DK1680681T3 - Fremgangsmåde og apparat til vurdering af polypeptidaggregering - Google Patents

Fremgangsmåde og apparat til vurdering af polypeptidaggregering

Info

Publication number
DK1680681T3
DK1680681T3 DK04791642.4T DK04791642T DK1680681T3 DK 1680681 T3 DK1680681 T3 DK 1680681T3 DK 04791642 T DK04791642 T DK 04791642T DK 1680681 T3 DK1680681 T3 DK 1680681T3
Authority
DK
Denmark
Prior art keywords
aggregation
sequence
propensities
polypeptide aggregation
predicted
Prior art date
Application number
DK04791642.4T
Other languages
English (en)
Inventor
Christopher Dobson
Fabrizio Chiti
Jesus Zurdo
Kateri Hayashi Dubay
Michele Vendruscolo
Original Assignee
Cambridge Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd
Application granted granted Critical
Publication of DK1680681T3 publication Critical patent/DK1680681T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04791642.4T 2003-11-05 2004-10-01 Fremgangsmåde og apparat til vurdering af polypeptidaggregering DK1680681T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0325817.5A GB0325817D0 (en) 2003-11-05 2003-11-05 Method and apparatus for assessing polypeptide aggregation
PCT/GB2004/050015 WO2005045442A1 (en) 2003-11-05 2004-10-01 Method and apparatus for assessing polypeptide aggregation

Publications (1)

Publication Number Publication Date
DK1680681T3 true DK1680681T3 (da) 2012-02-27

Family

ID=29725985

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04791642.4T DK1680681T3 (da) 2003-11-05 2004-10-01 Fremgangsmåde og apparat til vurdering af polypeptidaggregering

Country Status (7)

Country Link
US (2) US7698070B2 (da)
EP (2) EP1680681B1 (da)
AT (1) ATE532072T1 (da)
DK (1) DK1680681T3 (da)
ES (1) ES2376463T3 (da)
GB (1) GB0325817D0 (da)
WO (1) WO2005045442A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1586059T3 (da) * 2003-01-20 2010-06-14 Cambridge Entpr Ltd Beregningsfremgangsmåde og apparat til forudsigelse af et polypeptids aggregering eller opløselighed
GB0325817D0 (en) * 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation
EA016884B1 (ru) * 2006-08-04 2012-08-30 ЛОНЗА БАЙОЛОДЖИКС ПиЭлСи Способ предсказания агрегации белков и конструирования ингибиторов агрегации
JP5302212B2 (ja) 2006-12-18 2013-10-02 コヴァルクス・アーゲー 治療タンパク質の凝集体の直接質量分光分析
GB2455102A (en) * 2007-11-28 2009-06-03 Cambridge Entpr Ltd Protein Aggregation Prediction Systems
CN106822891A (zh) * 2008-06-20 2017-06-13 诺华公司 具有降低的聚集的免疫球蛋白
EP2310970B1 (en) 2008-06-20 2013-05-29 Novartis AG Methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
EP2437785B1 (en) 2009-06-04 2015-02-25 Novartis AG METHODS FOR IDENTIFICATION OF SITES FOR IgG CONJUGATION
GB0914691D0 (en) 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
US8717023B2 (en) * 2011-04-21 2014-05-06 Mark Griswold Relaxometry quantification self-justification fitting
US10431325B2 (en) 2012-08-03 2019-10-01 Novartis Ag Methods to identify amino acid residues involved in macromolecular binding and uses therefor
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
JP7060324B2 (ja) 2013-12-20 2022-04-26 ザ・ブロード・インスティテュート・インコーポレイテッド ネオ抗原ワクチンによる併用療法
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
EP3234130B1 (en) 2014-12-19 2020-11-25 The Broad Institute, Inc. Methods for profiling the t-cell- receptor repertoire
GB201809341D0 (en) * 2018-06-07 2018-07-25 Ucb Biopharma Sprl Multi-domain proteins with increased native state colloidal stability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1255209A3 (en) 1997-04-11 2009-02-11 California Institute Of Technology Apparatus and method for automated protein design
DK0974111T3 (da) * 1997-04-11 2003-04-22 California Inst Of Techn Apparat og metode til automatiseret design af proteiner
EP1115845A2 (en) 1998-09-21 2001-07-18 Isis Innovation Limited Fibrils
GB9924484D0 (en) * 1999-10-15 1999-12-15 Isis Innovation Altered polypeptide aggregation
WO2002042321A2 (en) 2000-11-24 2002-05-30 Isis Innovation Limited Mixed fibrils
GB0109438D0 (en) 2001-04-17 2001-06-06 Isis Innovation Peptides
JP3802416B2 (ja) * 2001-12-27 2006-07-26 セレスター・レキシコ・サイエンシズ株式会社 相互作用部位予測装置、相互作用部位予測方法、プログラム、および、記録媒体
DK1586059T3 (da) * 2003-01-20 2010-06-14 Cambridge Entpr Ltd Beregningsfremgangsmåde og apparat til forudsigelse af et polypeptids aggregering eller opløselighed
GB0325817D0 (en) * 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation

Also Published As

Publication number Publication date
US8155888B2 (en) 2012-04-10
EP2261670A2 (en) 2010-12-15
US20060271306A1 (en) 2006-11-30
EP2261670B1 (en) 2014-08-20
EP1680681A1 (en) 2006-07-19
EP1680681B1 (en) 2011-11-02
WO2005045442A1 (en) 2005-05-19
ATE532072T1 (de) 2011-11-15
GB0325817D0 (en) 2003-12-10
EP2261670A3 (en) 2011-03-23
ES2376463T3 (es) 2012-03-14
US20100261882A1 (en) 2010-10-14
US7698070B2 (en) 2010-04-13

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