DK1721992T3 - Fremgangsmåder og nukleinsyrer til analyser af cellulære proliferative sygdomme - Google Patents
Fremgangsmåder og nukleinsyrer til analyser af cellulære proliferative sygdommeInfo
- Publication number
- DK1721992T3 DK1721992T3 DK06007989T DK06007989T DK1721992T3 DK 1721992 T3 DK1721992 T3 DK 1721992T3 DK 06007989 T DK06007989 T DK 06007989T DK 06007989 T DK06007989 T DK 06007989T DK 1721992 T3 DK1721992 T3 DK 1721992T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleic acids
- detecting
- methods
- proliferative disease
- cellular proliferative
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67224205P | 2005-04-15 | 2005-04-15 | |
| US67699705P | 2005-05-02 | 2005-05-02 | |
| US69752105P | 2005-07-08 | 2005-07-08 | |
| US70486005P | 2005-08-01 | 2005-08-01 | |
| US70931805P | 2005-08-17 | 2005-08-17 | |
| US72360205P | 2005-10-04 | 2005-10-04 | |
| US78740206P | 2006-03-30 | 2006-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1721992T3 true DK1721992T3 (da) | 2009-02-02 |
Family
ID=36746665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06007989T DK1721992T3 (da) | 2005-04-15 | 2006-04-18 | Fremgangsmåder og nukleinsyrer til analyser af cellulære proliferative sygdomme |
Country Status (20)
| Country | Link |
|---|---|
| US (8) | US7951563B2 (fr) |
| EP (4) | EP1877577A2 (fr) |
| JP (2) | JP5341506B2 (fr) |
| KR (3) | KR101708544B1 (fr) |
| CN (3) | CN107663538B (fr) |
| AT (1) | ATE410524T1 (fr) |
| AU (1) | AU2006236620B2 (fr) |
| BR (1) | BRPI0607508B8 (fr) |
| CA (1) | CA2606296C (fr) |
| DE (1) | DE602006003012D1 (fr) |
| DK (1) | DK1721992T3 (fr) |
| EA (1) | EA013634B1 (fr) |
| ES (2) | ES2533767T3 (fr) |
| IL (1) | IL186556A (fr) |
| MX (1) | MX2007012782A (fr) |
| PL (1) | PL1721992T3 (fr) |
| PT (1) | PT1721992E (fr) |
| SG (1) | SG183708A1 (fr) |
| SI (1) | SI1721992T1 (fr) |
| WO (1) | WO2006113466A2 (fr) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1863927B (zh) | 2003-09-04 | 2010-08-11 | 人类遗传标记控股有限公司 | 核酸检测分析 |
| US7833942B2 (en) * | 2004-12-03 | 2010-11-16 | Human Genetic Signatures Pty. Ltd. | Methods for simplifying microbial nucleic acids by chemical modification of cytosines |
| EP1877577A2 (fr) | 2005-04-15 | 2008-01-16 | Epigenomics Inc. | Méhodes et acides nucléiques utilisés dans des analyses de troubles prolifératifs cellulaires |
| JP2008541705A (ja) * | 2005-05-26 | 2008-11-27 | ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド | 非標準塩基を含むプライマーを使用する等温鎖置換増幅 |
| WO2007030882A1 (fr) | 2005-09-14 | 2007-03-22 | Human Genetic Signatures Pty Ltd | Essai pour un état de santé |
| EP2013360A2 (fr) * | 2006-04-17 | 2009-01-14 | Epigenomics AG | Procédés et acides nucléiques pour détecter des troubles de prolifération de cellules colorectales |
| US20080050738A1 (en) * | 2006-05-31 | 2008-02-28 | Human Genetic Signatures Pty Ltd. | Detection of target nucleic acid |
| US20100143902A1 (en) * | 2006-07-21 | 2010-06-10 | Epigenomics Ag | Methods and nucleic acids for analyses of cellular proliferative disorders |
| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| US7662566B2 (en) * | 2006-11-22 | 2010-02-16 | Myriad Genetics, Inc. | Gene copy number profiling |
| US20080221056A1 (en) * | 2007-02-12 | 2008-09-11 | Johns Hopkins University | Early Detection and Prognosis of Colon Cancers |
| US20100092972A1 (en) * | 2007-03-16 | 2010-04-15 | Human Genetic Signatures Pty Ltd. | Assay for gene expression |
| WO2008122447A2 (fr) * | 2007-04-10 | 2008-10-16 | Epigenomics Ag | Dosage de méthylation d'adn permettant de réaliser le diagnostic ou le pronostic d'états pathologiques |
| SI3101141T1 (sl) | 2007-06-08 | 2020-03-31 | Epigenomics Ag | Postopek za metilacijsko analizo |
| FR2919061B1 (fr) * | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de la plastine-i pour le diagnostic in vitro du cancer colorectal. |
| CN101918595A (zh) | 2007-11-27 | 2010-12-15 | 人类遗传标记控股有限公司 | 用于扩增和复制亚硫酸氢盐修饰的核酸的酶 |
| AU2008334901A1 (en) * | 2007-12-11 | 2009-06-18 | Epigenomics Ag | Methods and nucleic acids for analyses of lung carcinoma |
| US20110003700A1 (en) * | 2007-12-20 | 2011-01-06 | Human Genetic Signatures Pty Ltd. | Elimination of contaminants associated with nucleic acid amplification |
| TW200927925A (en) * | 2007-12-27 | 2009-07-01 | Agriculture And Food Agency Council Of Agriculture | Specific Promoter Region Expresses in Actively Dividing Young Tissues and the Aging Tissues in Plants and its Application |
| WO2009115920A1 (fr) * | 2008-03-18 | 2009-09-24 | Epigenomics Ag | Procédé d’optimisation et de validation d’un essai permettant de déterminer la présence ou l’absence d’une condition médicale |
| EP2337868A4 (fr) * | 2008-10-09 | 2012-03-28 | British Columbia Cancer Agency | Détection de tumeurs de la granulosa |
| ES2534200T3 (es) * | 2009-08-03 | 2015-04-20 | Epigenomics Ag | Métodos para la preservación de la complejidad de la secuencia del ADN genómico |
| TWI434937B (zh) * | 2009-10-28 | 2014-04-21 | Univ Nat Chunghsing | 具有廣泛性抗木瓜輪點病毒特性的基因轉殖木瓜品系18-2-4之核酸分子及其檢測方法及應用 |
| GB201004147D0 (en) * | 2010-03-12 | 2010-04-28 | Dna Electronics Ltd | Method and apparatus for sensing methylation |
| KR101747191B1 (ko) | 2011-01-14 | 2017-06-14 | 에스케이하이닉스 주식회사 | 반도체 장치 |
| GB201107466D0 (en) | 2011-05-05 | 2011-06-15 | Loktionov Alexandre | Device and method for non-invasive collection of colorectal mucocellular layer and disease detection |
| WO2012167145A2 (fr) * | 2011-06-01 | 2012-12-06 | University Of Southern California | Analyse à l'échelle du génome d'une méthylation aberrante de l'adn dans le cancer colorectal |
| FI20115709A0 (fi) * | 2011-07-01 | 2011-07-01 | Helsingin Yliopisto | Menetelmä perinnöllisten syöpien diagnosointiin |
| PH12014500063A1 (en) * | 2011-07-08 | 2014-02-17 | Epigenomics Ag | Methods and nucleic acids for determining the prognosis of a cancer subject |
| BR112014005253B1 (pt) | 2011-09-07 | 2019-11-05 | Human Genetic Signatures Pty Ltd | método de detecção molecular |
| US9546403B1 (en) | 2011-12-14 | 2017-01-17 | University Of Utah Research Foundation | Substrate for methylated DNA testing |
| WO2013142545A1 (fr) * | 2012-03-20 | 2013-09-26 | Exact Sciences Corporation | Panel de marqueurs pour la détection du cancer |
| CA2883671A1 (fr) * | 2012-08-31 | 2014-03-06 | National Defense Medical Center | Methode de depistage du cancer |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| KR101476769B1 (ko) * | 2013-01-02 | 2014-12-26 | 대구대학교 산학협력단 | leucine-richα-2 glyprotein를 함유하는 대장암 진행예측용 바이오마커 조성물 및 이를 포함하는 대장암 진단용 바이오키트 |
| JP6369857B2 (ja) * | 2013-05-29 | 2018-08-08 | シスメックス株式会社 | 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット |
| KR101527283B1 (ko) * | 2013-08-13 | 2015-06-10 | 서울대학교산학협력단 | 당단백질의 탈당화 검출을 통한 암 마커 스크리닝 방법 및 간세포암 마커 |
| KR101438519B1 (ko) * | 2014-07-01 | 2014-09-17 | 대구대학교 산학협력단 | complement factor B를 함유하는 대장암 진행예측용 바이오마커 조성물 및 이를 포함하는 대장암 진단용 바이오키트 |
| US10342238B2 (en) | 2014-07-03 | 2019-07-09 | Aktiebolaget Electrolux | Household appliance mixing arrangement |
| US10258050B2 (en) | 2014-07-03 | 2019-04-16 | Aktiebolaget Electrolux | Household appliance mixing arragement |
| EP3543356B1 (fr) | 2014-07-18 | 2021-06-30 | The Chinese University of Hong Kong | Analyse de motifs de méthylation de tissus dans un mélange d'adn |
| CN104745575B (zh) | 2014-08-08 | 2019-03-12 | 博诚研究中心 | 用于检测细胞增殖性异常或疾病程度分级的基因组合物及其用途 |
| HRP20190787T1 (hr) * | 2014-12-19 | 2019-08-09 | Epigenomics Ag | Metoda otkrivanja cpg (na mjestima citozin-fosfat-guanin)metilacije i dijagnosticiranje karcinoma |
| US20180143198A1 (en) * | 2014-12-26 | 2018-05-24 | Peking University | Method for detecting differentially methylated cpg islands associated with abnormal state of human body |
| CN115181802A (zh) * | 2015-04-23 | 2022-10-14 | 博尔诚(北京)科技有限公司 | 一种检测Septin9基因甲基化的试剂盒及其应用 |
| CN104830855A (zh) * | 2015-05-21 | 2015-08-12 | 基因科技(上海)有限公司 | 一种检测sept9基因甲基化的探针及其应用 |
| US12300356B2 (en) * | 2016-05-04 | 2025-05-13 | Queen's University At Kingston | Cell-free detection of methylated tumour DNA |
| RU2630669C1 (ru) * | 2016-07-21 | 2017-09-11 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") | Способ определения метилирования сайтов PuCGPy регуляторных областей генов-онкомаркеров колоректального рака методом GLAD-ПЦР-анализа и набор олигонуклеотидных праймеров и флуоресцентно-меченых зондов для осуществления указанного способа |
| CN116445593A (zh) | 2016-08-10 | 2023-07-18 | 格里尔公司 | 测定一生物样品的一甲基化图谱的方法 |
| CN107723363A (zh) * | 2016-08-11 | 2018-02-23 | 博尔诚(北京)科技有限公司 | 肿瘤标志物的组合检测方法及其应用 |
| KR20260032575A (ko) | 2016-11-30 | 2026-03-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
| EP3360971A1 (fr) * | 2017-02-09 | 2018-08-15 | Epiontis GmbH | Procédé amélioré de comptage de cellules immunitaires épigénétiques |
| WO2018195217A1 (fr) | 2017-04-19 | 2018-10-25 | Singlera Genomics, Inc. | Compositions et procédés pour la construction de bibliothèques et l'analyse de séquences |
| CN109609629A (zh) * | 2017-09-30 | 2019-04-12 | 博尔诚(北京)科技有限公司 | 用于检测肝癌的组合物及其用途 |
| AU2019234843B2 (en) | 2018-03-13 | 2025-12-04 | Grail, Inc. | Anomalous fragment detection and classification |
| WO2019195268A2 (fr) | 2018-04-02 | 2019-10-10 | Grail, Inc. | Marqueurs de méthylation et panels de sondes de méthylation ciblés |
| CN108866191B (zh) * | 2018-07-26 | 2021-07-09 | 上海奕谱生物科技有限公司 | 基于甲基化修饰的肿瘤标记物stamp-ep2 |
| CN108866192B (zh) * | 2018-07-26 | 2021-06-22 | 上海奕谱生物科技有限公司 | 基于甲基化修饰的肿瘤标记物stamp-ep1 |
| CA3111887A1 (fr) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Marqueurs de methylation et panels de sondes de methylation ciblees |
| EP3899953A1 (fr) | 2018-12-21 | 2021-10-27 | Grail, Inc. | Source de déconvolution d'origine basée sur des fragments de méthylation dans des échantillons d'adn acellulaire |
| CN115786517A (zh) * | 2019-02-14 | 2023-03-14 | 博尔诚(北京)科技有限公司 | 一种肠癌患癌、癌前筛查组合物及其用途 |
| CN110211633B (zh) * | 2019-05-06 | 2021-08-31 | 臻和精准医学检验实验室无锡有限公司 | Mgmt基因启动子甲基化的检测方法、测序数据的处理方法及处理装置 |
| CN112063712A (zh) * | 2019-10-28 | 2020-12-11 | 北京康美天鸿生物科技有限公司 | 基于高分辨率熔解曲线检测septin9基因甲基化的特异引物对和试剂盒 |
| AU2020406068A1 (en) * | 2019-12-16 | 2022-07-14 | New Day Diagnostics Llc | Methods for detecting colorectal cancer |
| KR102637032B1 (ko) * | 2020-01-28 | 2024-02-15 | 주식회사 젠큐릭스 | 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도 |
| WO2023017001A1 (fr) | 2021-08-09 | 2023-02-16 | Epigenomics Ag | Méthodes améliorées de détection du cancer colorectal |
| CN113584032B (zh) * | 2021-08-20 | 2023-08-29 | 深圳市恩辑生物科技有限公司 | 一种迷你启动子pAPP及其应用 |
| CN113862349A (zh) * | 2021-10-26 | 2021-12-31 | 山东师范大学 | 一种肺纤维化诊断生物标志物 |
| CN114783511B (zh) * | 2022-02-25 | 2025-03-25 | 深圳市硬核酸生物科技有限公司 | 核酸分子溶液浓度推荐方法及装置、计算机设备 |
| WO2024074558A1 (fr) | 2022-10-04 | 2024-04-11 | Epigenomics Ag | Procédés améliorés de détection du cancer |
| WO2025019568A1 (fr) * | 2023-07-17 | 2025-01-23 | The Penn State Research Foundation | Amélioration de thérapies à base de cellules immunitaires contre des tumeurs solides avec des protéines de septine optogénétiquement modifiées |
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