DK1641780T3 - Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater - Google Patents
Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivaterInfo
- Publication number
- DK1641780T3 DK1641780T3 DK04736779T DK04736779T DK1641780T3 DK 1641780 T3 DK1641780 T3 DK 1641780T3 DK 04736779 T DK04736779 T DK 04736779T DK 04736779 T DK04736779 T DK 04736779T DK 1641780 T3 DK1641780 T3 DK 1641780T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzimidazol
- quinolin
- piperidin
- preparation
- methods
- Prior art date
Links
- ZPCBPHZWHMRXLJ-UHFFFAOYSA-N 1-[2-(benzimidazol-1-yl)quinolin-8-yl]piperidin-4-amine Chemical class C1CC(N)CCN1C1=CC=CC2=CC=C(N3C4=CC=CC=C4N=C3)N=C12 ZPCBPHZWHMRXLJ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48217603P | 2003-06-24 | 2003-06-24 | |
| PCT/IB2004/001983 WO2004113322A1 (en) | 2003-06-24 | 2004-06-14 | Processes for the preparation of 1-[(benzoimidazole-1yl) quinolin-8-yl] piperidin-4-ylamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1641780T3 true DK1641780T3 (da) | 2009-02-02 |
Family
ID=33539339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04736779T DK1641780T3 (da) | 2003-06-24 | 2004-06-14 | Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7183414B2 (de) |
| EP (1) | EP1641780B1 (de) |
| JP (1) | JP2007516168A (de) |
| KR (2) | KR100787649B1 (de) |
| CN (1) | CN100404530C (de) |
| AR (1) | AR044849A1 (de) |
| AT (1) | ATE414077T1 (de) |
| AU (1) | AU2004249511B2 (de) |
| BR (1) | BRPI0411794A (de) |
| CA (1) | CA2529032C (de) |
| CL (1) | CL2004001470A1 (de) |
| CO (1) | CO5650165A2 (de) |
| DE (1) | DE602004017731D1 (de) |
| DK (1) | DK1641780T3 (de) |
| ES (1) | ES2315663T3 (de) |
| IL (1) | IL172064A (de) |
| MX (1) | MXPA05014203A (de) |
| NO (1) | NO20060376L (de) |
| NZ (2) | NZ571898A (de) |
| RU (1) | RU2323214C2 (de) |
| SG (1) | SG161745A1 (de) |
| TW (1) | TWI294425B (de) |
| WO (1) | WO2004113322A1 (de) |
| ZA (1) | ZA200509253B (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| EP1799670A1 (de) * | 2004-10-07 | 2007-06-27 | Pfizer Products Inc. | Als antiproliferative mittel geeignete benzimidazolderivate |
| NZ562468A (en) * | 2005-04-05 | 2009-10-30 | Pharmacopeia Inc | Purine and imidazopyridine derivatives for immunosuppression |
| US7504513B2 (en) | 2006-02-27 | 2009-03-17 | Hoffman-La Roche Inc. | Thiazolyl-benzimidazoles |
| ES2378513T3 (es) | 2008-08-06 | 2012-04-13 | Pfizer Inc. | Compuestos 2-heterociclilamino piracinas sustituidas en posición 6 como inhibidores de CHK-1 |
| CA2745596A1 (en) | 2008-12-18 | 2010-10-28 | F. Hoffmann-La Roche Ag | Thiazolyl-benzimidazoles |
| CN101993416B (zh) * | 2009-08-27 | 2013-09-11 | 中国科学院上海药物研究所 | 喹啉类化合物、其制备方法、包含该化合物的药物组合物及该化合物的用途 |
| JP6407504B2 (ja) | 2012-09-21 | 2018-10-17 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法 |
| TWI599356B (zh) | 2012-09-26 | 2017-09-21 | 安羅格製藥有限責任公司 | 抑制突變型ｃ－ｋｉｔ的方法 |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| US11642340B2 (en) | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| BR112015016282A2 (en) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals, Inc. | crenolanib for treatment of mutated flt3 proliferative disorders |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| BR112019008762A2 (pt) | 2016-11-02 | 2019-07-16 | Arog Pharmaceuticals, Inc. | método para o tratamento de um distúrbio proliferativo mutado em flt3 |
| US12534764B2 (en) | 2016-11-02 | 2026-01-27 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| CN107382984B (zh) * | 2017-08-24 | 2020-07-10 | 扬州市三药制药有限公司 | 一种治疗白血病药物的制备方法 |
| CN110840893A (zh) | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| CN109678849A (zh) * | 2019-01-16 | 2019-04-26 | 北京悦康科创医药科技股份有限公司 | 一种抗癌药物的制备方法 |
| US11471451B2 (en) | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN117447376A (zh) * | 2019-12-09 | 2024-01-26 | 苏州恩华生物医药科技有限公司 | 连双环结构sigma-1受体抑制剂 |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| WO2022019998A1 (en) | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| JP2023536068A (ja) * | 2020-07-20 | 2023-08-23 | アログ・ファーマシューティカルズ・インコーポレイテッド | クレノラニブの結晶形態およびそれを用いる方法 |
| AU2021320860A1 (en) | 2020-08-05 | 2023-02-23 | The General Hospital Corporation | Salt inducible kinase inhibitors |
| US11524006B2 (en) | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| US20220079934A1 (en) * | 2020-09-17 | 2022-03-17 | Arog Pharmaceuticals, Inc. | Crenolanib for treating pain |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| WO2022090547A1 (en) | 2020-10-30 | 2022-05-05 | Dsm Ip Assets B.V. | Production of carotenoids by fermentation |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
| JP2023063189A (ja) | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4897401A (en) * | 1987-06-19 | 1990-01-30 | Janssen Pharmaceutical N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases |
| US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
| HU225960B1 (en) * | 1997-02-27 | 2008-01-28 | Takeda Pharmaceutical | Amine compounds, their production and use |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| WO2001042017A1 (en) * | 1999-12-10 | 2001-06-14 | Fujitsu Limited | Ink-jet head and printer |
| EP1321454A4 (de) * | 2000-09-14 | 2005-11-02 | Kaneka Corp | Verfahren zur abtrennung von nitrobenzenesulfonyl |
| PA8580301A1 (es) * | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
-
2004
- 2004-06-14 DK DK04736779T patent/DK1641780T3/da active
- 2004-06-14 RU RU2005138367/04A patent/RU2323214C2/ru active
- 2004-06-14 CA CA002529032A patent/CA2529032C/en not_active Expired - Lifetime
- 2004-06-14 JP JP2006516552A patent/JP2007516168A/ja active Pending
- 2004-06-14 CL CL200401470A patent/CL2004001470A1/es unknown
- 2004-06-14 MX MXPA05014203A patent/MXPA05014203A/es active IP Right Grant
- 2004-06-14 DE DE602004017731T patent/DE602004017731D1/de not_active Expired - Lifetime
- 2004-06-14 SG SG200700254-6A patent/SG161745A1/en unknown
- 2004-06-14 WO PCT/IB2004/001983 patent/WO2004113322A1/en not_active Ceased
- 2004-06-14 AU AU2004249511A patent/AU2004249511B2/en not_active Ceased
- 2004-06-14 EP EP04736779A patent/EP1641780B1/de not_active Expired - Lifetime
- 2004-06-14 KR KR1020057024593A patent/KR100787649B1/ko not_active Expired - Fee Related
- 2004-06-14 AT AT04736779T patent/ATE414077T1/de not_active IP Right Cessation
- 2004-06-14 ES ES04736779T patent/ES2315663T3/es not_active Expired - Lifetime
- 2004-06-14 NZ NZ571898A patent/NZ571898A/en not_active IP Right Cessation
- 2004-06-14 BR BRPI0411794-8A patent/BRPI0411794A/pt not_active IP Right Cessation
- 2004-06-14 KR KR1020077019713A patent/KR20070092333A/ko not_active Withdrawn
- 2004-06-14 CN CNB2004800175706A patent/CN100404530C/zh not_active Expired - Lifetime
- 2004-06-14 NZ NZ543714A patent/NZ543714A/en not_active IP Right Cessation
- 2004-06-22 AR ARP040102160A patent/AR044849A1/es unknown
- 2004-06-23 TW TW093118112A patent/TWI294425B/zh not_active IP Right Cessation
- 2004-06-23 US US10/875,030 patent/US7183414B2/en not_active Expired - Lifetime
-
2005
- 2005-11-15 ZA ZA200509253A patent/ZA200509253B/en unknown
- 2005-11-20 IL IL172064A patent/IL172064A/en active IP Right Grant
- 2005-12-20 CO CO05127734A patent/CO5650165A2/es active IP Right Grant
-
2006
- 2006-01-24 NO NO20060376A patent/NO20060376L/no not_active Application Discontinuation
- 2006-12-05 US US11/567,071 patent/US20070088032A1/en not_active Abandoned
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