DK162878C - Fremgangsmaade til fremstilling af en vandoploeselig fast dispersion af chlorthalidon, samt produkter indeholdende en saadan dispersion - Google Patents

Fremgangsmaade til fremstilling af en vandoploeselig fast dispersion af chlorthalidon, samt produkter indeholdende en saadan dispersion

Info

Publication number: DK162878C
Authority: DK; Denmark
Prior art keywords: dispersion; water soluble; alkanol; chlorthalidon; preparing
Prior art date: 1983-03-16

Application number

DK156784A

Other languages

English (en)

Other versions

DK162878B (da

DK156784D0 (da

DK156784A (da

Inventor

Nevedita Pandit

Stephen T Horhota

Original Assignee

Boehringer Ingelheim Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-03-16

Filing date

1984-03-15

Publication date

1992-05-18

1984-03-15 Application filed by Boehringer Ingelheim Ltd filed Critical Boehringer Ingelheim Ltd

1984-03-15 Publication of DK156784D0 publication Critical patent/DK156784D0/da

1984-09-17 Publication of DK156784A publication Critical patent/DK156784A/da

1991-12-23 Publication of DK162878B publication Critical patent/DK162878B/da

1992-05-18 Application granted granted Critical

1992-05-18 Publication of DK162878C publication Critical patent/DK162878C/da

Links

229960001523 chlortalidone Drugs 0.000 title abstract 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 3
239000006185 dispersion Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
JIVPVXMEBJLZRO-UHFFFAOYSA-N chlorthalidone Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-UHFFFAOYSA-N 0.000 title 1
239000007962 solid dispersion Substances 0.000 title 1
JIVPVXMEBJLZRO-CQSZACIVSA-N 2-chloro-5-[(1r)-1-hydroxy-3-oxo-2h-isoindol-1-yl]benzenesulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC([C@@]2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-CQSZACIVSA-N 0.000 abstract 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
150000005215 alkyl ethers Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
230000008020 evaporation Effects 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Compositions Of Macromolecular Compounds (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Indole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Adhesives Or Adhesive Processes (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Dental Preparations (AREA)

DK156784A 1983-03-16 1984-03-15 Fremgangsmaade til fremstilling af en vandoploeselig fast dispersion af chlorthalidon, samt produkter indeholdende en saadan dispersion DK162878C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47589883A	1983-03-16	1983-03-16
US47589883		1983-03-16

Publications (4)

Publication Number	Publication Date
DK156784D0 DK156784D0 (da)	1984-03-15
DK156784A DK156784A (da)	1984-09-17
DK162878B DK162878B (da)	1991-12-23
DK162878C true DK162878C (da)	1992-05-18

Family

ID=23889624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK156784A DK162878C (da)	1983-03-16	1984-03-15	Fremgangsmaade til fremstilling af en vandoploeselig fast dispersion af chlorthalidon, samt produkter indeholdende en saadan dispersion

Country Status (20)

Country	Link
EP (1)	EP0125420B1 (da)
JP (1)	JPS59176212A (da)
KR (1)	KR880001755B1 (da)
AT (1)	ATE31024T1 (da)
AU (1)	AU562929B2 (da)
CA (1)	CA1212329A (da)
DD (1)	DD220225A5 (da)
DE (1)	DE3467707D1 (da)
DK (1)	DK162878C (da)
ES (1)	ES8602633A1 (da)
FI (1)	FI82188C (da)
GR (1)	GR81478B (da)
HU (1)	HU191596B (da)
IE (1)	IE57031B1 (da)
IL (1)	IL71248A (da)
NO (1)	NO164956C (da)
NZ (1)	NZ207514A (da)
PT (1)	PT78259B (da)
YU (1)	YU43349B (da)
ZA (1)	ZA841916B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4933360A (en) *	1983-03-16	1990-06-12	Boehringer Ingelheim Pharmaceuticals, Inc.	Novel chlorthalidone process and product
DE3612212A1 (de) *	1986-04-11	1987-10-15	Basf Ag	Verfahren zur herstellung von festen pharmazeutischen formen
WO1988000040A1 (en) *	1986-07-02	1988-01-14	American Health Products Corporation	Topical hair growing composition and kit
US5955475A (en) *	1997-06-30	1999-09-21	Endo Pharmaceuticals Inc.	Process for manufacturing paroxetine solid dispersions
US6264981B1 (en) *	1999-10-27	2001-07-24	Anesta Corporation	Oral transmucosal drug dosage using solid solution

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3055904A (en) *	1957-11-04	1962-09-25	Geigy Chem Corp	New isoindoline derivatives
US4128632A (en) *	1978-02-13	1978-12-05	Merck & Co., Inc.	Solubilization of Rafoxanide
US4285665A (en) *	1978-05-08	1981-08-25	Johnson, Matthey & Co., Limited	Engines

1984
- 1984-03-14 FI FI841019A patent/FI82188C/fi not_active IP Right Cessation
- 1984-03-14 YU YU458/84A patent/YU43349B/xx unknown
- 1984-03-14 DD DD84260896A patent/DD220225A5/de not_active IP Right Cessation
- 1984-03-15 IL IL71248A patent/IL71248A/xx not_active IP Right Cessation
- 1984-03-15 NO NO841010A patent/NO164956C/no unknown
- 1984-03-15 HU HU841028A patent/HU191596B/hu not_active IP Right Cessation
- 1984-03-15 AT AT84102825T patent/ATE31024T1/de not_active IP Right Cessation
- 1984-03-15 CA CA000449692A patent/CA1212329A/en not_active Expired
- 1984-03-15 PT PT78259A patent/PT78259B/pt not_active IP Right Cessation
- 1984-03-15 KR KR1019840001307A patent/KR880001755B1/ko not_active Expired
- 1984-03-15 DE DE8484102825T patent/DE3467707D1/de not_active Expired
- 1984-03-15 NZ NZ207514A patent/NZ207514A/en unknown
- 1984-03-15 ZA ZA841916A patent/ZA841916B/xx unknown
- 1984-03-15 EP EP84102825A patent/EP0125420B1/en not_active Expired
- 1984-03-15 GR GR74116A patent/GR81478B/el unknown
- 1984-03-15 ES ES530628A patent/ES8602633A1/es not_active Expired
- 1984-03-15 DK DK156784A patent/DK162878C/da not_active IP Right Cessation
- 1984-03-15 IE IE647/84A patent/IE57031B1/en unknown
- 1984-03-16 JP JP59050836A patent/JPS59176212A/ja active Pending
- 1984-03-16 AU AU25696/84A patent/AU562929B2/en not_active Ceased

Also Published As

Publication number	Publication date
YU45884A (en)	1987-06-30
ATE31024T1 (de)	1987-12-15
FI82188C (fi)	1991-02-11
FI841019A0 (fi)	1984-03-14
HU191596B (en)	1987-03-30
EP0125420A2 (en)	1984-11-21
IE57031B1 (en)	1992-03-25
IL71248A0 (en)	1984-06-29
DK162878B (da)	1991-12-23
NO164956C (no)	1990-12-05
AU2569684A (en)	1984-09-20
NZ207514A (en)	1987-02-20
DE3467707D1 (en)	1988-01-07
EP0125420A3 (en)	1985-03-13
NO164956B (no)	1990-08-27
GR81478B (da)	1984-12-11
EP0125420B1 (en)	1987-11-25
PT78259A (en)	1984-04-01
YU43349B (en)	1989-06-30
IL71248A (en)	1987-02-27
AU562929B2 (en)	1987-06-25
NO841010L (no)	1984-09-17
HUT34343A (en)	1985-03-28
ES530628A0 (es)	1985-12-01
DD220225A5 (de)	1985-03-27
IE840647L (en)	1984-09-16
ZA841916B (en)	1985-11-27
DK156784D0 (da)	1984-03-15
DK156784A (da)	1984-09-17
JPS59176212A (ja)	1984-10-05
KR880001755B1 (ko)	1988-09-12
CA1212329A (en)	1986-10-07
ES8602633A1 (es)	1985-12-01
FI82188B (fi)	1990-10-31
KR840007874A (ko)	1984-12-11
FI841019L (fi)	1984-09-17
PT78259B (en)	1986-08-08

Legal Events

Date	Code	Title	Description
1991-07-29	PBP	Patent lapsed

Publication	Publication Date	Title
DE3362784D1 (en)	1986-05-07	Process for preparing free-flowing ethylcellulose microcapsules
ES484167A1 (es)	1980-09-01	Un procedimiento para preparar 9-(hidroxialcohil)-purinas
DK156784A (da)	1984-09-17	Fremgangsmaade til fremstilling af en vandoploeselig fast dispersion af chlorthalidon
PT72505B (fr)	1982-02-05	Procede de preparation de compositions aqueuses concentrees ge-neratrices de mousses utilisables pour eteindre des feux
JPS5266633A (en)	1977-06-02	Stable dispersion of agricultural chemicals
JPS57192392A (en)	1982-11-26	Production of 3-alkoxymethylcephalosporin
JPS57102902A (en)	1982-06-26	Water-soluble cellulose mixed ether containing phosphonomethyl substituent and manufacture
JPS5569554A (en)	1980-05-26	Beta-hydroxyalkylaminosulfonic acid compound
ES8100796A1 (es)	1980-11-01	Un procedimiento para la preparacion de derivados de n-(fenilcicloalquil)acelamida
JPS6426637A (en)	1989-01-27	Electrochemical polymerization of aniline and aniline derivative
ES8306102A1 (es)	1983-05-01	"procedimiento para preparar el herbicida fenmedifam".
ES8106750A1 (es)	1981-09-01	Procedimiento para la obtencion de soluciones concentradas de colorantes complejos.
BG30328A3 (en)	1981-05-15	Method for obtaining of o, o- dimethyl- o, 2, 2- dichlorvinyl- phosphate
JPS5246023A (en)	1977-04-12	Process for preparation of organosulfinic acid salts
JPS5794003A (en)	1982-06-11	Perfluorocarbon polymer and its production
GB1470011A (en)	1977-04-14	Ketone peroxide production
JPS5622755A (en)	1981-03-03	Preparation of phenylhydrazine
GB976092A (en)	1964-11-25	Preparation of hydroxyalkyl sulphonium halides
JPS5446779A (en)	1979-04-12	Preparation of 3-isoxazolylurea
JPS5339399A (en)	1978-04-11	Preparation of silicon polyme or oligomer
JPS5564548A (en)	1980-05-15	Preparation of ester
ES8404688A1 (es)	1984-05-16	Un procedimiento para preparar p-clorofenoxiacetil-piperonilpiperacina.
ES8303331A1 (es)	1983-02-01	Un procedimiento para preparar un pirrol-2-acetato de alquilo inferior sustituido en las posiciones 1 y 4.
JPS51133395A (en)	1976-11-19	A process for preparing a water soluble phenolic resin having improved storage stability
JPS5515446A (en)	1980-02-02	Preparation of n-chlorophenyl-n'-methoxy-n'-methylurea