DK173536B1 - cDNA-sekvens, som koder for modent humant vævsfaktorinhibitor-protein - Google Patents

cDNA-sekvens, som koder for modent humant vævsfaktorinhibitor-protein Download PDF

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Publication number
DK173536B1
DK173536B1 DK198804134A DK413488A DK173536B1 DK 173536 B1 DK173536 B1 DK 173536B1 DK 198804134 A DK198804134 A DK 198804134A DK 413488 A DK413488 A DK 413488A DK 173536 B1 DK173536 B1 DK 173536B1
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DK
Denmark
Prior art keywords
tfi
sequence
cdna
protein
tissue factor
Prior art date
Application number
DK198804134A
Other languages
Danish (da)
English (en)
Other versions
DK413488A (da
DK413488D0 (da
Inventor
Kuniko Kusano Kretzmer
Tze-Chein Wun
John Broze George Jr
Original Assignee
Univ Washington
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22410671&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK173536(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/123,753 external-priority patent/US4966852A/en
Application filed by Univ Washington, Monsanto Co filed Critical Univ Washington
Publication of DK413488D0 publication Critical patent/DK413488D0/da
Publication of DK413488A publication Critical patent/DK413488A/da
Priority to DK200001612A priority Critical patent/DK174754B1/da
Application granted granted Critical
Publication of DK173536B1 publication Critical patent/DK173536B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK198804134A 1987-11-23 1988-07-22 cDNA-sekvens, som koder for modent humant vævsfaktorinhibitor-protein DK173536B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200001612A DK174754B1 (da) 1987-11-23 2000-10-27 Humane vævsfaktorinhibitor (TFI), antistof med bindingsspecificitet herfor, fremgangsmåde til anvendelse af en TFI-peptid-kolonne til at oprense et antistof og fremgangsmåder til detektion af TFI eller et polypeptid omfattende....

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12375387 1987-11-23
US07/123,753 US4966852A (en) 1987-07-23 1987-11-23 DNA clone of human tissue factor inhibitor

Publications (3)

Publication Number Publication Date
DK413488D0 DK413488D0 (da) 1988-07-22
DK413488A DK413488A (da) 1989-05-24
DK173536B1 true DK173536B1 (da) 2001-02-05

Family

ID=22410671

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198804134A DK173536B1 (da) 1987-11-23 1988-07-22 cDNA-sekvens, som koder for modent humant vævsfaktorinhibitor-protein

Country Status (15)

Country Link
EP (1) EP0318451B1 (fr)
JP (5) JP2836823B2 (fr)
KR (1) KR930000274B1 (fr)
AT (1) ATE111518T1 (fr)
AU (1) AU604139B2 (fr)
CA (1) CA1341223C (fr)
DE (1) DE3851511T2 (fr)
DK (1) DK173536B1 (fr)
ES (1) ES2063769T3 (fr)
FI (1) FI93365C (fr)
IE (1) IE65393B1 (fr)
IL (1) IL87171A (fr)
NO (2) NO310466B1 (fr)
NZ (1) NZ225535A (fr)
PT (1) PT88076B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378614A (en) * 1989-08-18 1995-01-03 Novo Nordisk A/S Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
EP0439442B1 (fr) * 1990-01-25 1996-03-06 Washington University Protéine hybride, facteur X-LACI
CA2049873C (fr) * 1990-08-27 2001-12-04 Tze-Chein Wun Combinaison anticoagulante d'inhibiteur de coagulation associe a des lipoproteines (ical) et de polysaccharides sulfates
DK261490D0 (da) * 1990-10-31 1990-10-31 Novo Nordisk As New pharmaceutical compound
US5346991A (en) * 1991-06-13 1994-09-13 Genentech, Inc. Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US5455338A (en) 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
IL161407A0 (en) 2001-10-15 2004-09-27 Chiron Corp Treatment of severe pneumonia by administration of tissue factor pathway inhibitor (tfpi)
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
DK2311432T3 (en) 2002-06-07 2015-02-02 Dyax Corp Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US8828703B2 (en) 2005-12-29 2014-09-09 Dyax Corp. Protease inhibition
CA2747721C (fr) 2008-12-19 2021-07-20 Baxter International Inc. Inhibiteurs de tfpi et procedes d'utilisation
US8637454B2 (en) 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
ES2688093T3 (es) 2010-01-06 2018-10-30 Dyax Corp. Proteínas de unión a calicreína plasmática
EP2547355B1 (fr) 2010-03-19 2017-01-11 Baxalta GmbH Inhibiteurs de tfpi et procédés d'utilisation associés
IL269565B2 (en) 2011-01-06 2024-06-01 Dyax Corp Plasma kallikrein binding proteins
MY166974A (en) 2011-06-15 2018-07-27 Hoffmann La Roche Anti-human epo receptor antibodies and method of use
EP2827883B1 (fr) 2012-03-21 2019-05-08 Baxalta GmbH Inhibiteurs de tfpi et leurs utilisation
BR112018011622A2 (pt) 2015-12-11 2018-11-27 Dyax Corp método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae
CA3167336A1 (fr) 2020-01-13 2021-07-22 Takeda Pharmaceutical Company Limited Inhibiteurs de la kallicreine plasmatique et leurs utilisations pour traiter une crise d'angio-ƒdeme hereditaire pediatrique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington Method of isolating highly purified tissue factor inhibitor

Also Published As

Publication number Publication date
JP2002097200A (ja) 2002-04-02
JP2836823B2 (ja) 1998-12-14
DK413488A (da) 1989-05-24
FI93365C (fi) 1995-03-27
EP0318451A3 (en) 1990-03-28
JP2004201696A (ja) 2004-07-22
JP3565714B2 (ja) 2004-09-15
KR930000274B1 (ko) 1993-01-14
FI883487L (fi) 1989-05-24
IE65393B1 (en) 1995-10-18
KR890007750A (ko) 1989-07-05
PT88076B (pt) 1993-01-29
JPH01165383A (ja) 1989-06-29
JP2005306875A (ja) 2005-11-04
IL87171A0 (en) 1988-12-30
IE882243L (en) 1989-05-23
FI93365B (fi) 1994-12-15
AU1928788A (en) 1989-05-25
EP0318451A2 (fr) 1989-05-31
DK413488D0 (da) 1988-07-22
FI883487A0 (fi) 1988-07-22
DE3851511D1 (de) 1994-10-20
EP0318451B1 (fr) 1994-09-14
NO20013608D0 (no) 2001-07-20
AU604139B2 (en) 1990-12-06
PT88076A (pt) 1988-08-01
JPH1175875A (ja) 1999-03-23
NO883270L (no) 1989-05-24
NO310466B1 (no) 2001-07-09
ES2063769T3 (es) 1995-01-16
IL87171A (en) 1995-08-31
NZ225535A (en) 1990-11-27
NO883270D0 (no) 1988-07-22
JP4025035B2 (ja) 2007-12-19
CA1341223C (fr) 2001-05-01
DE3851511T2 (de) 1995-03-30
NO20013608L (no) 1989-05-24
ATE111518T1 (de) 1994-09-15

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