DK1656351T3 - Fremgangsmåde til fremstilling af 4-aryl-nicotinamidderivater - Google Patents
Fremgangsmåde til fremstilling af 4-aryl-nicotinamidderivaterInfo
- Publication number
- DK1656351T3 DK1656351T3 DK04763155T DK04763155T DK1656351T3 DK 1656351 T3 DK1656351 T3 DK 1656351T3 DK 04763155 T DK04763155 T DK 04763155T DK 04763155 T DK04763155 T DK 04763155T DK 1656351 T3 DK1656351 T3 DK 1656351T3
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- formula
- compound
- sup
- compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- AGJSNMGHAVDLRQ-HUUJSLGLSA-N methyl (2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,3-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(=O)N[C@@H](CCSC)C(=O)OC)CC1=CC=C(O)C(C)=C1C AGJSNMGHAVDLRQ-HUUJSLGLSA-N 0.000 abstract 1
- 239000002742 neurokinin 1 receptor antagonist Substances 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03015599 | 2003-07-15 | ||
| PCT/EP2004/007618 WO2005014549A1 (en) | 2003-07-15 | 2004-07-10 | Process for preparation of 4-aryl-nicotinamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1656351T3 true DK1656351T3 (da) | 2008-04-21 |
Family
ID=34042828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04763155T DK1656351T3 (da) | 2003-07-15 | 2004-07-10 | Fremgangsmåde til fremstilling af 4-aryl-nicotinamidderivater |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7288658B2 (de) |
| EP (1) | EP1656351B1 (de) |
| JP (1) | JP4575918B2 (de) |
| KR (1) | KR100742013B1 (de) |
| CN (1) | CN1835922B (de) |
| AT (1) | ATE381543T1 (de) |
| CA (1) | CA2532355C (de) |
| DE (1) | DE602004010820T2 (de) |
| DK (1) | DK1656351T3 (de) |
| ES (1) | ES2297457T3 (de) |
| IL (1) | IL173000A0 (de) |
| MX (1) | MXPA06000405A (de) |
| TW (1) | TWI280239B (de) |
| WO (1) | WO2005014549A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007000198A (es) * | 2004-07-06 | 2007-03-15 | Hoffmann La Roche | Proceso para la preparacion de derivados de carboxamida-piridina utilizados como intermediarios en la sintesis de antagonistas del receptor nk-1. |
| US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
| EP2410043A3 (de) | 2004-12-29 | 2013-01-23 | Hadasit Medical Research Services And Development Ltd. | Stammzellenkultursysteme |
| US8956866B2 (en) | 2007-04-18 | 2015-02-17 | Hadasit Medical Research Services And Development Ltd. | Retinal pigment epithelial cells differentiated from embryonic stem cells with nicotinamide and activin A |
| JP2018502575A (ja) | 2014-12-30 | 2018-02-01 | セル キュア ニューロサイエンシズ リミテッド | 網膜色素上皮細胞集団の評価法 |
| IL305070B2 (en) | 2014-12-30 | 2025-11-01 | Cell Cure Neurosciences Ltd | Rpe cell populations and methods of generating same |
| JP7055095B2 (ja) | 2015-07-29 | 2022-04-15 | ハダシット メディカル リサーチ サービシーズ アンド ディベロップメント リミテッド | 網膜色素上皮細胞の大規模生産 |
| US11090337B2 (en) | 2015-08-05 | 2021-08-17 | Cell Cure Neurosciences Ltd | Preparation of photoreceptors for the treatment of retinal diseases |
| DK3331994T3 (da) | 2015-08-05 | 2022-11-21 | Cell Cure Neurosciences Ltd | Fremstilling af retinale pigmentepitelceller |
| HRP20250311T1 (hr) | 2015-10-26 | 2025-07-18 | Cell Cure Neurosciences Ltd. | Priprema stanica pigmentnog epitela mrežnice |
| CN106892864A (zh) * | 2015-12-21 | 2017-06-27 | 上海科胜药物研发有限公司 | 一种奈妥皮坦游离碱的晶型a及其制备方法 |
| CA3052872A1 (en) | 2017-02-08 | 2018-08-16 | Hadasit Medical Research Services And Development Ltd. | Photoreceptor cells for the treatment of retinal diseases |
| CA3056653A1 (en) | 2017-03-16 | 2018-09-20 | Lineage Cell Therapeutics, Inc. | Methods for the treatment of retinal diseases |
| CN111741735A (zh) | 2017-12-29 | 2020-10-02 | 细胞治疗神经科学有限公司 | 视网膜色素上皮细胞组合物 |
| CN113038951B (zh) | 2018-09-20 | 2024-04-30 | 耶达研究及发展有限公司 | 治疗肌萎缩侧索硬化的方法 |
| EP3754014A1 (de) | 2019-06-21 | 2020-12-23 | Centre d'Etude des Cellules Souches (CECS) | Automatisiertes verfahren zur herstellung von retinalen pigmentepithelzellen |
| CN110862364B (zh) * | 2019-11-14 | 2022-12-30 | 中国科学技术大学 | 制备呋喃基醛类化合物的方法 |
| TWI853255B (zh) | 2021-06-09 | 2024-08-21 | 美商譜系細胞治療公司 | 治療視網膜疾病及病況之方法及組成物 |
| MX2024001213A (es) | 2021-07-28 | 2024-03-14 | Lineage Cell Therapeutics Inc | Expansion de celulas del epitelio pigmentario retiniano. |
| CN114181142B (zh) * | 2021-12-31 | 2023-10-20 | 浙江工业大学 | 一种6-(4-甲基哌嗪-1-基)-4-邻甲苯基烟酰胺的合成方法 |
| IL316305A (en) | 2022-04-25 | 2024-12-01 | Hadasit Med Res Service | Methods and preparations for treating vision loss |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1557420A (en) | 1977-03-10 | 1979-12-12 | Soc D Etudes Prod Chimique | Preparation of isobutyramide derivatives |
| KR810001320B1 (ko) | 1977-03-17 | 1981-10-14 | 삐에르 위브 | 신규한 이소부티라미드류의 제조방법 |
| KR810001697B1 (ko) | 1978-02-06 | 1981-10-27 | 삐에르 위브 | 이소부티라미드 유도체의 신규한 제조방법 |
| EP0089765A3 (de) | 1982-03-17 | 1984-05-23 | Smith Kline & French Laboratories Limited | Pyridin-Derivate |
| US4745123A (en) | 1986-02-18 | 1988-05-17 | Warner-Lambert Company | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
| GB8607312D0 (en) | 1986-03-25 | 1986-04-30 | Ici Plc | Therapeutic agents |
| GB8607313D0 (en) | 1986-03-25 | 1986-04-30 | Ici Plc | Pharmaceutical compositions |
| CA1339423C (en) | 1988-09-14 | 1997-09-02 | Yuji Ono | Pyridine compounds and pharmaceutical use thereof |
| US4994456A (en) | 1989-03-01 | 1991-02-19 | Nisshin Flour Milling Co., Ltd. | Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same |
| US4973597A (en) | 1989-06-30 | 1990-11-27 | Eli Lilly And Company | Anticonvulsant agents |
| HU207047B (en) | 1989-11-07 | 1993-03-01 | Richter Gedeon Vegyeszet | Process for producing new pyridine derivatives and pharmaceutical copositions comprising same |
| US5364943A (en) | 1991-11-27 | 1994-11-15 | Pfizer Inc. | Preparation of substituted piperidines |
| GB9021056D0 (en) | 1990-09-27 | 1990-11-07 | Pfizer Ltd | Antiarrhythmic agents |
| GB9214120D0 (en) | 1991-07-25 | 1992-08-12 | Ici Plc | Therapeutic amides |
| US5719147A (en) | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| WO1994003429A1 (en) | 1992-07-31 | 1994-02-17 | Merck Sharp & Dohme Limited | Substituted amines as tachykinin receptor antagonists |
| US5387595A (en) | 1992-08-26 | 1995-02-07 | Merck & Co., Inc. | Alicyclic compounds as tachykinin receptor antagonists |
| GB9305672D0 (en) | 1993-03-19 | 1993-05-05 | Wyeth John & Brother Ltd | Amide derivatives |
| AU6807994A (en) | 1993-05-28 | 1994-12-20 | Taisho Pharmaceutical Co., Ltd. | Medicinal use of pyridine derivative |
| NZ264063A (en) | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| DE69434063D1 (de) | 1993-12-29 | 2004-11-11 | Merck Sharp & Dohme | Substituierte Morpholinderivate und ihre Verwendung als therapeutische Mittel |
| IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
| ATE206710T1 (de) | 1994-06-06 | 2001-10-15 | Warner Lambert Co | Tachykinin (nk1) rezeptor antagonisten |
| AU2753195A (en) | 1994-06-24 | 1996-01-19 | Taisho Pharmaceutical Co., Ltd. | Pyridine derivative |
| US6294537B1 (en) | 1995-03-17 | 2001-09-25 | Sanofi-Synthelabo | Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools |
| TW394773B (en) | 1995-03-24 | 2000-06-21 | Takeda Chemical Industries Ltd | Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition |
| AR004735A1 (es) | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
| UA49006C2 (uk) | 1996-03-29 | 2002-09-16 | Файзер Інк. | Похідні 6-фенілпіридил-2-аміну, фармацевтична композиція, спосіб інгібування синтази оксиду нітрогену у ссавців та спосіб лікування |
| AU4885097A (en) | 1996-11-08 | 1998-06-03 | Sankyo Company Limited | Arylureas or arylmethylcarbamoyl derivatives |
| US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| WO2000050398A2 (en) | 1999-02-24 | 2000-08-31 | F. Hoffmann-La Roche Ag | Phenyl- and pyridinyl derivatives as neurokinin 1 antagonists |
| DK1394150T3 (da) * | 1999-02-24 | 2011-03-21 | Hoffmann La Roche | 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister |
| EP1103545B1 (de) | 1999-11-29 | 2003-11-05 | F. Hoffmann-La Roche Ag | 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramid |
| US6303790B1 (en) | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
| TWI287003B (en) | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
-
2004
- 2004-07-09 US US10/888,912 patent/US7288658B2/en not_active Expired - Lifetime
- 2004-07-09 TW TW093120669A patent/TWI280239B/zh not_active IP Right Cessation
- 2004-07-10 DK DK04763155T patent/DK1656351T3/da active
- 2004-07-10 JP JP2006519843A patent/JP4575918B2/ja not_active Expired - Lifetime
- 2004-07-10 ES ES04763155T patent/ES2297457T3/es not_active Expired - Lifetime
- 2004-07-10 CA CA2532355A patent/CA2532355C/en not_active Expired - Lifetime
- 2004-07-10 DE DE602004010820T patent/DE602004010820T2/de not_active Expired - Lifetime
- 2004-07-10 AT AT04763155T patent/ATE381543T1/de active
- 2004-07-10 KR KR1020067000860A patent/KR100742013B1/ko not_active Expired - Lifetime
- 2004-07-10 CN CN2004800232840A patent/CN1835922B/zh not_active Expired - Lifetime
- 2004-07-10 WO PCT/EP2004/007618 patent/WO2005014549A1/en not_active Ceased
- 2004-07-10 MX MXPA06000405A patent/MXPA06000405A/es active IP Right Grant
- 2004-07-10 EP EP04763155A patent/EP1656351B1/de not_active Expired - Lifetime
-
2006
- 2006-01-05 IL IL173000A patent/IL173000A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1835922B (zh) | 2011-08-31 |
| TW200524872A (en) | 2005-08-01 |
| KR20060036090A (ko) | 2006-04-27 |
| TWI280239B (en) | 2007-05-01 |
| CA2532355C (en) | 2012-05-15 |
| JP4575918B2 (ja) | 2010-11-04 |
| DE602004010820T2 (de) | 2008-12-04 |
| EP1656351B1 (de) | 2007-12-19 |
| US7288658B2 (en) | 2007-10-30 |
| ATE381543T1 (de) | 2008-01-15 |
| CN1835922A (zh) | 2006-09-20 |
| MXPA06000405A (es) | 2006-03-17 |
| WO2005014549A1 (en) | 2005-02-17 |
| CA2532355A1 (en) | 2005-02-17 |
| IL173000A0 (en) | 2006-06-11 |
| US20050014792A1 (en) | 2005-01-20 |
| JP2009500292A (ja) | 2009-01-08 |
| EP1656351A1 (de) | 2006-05-17 |
| DE602004010820D1 (de) | 2008-01-31 |
| ES2297457T3 (es) | 2008-05-01 |
| KR100742013B1 (ko) | 2007-07-23 |
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