DK167558B1 - Salbutamolpraeparater og fremgangsmaade til fremstilling heraf - Google Patents

Salbutamolpraeparater og fremgangsmaade til fremstilling heraf Download PDF

Info

Publication number: DK167558B1
Authority: DK; Denmark
Prior art keywords: cellulose; salbutamol; composition according; physiologically acceptable; acceptable salts
Prior art date: 1982-05-27

Application number

DK241783A

Other languages

Danish (da)

English (en)

Other versions

DK241783A (da

DK241783D0 (da

Inventor

John Malcolm Padfield

Cheryl Vanessa Groom

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-27

Filing date

1983-05-27

Publication date

1993-11-22

1983-05-27 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1983-05-27 Publication of DK241783D0 publication Critical patent/DK241783D0/da

1983-11-28 Publication of DK241783A publication Critical patent/DK241783A/da

1993-11-22 Application granted granted Critical

1993-11-22 Publication of DK167558B1 publication Critical patent/DK167558B1/da

Links

NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 title claims description 26
229960002052 salbutamol Drugs 0.000 title claims description 24
238000002360 preparation method Methods 0.000 title claims description 9
238000000034 method Methods 0.000 title claims description 6
239000000203 mixture Substances 0.000 claims description 35
229920002678 cellulose Polymers 0.000 claims description 21
239000001913 cellulose Substances 0.000 claims description 21
150000003839 salts Chemical class 0.000 claims description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
239000008194 pharmaceutical composition Substances 0.000 claims description 14
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 9
-1 hydroxyalkyl ethers Chemical class 0.000 claims description 9
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 9
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
239000007788 liquid Substances 0.000 claims description 8
239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 7
125000000217 alkyl group Chemical group 0.000 claims description 7
238000009472 formulation Methods 0.000 claims description 7
BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 claims description 4
239000000470 constituent Substances 0.000 claims description 3
239000006185 dispersion Substances 0.000 claims description 3
239000012153 distilled water Substances 0.000 claims description 3
239000012458 free base Substances 0.000 claims description 3
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 2
239000001856 Ethyl cellulose Substances 0.000 claims description 2
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical group CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 2
239000004480 active ingredient Substances 0.000 claims description 2
229960002303 citric acid monohydrate Drugs 0.000 claims description 2
229920001249 ethyl cellulose Polymers 0.000 claims description 2
235000019325 ethyl cellulose Nutrition 0.000 claims description 2
239000001761 ethyl methyl cellulose Substances 0.000 claims description 2
235000010944 ethyl methyl cellulose Nutrition 0.000 claims description 2
229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 2
229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 2
239000004615 ingredient Substances 0.000 claims description 2
229920000609 methyl cellulose Polymers 0.000 claims description 2
239000001923 methylcellulose Substances 0.000 claims description 2
235000010981 methylcellulose Nutrition 0.000 claims description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
239000001509 sodium citrate Substances 0.000 claims description 2
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims 1
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
239000007864 aqueous solution Substances 0.000 claims 1
239000012530 fluid Substances 0.000 claims 1
239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
239000008213 purified water Substances 0.000 claims 1
229940085605 saccharin sodium Drugs 0.000 claims 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
235000010234 sodium benzoate Nutrition 0.000 claims 1
239000004299 sodium benzoate Substances 0.000 claims 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
239000000872 buffer Substances 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000001246 colloidal dispersion Methods 0.000 description 3
239000000243 solution Substances 0.000 description 3
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
239000002562 thickening agent Substances 0.000 description 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000013011 aqueous formulation Substances 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
239000000337 buffer salt Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
229960004106 citric acid Drugs 0.000 description 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
229920013819 hydroxyethyl ethylcellulose Polymers 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229960000999 sodium citrate dihydrate Drugs 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK241783A 1982-05-27 1983-05-27 Salbutamolpraeparater og fremgangsmaade til fremstilling heraf DK167558B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8215502		1982-05-27
GB8215502		1982-05-27

Publications (3)

Publication Number	Publication Date
DK241783D0 DK241783D0 (da)	1983-05-27
DK241783A DK241783A (da)	1983-11-28
DK167558B1 true DK167558B1 (da)	1993-11-22

Family

ID=10530673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK241783A DK167558B1 (da)	1982-05-27	1983-05-27	Salbutamolpraeparater og fremgangsmaade til fremstilling heraf

Country Status (25)

Country	Link
JP (1)	JPH0629181B2 (fr)
AT (1)	AT390191B (fr)
AU (1)	AU567675B2 (fr)
BE (1)	BE896870A (fr)
CA (1)	CA1203176A (fr)
CH (1)	CH656308A5 (fr)
DE (1)	DE3319356C2 (fr)
DK (1)	DK167558B1 (fr)
ES (1)	ES8502336A1 (fr)
FI (1)	FI81257C (fr)
FR (1)	FR2527442B1 (fr)
GR (1)	GR82681B (fr)
IE (1)	IE55139B1 (fr)
IL (1)	IL68805A0 (fr)
IT (1)	IT1174759B (fr)
LU (1)	LU84828A1 (fr)
MY (1)	MY8700275A (fr)
NL (1)	NL192663C (fr)
NO (1)	NO163166C (fr)
NZ (1)	NZ204385A (fr)
PH (1)	PH19601A (fr)
PT (1)	PT76773B (fr)
SE (1)	SE454946B (fr)
ZA (1)	ZA833854B (fr)
ZW (1)	ZW11883A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3624213A (en) *	1963-10-30	1971-11-30	Merck & Co Inc	Method of sterilizing aqueous pharmaceutical solutions employing propylene oxide and entrained air
GB1200886A (en) *	1966-09-23	1970-08-05	Allen & Hanburys Ltd	Phenylaminoethanol derivatives
GB1453034A (en) *	1972-12-15	1976-10-20	Boehringer Sohn Ingelheim	Pharmaceutical composition for treating spasticity
JPS5831210B2 (ja) *	1973-04-09	1983-07-05	武田薬品工業株式会社	アンテイナスイセイケンダクエキノセイゾウホウ
DE2714065A1 (de) *	1977-03-30	1978-10-12	Boehringer Mannheim Gmbh	Instillationszubereitung

1983
- 1983-05-20 CH CH2779/83A patent/CH656308A5/fr not_active IP Right Cessation
- 1983-05-24 GR GR71454A patent/GR82681B/el unknown
- 1983-05-26 NO NO831875A patent/NO163166C/no not_active IP Right Cessation
- 1983-05-26 FR FR8308722A patent/FR2527442B1/fr not_active Expired
- 1983-05-27 FI FI831893A patent/FI81257C/fi not_active IP Right Cessation
- 1983-05-27 CA CA000429095A patent/CA1203176A/fr not_active Expired
- 1983-05-27 PH PH28974A patent/PH19601A/en unknown
- 1983-05-27 NL NL8301900A patent/NL192663C/nl not_active IP Right Cessation
- 1983-05-27 PT PT76773A patent/PT76773B/pt unknown
- 1983-05-27 DK DK241783A patent/DK167558B1/da not_active IP Right Cessation
- 1983-05-27 ZA ZA833854A patent/ZA833854B/xx unknown
- 1983-05-27 LU LU84828A patent/LU84828A1/fr unknown
- 1983-05-27 IT IT48384/83A patent/IT1174759B/it active Protection Beyond IP Right Term
- 1983-05-27 AT AT0195283A patent/AT390191B/de not_active IP Right Cessation
- 1983-05-27 ZW ZW118/83A patent/ZW11883A1/xx unknown
- 1983-05-27 JP JP58093896A patent/JPH0629181B2/ja not_active Expired - Lifetime
- 1983-05-27 AU AU15039/83A patent/AU567675B2/en not_active Expired
- 1983-05-27 IE IE1267/83A patent/IE55139B1/en not_active IP Right Cessation
- 1983-05-27 NZ NZ204385A patent/NZ204385A/en unknown
- 1983-05-27 IL IL68805A patent/IL68805A0/xx not_active IP Right Cessation
- 1983-05-27 BE BE0/210866A patent/BE896870A/fr not_active IP Right Cessation
- 1983-05-27 SE SE8303012A patent/SE454946B/sv not_active IP Right Cessation
- 1983-05-27 ES ES522752A patent/ES8502336A1/es not_active Expired
- 1983-05-27 DE DE3319356A patent/DE3319356C2/de not_active Expired - Lifetime
1987
- 1987-12-30 MY MY275/87A patent/MY8700275A/xx unknown

Also Published As

Publication number	Publication date
SE454946B (sv)	1988-06-13
NO163166B (no)	1990-01-08
AU1503983A (en)	1983-12-01
BE896870A (fr)	1983-11-28
FI831893L (fi)	1983-11-28
ES522752A0 (es)	1985-01-01
PT76773A (en)	1983-06-01
PT76773B (en)	1986-03-27
NL192663C (nl)	1997-12-02
SE8303012L (sv)	1983-11-28
CH656308A5 (fr)	1986-06-30
CA1203176A (fr)	1986-04-15
FI81257B (fi)	1990-06-29
SE8303012D0 (sv)	1983-05-27
DK241783A (da)	1983-11-28
IE55139B1 (en)	1990-06-06
FI81257C (fi)	1990-10-10
FR2527442A1 (fr)	1983-12-02
NL8301900A (nl)	1983-12-16
PH19601A (en)	1986-05-27
AT390191B (de)	1990-03-26
IL68805A0 (en)	1983-09-30
NZ204385A (en)	1986-07-11
ZW11883A1 (en)	1984-12-19
JPH0629181B2 (ja)	1994-04-20
NL192663B (fr)	1997-08-01
FR2527442B1 (fr)	1987-07-17
DE3319356C2 (de)	1996-07-04
LU84828A1 (fr)	1985-03-21
AU567675B2 (en)	1987-12-03
IT1174759B (it)	1987-07-01
NO831875L (no)	1983-11-28
GR82681B (fr)	1985-02-07
DK241783D0 (da)	1983-05-27
JPS591411A (ja)	1984-01-06
ES8502336A1 (es)	1985-01-01
IE831267L (en)	1983-11-27
IT8348384A0 (it)	1983-05-27
ZA833854B (en)	1985-01-30
MY8700275A (en)	1987-12-31
NO163166C (no)	1990-05-02
ATA195283A (de)	1989-09-15
DE3319356A1 (de)	1983-12-01
FI831893A0 (fi)	1983-05-27

Legal Events

Date	Code	Title	Description
1993-11-22	B1	Patent granted (law 1993)
2003-06-16	PUP	Patent expired

Publication	Publication Date	Title
RU2004108111A (ru)	2005-03-20	Пленка, освежающая дыхание
DK165663B (da)	1993-01-04	Ranitidinpraeparater samt fremgangsmaade til fremstilling heraf
EA025945B1 (ru)	2017-02-28	Спрей для носа
JP2011503105A (ja)	2011-01-27	バルサルタン含有液体組成物
JP2590156B2 (ja)	1997-03-12	経口投与用医薬組成物
WO2020004193A1 (fr)	2020-01-02	Composition à usage externe
RU2363462C2 (ru)	2009-08-10	Фармацевтическая композиция, содержащая 5-метил-2-(2′-хлор-6′-фторанилин)фенилуксусную кислоту
US4594359A (en)	1986-06-10	Pharmaceutical compositions
JP2019011272A (ja)	2019-01-24	口腔用組成物
FI81257B (fi)	1990-06-29	Foerfarande foer framstaellning av en vattenbaserad farmaceutisk blandning.
GB2120942A (en)	1983-12-14	Salbutamol compositions
CZ256592A3 (en)	1993-03-17	Pharmaceutical composition containing bradykinin antagonists for local use in nose and eye
JP2019011271A (ja)	2019-01-24	口腔用組成物
JP2893807B2 (ja)	1999-05-24	アズレン誘導体含有液剤
JP3364453B2 (ja)	2003-01-08	センノシド含有水性液剤
JP6728300B2 (ja)	2020-07-22	口腔用組成物
JP2025114493A (ja)	2025-08-05	外用組成物
HK1086492B (en)	2009-07-24	Pharmaceutical composition comprising 5-methyl-2-2'-(chloro-6'-fluoroanilino)phenylacetic acid
JPS59118708A (ja)	1984-07-09	液状合剤