DK1680681T3 - Fremgangsmåde og apparat til vurdering af polypeptidaggregering - Google Patents

Fremgangsmåde og apparat til vurdering af polypeptidaggregering

Info

Publication number
DK1680681T3
DK1680681T3 DK04791642.4T DK04791642T DK1680681T3 DK 1680681 T3 DK1680681 T3 DK 1680681T3 DK 04791642 T DK04791642 T DK 04791642T DK 1680681 T3 DK1680681 T3 DK 1680681T3
Authority
DK
Denmark
Prior art keywords
aggregation
sequence
propensities
polypeptide aggregation
predicted
Prior art date
Application number
DK04791642.4T
Other languages
English (en)
Inventor
Christopher Dobson
Fabrizio Chiti
Jesus Zurdo
Kateri Hayashi Dubay
Michele Vendruscolo
Original Assignee
Cambridge Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Entpr Ltd filed Critical Cambridge Entpr Ltd
Application granted granted Critical
Publication of DK1680681T3 publication Critical patent/DK1680681T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Theoretical Computer Science (AREA)
  • Cell Biology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04791642.4T 2003-11-05 2004-10-01 Fremgangsmåde og apparat til vurdering af polypeptidaggregering DK1680681T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0325817.5A GB0325817D0 (en) 2003-11-05 2003-11-05 Method and apparatus for assessing polypeptide aggregation
PCT/GB2004/050015 WO2005045442A1 (en) 2003-11-05 2004-10-01 Method and apparatus for assessing polypeptide aggregation

Publications (1)

Publication Number Publication Date
DK1680681T3 true DK1680681T3 (da) 2012-02-27

Family

ID=29725985

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04791642.4T DK1680681T3 (da) 2003-11-05 2004-10-01 Fremgangsmåde og apparat til vurdering af polypeptidaggregering

Country Status (7)

Country Link
US (2) US7698070B2 (da)
EP (2) EP2261670B1 (da)
AT (1) ATE532072T1 (da)
DK (1) DK1680681T3 (da)
ES (1) ES2376463T3 (da)
GB (1) GB0325817D0 (da)
WO (1) WO2005045442A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1586059T3 (da) 2003-01-20 2010-06-14 Cambridge Entpr Ltd Beregningsfremgangsmåde og apparat til forudsigelse af et polypeptids aggregering eller opløselighed
GB0325817D0 (en) * 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation
CA2657847A1 (en) 2006-08-04 2008-02-07 Lonza Biologics Plc Method for predicting protein aggregation and designing aggregation inhibitors
US7943387B2 (en) 2006-12-18 2011-05-17 Covalx Ag Direct mass spectrometric analysis of aggregates of therapeutic proteins
GB2455102A (en) * 2007-11-28 2009-06-03 Cambridge Entpr Ltd Protein Aggregation Prediction Systems
KR101784231B1 (ko) 2008-06-20 2017-11-08 노파르티스 아게 응집이 감소된 면역글로불린
MX2010014062A (es) 2008-06-20 2011-02-22 Novartis Ag Metodos para identificar regiones de enlace a macromoleculas y con tendencia a la agregacion en proteinas y usos de las mismas.
CA2763935A1 (en) 2009-06-04 2010-12-09 Novartis Ag Methods for identification of sites for igg conjugation
GB0914691D0 (en) 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
US8717023B2 (en) * 2011-04-21 2014-05-06 Mark Griswold Relaxometry quantification self-justification fitting
US10431325B2 (en) 2012-08-03 2019-10-01 Novartis Ag Methods to identify amino acid residues involved in macromolecular binding and uses therefor
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
WO2015085147A1 (en) 2013-12-05 2015-06-11 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
EP3082853A2 (en) 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
GB201809341D0 (en) * 2018-06-07 2018-07-25 Ucb Biopharma Sprl Multi-domain proteins with increased native state colloidal stability

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1255209A3 (en) 1997-04-11 2009-02-11 California Institute Of Technology Apparatus and method for automated protein design
EP0974111B1 (en) 1997-04-11 2003-01-08 California Institute Of Technology Apparatus and method for automated protein design
EP1115845A2 (en) 1998-09-21 2001-07-18 Isis Innovation Limited Fibrils
GB9924484D0 (en) * 1999-10-15 1999-12-15 Isis Innovation Altered polypeptide aggregation
AU2002223886A1 (en) 2000-11-24 2002-06-03 Isis Innovation Limited Mixed fibrils
GB0109438D0 (en) 2001-04-17 2001-06-06 Isis Innovation Peptides
JP3802416B2 (ja) * 2001-12-27 2006-07-26 セレスター・レキシコ・サイエンシズ株式会社 相互作用部位予測装置、相互作用部位予測方法、プログラム、および、記録媒体
DK1586059T3 (da) 2003-01-20 2010-06-14 Cambridge Entpr Ltd Beregningsfremgangsmåde og apparat til forudsigelse af et polypeptids aggregering eller opløselighed
GB0325817D0 (en) 2003-11-05 2003-12-10 Univ Cambridge Tech Method and apparatus for assessing polypeptide aggregation

Also Published As

Publication number Publication date
ES2376463T3 (es) 2012-03-14
US20100261882A1 (en) 2010-10-14
EP2261670A3 (en) 2011-03-23
EP2261670A2 (en) 2010-12-15
US20060271306A1 (en) 2006-11-30
US7698070B2 (en) 2010-04-13
ATE532072T1 (de) 2011-11-15
EP1680681B1 (en) 2011-11-02
EP1680681A1 (en) 2006-07-19
EP2261670B1 (en) 2014-08-20
US8155888B2 (en) 2012-04-10
GB0325817D0 (en) 2003-12-10
WO2005045442A1 (en) 2005-05-19

Similar Documents

Publication Publication Date Title
DK1680681T3 (da) Fremgangsmåde og apparat til vurdering af polypeptidaggregering
DK2046951T3 (da) Proteasesreeningsmetoder og proteaser identificeret dermed
ATE406639T1 (de) Rfid-einrichtungstester und verfahren
ATE372578T1 (de) Automatischer abnutzungsausgleich in einem nicht- flüchtigen speichersystem
DK1510492T3 (da) Fremgangsmåde til afprövning af et elevatoranlæg og elevatoranlæg
ATE512406T1 (de) Kontrolle von testfallvererbung durch attribute
DE602004032466D1 (de) Durchführung von prüfungen an der betriebsmittelbenutzung von computerprogrammen
ATE545460T1 (de) Proteomanalyseverfahren für phosphoryliertes protein
WO2005048107A3 (en) System, method, and computer program product for identifying code development errors
ATE519168T1 (de) Verfahren zur analyse von ein teil von multimedia-inhalten und entsprechenden computer software produkt-und-analyse-gerät
ATE379902T1 (de) Verfahren zur authentifizierung von zugangspunkten eines drahtlosen netzes
DE602005019156D1 (de) Verfahren zur auswertung von ribonukleotidsequenzen
BRPI0600265A (pt) métodos e sistema para a inspeção de componentes fabricados
ATE469238T1 (de) Verwendung von fluor-nmr zum screening mit hohem durchsatz
ATE456797T1 (de) Verwendung von nogo-c bei der beurteilung von herzversagen
DE60208415D1 (de) Verfahren zur optimierung von testdaten
ATE504833T1 (de) Verfahren zur bestimmung des phänotyps von zellen
ATE326982T1 (de) Testsystem zur evaluierung der kompatibilität biologisch aktiver substanzen mit copolymeren
ATE410679T1 (de) Verfahren zur identifikation von antivirale substanzen
ATE484023T1 (de) Vorrichtung und verfahren zur vermeidung von gleitkommasteueranweisungen bei der konvertierung von gleitkomma- zu ganzzahldaten
DE60327776D1 (de) Sonden zum nachweis von tumorzellen
EP2000935A3 (en) Method of processing protein peptide data and system
DE50312072D1 (de) Verfahren zur identifizierung von substanzen
ATE444493T1 (de) Verfahren zur identifikation von salzempfindlichen personen
ATE481621T1 (de) Anordnung und verfahren zur knotenidentifizierung