DK1644351T3 - Imidazolderivater og anvendelsen deraf i behandlingen af mGluR5-receptormedierede lidelser - Google Patents

Imidazolderivater og anvendelsen deraf i behandlingen af mGluR5-receptormedierede lidelser

Info

Publication number
DK1644351T3
DK1644351T3 DK04740542T DK04740542T DK1644351T3 DK 1644351 T3 DK1644351 T3 DK 1644351T3 DK 04740542 T DK04740542 T DK 04740542T DK 04740542 T DK04740542 T DK 04740542T DK 1644351 T3 DK1644351 T3 DK 1644351T3
Authority
DK
Denmark
Prior art keywords
treatment
imidazole derivatives
mediated disorders
mglur5 receptor
mglur5
Prior art date
Application number
DK04740542T
Other languages
Danish (da)
English (en)
Inventor
Bernd Buettelmann
Simona Maria Ceccarelli
Georg Jaeschke
Sabine Kolczewski
Richard Hugh Philip Porter
Eric Vieira
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1644351T3 publication Critical patent/DK1644351T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK04740542T 2003-07-03 2004-07-01 Imidazolderivater og anvendelsen deraf i behandlingen af mGluR5-receptormedierede lidelser DK1644351T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03014512 2003-07-03
PCT/EP2004/007177 WO2005003117A1 (en) 2003-07-03 2004-07-01 Imidazole derivatives iii

Publications (1)

Publication Number Publication Date
DK1644351T3 true DK1644351T3 (da) 2008-06-23

Family

ID=33560749

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04740542T DK1644351T3 (da) 2003-07-03 2004-07-01 Imidazolderivater og anvendelsen deraf i behandlingen af mGluR5-receptormedierede lidelser

Country Status (27)

Country Link
US (1) US7091222B2 (de)
EP (1) EP1644351B1 (de)
JP (1) JP4571631B2 (de)
KR (1) KR100719653B1 (de)
CN (1) CN100562520C (de)
AR (1) AR044973A1 (de)
AT (1) ATE388145T1 (de)
AU (1) AU2004253657B2 (de)
BR (1) BRPI0412158A (de)
CA (1) CA2531210C (de)
CO (1) CO5660258A2 (de)
DE (1) DE602004012268T2 (de)
DK (1) DK1644351T3 (de)
ES (1) ES2300789T3 (de)
HR (1) HRP20080173T3 (de)
IL (1) IL172821A (de)
MX (1) MXPA06000193A (de)
MY (1) MY142085A (de)
NO (1) NO20060112L (de)
NZ (1) NZ544454A (de)
PL (1) PL1644351T3 (de)
PT (1) PT1644351E (de)
RU (1) RU2360911C2 (de)
SI (1) SI1644351T1 (de)
TW (1) TWI252849B (de)
WO (1) WO2005003117A1 (de)
ZA (1) ZA200600026B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
HRP20080363T3 (hr) 2004-06-01 2008-09-30 F. Hoffmann - La Roche Ag Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora
EP1756086B1 (de) * 2004-06-01 2008-06-04 F.Hoffmann-La Roche Ag Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors
US20060173048A1 (en) * 2005-02-03 2006-08-03 Mcarthur Silvia G Imidazole derivatives
DE102005062987A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
AU2007336369B2 (en) * 2006-12-21 2013-01-17 F. Hoffmann-La Roche Ag Polymorphs of a mGluR5 receptor antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US304910A (en) * 1884-09-09 Robeet h
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
US7531529B2 (en) * 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives

Also Published As

Publication number Publication date
US20050009878A1 (en) 2005-01-13
CO5660258A2 (es) 2006-07-31
EP1644351B1 (de) 2008-03-05
KR100719653B1 (ko) 2007-05-18
JP2009500291A (ja) 2009-01-08
IL172821A (en) 2011-01-31
NZ544454A (en) 2008-08-29
CA2531210C (en) 2012-05-29
RU2006103009A (ru) 2006-08-27
MXPA06000193A (es) 2006-04-11
KR20060029677A (ko) 2006-04-06
MY142085A (en) 2010-08-30
TW200514779A (en) 2005-05-01
NO20060112L (no) 2006-01-24
HRP20080173T3 (hr) 2008-06-30
TWI252849B (en) 2006-04-11
ATE388145T1 (de) 2008-03-15
PT1644351E (pt) 2008-04-21
BRPI0412158A (pt) 2006-08-22
CA2531210A1 (en) 2005-01-13
CN1823054A (zh) 2006-08-23
RU2360911C2 (ru) 2009-07-10
JP4571631B2 (ja) 2010-10-27
ES2300789T3 (es) 2008-06-16
DE602004012268D1 (de) 2008-04-17
EP1644351A1 (de) 2006-04-12
CN100562520C (zh) 2009-11-25
ZA200600026B (en) 2007-05-30
WO2005003117A1 (en) 2005-01-13
SI1644351T1 (sl) 2008-06-30
AU2004253657B2 (en) 2009-09-03
AU2004253657A1 (en) 2005-01-13
IL172821A0 (en) 2006-06-11
AR044973A1 (es) 2005-10-12
DE602004012268T2 (de) 2009-03-12
PL1644351T3 (pl) 2008-08-29
US7091222B2 (en) 2006-08-15

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