DK1674456T3 - Nye 1,4-benzothiazepin-1,1-dioxid-derivater med forbedrede egenskaber, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse - Google Patents

Nye 1,4-benzothiazepin-1,1-dioxid-derivater med forbedrede egenskaber, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse

Info

Publication number: DK1674456T3
Authority: DK; Denmark
Prior art keywords: benzothiazepine; compounds; preparation; new; improved properties
Prior art date: 2001-09-21

Application number

DK05016160T

Other languages

English (en)

Inventor

Thierry Gallet

Patrick Lardenois

Alistair Lochead

Severine Marguerie

Alain Nedelec

Mourad Saady

Franck Slowinski

Philippe Yaiche

Original Assignee

Sanofi Aventis

Mitsubishi Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-21

Filing date

2002-09-19

Publication date

2008-10-27

2001-09-21 Priority claimed from EP01402432A external-priority patent/EP1295885A1/en

2002-02-28 Priority claimed from EP02290489A external-priority patent/EP1340761A1/en

2002-09-19 Application filed by Sanofi Aventis, Mitsubishi Pharma Corp filed Critical Sanofi Aventis

2008-10-27 Application granted granted Critical

2008-10-27 Publication of DK1674456T3 publication Critical patent/DK1674456T3/da

Links

IVGHNDNOFMTFMK-UHFFFAOYSA-N 1$l^{6},4-benzothiazepine 1,1-dioxide Chemical class O=S1(=O)C=CN=CC2=CC=CC=C12 IVGHNDNOFMTFMK-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Agronomy & Crop Science (AREA)
Dentistry (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Psychology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Vascular Medicine (AREA)
Wood Science & Technology (AREA)

DK05016160T 2001-09-21 2002-09-19 Nye 1,4-benzothiazepin-1,1-dioxid-derivater med forbedrede egenskaber, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse DK1674456T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01402432A EP1295885A1 (en)	2001-09-21	2001-09-21	Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives
EP02290489A EP1340761A1 (en)	2002-02-28	2002-02-28	Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives
PCT/EP2002/011128 WO2003027116A2 (en)	2001-09-21	2002-09-19	Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)one derivatives

Publications (1)

Publication Number	Publication Date
DK1674456T3 true DK1674456T3 (da)	2008-10-27

Family

ID=26077256

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02785157T DK1430057T3 (da)	2001-09-21	2002-09-19	Substituerede 2-pyridinyl-6,7,8, 9-tetrahydropyrimido [1,2-a] pyrimidin-4-on- og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivater
DK05016160T DK1674456T3 (da)	2001-09-21	2002-09-19	Nye 1,4-benzothiazepin-1,1-dioxid-derivater med forbedrede egenskaber, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK02785157T DK1430057T3 (da)	2001-09-21	2002-09-19	Substituerede 2-pyridinyl-6,7,8, 9-tetrahydropyrimido [1,2-a] pyrimidin-4-on- og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)onderivater

Country Status (24)

Country	Link
US (2)	US7214682B2 (da)
EP (2)	EP1674456B1 (da)
JP (3)	JP4570362B2 (da)
KR (1)	KR100868841B1 (da)
CN (2)	CN100398541C (da)
AR (1)	AR036600A1 (da)
AT (2)	ATE303388T1 (da)
AU (1)	AU2002350487C1 (da)
BR (1)	BR0212896A (da)
CA (1)	CA2457965C (da)
CY (1)	CY1108341T1 (da)
DE (2)	DE60205921T2 (da)
DK (2)	DK1430057T3 (da)
EA (1)	EA006859B1 (da)
ES (2)	ES2310787T3 (da)
HU (1)	HUP0500328A3 (da)
IL (2)	IL160402A0 (da)
MX (1)	MXPA04002629A (da)
NO (1)	NO329565B1 (da)
NZ (2)	NZ547205A (da)
PL (1)	PL370349A1 (da)
PT (1)	PT1674456E (da)
SI (1)	SI1430057T1 (da)
WO (1)	WO2003027116A2 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0212896A (pt) *	2001-09-21	2004-10-13	Sanofi Synthelabo	Derivados de 2-piridinil-6,7,8,9-tetrahidropirimido[1,2-a]pirimidin-4- ona e 7-piridinil-2,3dihidroimidazo[1,2-a] pirimidin-5(1h)ona substituìdos
TW201041580A (en)	2001-09-27	2010-12-01	Alcon Inc	Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
EP1454909B1 (en) *	2003-03-07	2008-08-20	Sanofi Aventis	8'-pyridinyl-dihydrospiro- (cycloalkyl) -pyrimido (1,2-a) pyrimidin-6-one and 8'-pyrimidinyl-dihydrospiro (cycloalkyl) -pyrimido (1,2-a) pyrimidin-6-one derivatives and their use against neurodegenerative diseases
EP1454900A1 (en)	2003-03-07	2004-09-08	Sanofi-Synthelabo	Process for the preparation of pyridinyl and pyrimidinyl mono-fluorinated beta keto-esters
EP1557417B1 (en) *	2003-12-19	2007-03-07	Sanofi-Aventis	Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-a] pyrimidin-6-one derivatives
ES2304690T3 (es)	2004-01-22	2008-10-16	Amgen Inc.	Compuestos heterociclicos sustituidos y sus metodos de utilizacion.
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
EP2275096A3 (en)	2005-08-26	2011-07-13	Braincells, Inc.	Neurogenesis via modulation of the muscarinic receptors
WO2007047978A2 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2021000A2 (en)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenesis by modulating angiotensin
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
CN101735211B (zh) *	2008-11-04	2012-11-14	复旦大学	2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
PL2448940T3 (pl) *	2009-07-02	2014-10-31	Sanofi Sa	Pochodne 6,7,8,9-tetrahydro-pirymido{1,2-a} pirymidyn-4-onu, ich wytwarzanie i zastosowanie farmaceutyczne
FR2947551B1 (fr) *	2009-07-02	2012-05-18	Sanofi Aventis	Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a)pyrimidin-6-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt (pkb)
FR2947550B1 (fr) *	2009-07-02	2012-05-18	Sanofi Aventis	Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt (pkb)
KR101745028B1 (ko)	2009-07-02	2017-06-08	사노피	신규 ２,３-디히드로-１ｈ-이미다조（１,２-ａ）피리미딘-５-온 유도체, 그의 제조법 및 그의 제약 용도
PT2655375E (pt)	2010-12-23	2015-03-02	Sanofi Sa	Derivados de pirimidinona, sua preparação e sua utilização farmacêutica
FR2992314B1 (fr)	2012-06-22	2015-10-16	Sanofi Sa	Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
WO2015155738A2 (en)	2014-04-09	2015-10-15	Christopher Rudd	Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity
CN109836427B (zh) *	2017-11-29	2022-04-15	暨南大学	嘧啶并嘧啶酮类化合物及其应用
CN114957246B (zh) *	2021-02-19	2025-11-11	苏州恩华生物医药科技有限公司	5,6,7,8-四氢吡啶并[4,3-d]嘧啶-4（3H）-酮衍生物及其应用

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Publication number	Priority date	Publication date	Assignee	Title
WO1998016528A1 (en)	1996-10-11	1998-04-23	Chiron Corporation	Purine inhibitors of glycogen synthase kinase 3 (gsk3)
CA2274093C (en) *	1996-12-05	2006-11-07	Amgen Inc.	Substituted pyrimidinone and pyridinone compounds and their use
DE69919707T2 (de)	1998-06-19	2005-09-01	Chiron Corp., Emeryville	Glycogen synthase kinase 3 inhibitoren
AR023052A1 (es) *	1998-09-25	2002-09-04	Mitsuharu Yoshimura Milton	Derivados de pirimidona
JP2000264888A (ja) *	1999-01-11	2000-09-26	Sagami Chem Res Center	双環性ピリミジン誘導体、それらの製造中間体及びそれらの製造方法、並びにそれらを有効成分とする除草剤
YU74601A (sh) *	1999-03-22	2004-05-12	Ortho-Mcneil Pharmaceutical Inc., U.S.	POSTUPAK ZA DOBIJANJE (S-(R,S)]-p-[[[1-OkSO-3-(4-PIPERIDINIL)PROPIL]-3-PIPERIDINIL]KARBONIL]AMINO]-3-PIPERIDINPROPIONSKE KISELINE I NJENIH DERIVATA
AU1734401A (en) *	1999-12-09	2001-06-18	Mitsubishi Pharma Corporation	Carboxyamido derivatives
ES2246927T3 (es)	1999-12-17	2006-03-01	Chiron Corporation	Inhibidores biciclicos de glucogeno sintasa quinasa 3.
DE60103909T2 (de) *	2000-09-01	2005-09-22	Sanofi-Aventis	2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on- und 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5 1honderivate
BR0212896A (pt) *	2001-09-21	2004-10-13	Sanofi Synthelabo	Derivados de 2-piridinil-6,7,8,9-tetrahidropirimido[1,2-a]pirimidin-4- ona e 7-piridinil-2,3dihidroimidazo[1,2-a] pirimidin-5(1h)ona substituìdos

2002
- 2002-09-19 BR BR0212896-9A patent/BR0212896A/pt not_active Application Discontinuation
- 2002-09-19 ES ES05016160T patent/ES2310787T3/es not_active Expired - Lifetime
- 2002-09-19 AU AU2002350487A patent/AU2002350487C1/en not_active Ceased
- 2002-09-19 PL PL02370349A patent/PL370349A1/xx unknown
- 2002-09-19 DE DE60205921T patent/DE60205921T2/de not_active Expired - Lifetime
- 2002-09-19 NZ NZ547205A patent/NZ547205A/en not_active IP Right Cessation
- 2002-09-19 AT AT02785157T patent/ATE303388T1/de active
- 2002-09-19 EP EP05016160A patent/EP1674456B1/en not_active Expired - Lifetime
- 2002-09-19 SI SI200230201T patent/SI1430057T1/sl unknown
- 2002-09-19 DE DE60227718T patent/DE60227718D1/de not_active Expired - Lifetime
- 2002-09-19 MX MXPA04002629A patent/MXPA04002629A/es active IP Right Grant
- 2002-09-19 EP EP02785157A patent/EP1430057B1/en not_active Expired - Lifetime
- 2002-09-19 CA CA2457965A patent/CA2457965C/en not_active Expired - Fee Related
- 2002-09-19 KR KR1020047004139A patent/KR100868841B1/ko not_active Expired - Fee Related
- 2002-09-19 EA EA200400237A patent/EA006859B1/ru not_active IP Right Cessation
- 2002-09-19 AT AT05016160T patent/ATE401309T1/de active
- 2002-09-19 JP JP2003530704A patent/JP4570362B2/ja not_active Expired - Fee Related
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- 2002-09-19 CN CNB2006100043835A patent/CN100398541C/zh not_active Expired - Fee Related
- 2002-09-19 IL IL16040202A patent/IL160402A0/xx active IP Right Grant
- 2002-09-19 HU HU0500328A patent/HUP0500328A3/hu unknown
- 2002-09-19 PT PT05016160T patent/PT1674456E/pt unknown
- 2002-09-19 CN CNB02818338XA patent/CN1247585C/zh not_active Expired - Fee Related
- 2002-09-19 DK DK02785157T patent/DK1430057T3/da active
- 2002-09-19 ES ES02785157T patent/ES2247398T3/es not_active Expired - Lifetime
- 2002-09-19 WO PCT/EP2002/011128 patent/WO2003027116A2/en not_active Ceased
- 2002-09-19 US US10/490,135 patent/US7214682B2/en not_active Expired - Fee Related
- 2002-09-19 DK DK05016160T patent/DK1674456T3/da active
- 2002-09-20 AR ARP020103541A patent/AR036600A1/es unknown
2004
- 2004-02-15 IL IL160402A patent/IL160402A/en not_active IP Right Cessation
- 2004-03-18 NO NO20041141A patent/NO329565B1/no not_active IP Right Cessation
2007
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2008
- 2008-09-16 CY CY20081100994T patent/CY1108341T1/el unknown
2010
- 2010-04-22 JP JP2010098978A patent/JP2010209089A/ja active Pending
- 2010-04-22 JP JP2010098977A patent/JP2010159303A/ja active Pending

Also Published As

Publication number	Publication date
ES2247398T3 (es)	2006-03-01
WO2003027116A3 (en)	2003-08-28
DE60205921T2 (de)	2006-06-22
JP4570362B2 (ja)	2010-10-27
SI1430057T1 (sl)	2006-02-28
ATE401309T1 (de)	2008-08-15
CN1817884A (zh)	2006-08-16
CN1247585C (zh)	2006-03-29
US20070167461A1 (en)	2007-07-19
IL160402A0 (en)	2004-07-25
HK1091208A1 (zh)	2007-01-12
NZ531243A (en)	2006-08-31
DE60227718D1 (de)	2008-08-28
EP1674456A3 (en)	2006-07-05
NO20041141L (no)	2004-06-21
AU2002350487B2 (en)	2008-01-31
NZ547205A (en)	2007-11-30
DE60205921D1 (de)	2005-10-06
US7462621B2 (en)	2008-12-09
PT1674456E (pt)	2008-09-11
US20050049261A1 (en)	2005-03-03
EP1674456A2 (en)	2006-06-28
KR100868841B1 (ko)	2008-11-14
KR20040029486A (ko)	2004-04-06
DK1430057T3 (da)	2006-01-16
AR036600A1 (es)	2004-09-22
WO2003027116A2 (en)	2003-04-03
CN100398541C (zh)	2008-07-02
IL160402A (en)	2008-08-07
BR0212896A (pt)	2004-10-13
JP2010159303A (ja)	2010-07-22
PL370349A1 (en)	2005-05-16
CN1556809A (zh)	2004-12-22
ATE303388T1 (de)	2005-09-15
NO329565B1 (no)	2010-11-15
CY1108341T1 (el)	2014-02-12
JP2010209089A (ja)	2010-09-24
CA2457965A1 (en)	2003-04-03
HUP0500328A2 (hu)	2005-07-28
CA2457965C (en)	2010-06-01
EA200400237A1 (ru)	2004-10-28
JP2005504810A (ja)	2005-02-17
HUP0500328A3 (en)	2009-12-28
EP1674456B1 (en)	2008-07-16
MXPA04002629A (es)	2005-02-17
EA006859B1 (ru)	2006-04-28
AU2002350487C1 (en)	2008-10-02
ES2310787T3 (es)	2009-01-16
EP1430057A2 (en)	2004-06-23
EP1430057B1 (en)	2005-08-31
US7214682B2 (en)	2007-05-08

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