CA1203176A - Produits pharmaceutiques - Google Patents

Produits pharmaceutiques

Info

Publication number: CA1203176A
Authority: CA; Canada
Prior art keywords: cellulose; pharmaceutical composition; salbutamol; physiologically acceptable; acceptable salts
Prior art date: 1982-05-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000429095A

Other languages

English (en)

Inventor

John M. Padfield

Cheryl V. Groom

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-27

Filing date

1983-05-27

Publication date

1986-04-15

1983-05-27 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1986-04-15 Application granted granted Critical

1986-04-15 Publication of CA1203176A publication Critical patent/CA1203176A/fr

Status Expired legal-status Critical Current

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 33
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims abstract description 35
229920002678 cellulose Polymers 0.000 claims abstract description 32
239000001913 cellulose Substances 0.000 claims abstract description 31
229960002052 salbutamol Drugs 0.000 claims abstract description 25
150000003839 salts Chemical class 0.000 claims abstract description 25
239000000203 mixture Substances 0.000 claims abstract description 15
239000004480 active ingredient Substances 0.000 claims abstract description 3
235000010980 cellulose Nutrition 0.000 claims description 29
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
239000007788 liquid Substances 0.000 claims description 13
238000002360 preparation method Methods 0.000 claims description 9
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 8
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 8
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 6
125000000217 alkyl group Chemical group 0.000 claims description 4
239000006185 dispersion Substances 0.000 claims description 3
239000001761 ethyl methyl cellulose Substances 0.000 claims description 3
235000010944 ethyl methyl cellulose Nutrition 0.000 claims description 3
-1 hydroxyalkyl ether Chemical compound 0.000 claims description 3
229920013819 hydroxyethyl ethylcellulose Polymers 0.000 claims description 3
229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 3
229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 3
229920000609 methyl cellulose Polymers 0.000 claims description 3
239000001923 methylcellulose Substances 0.000 claims description 3
235000010981 methylcellulose Nutrition 0.000 claims description 3
229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 2
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
238000000034 method Methods 0.000 claims 15
235000002639 sodium chloride Nutrition 0.000 claims 14
229920002134 Carboxymethyl cellulose Polymers 0.000 claims 4
239000001768 carboxy methyl cellulose Substances 0.000 claims 4
235000010948 carboxy methyl cellulose Nutrition 0.000 claims 4
239000008112 carboxymethyl-cellulose Substances 0.000 claims 4
229940105329 carboxymethylcellulose Drugs 0.000 claims 4
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 2
239000001856 Ethyl cellulose Substances 0.000 claims 2
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical group CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
229920001249 ethyl cellulose Polymers 0.000 claims 2
235000019325 ethyl cellulose Nutrition 0.000 claims 2
229960002900 methylcellulose Drugs 0.000 claims 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
229940071826 hydroxyethyl cellulose Drugs 0.000 claims 1
229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
238000001246 colloidal dispersion Methods 0.000 abstract description 4
239000002562 thickening agent Substances 0.000 abstract description 3
239000013011 aqueous formulation Substances 0.000 abstract description 2
239000012669 liquid formulation Substances 0.000 abstract 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
238000009472 formulation Methods 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
239000000872 buffer Substances 0.000 description 3
239000012153 distilled water Substances 0.000 description 3
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
239000001509 sodium citrate Substances 0.000 description 3
239000000243 solution Substances 0.000 description 3
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
229960004106 citric acid Drugs 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
229940085605 saccharin sodium Drugs 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
JCLFHZLOKITRCE-UHFFFAOYSA-N 4-pentoxyphenol Chemical compound CCCCCOC1=CC=C(O)C=C1 JCLFHZLOKITRCE-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000005215 alkyl ethers Chemical class 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229960002303 citric acid monohydrate Drugs 0.000 description 1
238000004040 coloring Methods 0.000 description 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000008213 purified water Substances 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
229960000999 sodium citrate dihydrate Drugs 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CA000429095A 1982-05-27 1983-05-27 Produits pharmaceutiques Expired CA1203176A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8215502		1982-05-27
GB8215502		1982-05-27

Publications (1)

Publication Number	Publication Date
CA1203176A true CA1203176A (fr)	1986-04-15

Family

ID=10530673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000429095A Expired CA1203176A (fr)	1982-05-27	1983-05-27	Produits pharmaceutiques

Country Status (25)

Country	Link
JP (1)	JPH0629181B2 (fr)
AT (1)	AT390191B (fr)
AU (1)	AU567675B2 (fr)
BE (1)	BE896870A (fr)
CA (1)	CA1203176A (fr)
CH (1)	CH656308A5 (fr)
DE (1)	DE3319356C2 (fr)
DK (1)	DK167558B1 (fr)
ES (1)	ES8502336A1 (fr)
FI (1)	FI81257C (fr)
FR (1)	FR2527442B1 (fr)
GR (1)	GR82681B (fr)
IE (1)	IE55139B1 (fr)
IL (1)	IL68805A0 (fr)
IT (1)	IT1174759B (fr)
LU (1)	LU84828A1 (fr)
MY (1)	MY8700275A (fr)
NL (1)	NL192663C (fr)
NO (1)	NO163166C (fr)
NZ (1)	NZ204385A (fr)
PH (1)	PH19601A (fr)
PT (1)	PT76773B (fr)
SE (1)	SE454946B (fr)
ZA (1)	ZA833854B (fr)
ZW (1)	ZW11883A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3624213A (en) *	1963-10-30	1971-11-30	Merck & Co Inc	Method of sterilizing aqueous pharmaceutical solutions employing propylene oxide and entrained air
GB1200886A (en) *	1966-09-23	1970-08-05	Allen & Hanburys Ltd	Phenylaminoethanol derivatives
GB1453034A (en) *	1972-12-15	1976-10-20	Boehringer Sohn Ingelheim	Pharmaceutical composition for treating spasticity
JPS5831210B2 (ja) *	1973-04-09	1983-07-05	武田薬品工業株式会社	アンテイナスイセイケンダクエキノセイゾウホウ
DE2714065A1 (de) *	1977-03-30	1978-10-12	Boehringer Mannheim Gmbh	Instillationszubereitung

1983
- 1983-05-20 CH CH2779/83A patent/CH656308A5/fr not_active IP Right Cessation
- 1983-05-24 GR GR71454A patent/GR82681B/el unknown
- 1983-05-26 NO NO831875A patent/NO163166C/no not_active IP Right Cessation
- 1983-05-26 FR FR8308722A patent/FR2527442B1/fr not_active Expired
- 1983-05-27 PH PH28974A patent/PH19601A/en unknown
- 1983-05-27 DE DE3319356A patent/DE3319356C2/de not_active Expired - Lifetime
- 1983-05-27 NL NL8301900A patent/NL192663C/nl not_active IP Right Cessation
- 1983-05-27 FI FI831893A patent/FI81257C/fi not_active IP Right Cessation
- 1983-05-27 IE IE1267/83A patent/IE55139B1/en not_active IP Right Cessation
- 1983-05-27 ZW ZW118/83A patent/ZW11883A1/xx unknown
- 1983-05-27 BE BE0/210866A patent/BE896870A/fr not_active IP Right Cessation
- 1983-05-27 AU AU15039/83A patent/AU567675B2/en not_active Expired
- 1983-05-27 SE SE8303012A patent/SE454946B/sv not_active IP Right Cessation
- 1983-05-27 AT AT0195283A patent/AT390191B/de not_active IP Right Cessation
- 1983-05-27 NZ NZ204385A patent/NZ204385A/en unknown
- 1983-05-27 IL IL68805A patent/IL68805A0/xx not_active IP Right Cessation
- 1983-05-27 JP JP58093896A patent/JPH0629181B2/ja not_active Expired - Lifetime
- 1983-05-27 LU LU84828A patent/LU84828A1/fr unknown
- 1983-05-27 IT IT48384/83A patent/IT1174759B/it active Protection Beyond IP Right Term
- 1983-05-27 CA CA000429095A patent/CA1203176A/fr not_active Expired
- 1983-05-27 PT PT76773A patent/PT76773B/pt unknown
- 1983-05-27 DK DK241783A patent/DK167558B1/da not_active IP Right Cessation
- 1983-05-27 ZA ZA833854A patent/ZA833854B/xx unknown
- 1983-05-27 ES ES522752A patent/ES8502336A1/es not_active Expired
1987
- 1987-12-30 MY MY275/87A patent/MY8700275A/xx unknown

Also Published As

Publication number	Publication date
FI81257C (fi)	1990-10-10
NZ204385A (en)	1986-07-11
DK241783A (da)	1983-11-28
DK241783D0 (da)	1983-05-27
AT390191B (de)	1990-03-26
NL192663C (nl)	1997-12-02
LU84828A1 (fr)	1985-03-21
FI831893A0 (fi)	1983-05-27
SE8303012D0 (sv)	1983-05-27
DK167558B1 (da)	1993-11-22
IL68805A0 (en)	1983-09-30
PT76773A (en)	1983-06-01
AU567675B2 (en)	1987-12-03
MY8700275A (en)	1987-12-31
IT1174759B (it)	1987-07-01
ES522752A0 (es)	1985-01-01
SE8303012L (sv)	1983-11-28
CH656308A5 (fr)	1986-06-30
ZW11883A1 (en)	1984-12-19
PH19601A (en)	1986-05-27
ATA195283A (de)	1989-09-15
AU1503983A (en)	1983-12-01
PT76773B (en)	1986-03-27
SE454946B (sv)	1988-06-13
DE3319356C2 (de)	1996-07-04
NL8301900A (nl)	1983-12-16
NL192663B (fr)	1997-08-01
DE3319356A1 (de)	1983-12-01
BE896870A (fr)	1983-11-28
IE55139B1 (en)	1990-06-06
NO163166B (no)	1990-01-08
NO831875L (no)	1983-11-28
IE831267L (en)	1983-11-27
FR2527442B1 (fr)	1987-07-17
ES8502336A1 (es)	1985-01-01
JPH0629181B2 (ja)	1994-04-20
JPS591411A (ja)	1984-01-06
ZA833854B (en)	1985-01-30
NO163166C (no)	1990-05-02
IT8348384A0 (it)	1983-05-27
FR2527442A1 (fr)	1983-12-02
FI831893L (fi)	1983-11-28
GR82681B (fr)	1985-02-07
FI81257B (fi)	1990-06-29

Legal Events

Date	Code	Title	Description
2003-05-27	MKEX	Expiry

Publication	Publication Date	Title
US5024997A (en)	1991-06-18	Palatable ibuprofen solutions
US4499108A (en)	1985-02-12	Stable pleasant-tasting albuterol sulfate pharmaceutical formulations
US5498426A (en)	1996-03-12	Liquid antacid compositions
US20090048344A1 (en)	2009-02-19	Pharmaceutical composition comprising 5-methyl-2-2' (chloro-6'-fluoroanilino phe nylacetic acid
MXPA97002456A (en)	1997-06-01	Liquid antiacidal compositions containing calcium carbonate and possibly simeticone as active compounds and monobasic potassium phosphate and potassium bicarbonate as regula
US5182101A (en)	1993-01-26	Anti-plaque toothpaste
JP2590156B2 (ja)	1997-03-12	経口投与用医薬組成物
EP4216970A1 (fr)	2023-08-02	Composition d'hydroxyapatite pour le traitement et/ou la prévention d'une infection virale
JP2002179541A (ja)	2002-06-26	カチオン性殺菌剤を含む口腔用組成物
CA1326453C (fr)	1994-01-25	Composition pharmaceutique a base de pentamidine
US4594359A (en)	1986-06-10	Pharmaceutical compositions
JPS6351341A (ja)	1988-03-04	アズレン含有液剤
GB2120942A (en)	1983-12-14	Salbutamol compositions
KR20120078754A (ko)	2012-07-10	텔비부딘을 함유하는 경구 제약 용액제
EP0468232B1 (fr)	1999-02-03	Sirops ayant des propriétés de mise en suspension
JPH1029937A (ja)	1998-02-03	メフェナム酸水溶液製剤
FI81257C (fi)	1990-10-10	Foerfarande foer framstaellning av en vattenbaserad farmaceutisk blandning.
JP3136421B2 (ja)	2001-02-19	セチルピリジニウムの安定剤
HUT63060A (en)	1993-07-28	Process for producing pharmaceutical compositions locally applicable on nose and eye, comprising bradykinin antagonists
US4666926A (en)	1987-05-19	Transdermal formulations
JP2001131055A (ja)	2001-05-15	液剤、液剤の白濁解消方法及び液剤の経粘膜吸収促進方法
US5879711A (en)	1999-03-09	Stable antiandrogenic gel composition
JP2893807B2 (ja)	1999-05-24	アズレン誘導体含有液剤
JPH01313430A (ja)	1989-12-18	コクシジウム抑制剤の水溶性製剤
JPS6348211A (ja)	1988-02-29	アズレン系抗炎症剤