DK165112C - 2,2'-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse - Google Patents

2,2'-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse

Info

Publication number: DK165112C
Authority: DK; Denmark
Prior art keywords: iminobisethanold; procedures; derivatives; preparing; pharmaceutical preparations
Prior art date: 1983-12-05

Application number

DK577084A

Other languages

Danish (da)

English (en)

Other versions

DK165112B (da

DK577084D0 (da

DK577084A (da

Inventor

Guy Rasalia Eugene Van Lommen

Marcel Frans Leopold De Bruyn

Marc Francis Josephin Schroven

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-05

Filing date

1984-12-04

Publication date

1993-03-01

1984-12-04 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1984-12-04 Publication of DK577084D0 publication Critical patent/DK577084D0/da

1985-06-06 Publication of DK577084A publication Critical patent/DK577084A/da

1992-10-12 Publication of DK165112B publication Critical patent/DK165112B/da

1993-03-01 Application granted granted Critical

1993-03-01 Publication of DK165112C publication Critical patent/DK165112C/da

Links

238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK577084A 1983-12-05 1984-12-04 2,2'-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse DK165112C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55808183A	1983-12-05	1983-12-05
US55808183		1983-12-05

Publications (4)

Publication Number	Publication Date
DK577084D0 DK577084D0 (da)	1984-12-04
DK577084A DK577084A (da)	1985-06-06
DK165112B DK165112B (da)	1992-10-12
DK165112C true DK165112C (da)	1993-03-01

Family

ID=24228139

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK577084A DK165112C (da)	1983-12-05	1984-12-04	2,2'-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse
DK011892A DK165321C (da)	1983-12-05	1992-01-31	Oxiranderivater og fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK011892A DK165321C (da)	1983-12-05	1992-01-31	Oxiranderivater og fremgangsmaade til fremstilling deraf

Country Status (32)

Country	Link
EP (1)	EP0145067B1 (2)
JP (1)	JPS60132977A (2)
KR (1)	KR870000923B1 (2)
AR (1)	AR241414A1 (2)
AT (1)	ATE40361T1 (2)
AU (1)	AU573658B2 (2)
BG (1)	BG43866A3 (2)
CA (1)	CA1337429C (2)
CS (1)	CS250242B2 (2)
CY (1)	CY1609A (2)
DD (1)	DD235453A5 (2)
DE (1)	DE3476388D1 (2)
DK (2)	DK165112C (2)
DZ (1)	DZ712A1 (2)
ES (1)	ES8603870A1 (2)
FI (1)	FI82460C (2)
GR (1)	GR81098B (2)
HK (1)	HK52791A (2)
HU (1)	HU202219B (2)
IE (1)	IE57831B1 (2)
IL (1)	IL73706A (2)
MA (1)	MA20292A1 (2)
NO (2)	NO169839C (2)
NZ (1)	NZ210388A (2)
PH (1)	PH22432A (2)
PL (1)	PL146342B1 (2)
PT (1)	PT79609B (2)
RO (1)	RO91184B (2)
SG (1)	SG47091G (2)
SU (1)	SU1428199A3 (2)
ZA (1)	ZA849445B (2)
ZW (1)	ZW19784A1 (2)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1337432C (en) *	1988-03-23	1995-10-24	Raymond M. Xhonneux	Method of lowering the blood pressure
JPH02103116U (2) *	1989-02-01	1990-08-16
JPH02218675A (ja) *	1989-02-21	1990-08-31	Nippon Kayaku Co Ltd	６―フルオロクロモン―２―カルボン酸及びその製造法
TW199152B (2) *	1990-11-01	1993-02-01	Takeda Pharm Industry Co Ltd
ATE256130T1 (de) *	1993-08-19	2003-12-15	Janssen Pharmaceutica Nv	Gefässverengende dihydrobenzopyranderivate
TW355683B (en) *	1994-02-17	1999-04-11	Janssen Pharmaceutica Nv	Composition containing micronized nebivolol
ES2169102T3 (es) *	1994-10-14	2002-07-01	Merck Patent Gmbh	(r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central.
AU733669B2 (en) *	1996-06-07	2001-05-24	Vanderbilt University	Dihydrobenzopyran and related compounds useful as anti-inflammatory agents
DK1040106T3 (da) *	1997-12-19	2002-12-02	Bayer Ag	Carboxylsubstituerede chromanderivater til anvendelse som beta 3 adrenoreceptor-agonister
US6713651B1 (en)	1999-06-07	2004-03-30	Theravance, Inc.	β2-adrenergic receptor agonists
US6362371B1 (en)	1998-06-08	2002-03-26	Advanced Medicine, Inc.	β2- adrenergic receptor agonists
US6593497B1 (en)	1999-06-02	2003-07-15	Theravance, Inc.	β2-adrenergic receptor agonists
US6683115B2 (en)	1999-06-02	2004-01-27	Theravance, Inc.	β2-adrenergic receptor agonists
UA73965C2 (en)	1999-12-08	2005-10-17	Theravance Inc	b2 ADRENERGIC RECEPTOR ANTAGONISTS
UA73981C2 (en)	2000-03-10	2005-10-17	Merck Patent Gmbh	(r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
ATE437637T1 (de)	2001-05-02	2009-08-15	Nitromed Inc	Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
ATE352302T1 (de)	2001-07-26	2007-02-15	Merck Patent Gmbh	Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze
US6653323B2 (en)	2001-11-13	2003-11-25	Theravance, Inc.	Aryl aniline β2 adrenergic receptor agonists
TWI249515B (en)	2001-11-13	2006-02-21	Theravance Inc	Aryl aniline beta2 adrenergic receptor agonists
WO2006025070A2 (en)	2004-07-30	2006-03-09	Torrent Pharmaceuticals Limited	Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol
ES2341250T3 (es) *	2004-08-11	2010-06-17	Hetero Drugs Limited	Procedimiento novedoso de preparacion de intermediarios de nebivolol.
CN100341866C (zh) *	2004-08-30	2007-10-10	中国科学院理化技术研究所	α，α’－[亚氨基二（亚甲基）]－双－（6－氟－3，4－二氢－2H－1－苯并吡喃－2－甲醇）甲烷磺酸盐的合成方法
NZ560386A (en)	2005-01-31	2009-12-24	Mylan Lab Inc	Pharmaceutical composition comprising hydroxylated nebivolol
WO2006083780A2 (en) *	2005-01-31	2006-08-10	Mylan Laboratories, Inc.	Glucuronidated nebivolol
WO2006084684A1 (de) *	2005-02-11	2006-08-17	Stada Arzneimittel Ag	Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer
AT502220A1 (de) *	2005-07-19	2007-02-15	Pharmacon Forschung & Beratung	Verfahren zur herstellung von nebivolol
RU2392277C2 (ru) *	2005-12-28	2010-06-20	Асино Фарма Аг	Способ получения рацемического небиволола
EP1803716B1 (en) *	2005-12-28	2012-07-25	Acino Pharma AG	A process for preparation of racemic nebivolol
US7560575B2 (en)	2005-12-28	2009-07-14	Acino Pharma Ag	Process for preparation of racemic Nebivolol
US7858812B2 (en)	2006-01-18	2010-12-28	Hetero Drugs Limited	Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) *	2006-10-03	2008-04-04	Zambon Spa	Processo di preparazione di nebivololo
PL2099790T3 (pl)	2006-11-27	2010-12-31	Zach System Spa	Sposób wytwarzania nebiwololu
US20100137424A1 (en)	2007-01-22	2010-06-03	Mostafa Akbarieh	Pharmaceutical compositions comprising nebivolol or a nebivolol analogue
CN101463024B (zh)	2007-12-21	2011-06-08	上海现代制药股份有限公司	一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
ITMI20080547A1 (it) *	2008-03-31	2009-10-01	Zach System Spa	Processo di preparazione di nebivololo
IT1392067B1 (it) *	2008-10-31	2012-02-09	Zach System Spa	Processo di preparazione di nebivololo
IT1395354B1 (it) *	2009-07-23	2012-09-14	Zach System Spa	Processo di preparazione di nebivololo
DE102010005953A1 (de)	2010-01-27	2011-07-28	Corden PharmaChem GmbH, 68305	Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it)	2010-02-11	2013-02-04	Menarini Int Operations Lu Sa	Processo per la preparazione del nebivololo.
IT1402974B1 (it)	2010-11-30	2013-09-27	Menarini Int Operations Lu Sa	Processo per la preparazione del nebivololo.
ITRM20110418A1 (it)	2011-08-02	2013-02-03	Menarini Int Operations Lu Sa	Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
EP2907809B1 (en)	2014-02-14	2018-08-22	Corden Pharma International GmbH	Base-free process for the preparation of ketone intermediates usable for manufacture of nebivolol
EP2907810A1 (en)	2014-02-14	2015-08-19	Corden Pharma International GmbH	A new method for producing nebivolol hydrochloride of high purity
DE102014107132A1 (de)	2014-05-20	2015-11-26	Corden Pharma International Gmbh	Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
CN107531662B (zh)	2015-05-19	2021-08-06	浙江奥翔药业股份有限公司	奈必洛尔的合成方法及其中间体化合物
CN105085499B (zh) *	2015-08-07	2018-09-25	上海现代制药海门有限公司	盐酸奈必洛尔中间体混合物的结晶分离方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1054655A (2) *	1964-01-24
US4313955A (en) *	1980-10-14	1982-02-02	Ciba-Geigy Corporation	1,5-Bis(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols
GB8418472D0 (en) *	1984-07-19	1984-08-22	Beecham Group Plc	Compounds

1984
- 1984-11-19 CA CA000468108A patent/CA1337429C/en not_active Expired - Fee Related
- 1984-11-21 PL PL1984250524A patent/PL146342B1/pl unknown
- 1984-11-22 DE DE8484201693T patent/DE3476388D1/de not_active Expired
- 1984-11-22 AT AT84201693T patent/ATE40361T1/de not_active IP Right Cessation
- 1984-11-22 EP EP84201693A patent/EP0145067B1/en not_active Expired
- 1984-11-26 KR KR1019840007404A patent/KR870000923B1/ko not_active Expired
- 1984-11-29 GR GR81098A patent/GR81098B/el unknown
- 1984-11-29 NZ NZ210388A patent/NZ210388A/en unknown
- 1984-11-30 JP JP59252038A patent/JPS60132977A/ja active Granted
- 1984-12-02 DZ DZ847346A patent/DZ712A1/fr active
- 1984-12-03 DD DD84270216A patent/DD235453A5/de not_active IP Right Cessation
- 1984-12-03 AR AR84298819A patent/AR241414A1/es active
- 1984-12-03 IL IL73706A patent/IL73706A/xx not_active IP Right Cessation
- 1984-12-03 RO RO116496A patent/RO91184B/ro unknown
- 1984-12-04 IE IE3103/84A patent/IE57831B1/en not_active IP Right Cessation
- 1984-12-04 NO NO844845A patent/NO169839C/no not_active IP Right Cessation
- 1984-12-04 BG BG067765A patent/BG43866A3/xx unknown
- 1984-12-04 FI FI844777A patent/FI82460C/fi active IP Right Grant
- 1984-12-04 PH PH31525A patent/PH22432A/en unknown
- 1984-12-04 ES ES538256A patent/ES8603870A1/es not_active Expired
- 1984-12-04 HU HU844482A patent/HU202219B/hu unknown
- 1984-12-04 ZA ZA849445A patent/ZA849445B/xx unknown
- 1984-12-04 SU SU843826501A patent/SU1428199A3/ru active
- 1984-12-04 MA MA20516A patent/MA20292A1/fr unknown
- 1984-12-04 CS CS849320A patent/CS250242B2/cs unknown
- 1984-12-04 PT PT79609A patent/PT79609B/pt unknown
- 1984-12-04 DK DK577084A patent/DK165112C/da not_active IP Right Cessation
- 1984-12-04 ZW ZW197/84A patent/ZW19784A1/xx unknown
- 1984-12-05 AU AU36326/84A patent/AU573658B2/en not_active Expired
1991
- 1991-06-18 SG SG47091A patent/SG47091G/en unknown
- 1991-07-11 HK HK527/91A patent/HK52791A/en not_active IP Right Cessation
1992
- 1992-01-31 DK DK011892A patent/DK165321C/da not_active IP Right Cessation
- 1992-04-03 CY CY1609A patent/CY1609A/xx unknown
2004
- 2004-11-26 NO NO2004007C patent/NO2004007I2/no unknown

Also Published As

Publication number	Publication date
DK11892D0 (da)	1992-01-31
ATE40361T1 (de)	1989-02-15
AU3632684A (en)	1985-06-13
ES538256A0 (es)	1986-01-01
EP0145067B1 (en)	1989-01-25
GR81098B (en)	1984-12-17
DK165112B (da)	1992-10-12
JPH0250114B2 (2)	1990-11-01
ZW19784A1 (en)	1986-07-02
DE3476388D1 (en)	1989-03-02
DK577084D0 (da)	1984-12-04
IL73706A (en)	1988-07-31
KR870000923B1 (ko)	1987-05-07
NZ210388A (en)	1987-07-31
FI82460C (fi)	1991-03-11
HUT37418A (en)	1985-12-28
RO91184A (ro)	1987-07-30
CA1337429C (en)	1995-10-24
FI82460B (fi)	1990-11-30
DK165321C (da)	1993-03-29
ZA849445B (en)	1986-07-30
PT79609B (en)	1986-12-12
EP0145067A3 (en)	1986-03-26
SG47091G (en)	1991-07-26
PL250524A1 (en)	1986-02-25
EP0145067A2 (en)	1985-06-19
IE843103L (en)	1985-06-05
FI844777L (fi)	1985-06-06
HK52791A (en)	1991-07-19
DK165321B (da)	1992-11-09
DK11892A (da)	1992-01-31
NO844845L (no)	1985-06-06
CS250242B2 (en)	1987-04-16
DD235453A5 (de)	1986-05-07
NO2004007I2 (no)	2005-05-09
PL146342B1 (en)	1989-01-31
NO169839B (no)	1992-05-04
ES8603870A1 (es)	1986-01-01
HU202219B (en)	1991-02-28
PH22432A (en)	1988-09-12
BG43866A3 (en)	1988-08-15
MA20292A1 (fr)	1985-07-01
RO91184B (ro)	1987-07-31
PT79609A (en)	1985-01-01
IL73706A0 (en)	1985-03-31
SU1428199A3 (ru)	1988-09-30
DK577084A (da)	1985-06-06
KR850004485A (ko)	1985-07-15
NO2004007I1 (no)	2004-12-20
AR241414A1 (es)	1992-07-31
NO169839C (no)	1992-08-12
IE57831B1 (en)	1993-04-21
DZ712A1 (fr)	2004-09-13
CY1609A (en)	1992-04-03
JPS60132977A (ja)	1985-07-16
AU573658B2 (en)	1988-06-16
FI844777A0 (fi)	1984-12-04

Legal Events

Date	Code	Title	Description
2004-12-20	PUP	Patent expired

Publication	Publication Date	Title
DK214090D0 (da)	1990-09-06	5-aminosulfonylalkyl-indolderivater, fremgangsmaade og mellemprodukt til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK162445C (da)	1992-03-23	Pyranopyridiner, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende pyranopyridinerne
DK539789A (da)	1990-05-01	Carbostyrilderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant carbostyrilderivat
DK211084D0 (da)	1984-04-27	Hurtigtoploesende laegemiddelpraeparater og fremgangsmaade til fremstilling heraf
NO893896L (no)	1990-03-30	Farmasoeytiske formuleringer og fremgangsmaate for fremstilling av disse.
DK577084A (da)	1985-06-06	2,2'iminobisethanol-derivater og fremgangsmaade til fremstilling deraf
DK560784D0 (da)	1984-11-27	Hoejrenset protein, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende det
DK288184A (da)	1984-12-16	13alfa-alkylgonaner, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK431586A (da)	1987-03-12	Benzimidazolderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende disse
DK213085D0 (da)	1985-05-14	Aminotetralinderivater, laegemidler indeholdende disse og fremgangsmaade til forbindelsernes fremstilling
DK166583C (da)	1993-10-25	1-pyrimidinyloxy-3-alkylamino-2-propanoler, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK160150C (da)	1991-07-01	Benzothiazinderivater, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende samme
DK162221C (da)	1992-03-02	Cinnolinforbindelser, fremgangsmaade til fremstilling deraf og farmaceutiske midler indeholdende forbindelserne
DK162600C (da)	1992-04-06	Oe4-(2-hydroxycyklohexylmethyl)phenylaaalkansyrederivater og fremgangsmaade til fremstilling deraf samt farmaceutiske midler indeholdende disse
DK183986D0 (da)	1986-04-22	Cyklopentylaetere, fremgangsmaade til fremstilling deraf og laegemiddelpraeparat indeholdende saadanne forbindelser
DK396385A (da)	1986-04-15	2,3-dihydro-lh-indenderivater, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende disse forbindelser
DK92789A (da)	1989-10-11	Polypeptidderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse
DK494088D0 (da)	1988-09-06	4-oxo-3-quinolincarboxylsyrer, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse
DK262286D0 (da)	1986-06-04	Fenantrenderivater, fremgangsmaade til fremstilling deraf og fungicide praeparater indeholdende saadanne forbindelser
DK493988D0 (da)	1988-09-06	4-oxo-3-quinolincarboxylsyrer, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse forbindelser
DK237287A (da)	1987-11-13	Propargyloxybenzen-derivater, fremgangsmaade til fremstilling deraf og praeparater med fungicid virkning indeholdende disse derivater
NO840559L (no)	1984-08-20	3-acyl-2-nitrometylen-tetrahydro-2h-1,3-tiaziner, fremgangsmaate for fremstilling derav og pesticide preparater inneholdende disse
DK159779C (da)	1991-04-22	Substituerede phenoxypropylthiopyrazolo(1,5-a)-pyridin- eller -benzimidazolderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende disse forbindelser
DK26591A (da)	1991-02-15	Cytidin-5'-diphosphatalkanoler og -glyceroler, fremgangsmaade til fremstilling heraf og praeparater indeholdende disse forbindelser
DK575387A (da)	1988-05-05	Hydrofluorenderivater, fremgangsmaade til fremstilling deraf og praeparater indeholdende saadanne forbindelser