DK175584B1 - 0-(3-amino-2-hydroxypropyl)-hydroximsyrehalogenider og fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende en eller flere af halogeniderne og disses anvendelse - Google Patents
0-(3-amino-2-hydroxypropyl)-hydroximsyrehalogenider og fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende en eller flere af halogeniderne og disses anvendelse Download PDFInfo
- Publication number
- DK175584B1 DK175584B1 DK199001497A DK149790A DK175584B1 DK 175584 B1 DK175584 B1 DK 175584B1 DK 199001497 A DK199001497 A DK 199001497A DK 149790 A DK149790 A DK 149790A DK 175584 B1 DK175584 B1 DK 175584B1
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- DK
- Denmark
- Prior art keywords
- general formula
- compounds
- aldoxime
- hydrogen
- reaction
- Prior art date
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- -1 3-Amino-2-hydroxypropyl Chemical group 0.000 title claims description 21
- 230000008569 process Effects 0.000 title claims description 18
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- 238000002360 preparation method Methods 0.000 title claims description 8
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU540588 | 1988-10-20 | ||
| HU885405A HU207988B (en) | 1988-10-20 | 1988-10-20 | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| PCT/HU1989/000048 WO1990004584A1 (fr) | 1988-10-20 | 1989-10-19 | Nouveaux halogenures d'acide o-(3-amino-2-hydroxy-propyle)-hydroximique et leur procede de preparation |
| HU8900048 | 1989-10-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK149790D0 DK149790D0 (da) | 1990-06-19 |
| DK149790A DK149790A (da) | 1990-06-19 |
| DK175584B1 true DK175584B1 (da) | 2004-12-13 |
Family
ID=10970243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK199001497A DK175584B1 (da) | 1988-10-20 | 1990-06-19 | 0-(3-amino-2-hydroxypropyl)-hydroximsyrehalogenider og fremgangsmåde til fremstilling deraf samt farmaceutiske midler indeholdende en eller flere af halogeniderne og disses anvendelse |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US5147879A (fr) |
| EP (1) | EP0417210B1 (fr) |
| JP (1) | JPH0819078B2 (fr) |
| KR (1) | KR0154117B1 (fr) |
| AU (1) | AU620460B2 (fr) |
| CA (1) | CA2000830C (fr) |
| DE (1) | DE68913737T2 (fr) |
| DK (1) | DK175584B1 (fr) |
| ES (1) | ES2020030A6 (fr) |
| FI (1) | FI93214C (fr) |
| GR (1) | GR1002253B (fr) |
| HU (1) | HU207988B (fr) |
| IE (1) | IE65113B1 (fr) |
| IL (1) | IL92000A (fr) |
| NO (1) | NO178148C (fr) |
| PL (1) | PL164547B1 (fr) |
| PT (1) | PT92041B (fr) |
| RU (1) | RU2093508C1 (fr) |
| UA (1) | UA34412C2 (fr) |
| WO (1) | WO1990004584A1 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0758315B1 (fr) * | 1994-05-06 | 1998-08-26 | Biorex Kutato Es Fejlesztö Rt. | Nouveaux derives d'acide hydroximique, compositions pharmaceutiques les contenant, et leur procede de preparation |
| US5665756A (en) * | 1994-08-03 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders |
| HU9502843D0 (en) * | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| US6884424B2 (en) | 1995-12-22 | 2005-04-26 | N-Gene Research Laboratories Inc. | Method for treating the pathological lesions of the skin that develop by ultraviolet radiation of the sunlight |
| AU745987B2 (en) * | 1995-12-22 | 2002-04-11 | N-Gene Research Laboratories Inc. | A cosmetic composition and a method for reducing the ageing processes of skin |
| US6458371B1 (en) | 1995-12-22 | 2002-10-01 | Medgene, Limited | Cosmetic composition and a method for the prevention and/or reduction of the photoaging processes of the skin |
| HUT78138A (hu) * | 1995-12-22 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt | Hidroximsavszármazékot tartalmazó készítmény a növénytermesztés elősegítésére és alkalmazása |
| HUT78139A (hu) * | 1995-12-22 | 2000-11-28 | BIOREX Kutató és Fejlesztő Rt. | Készítmény, különösen a bőr öregedési folyamatainak mérséklésére |
| DE19607960A1 (de) * | 1996-03-01 | 1997-09-04 | Hoechst Schering Agrevo Gmbh | Verfahren zur Herstellung von Ketonoximether durch Boronsäurekupplung |
| GB9613339D0 (en) * | 1996-06-26 | 1996-08-28 | Kritzinger Ann C | Limp bookbinding assembly technique for two books in one pass |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
| HU220971B1 (hu) * | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
| HU9701081D0 (en) * | 1997-06-23 | 1997-08-28 | Gene Research Lab Inc N | Pharmaceutical composition of antitumoral activity |
| AU5296799A (en) * | 1998-08-03 | 2000-02-28 | N-Gene Kutato Kft. | Pharmaceutical compositions against autoimmune diseases |
| HUP9900475D0 (en) | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| US6933104B1 (en) | 1999-04-23 | 2005-08-23 | Shiva Biomedical, Llc | Diagnosis and treatment of human kidney diseases |
| HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| BR0210744A (pt) * | 2001-07-17 | 2004-07-20 | N Gene Res Lab Inc | Combinação farmacêutica sinergìstica para a prevenção ou tratamento de diabetes |
| HUP0105205A2 (hu) * | 2001-11-29 | 2003-08-28 | BIOREX Kutató és Fejlesztő Rt. | Metformint és egy hidroxilaminszármazékot tartalmazó, gyógyászati készítmény |
| ATE384554T1 (de) * | 2001-12-21 | 2008-02-15 | Rhodia | Kombinierte stabile kationische und anionische tensidzusammensetzungen |
| WO2003057664A1 (fr) | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Derives de carboxamidine et leur utilisation pour traiter des troubles vasculaires |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| DE10351448A1 (de) * | 2003-11-04 | 2005-06-09 | Bayer Healthcare Ag | Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften |
| WO2008039514A1 (fr) * | 2006-09-26 | 2008-04-03 | Cytrx Corporation | Compositions pharmaceutiques et procédés destinés à traiter des maladies associées à une neurodégénérecence |
| US7763601B2 (en) * | 2006-11-02 | 2010-07-27 | N-Gene Research Laboratories, Inc. | Prevention and treatment of obesity |
| US20110224200A1 (en) | 2008-11-18 | 2011-09-15 | Shin-Ichiro Hirai | Therapeutic agent for chorioretinal degenerative disease containing pyridine-3-carbaldehyde 0-(piperidin-1-yl-propyl)-oxime derivative as active ingredient |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| US20210145815A1 (en) | 2017-09-22 | 2021-05-20 | The University Of Adelaide | Methods and products for improving sperm quality |
| KR101995300B1 (ko) | 2018-03-30 | 2019-10-17 | 주식회사 아세아텍 | 다목적 관리기용 작업기 탈부착장치 |
| HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
| CN112174853B (zh) * | 2020-11-03 | 2023-07-25 | 湖南经世新材料有限责任公司 | 一种氨解法制备（z）-n-羟基苯脒的方法 |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
| WO2023053008A1 (fr) * | 2021-09-28 | 2023-04-06 | Kempharm Denmark A/S | Oximes et leur utilisation dans le traitement de maladies associées à gba |
| AU2023454616A1 (en) | 2023-07-10 | 2026-01-22 | Adelaide university | Increasing telomere length and/or suppressing telomere shortening |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670497C3 (de) * | 1967-06-06 | 1973-12-20 | Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt, Budapest | Isochinohnderivate und Verfahren zu deren Herstellung |
| HU177578B (en) * | 1976-08-27 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
| US4187220A (en) * | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| US4308399A (en) * | 1977-08-30 | 1981-12-29 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| EP0369944A1 (fr) * | 1988-11-18 | 1990-05-23 | Ciba-Geigy Ag | Oxadiaminobutanes substitués |
| FR2639942B1 (fr) * | 1988-12-02 | 1991-03-29 | Sanofi Sa | Ethers oximes de propenone, procede pour leur preparation et compositions pharmaceutiques les contenant |
| HUT54347A (en) * | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
-
1988
- 1988-10-20 HU HU885405A patent/HU207988B/hu unknown
-
1989
- 1989-10-16 IL IL9200089A patent/IL92000A/en not_active IP Right Cessation
- 1989-10-17 CA CA002000830A patent/CA2000830C/fr not_active Expired - Lifetime
- 1989-10-19 GR GR890100669A patent/GR1002253B/el not_active IP Right Cessation
- 1989-10-19 AU AU44186/89A patent/AU620460B2/en not_active Expired
- 1989-10-19 IE IE336489A patent/IE65113B1/en not_active IP Right Cessation
- 1989-10-19 PT PT92041A patent/PT92041B/pt not_active IP Right Cessation
- 1989-10-19 UA UA4830570A patent/UA34412C2/uk unknown
- 1989-10-19 DE DE68913737T patent/DE68913737T2/de not_active Expired - Lifetime
- 1989-10-19 WO PCT/HU1989/000048 patent/WO1990004584A1/fr not_active Ceased
- 1989-10-19 RU SU894830570A patent/RU2093508C1/ru active
- 1989-10-19 KR KR1019900701346A patent/KR0154117B1/ko not_active Expired - Fee Related
- 1989-10-19 EP EP89911590A patent/EP0417210B1/fr not_active Expired - Lifetime
- 1989-10-19 JP JP1510821A patent/JPH0819078B2/ja not_active Expired - Fee Related
- 1989-10-19 PL PL89281898A patent/PL164547B1/pl unknown
- 1989-10-19 US US07/499,318 patent/US5147879A/en not_active Expired - Lifetime
- 1989-10-20 ES ES8903542A patent/ES2020030A6/es not_active Expired - Fee Related
-
1990
- 1990-06-18 NO NO902703A patent/NO178148C/no unknown
- 1990-06-19 DK DK199001497A patent/DK175584B1/da not_active IP Right Cessation
- 1990-06-19 FI FI903075A patent/FI93214C/fi active IP Right Grant
-
1992
- 1992-07-01 US US07/906,402 patent/US5296606A/en not_active Expired - Lifetime
-
1993
- 1993-06-07 US US08/072,765 patent/US5328906A/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed | ||
| PUP | Patent expired |