DK1663963T3 - Fremgangsmåde til enantioselektiv syntese af enkelte enantiomerer af modafinil ved asymmetrisk oxidation - Google Patents

Fremgangsmåde til enantioselektiv syntese af enkelte enantiomerer af modafinil ved asymmetrisk oxidation

Info

Publication number: DK1663963T3
Authority: DK; Denmark
Prior art keywords: modafinil; single enantiomers; enantioselective synthesis; formula; asymmetric oxidation
Prior art date: 2003-09-19

Application number

DK04769402T

Other languages

English (en)

Inventor

Francois Rebiere

Gerard Duret

Laurence Prat

Original Assignee

Cephalon France

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-19

Filing date

2004-09-17

Publication date

2007-10-29

2004-09-17 Application filed by Cephalon France filed Critical Cephalon France

2007-10-29 Application granted granted Critical

2007-10-29 Publication of DK1663963T3 publication Critical patent/DK1663963T3/da

Links

238000000034 method Methods 0.000 title abstract 2
YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
229960001165 modafinil Drugs 0.000 title 1
230000003647 oxidation Effects 0.000 title 1
238000007254 oxidation reaction Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000007800 oxidant agent Substances 0.000 abstract 1
-1 sulphoxide compound Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)

DK04769402T 2003-09-19 2004-09-17 Fremgangsmåde til enantioselektiv syntese af enkelte enantiomerer af modafinil ved asymmetrisk oxidation DK1663963T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP03292312A EP1516869A1 (en)	2003-09-19	2003-09-19	Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US50708903P	2003-10-01	2003-10-01
PCT/IB2004/003026 WO2005028428A1 (en)	2003-09-19	2004-09-17	Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

Publications (1)

Publication Number	Publication Date
DK1663963T3 true DK1663963T3 (da)	2007-10-29

Family

ID=34178643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04769402T DK1663963T3 (da)	2003-09-19	2004-09-17	Fremgangsmåde til enantioselektiv syntese af enkelte enantiomerer af modafinil ved asymmetrisk oxidation

Country Status (21)

Country	Link
US (2)	US7317126B2 (da)
EP (2)	EP1516869A1 (da)
JP (1)	JP4713480B2 (da)
KR (1)	KR101136703B1 (da)
CN (1)	CN100404502C (da)
AT (1)	ATE365711T1 (da)
AU (1)	AU2004274248B2 (da)
BR (1)	BRPI0414298B1 (da)
CA (1)	CA2538697C (da)
DE (1)	DE602004007278T2 (da)
DK (1)	DK1663963T3 (da)
EA (1)	EA009385B1 (da)
ES (1)	ES2289556T3 (da)
MX (1)	MXPA06002935A (da)
NZ (1)	NZ545739A (da)
PL (1)	PL1663963T3 (da)
PT (1)	PT1663963E (da)
SI (1)	SI1663963T1 (da)
UA (1)	UA85196C2 (da)
WO (1)	WO2005028428A1 (da)
ZA (1)	ZA200601962B (da)

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EP1516869A1 (en) *	2003-09-19	2005-03-23	Cephalon France	Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7368591B2 (en)	2003-09-19	2008-05-06	Cephalon France	Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1702915A1 (en)	2005-03-14	2006-09-20	Cephalon France	Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
CN1321978C (zh) *	2005-04-29	2007-06-20	浙江工业大学	一种2－（二苯基甲基亚硫酰基）乙酰胺的合成方法
WO2007027328A2 (en) *	2005-07-28	2007-03-08	University Of Iowa Research Foundation	Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
JP2009508880A (ja) *	2006-02-21	2009-03-05	テバファーマシューティカルインダストリーズリミティド	アルモダフィニルの新規な結晶形とその調製方法
WO2007103221A2 (en)	2006-03-01	2007-09-13	Teva Pharmaceutical Industries Ltd.	An improved process for the preparation of armodafinil
US20080214862A1 (en) *	2006-12-06	2008-09-04	Ben-Zion Dolitzky	Processes for preparing armodafinil intermediate
AU2008259588A1 (en) *	2007-06-04	2008-12-11	Generics [Uk] Limited	Novel process
WO2009024863A2 (en) *	2007-06-26	2009-02-26	Actavis Group Ptc Ehf	Process for the preparation of modafinil enantiomers
US7960586B2 (en)	2007-08-16	2011-06-14	Teva Pharmaceutical Industries Ltd.	Purification of armodafinil
ES2525535T3 (es)	2009-07-16	2014-12-26	Bayer Intellectual Property Gmbh	Procedimiento para la preparación de derivados de 3-triazolil-sulfóxido quirales
US20110224196A1 (en) *	2010-01-07	2011-09-15	Vivus, Inc.	Treatment of obstructive sleep apnea syndrome with a combination of a carbonic anhydrase inhibitor and an additional active agent
RU2448954C1 (ru) *	2010-10-18	2012-04-27	Учреждение Российской академии наук Институт катализа им. Г.К. Борескова Сибирского отделения РАН	Способ получения сульфоксидов
HUE037616T2 (hu)	2010-12-08	2018-09-28	Codexis Inc	Biokatalizátorok és eljárások armodafinil szintéziséhez
FR2970711B1 (fr) *	2011-01-20	2016-03-04	Hopitaux Paris Assist Publique	La lauflumide et ses enantiomeres, preparation et utilisations therapeutiques
RU2477316C1 (ru) *	2011-12-29	2013-03-10	Учреждение Российской академии наук Институт экологии и генетики микроорганизмов Уральского отделения РАН	Биокаталитический способ получения (r)-фенилметилового сульфоксида
CN104447440B (zh) *	2013-09-12	2016-05-18	中国科学院大连化学物理研究所	一种催化不对称氧化硫醚的方法
CN104045588A (zh) *	2014-06-11	2014-09-17	江苏斯威森生物医药工程研究中心有限公司	一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
CA2989243C (en)	2014-08-13	2023-03-14	Red Bull Gmbh	Heterocyclic compounds with working memory enhancing activity
PL2985279T3 (pl)	2014-08-13	2018-03-30	Red Bull Gmbh	Związki heterocykliczne mające działanie poprawiające pamięć roboczą
US9616068B2 (en)	2014-10-27	2017-04-11	Pohela LLC	Animal training using cognitive enhancement
CN110698482A (zh) *	2019-10-29	2020-01-17	株洲千金药业股份有限公司	一种s型手性亚砜类化合物的制备方法
CN110746428A (zh) *	2019-10-29	2020-02-04	株洲千金药业股份有限公司	一种r型手性亚砜类化合物的制备方法

Family Cites Families (10)

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US4098824A (en) *	1975-10-02	1978-07-04	Laboratoire L. Lafon	Benzhydrylsulphinyl derivatives
GB1584462A (en) *	1977-03-31	1981-02-11	Lafon Labor	N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2528038B2 (fr) *	1982-06-04	1985-08-09	Lafon Labor	Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
FR2593809B1 (fr) *	1986-01-31	1988-07-22	Lafon Labor	Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
DK1787980T3 (da) *	2000-07-27	2010-04-26	Teva Pharma	Krystallint og rent modafinil og fremgangsmåde til atfremstille dette
IL143106A (en) *	2001-05-13	2005-11-20	Chemagis Ltd	Process for the preparation of diphenylmethylthioacetamide
US20040048931A1 (en)	2002-07-12	2004-03-11	Craig Heacock	Modafinil pharmaceutical compositions
FR2849029B1 (fr)	2002-12-20	2005-03-18	Lafon Labor	Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1437345A1 (en)	2003-01-13	2004-07-14	Organisation de Synthese Mondiale Orsymonde	Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
EP1516869A1 (en) *	2003-09-19	2005-03-23	Cephalon France	Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

2003
- 2003-09-19 EP EP03292312A patent/EP1516869A1/en not_active Withdrawn
2004
- 2004-09-17 AT AT04769402T patent/ATE365711T1/de active
- 2004-09-17 KR KR1020067007002A patent/KR101136703B1/ko not_active Expired - Fee Related
- 2004-09-17 SI SI200430411T patent/SI1663963T1/sl unknown
- 2004-09-17 JP JP2006526728A patent/JP4713480B2/ja not_active Expired - Fee Related
- 2004-09-17 NZ NZ545739A patent/NZ545739A/en not_active IP Right Cessation
- 2004-09-17 DE DE602004007278T patent/DE602004007278T2/de not_active Expired - Lifetime
- 2004-09-17 PL PL04769402T patent/PL1663963T3/pl unknown
- 2004-09-17 DK DK04769402T patent/DK1663963T3/da active
- 2004-09-17 PT PT04769402T patent/PT1663963E/pt unknown
- 2004-09-17 EP EP04769402A patent/EP1663963B1/en not_active Expired - Lifetime
- 2004-09-17 CN CNB2004800298265A patent/CN100404502C/zh not_active Expired - Fee Related
- 2004-09-17 UA UAA200604415A patent/UA85196C2/ru unknown
- 2004-09-17 ES ES04769402T patent/ES2289556T3/es not_active Expired - Lifetime
- 2004-09-17 MX MXPA06002935A patent/MXPA06002935A/es active IP Right Grant
- 2004-09-17 AU AU2004274248A patent/AU2004274248B2/en not_active Expired
- 2004-09-17 US US10/943,360 patent/US7317126B2/en not_active Expired - Fee Related
- 2004-09-17 EA EA200600593A patent/EA009385B1/ru not_active IP Right Cessation
- 2004-09-17 CA CA2538697A patent/CA2538697C/en not_active Expired - Fee Related
- 2004-09-17 WO PCT/IB2004/003026 patent/WO2005028428A1/en not_active Ceased
- 2004-09-17 BR BRPI0414298-5A patent/BRPI0414298B1/pt not_active IP Right Cessation
2006
- 2006-03-08 ZA ZA200601962A patent/ZA200601962B/en unknown
2007
- 2007-10-30 US US11/929,030 patent/US7812193B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE602004007278T2 (de)	2008-02-28
EA009385B1 (ru)	2007-12-28
EA200600593A1 (ru)	2006-08-25
AU2004274248B2 (en)	2010-08-26
CA2538697A1 (en)	2005-03-31
SI1663963T1 (sl)	2007-12-31
US7812193B2 (en)	2010-10-12
MXPA06002935A (es)	2006-06-14
KR101136703B1 (ko)	2012-05-24
CA2538697C (en)	2012-11-13
US20080171896A1 (en)	2008-07-17
PT1663963E (pt)	2007-10-19
EP1663963A1 (en)	2006-06-07
UA85196C2 (ru)	2009-01-12
AU2004274248A1 (en)	2005-03-31
JP4713480B2 (ja)	2011-06-29
ES2289556T3 (es)	2008-02-01
PL1663963T3 (pl)	2007-11-30
CN100404502C (zh)	2008-07-23
ATE365711T1 (de)	2007-07-15
US7317126B2 (en)	2008-01-08
JP2007505891A (ja)	2007-03-15
WO2005028428A1 (en)	2005-03-31
ZA200601962B (en)	2007-06-27
CN1867544A (zh)	2006-11-22
EP1663963B1 (en)	2007-06-27
EP1516869A1 (en)	2005-03-23
KR20070009968A (ko)	2007-01-19
US20050080256A1 (en)	2005-04-14
NZ545739A (en)	2010-01-29
DE602004007278D1 (de)	2007-08-09
BRPI0414298B1 (pt)	2021-06-08
BRPI0414298A (pt)	2006-11-14

Publication	Publication Date	Title
PL1663963T3 (pl)	2007-11-30	Proces enancjoselektywnej syntezy pojedynczych enancjomerów modafinilu przez asymetryczne utlenianie
DE60124692D1 (de)	2007-01-04	Verfahren zur herstellung von optisch-aktiven sulfoxid-derivaten
CY1108866T1 (el)	2014-07-02	Βελτιωμενη μεθοδος για την παρασκευη ενωσεων 3-υδροξυ-4-υδροξυμεθυλ-πυρρολιδινης
SE9904850D0 (sv)	1999-12-30	Novel process and intermediates
NO20074438L (no)	2007-10-15	Fremgangsmate for enantioselektiv syntese av enkeltenantiomerer av tio-substituerte arylmetansulfinylderivater fra asymmetriske oksidasjon
DE602005026223D1 (de)	2011-03-17	Ölavivage für carbonfaser-präkursorfaser, carbonfaser sowie verfahren zur herstellung von carbonfaser
DE602005016705D1 (de)	2009-10-29	Verfahren zur herstellung substituierter sulfoxide
ATE513801T1 (de)	2011-07-15	Verfahren zur synthese von propargylatierten aminoindanderivativen
MY148301A (en)	2013-03-29	Process for the preparation of optically pure or optically enriched enantiomers of sulphoxide compounds
WO2008071951A3 (en)	2008-10-02	Catalytic process for asymmetric hydrogenation
HRP20051019A2 (en)	2006-02-28	A method for the preparation of enantiomerically pure mirtazapine
DE69905746D1 (de)	2003-04-10	Chirale ligande für asymmetrische katalysis
NO20061350L (no)	2006-04-05	Fremgangsmate for enantioselektiv syntese av enkelt enantiomerer av modafinil ved assymetrisk oksidasjon
WO2009116883A8 (en)	2009-12-10	Process
ATE526312T1 (de)	2011-10-15	Verfahren zur herstellung von reinen 4- pyrrolidinophenylbenzyletherderivaten als maob- inhibitoren
UA92050C2 (ru)	2010-09-27	Энантиоселективное получение производных бензимидазола и их солей
Yoshimura et al.	2003	Enantiocontrolled synthesis of (+)-curcuquinone and (-)-curcuhydroquinone
ATE541838T1 (de)	2012-02-15	Neue zur synthese von s- und r-omeprazol geeignete verbindungen und ein verfahren zu deren herstellung
DE602004006021D1 (de)	2007-05-31	Verfahren zur racematspaltung von nefopam
WO2002057227A8 (en)	2002-12-27	Process of enantiomerically enriched flavor and fragrance components
WO2009136803A3 (en)	2010-07-22	Catalytic process for asymmetric hydrogenation
ATE415388T1 (de)	2008-12-15	Verfahren zur herstellung von enantiomerenreinen 4-pyrrolidinophenyl- benzyletherderivaten
ATE260264T1 (de)	2004-03-15	Verfahren zur herstellung von oxazol-derivaten
ATE461204T1 (de)	2010-04-15	Bisphosphit und verfahren zur herstellung einer aldehydverbindung mit dem bisphosphit