DK1648496T3 - Fremgangsmåde til stabilisering af et kryopræcipitat af plasmatiske proteiner, som er beregnet til at udsættes for en varmebehandling til virusinaktivering - Google Patents

Fremgangsmåde til stabilisering af et kryopræcipitat af plasmatiske proteiner, som er beregnet til at udsættes for en varmebehandling til virusinaktivering

Info

Publication number
DK1648496T3
DK1648496T3 DK04767620.0T DK04767620T DK1648496T3 DK 1648496 T3 DK1648496 T3 DK 1648496T3 DK 04767620 T DK04767620 T DK 04767620T DK 1648496 T3 DK1648496 T3 DK 1648496T3
Authority
DK
Denmark
Prior art keywords
stabilizing
proteins
cryoprecipitate
subjected
heat treatment
Prior art date
Application number
DK04767620.0T
Other languages
English (en)
Inventor
Annie Bardat
Edith Begin
Original Assignee
Lab Francais Du Fractionnement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Francais Du Fractionnement filed Critical Lab Francais Du Fractionnement
Application granted granted Critical
Publication of DK1648496T3 publication Critical patent/DK1648496T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK04767620.0T 2003-07-09 2004-07-08 Fremgangsmåde til stabilisering af et kryopræcipitat af plasmatiske proteiner, som er beregnet til at udsættes for en varmebehandling til virusinaktivering DK1648496T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0308403A FR2857267B1 (fr) 2003-07-09 2003-07-09 Formulation stabilisante et solubilisante pour les proteines cryoprecipitables.
PCT/FR2004/001788 WO2005004901A1 (fr) 2003-07-09 2004-07-08 Procede de stabilisation d’un cryoprecipite de proteines plasmatiques destine a etre soumis a un traitement thermique d’inactivation virale

Publications (1)

Publication Number Publication Date
DK1648496T3 true DK1648496T3 (da) 2012-05-07

Family

ID=33522899

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04767620.0T DK1648496T3 (da) 2003-07-09 2004-07-08 Fremgangsmåde til stabilisering af et kryopræcipitat af plasmatiske proteiner, som er beregnet til at udsættes for en varmebehandling til virusinaktivering

Country Status (13)

Country Link
US (1) US7727743B2 (da)
EP (1) EP1648496B1 (da)
JP (2) JP4925822B2 (da)
AT (1) ATE546155T1 (da)
AU (1) AU2004255503B2 (da)
BR (1) BRPI0412441A (da)
CA (1) CA2531419C (da)
DK (1) DK1648496T3 (da)
ES (1) ES2382934T3 (da)
FR (1) FR2857267B1 (da)
IL (1) IL172844A (da)
PL (1) PL1648496T3 (da)
WO (1) WO2005004901A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100624013B1 (ko) * 2004-06-25 2006-09-19 주식회사 녹십자홀딩스 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
US20060019234A1 (en) * 2004-07-22 2006-01-26 Shanbrom Technologies, Llc Modern blood banking employing improved cell preservation composition
FR2874216B1 (fr) 2004-08-16 2006-11-03 Lab Francais Du Fractionnement Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu
RU2293570C2 (ru) * 2005-02-01 2007-02-20 Государственное учреждение Гематологический научный центр РАМН (ГУ ГНЦ РАМН) Способ обогащения фактором viii криопреципитата плазмы донорской крови
FR2894831B1 (fr) * 2005-12-16 2008-02-15 Lab Francais Du Fractionnement Colle biologique exempte de thrombine et son utilisation comme medicament.
ES2264403B1 (es) * 2006-06-22 2007-11-01 Grifols S.A. Medio de suspension de hematies.
EP2170268A2 (en) 2007-06-25 2010-04-07 Amgen, Inc. Compositions of specific binding agents to hepatocyte growth factor
US8349367B2 (en) * 2007-10-12 2013-01-08 Bakaltcheva Irina B Freeze-dried plasma formats for the trauma care field
FR2947181B1 (fr) 2009-06-26 2012-05-04 Lfb Biotechnologies Composition de facteur vii
TW201335181A (zh) * 2012-01-31 2013-09-01 Kieu Hoang ５５種新發現的蛋白質之序列及其應用
FR3053592B1 (fr) * 2016-07-06 2020-05-29 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Fibrinogene liquide stable
KR20190026000A (ko) * 2016-07-06 2019-03-12 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 안정적 액체 피브리노겐
FR3061020B1 (fr) * 2016-12-22 2019-05-17 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Composition de fibrinogene humain
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
CN113597532B (zh) 2019-03-14 2023-02-17 泰尔茂比司特生物技术有限公司 冻干容器填充固定装置、系统及使用方法
US20250073313A1 (en) 2021-12-21 2025-03-06 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions
CN118344463B (zh) * 2024-05-15 2024-12-13 广东丹霞生物制药有限公司 一种人纤维蛋白原的制备方法及产品

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4456590B2 (en) 1981-11-02 1989-05-30 Heat treatment of lyphilized blood clotting factor viii concentrate
DE3203775A1 (de) * 1982-02-04 1983-08-11 Behringwerke Ag, 3550 Marburg Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
US4470968A (en) * 1983-01-13 1984-09-11 Miles Laboratories, Inc. Pasteurized therapeutically active blood coagulation factor concentrates
CA1260389A (en) 1984-10-10 1989-09-26 Jay A. Levy Human plasma, plasma fractions, and compositions thereof substantially free of infectious viruses, bacteria and retroviruses
JPS6289628A (ja) * 1985-09-11 1987-04-24 Green Cross Corp:The 人フイブリノゲン製剤の加熱処理法
DE3622642A1 (de) * 1986-07-05 1988-01-14 Behringwerke Ag Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
JPS6419023A (en) * 1987-04-21 1989-01-23 Green Cross Corp Heat treatment of fibrinogen and fibrinogen preparation
DE3729863A1 (de) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh Stabilisierte erythropoietin-lyophilisate
FR2632309B1 (fr) 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
WO1993022336A1 (en) * 1992-04-30 1993-11-11 Alpha Therapeutic Corporation Improved solubilization and stabilization of factor viii complex
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
GB9424732D0 (en) * 1994-12-08 1995-02-08 Common Services Agency Heat treated blood plasma proteins
AUPO871997A0 (en) * 1997-08-25 1997-09-18 Csl Limited Dried biologically or therapeutically active preparations
ID24279A (id) * 1998-06-26 2000-07-13 Otsuka Pharma Co Ltd Komposisi kering yang terlarut dalam air
JP2000247903A (ja) * 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
JP2001270900A (ja) * 2000-03-23 2001-10-02 Nihon Pharmaceutical Co Ltd フィブリノゲンのウイルス不活化法
US6623717B2 (en) * 2001-03-28 2003-09-23 Council Of Scientific And Industrial Research Process for the preparation of LiBF4
JP2003055257A (ja) * 2001-08-10 2003-02-26 Nihon Pharmaceutical Co Ltd 安定な血液凝固第ｘｉｉｉ因子製剤

Also Published As

Publication number Publication date
EP1648496A1 (fr) 2006-04-26
US7727743B2 (en) 2010-06-01
FR2857267A1 (fr) 2005-01-14
WO2005004901A1 (fr) 2005-01-20
IL172844A (en) 2011-11-30
CA2531419A1 (fr) 2005-01-20
JP4925822B2 (ja) 2012-05-09
AU2004255503B2 (en) 2010-12-16
PL1648496T3 (pl) 2012-07-31
ATE546155T1 (de) 2012-03-15
IL172844A0 (en) 2006-06-11
JP5719266B2 (ja) 2015-05-13
FR2857267B1 (fr) 2006-03-10
JP2007516187A (ja) 2007-06-21
CA2531419C (fr) 2014-12-23
BRPI0412441A (pt) 2006-09-05
JP2012051895A (ja) 2012-03-15
EP1648496B1 (fr) 2012-02-22
ES2382934T3 (es) 2012-06-14
US20060247426A1 (en) 2006-11-02
AU2004255503A1 (en) 2005-01-20

Similar Documents

Publication Publication Date Title
DK1648496T3 (da) Fremgangsmåde til stabilisering af et kryopræcipitat af plasmatiske proteiner, som er beregnet til at udsættes for en varmebehandling til virusinaktivering
DE602004031134D1 (de) Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
ATE481106T1 (de) Heterocyclische sulfonamid-hepatitis-c-virus- hemmer
EA200201279A1 (ru) Способы и композиции для лечения вирусного гепатита c
NO20050490L (no) 2'-C-metyl-3'-O-L-valinester ribofuranosylcytidin for behandling av flaviviridae infeksjoner
NO20044897L (no) Hepatitt C virus inhibitorer
EA200500584A1 (ru) Нуклеозидные производные для лечения инфекционных заболеваний, вызванных вирусом гепатита c
CY1109012T1 (el) Παραγωγα νουκλεοσιδιου σαν αναστολεις της rna-εξαρτωμενης rna iϊκης πολυμepασης
EA200601467A1 (ru) Макроциклические соединения в качестве ингибиторов вирусной репликации
ES2140418T3 (es) Flavivirus quimericos y/o flavivirus de crecimiento restringido.
EA200401525A1 (ru) Способы лечения гепатита (варианты )
DK1387681T3 (da) Anvendelse af castanosperinderivater til behandling af hepatitis C
FR2827605B1 (fr) Nouveaux peptides derives de la proteine g du vrs et leur utilisation dans un vaccin
EA201892493A1 (ru) Жидкая композиция нейротоксина, стабилизированная триптофаном или тирозином
DE60319083D1 (de) Pharmazeutische verbindung und methoden zur behandlung von menschlichen karzinomen mittels arginin entzug
DE502004011851D1 (de) Caspase 3, 8, 9 oder 10 Inhibitoren in Kombination mit MEK Inhibitoren zur Behandlung von Influenza
EP1544214A4 (en) Non-neutralizing anti-aPC antibodies
ATE477810T1 (de) Stabilisierte albumin-zubereitungen
DE60204224D1 (de) Verwendung bestimmter substituierter pyrrolidone wie z.b. piracetam bei der behandlung von viralen und anderen erkrankungen
NO993407L (no) Fremstilling av proteinpreparater med nedsatt aggregatinnhold
DE602006014720D1 (de) Immunstimulatorische kombination zur vorbeugung und behandlung von hepatitis c
DK1341813T3 (da) Anvendelse af L-carnitin som stabiliseringsmiddel af proteiner
DE602005006809D1 (de) Behandlung von nicht-alkoholischer steatotischer hepatitis (nash)
NO20051159L (no) Preparater og fremgangsmater for behandling av sykdommer som viser feilsammensetting av aggregering av protein
ATE407925T1 (de) 1,4-dihydropyridinverbindungen, pharmazeutische verbindungen, und verfahren zur behandlung von herzkreislauferkrankungen