DK169675B1 - 4-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne - Google Patents

4-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne Download PDF

Info

Publication number: DK169675B1
Authority: DK; Denmark
Prior art keywords: methyl; compound; formula; alkyl; compounds
Prior art date: 1986-11-28

Application number

DK624887A

Other languages

Danish (da)

English (en)

Other versions

DK624887A (da

DK624887D0 (da

Inventor

Ian Harold Coates

John Bradshaw

James Angus Bell

David Cedric Humber

George Blanch Ewan

William Leonard Mitchell

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-28

Filing date

1987-11-27

Publication date

1995-01-09

1986-11-28 Priority claimed from GB868628473A external-priority patent/GB8628473D0/en

1987-11-12 Priority claimed from GB878726537A external-priority patent/GB8726537D0/en

1987-11-27 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1987-11-27 Publication of DK624887D0 publication Critical patent/DK624887D0/da

1988-05-29 Publication of DK624887A publication Critical patent/DK624887A/da

1995-01-09 Application granted granted Critical

1995-01-09 Publication of DK169675B1 publication Critical patent/DK169675B1/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK624887A 1986-11-28 1987-11-27 4-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne DK169675B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB8628473		1986-11-28
GB868628473A GB8628473D0 (en)	1986-11-28	1986-11-28	Chemical compounds
GB878726537A GB8726537D0 (en)	1987-11-12	1987-11-12	Tricyclic ketones
GB8726537		1987-11-12

Publications (3)

Publication Number	Publication Date
DK624887D0 DK624887D0 (da)	1987-11-27
DK624887A DK624887A (da)	1988-05-29
DK169675B1 true DK169675B1 (da)	1995-01-09

Family

ID=26291603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK624887A DK169675B1 (da)	1986-11-28	1987-11-27	4-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne

Country Status (24)

Country	Link
US (1)	US4822881A (2)
AT (1)	AT396933B (2)
AU (1)	AU605805B2 (2)
BE (1)	BE1001004A4 (2)
CA (1)	CA1326032C (2)
CH (1)	CH676120A5 (2)
CZ (1)	CZ404591A3 (2)
DE (1)	DE3740352A1 (2)
DK (1)	DK169675B1 (2)
ES (1)	ES2008360A6 (2)
FI (1)	FI92062C (2)
FR (1)	FR2611366B1 (2)
GB (1)	GB2202530B (2)
GR (1)	GR871809B (2)
HK (1)	HK51591A (2)
IE (1)	IE61510B1 (2)
IL (1)	IL84635A (2)
IT (1)	IT1211936B (2)
NL (1)	NL8702851A (2)
NO (1)	NO172581C (2)
NZ (1)	NZ222725A (2)
PH (1)	PH30436A (2)
SE (1)	SE467255B (2)
SG (1)	SG46591G (2)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8518742D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Process
GB8812002D0 (en) *	1988-05-20	1988-06-22	Glaxo Group Ltd	Chemical compounds
US5202343A (en) *	1986-11-28	1993-04-13	Glaxo Group Limited	Tricyclic ketones useful as HT3 -receptor antagonists
DE3822792C2 (de) *	1987-07-11	1997-11-27	Sandoz Ag	Neue Verwendung von 5HT¶3¶-Antagonisten
GB8720693D0 (en) *	1987-09-03	1987-10-07	Glaxo Group Ltd	Chemical compounds
US5360800A (en) *	1987-09-03	1994-11-01	Glaxo Group Limited	Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
JPH01258673A (ja) *	1987-10-22	1989-10-16	Glaxo Group Ltd	ケトン誘導体
EP0336759A1 (en) *	1988-04-07	1989-10-11	Glaxo Group Limited	Imidazole derivatives
DK185489A (da) *	1988-04-22	1989-10-23	Duphar Int Res	Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
US4985422A (en) *	1988-04-27	1991-01-15	Glaxo Group Limited	Lactam derivatives
GB8812636D0 (en) *	1988-05-27	1988-06-29	Glaxo Group Ltd	Chemical compounds
EP0350129A1 (en) *	1988-07-07	1990-01-10	Duphar International Research B.V	New annelated indoleketones with an imidazolylalkyl substituent
HU207078B (en) *	1988-08-02	1993-03-01	Glaxo Group Ltd	Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
AU631131B2 (en) *	1988-08-02	1992-11-19	Glaxo Group Limited	Lactam derivatives
JPH02167280A (ja) *	1988-08-15	1990-06-27	Glaxo Group Ltd	ラクタム誘導体
GB8820650D0 (en) *	1988-09-01	1988-10-05	Glaxo Group Ltd	Medicaments
US4997831A (en) *	1988-09-01	1991-03-05	Glaxo Group Limited	Lactam derivatives
GB8820653D0 (en) *	1988-09-01	1988-10-05	Glaxo Group Ltd	Medicaments
GB8820651D0 (en) *	1988-09-01	1988-10-05	Glaxo Group Ltd	Medicaments
AU627221B2 (en) *	1988-09-27	1992-08-20	Fujisawa Pharmaceutical Co., Ltd.	Pyridoindole derivatives and processes for preparation thereof
GB8823980D0 (en) *	1988-10-13	1988-11-23	Glaxo Group Ltd	Chemical compounds
US5223625A (en) *	1988-12-22	1993-06-29	Duphar International Research B.V.	Annelated indolo [3,2,-C]lactams
GB8904551D0 (en) *	1989-02-28	1989-04-12	Glaxo Group Ltd	Chemical compounds
HU204049B (en) *	1989-02-28	1991-11-28	Glaxo Group Ltd	Process for producing lactam derivatives and pharmaceutical compositions comprising same
GB8904552D0 (en)	1989-02-28	1989-04-12	Glaxo Group Ltd	Chemical process
AU631632B2 (en)	1989-04-21	1992-12-03	Novartis Ag	Therapeutic use of 5-ht3 receptor antagonists
GB8928208D0 (en) *	1989-12-13	1990-02-14	Glaxo Group Ltd	Medicaments
HU211081B (en) *	1990-12-18	1995-10-30	Sandoz Ag	Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
KR100368895B1 (ko) *	2000-03-30	2003-01-24	하나제약 주식회사	1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법
WO2003061657A1 (en) *	2002-01-18	2003-07-31	Aryx Therapeutics	5-ht3 receptor antagonists and methods of use
EP2253316B1 (en)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
CN102458400B (zh)	2009-05-20	2014-10-08	国立健康与医学研究所	用于治疗病灶性前庭功能障碍的血清素5-ht3受体拮抗剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3740404A (en) *	1969-05-09	1973-06-19	American Cyanamid Co	Piperidinomethylenedihydrocarbazolones
US3634420A (en) *	1969-05-09	1972-01-11	American Cyanamid Co	3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
GB1365296A (en) *	1970-10-30	1974-08-29	Unilever Ltd	Dentifrice compositions
US4176230A (en) *	1977-08-04	1979-11-27	Hoffmann-La Roche Inc.	5-(6-Alkylindol-3-ylmethylene)-1,3-dimethyl-2-(methylimino)-4-imidazolidinones
PH14576A (en) *	1978-11-01	1981-09-24	Wellcome Found	9-(3-(3,5-cis-dimethylpiperazino)prophyl)carrazole,salts and solvates thereof and pharmaceutical compositions containing same
DK151884C (da) *	1979-03-07	1988-06-13	Pfizer	Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf
LU88268I2 (2) *	1984-01-25	1994-02-03
US4695578A (en) *	1984-01-25	1987-09-22	Glaxo Group Limited	1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
AU583343B2 (en) *	1985-01-23	1989-04-27	Glaxo Group Limited	Heterocyclic compounds
GB8518743D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8518745D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Heterocyclic compounds
GB8518741D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Process

1987
- 1987-11-26 GR GR871809A patent/GR871809B/el unknown
- 1987-11-27 FI FI875235A patent/FI92062C/fi not_active IP Right Cessation
- 1987-11-27 ES ES8703405A patent/ES2008360A6/es not_active Expired
- 1987-11-27 IL IL84635A patent/IL84635A/xx not_active IP Right Cessation
- 1987-11-27 PH PH36132A patent/PH30436A/en unknown
- 1987-11-27 SE SE8704746A patent/SE467255B/sv not_active IP Right Cessation
- 1987-11-27 CH CH4614/87A patent/CH676120A5/fr not_active IP Right Cessation
- 1987-11-27 AT AT0312487A patent/AT396933B/de not_active IP Right Cessation
- 1987-11-27 AU AU81845/87A patent/AU605805B2/en not_active Ceased
- 1987-11-27 FR FR878716488A patent/FR2611366B1/fr not_active Expired - Fee Related
- 1987-11-27 NL NL8702851A patent/NL8702851A/nl not_active Application Discontinuation
- 1987-11-27 DK DK624887A patent/DK169675B1/da active
- 1987-11-27 IE IE323287A patent/IE61510B1/en not_active IP Right Cessation
- 1987-11-27 GB GB8727835A patent/GB2202530B/en not_active Expired - Fee Related
- 1987-11-27 NZ NZ222725A patent/NZ222725A/xx unknown
- 1987-11-27 NO NO874959A patent/NO172581C/no unknown
- 1987-11-27 US US07/126,202 patent/US4822881A/en not_active Expired - Fee Related
- 1987-11-27 DE DE19873740352 patent/DE3740352A1/de not_active Ceased
- 1987-11-27 BE BE8701353A patent/BE1001004A4/fr not_active IP Right Cessation
- 1987-11-27 CA CA000552963A patent/CA1326032C/en not_active Expired - Fee Related
- 1987-11-27 IT IT8748642A patent/IT1211936B/it active
1991
- 1991-06-18 SG SG46591A patent/SG46591G/en unknown
- 1991-07-04 HK HK515/91A patent/HK51591A/xx not_active IP Right Cessation
- 1991-12-23 CZ CS914045A patent/CZ404591A3/cs unknown

Also Published As

Publication number	Publication date
DE3740352A1 (de)	1988-06-09
IL84635A0 (en)	1988-04-29
HK51591A (en)	1991-07-12
GB2202530A (en)	1988-09-28
GB2202530B (en)	1990-04-18
BE1001004A4 (fr)	1989-06-06
PH30436A (en)	1997-05-09
IE873232L (en)	1988-05-28
NZ222725A (en)	1990-08-28
CH676120A5 (2)	1990-12-14
FI92062B (fi)	1994-06-15
IT8748642A0 (it)	1987-11-27
DK624887A (da)	1988-05-29
DK624887D0 (da)	1987-11-27
SE467255B (sv)	1992-06-22
NL8702851A (nl)	1988-06-16
FR2611366A1 (fr)	1988-09-02
SE8704746D0 (sv)	1987-11-27
IL84635A (en)	1993-01-31
ATA312487A (de)	1993-05-15
US4822881A (en)	1989-04-18
NO172581B (no)	1993-05-03
GB8727835D0 (en)	1987-12-31
ES2008360A6 (es)	1989-07-16
NO874959L (no)	1988-05-30
SG46591G (en)	1991-07-26
CZ404591A3 (en)	1993-08-11
NO874959D0 (no)	1987-11-27
FR2611366B1 (fr)	1990-03-16
IT1211936B (it)	1989-11-08
GR871809B (en)	1988-03-07
FI875235A7 (fi)	1988-05-29
SE8704746L (sv)	1988-05-29
FI875235A0 (fi)	1987-11-27
FI92062C (fi)	1994-09-26
AU8184587A (en)	1988-06-02
AU605805B2 (en)	1991-01-24
AT396933B (de)	1993-12-27
NO172581C (no)	1993-08-11
IE61510B1 (en)	1994-11-16
CA1326032C (en)	1994-01-11

Publication	Publication Date	Title
DK169675B1 (da)	1995-01-09	4-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne
DK169521B1 (da)	1994-11-21	3-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne
DE3851597T2 (de)	1995-01-26	Lactamderivate.
DK169922B1 (da)	1995-04-03	Substituerede (imidazol-4-yl)methylpyrido-, og -azepino-, indolonderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne
US4997831A (en)	1991-03-05	Lactam derivatives
EP0705832B1 (en)	2003-08-13	Serotonergic modulators
CZ151297A3 (cs)	1998-07-15	Dihydropyrimidinové sloučeniny a farmaceutické prostředky na jejich bázi
JPH0256485A (ja)	1990-02-26	ラクタム誘導体
US5045545A (en)	1991-09-03	[(Imidazol-4(and 5)-yl)methyl] tetracyclic ketones having 5-HT3 antagonist activity
JPS60215683A (ja)	1985-10-29	新規縮合ジアゼピノン
NO884174L (no)	1989-03-22	Framgangsmaate for fremstilling av terapeutisk aktive tricykliske amidinoderivater.
US6506768B2 (en)	2003-01-14	Tetrahydro γ-carbolines
US5563147A (en)	1996-10-08	Serotonerbic tetrahydropyridoindoles
US5006544A (en)	1991-04-09	Imidazole derivatives and pharmaceutical use thereof
US4859662A (en)	1989-08-22	Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
DE3876006T2 (de)	1993-03-25	Keton-derivate.
US5360800A (en)	1994-11-01	Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
HU207078B (en)	1993-03-01	Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
US5204470A (en)	1993-04-20	Azabicyclic derivatives
US6127388A (en)	2000-10-03	Azetidine, pyrrolidine and piperidine derivatives as 5-HT1D receptor agonists
DK170506B1 (da)	1995-10-02	Pyrido- og azepino-indolforbindelser, fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende dem samt anvendelse af forbindelserne
US5202343A (en)	1993-04-13	Tricyclic ketones useful as HT3 -receptor antagonists
HU199142B (en)	1990-01-29	Process for producing tricyclic ketones and pharmaceutical compositions comprising same as active ingredient
RU2081117C1 (ru)	1997-06-10	Производные лактама или их физиологические приемлемые соли или сольваты
FI89484B (fi)	1993-06-30	Foerfarande foer framstaellning av terapeutiskt aktiva tetrahydro-2-/(imidazol-4-yl)metyl/pyrido(4,3-b)indol- och azepino-/4,3-b/indol-1-oner