DK163429C - Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling - Google Patents

Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling

Info

Publication number: DK163429C
Authority: DK; Denmark
Prior art keywords: carbonly; carrially; carbostyle; car; division
Prior art date: 1986-12-23

Application number

DK680887A

Other languages

Danish (da)

English (en)

Other versions

DK163429B (da

DK680887D0 (da

DK680887A (da

Inventor

Arthur Page Phillips

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-23

Filing date

1987-12-22

Publication date

1992-07-20

1987-12-22 Application filed by Wellcome Found filed Critical Wellcome Found

1987-12-22 Publication of DK680887D0 publication Critical patent/DK680887D0/da

1988-06-24 Publication of DK680887A publication Critical patent/DK680887A/da

1992-03-02 Publication of DK163429B publication Critical patent/DK163429B/da

1992-07-20 Application granted granted Critical

1992-07-20 Publication of DK163429C publication Critical patent/DK163429C/da

Links

150000003839 salts Chemical class 0.000 title abstract 2
230000000297 inotrophic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Secondary Cells (AREA)
Carbon And Carbon Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK680887A 1986-12-23 1987-12-22 Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling DK163429C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8630702		1986-12-23
GB868630702A GB8630702D0 (en)	1986-12-23	1986-12-23	Quinoline compound

Publications (4)

Publication Number	Publication Date
DK680887D0 DK680887D0 (da)	1987-12-22
DK680887A DK680887A (da)	1988-06-24
DK163429B DK163429B (da)	1992-03-02
DK163429C true DK163429C (da)	1992-07-20

Family

ID=10609475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK680887A DK163429C (da)	1986-12-23	1987-12-22	Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling

Country Status (22)

Country	Link
US (1)	US4937248A (de)
EP (1)	EP0272910B1 (de)
JP (1)	JPS63166866A (de)
KR (1)	KR880007514A (de)
AT (1)	ATE65993T1 (de)
AU (1)	AU594220B2 (de)
CA (1)	CA1318671C (de)
DE (1)	DE3772015D1 (de)
DK (1)	DK163429C (de)
ES (1)	ES2029842T3 (de)
FI (1)	FI90768C (de)
GB (1)	GB8630702D0 (de)
GR (1)	GR3002445T3 (de)
HU (1)	HU196991B (de)
IE (1)	IE60619B1 (de)
IL (1)	IL84917A (de)
MX (1)	MX9203788A (de)
MY (1)	MY102277A (de)
NZ (1)	NZ223036A (de)
PH (1)	PH23448A (de)
PT (1)	PT86448B (de)
ZA (1)	ZA879615B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5166160A (en) *	1986-12-23	1992-11-24	Burroughs Wellcome Co.	Quinoline compound
GB8820174D0 (en) *	1988-08-25	1988-09-28	Wellcome Found	Quinoline compound
EP1017691A1 (de) *	1997-09-24	2000-07-12	Orion Corporation (Orion-Yhtyma Oy)	Diether von 1-oxa-, aza- und thianaphthalin-2-onen als phospholambanhemmer
US6566372B1 (en)	1999-08-27	2003-05-20	Ligand Pharmaceuticals Incorporated	Bicyclic androgen and progesterone receptor modulator compounds and methods
KR20020038741A (ko)	1999-08-27	2002-05-23	윌리암 엘. 레스페스	안드로겐 수용체 조절 화합물 및 방법
JP2003508397A (ja)	1999-08-27	2003-03-04	リガンド・ファーマシューティカルズ・インコーポレイテッド	アンドロゲンレセプターモジュレーターとしての８−置換−６−トリフルオロメチル−９−ピリド［３，２−ｇ］キノリン化合物
AU7586600A (en)	1999-09-14	2001-04-17	Ligand Pharmaceuticals Incorporated	Rxr modulators with improved pharmacologic profile
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
MXPA06001751A (es)	2003-08-22	2006-05-12	Ligand Pharm Inc	Derivados de 6-cicloamino-2-quinolinona como compuestos moduladores de receptor de androgeno.
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es)	2008-06-04	2014-11-19	Synergy Pharmaceuticals Inc.	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en)	2011-03-01	2018-04-16	Synergy Pharmaceuticals Inc	PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
WO2014131024A2 (en)	2013-02-25	2014-08-28	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
BR112015030326A2 (pt)	2013-06-05	2017-08-29	Synergy Pharmaceuticals Inc	Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
AU2014305843B2 (en)	2013-08-09	2019-08-29	Ardelyx, Inc.	Compounds and methods for inhibiting phosphate transport
EP4706758A3 (de)	2019-05-21	2026-05-06	Ardelyx, Inc.	Verfahren zur hemmung des phosphattransports

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2616855A (en) *	1948-01-15	1952-11-04	Procter & Gamble	Detergent composition
US4329347A (en) *	1978-02-17	1982-05-11	Boehringer Ingelheim Gmbh	Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril
JPS5777676A (en) *	1980-10-31	1982-05-15	Otsuka Pharmaceut Co Ltd	Carbostyril derivative
US4710507A (en) *	1983-12-22	1987-12-01	Pfizer Inc.	Quinolone inotropic agents
CA1292234C (en) *	1984-05-29	1991-11-19	Simon Fraser Campbell	Heterocyclic-substituted quinolone inotropic agents
US4760064A (en) *	1984-12-18	1988-07-26	Otsuka Pharmaceutical Co., Ltd.	Carbostyril compounds, compositions containing same and processes for preparing same
US4845100A (en) *	1985-04-12	1989-07-04	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
FR2580646A1 (fr) *	1985-04-19	1986-10-24	Synthelabo	Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique
GB8529362D0 (en) *	1985-11-28	1986-01-02	Pfizer Ltd	Quinolone cardiac stimulants
DK111387A (da) *	1986-03-05	1987-09-06	Otsuka Pharma Co Ltd	Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
ES2053480T3 (es) *	1986-07-31	1994-08-01	Otsuka Pharma Co Ltd	Un procedimiento para preparar un derivado de carboestirilo.

1986
- 1986-12-23 GB GB868630702A patent/GB8630702D0/en active Pending
1987
- 1987-12-21 US US07/135,654 patent/US4937248A/en not_active Expired - Fee Related
- 1987-12-21 MY MYPI87003231A patent/MY102277A/en unknown
- 1987-12-22 ES ES198787311275T patent/ES2029842T3/es not_active Expired - Lifetime
- 1987-12-22 DK DK680887A patent/DK163429C/da not_active IP Right Cessation
- 1987-12-22 DE DE8787311275T patent/DE3772015D1/de not_active Expired - Fee Related
- 1987-12-22 ZA ZA879615A patent/ZA879615B/xx unknown
- 1987-12-22 FI FI875666A patent/FI90768C/fi not_active IP Right Cessation
- 1987-12-22 KR KR870014675A patent/KR880007514A/ko not_active Ceased
- 1987-12-22 IE IE349087A patent/IE60619B1/en not_active IP Right Cessation
- 1987-12-22 IL IL84917A patent/IL84917A/xx not_active IP Right Cessation
- 1987-12-22 JP JP62325121A patent/JPS63166866A/ja active Pending
- 1987-12-22 PH PH36289A patent/PH23448A/en unknown
- 1987-12-22 CA CA000555175A patent/CA1318671C/en not_active Expired - Fee Related
- 1987-12-22 PT PT86448A patent/PT86448B/pt not_active IP Right Cessation
- 1987-12-22 EP EP87311275A patent/EP0272910B1/de not_active Expired - Lifetime
- 1987-12-22 AU AU82933/87A patent/AU594220B2/en not_active Ceased
- 1987-12-22 NZ NZ223036A patent/NZ223036A/en unknown
- 1987-12-22 AT AT87311275T patent/ATE65993T1/de active
- 1987-12-22 HU HU875962A patent/HU196991B/hu not_active IP Right Cessation
1991
- 1991-08-08 GR GR91401029T patent/GR3002445T3/el unknown
1992
- 1992-06-29 MX MX9203788A patent/MX9203788A/es unknown

Also Published As

Publication number	Publication date
KR880007514A (ko)	1988-08-27
DK163429B (da)	1992-03-02
AU594220B2 (en)	1990-03-01
MY102277A (en)	1992-05-15
GB8630702D0 (en)	1987-02-04
US4937248A (en)	1990-06-26
FI875666A0 (fi)	1987-12-22
ES2029842T3 (es)	1992-10-01
FI90768C (fi)	1994-03-25
DK680887D0 (da)	1987-12-22
PT86448A (en)	1988-01-01
EP0272910B1 (de)	1991-08-07
IE873490L (en)	1988-06-23
GR3002445T3 (en)	1992-12-30
ATE65993T1 (de)	1991-08-15
NZ223036A (en)	1990-11-27
MX9203788A (es)	1992-07-01
FI875666L (fi)	1988-06-24
IL84917A0 (en)	1988-06-30
HU196991B (en)	1989-02-28
AU8293387A (en)	1988-06-23
EP0272910A1 (de)	1988-06-29
HUT45984A (en)	1988-09-28
JPS63166866A (ja)	1988-07-11
FI90768B (fi)	1993-12-15
DE3772015D1 (de)	1991-09-12
IE60619B1 (en)	1994-07-27
DK680887A (da)	1988-06-24
PH23448A (en)	1989-08-07
IL84917A (en)	1991-08-16
PT86448B (pt)	1990-11-20
ZA879615B (en)	1989-08-30
CA1318671C (en)	1993-06-01

Legal Events

Date	Code	Title	Description
1996-08-19	PBP	Patent lapsed

Publication	Publication Date	Title
DK163429C (da)	1992-07-20	Carbostyrilderivat og farmaceutisk acceptable salte deraf, saadanne forbindelser til anvendelse som positive inotropiske midler, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater, farmaceutiske praeparater indeholdende en saadan forbindelse, samt fremgangsmaade til forbindelsernes fremstilling
DK43882A (da)	1982-08-03	Fremgangsmaade til fremstilling af cephemforbindelser
DK502781A (da)	1982-05-15	Fremgangsmaade til fremstilling af 3-aryloxy-3-phenylpropylaminer
DE69132435D1 (de)	2000-11-09	Inhibitoren retroviraler Proteasen
FI903331A0 (fi)	1990-07-02	Substituerade kinazolinoner, vilka aer anvaendbara som angiotensin-ii-antagonister.
DK262585A (da)	1985-12-15	Polypeptider og salte deraf samt fremgangsmaade til fremstilling af saadanne forbindelser
NO892982D0 (no)	1989-07-20	Tetrahydro-1-benz-(c,d)-indolpropionsyre-sulfonamider.
ES554895A0 (es)	1988-04-01	Un procedimiento para preparar derivados de (benzoil-4-piperidinil-1)-2-fenil-1-alcanoles
DK397387A (da)	1988-02-01	Carbostyrilderivater og salte deraf samt fremgangsmaade til fremstilling af saadanne forbindelser
DK471586A (da)	1987-04-05	3-vinyl- og 3-ethynyl-beta-carbolinderivater, deres fremstilling og deres anvendelse som laegemiddel
DK262485A (da)	1985-12-15	Polypeptider og salte deraf samt fremgangsmaade til fremstilling af saadanne forbindelser
ES2086917T3 (es)	1996-07-01	Procedimiento para preparar compuestos de diestirilbifenilo.
ES524386A0 (es)	1985-04-16	Procedimiento para la obtencion de muramilpeptidos
DK0480155T3 (da)	1996-06-10	4-Substituerede dihydropyrido(4,3-d)pyrimidiner som analgetica og topiske antiinflammatoriske midler til behandling af hudlidelser
DK262685D0 (da)	1985-06-12	Polypeptider og salte deraf samt fremgangsmaade til fremstilling af saadanne forbindelser
DK0566175T3 (da)	1998-01-26	3,4-diaryl-(5H)-furan-2-on-baserede forbindelser med fungicid aktivitet
DK0676399T3 (da)	2000-03-20	Methotrexaderivater
FI863625A0 (fi)	1986-09-09	Difenyleterherbicider.
ATE63910T1 (de)	1991-06-15	Diphenyletherderivate.
DE69315712D1 (de)	1998-01-29	2,4-Diamino-1,3,5-Triazinyl-6-Phosphonsäurederivate
DK232883D0 (da)	1983-05-24	Fremgangsmade til fremstilling af optisk aktive imidazolylpropanolforbindelser
ES544710A0 (es)	1986-01-16	Procedimiento para la obtencion de iminosulfonamidas
ATE47841T1 (de)	1989-11-15	5-sulfonamido-1-aryl-pyrazole.