822B2 (en)	2010-11-30
ES2311838T3 (es)	2009-02-16
US20070106082A1 (en)	2007-05-10
PL1626974T3 (pl)	2009-01-30
CY1110443T1 (el)	2015-04-29
AU2004232798A1 (en)	2004-11-04
WO2004094400A3 (en)	2005-02-24
CN1777614A (zh)	2006-05-24
US7585985B2 (en)	2009-09-08
US20080312312A1 (en)	2008-12-18
US7442812B2 (en)	2008-10-28
BRPI0409588A (pt)	2006-04-18
DE602004016150D1 (de)	2008-10-09
JP2006524240A (ja)	2006-10-26
ATE406373T1 (de)	2008-09-15
SI1626974T1 (sl)	2009-02-28
WO2004094400A2 (en)	2004-11-04
JP4481300B2 (ja)	2010-06-16
MXPA05011243A (es)	2005-12-15
PT1626974E (pt)	2008-11-14
EP1626974A2 (de)	2006-02-22
AU2004232798B2 (en)	2010-04-22
US20090298925A1 (en)	2009-12-03
EP1626974B1 (de)	2008-08-27
CA2518819A1 (en)	2004-11-04

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IL185867A0 (en)	2008-01-06	Substituted benzopyrans as selective estrogen receptor-beta agonists
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