DK1784497T3 - Fremgangsmåde til fremstilling af mycophenolatmofetil ved enzymatisk transesterificering - Google Patents
Fremgangsmåde til fremstilling af mycophenolatmofetil ved enzymatisk transesterificeringInfo
- Publication number
- DK1784497T3 DK1784497T3 DK05772045T DK05772045T DK1784497T3 DK 1784497 T3 DK1784497 T3 DK 1784497T3 DK 05772045 T DK05772045 T DK 05772045T DK 05772045 T DK05772045 T DK 05772045T DK 1784497 T3 DK1784497 T3 DK 1784497T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- mycophenolate mofetil
- enzymatic transesterification
- transesterification
- enzymatic
- Prior art date
Links
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 title 1
- 229960004866 mycophenolate mofetil Drugs 0.000 title 1
- 238000005809 transesterification reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001703A ITMI20041703A1 (it) | 2004-09-03 | 2004-09-03 | Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica |
| PCT/EP2005/053629 WO2006024582A1 (en) | 2004-09-03 | 2005-07-26 | A method for the preparation of mycophenolate mofetil by enzimatic transesterification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1784497T3 true DK1784497T3 (da) | 2008-05-13 |
Family
ID=35064927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05772045T DK1784497T3 (da) | 2004-09-03 | 2005-07-26 | Fremgangsmåde til fremstilling af mycophenolatmofetil ved enzymatisk transesterificering |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7727751B2 (de) |
| EP (1) | EP1784497B1 (de) |
| JP (1) | JP4880604B2 (de) |
| CN (1) | CN101035904B (de) |
| AR (1) | AR050289A1 (de) |
| AT (1) | ATE384802T1 (de) |
| DE (1) | DE602005004557T2 (de) |
| DK (1) | DK1784497T3 (de) |
| HR (1) | HRP20080081T3 (de) |
| IT (1) | ITMI20041703A1 (de) |
| NO (1) | NO20071602L (de) |
| TW (1) | TWI354703B (de) |
| WO (1) | WO2006024582A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06005659A (es) | 2004-04-26 | 2007-04-10 | Teva Gyogyszergyar Zartkoruen | Proceso para preparacion de acido micofenolico y derivados de ester del mismo. |
| US20080281111A1 (en) * | 2005-04-26 | 2008-11-13 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
| US20080188653A1 (en) | 2007-02-04 | 2008-08-07 | Formosa Laboratories, Inc. | Process for Preparation of Mycophenolate Mofetil |
| IT1394309B1 (it) | 2009-05-22 | 2012-06-06 | Poli Ind Chimica Spa | Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus |
| CN102391225B (zh) * | 2011-12-07 | 2013-07-31 | 中国科学院南海海洋研究所 | 霉酚酸衍生物a、b、c及其在制备免疫抑制药物中的应用 |
| CN102924413B (zh) * | 2012-10-23 | 2014-12-31 | 福建科瑞药业有限公司 | 一种霉酚酸莫啡酯纯化脱色方法 |
| WO2020039263A2 (en) | 2018-08-18 | 2020-02-27 | Ftf Pharma Private Limited | Pharmaceutical suspension for oral dosage |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08217783A (ja) * | 1995-02-16 | 1996-08-27 | Mitsubishi Chem Corp | ショ糖脂肪酸エステルの製造方法 |
| IN188985B (de) * | 1998-12-09 | 2002-11-30 | Biocon Ltd | |
| CZ292123B6 (cs) * | 2001-06-08 | 2003-08-13 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy mykofenolátu mofetilu |
| WO2003042393A1 (en) | 2001-11-16 | 2003-05-22 | Biocon Limited | Enzymatic preparation of mycophenolate mofetil |
| TWI221414B (en) | 2003-02-21 | 2004-10-01 | Chunghwa Chemical Synthesis & | Method of making mycophenolate mofetil using transesterification |
-
2004
- 2004-09-03 IT IT001703A patent/ITMI20041703A1/it unknown
-
2005
- 2005-07-25 US US11/661,913 patent/US7727751B2/en not_active Expired - Fee Related
- 2005-07-26 WO PCT/EP2005/053629 patent/WO2006024582A1/en not_active Ceased
- 2005-07-26 JP JP2007529349A patent/JP4880604B2/ja not_active Expired - Fee Related
- 2005-07-26 EP EP05772045A patent/EP1784497B1/de not_active Expired - Lifetime
- 2005-07-26 DE DE602005004557T patent/DE602005004557T2/de not_active Expired - Lifetime
- 2005-07-26 CN CN2005800296809A patent/CN101035904B/zh not_active Expired - Fee Related
- 2005-07-26 DK DK05772045T patent/DK1784497T3/da active
- 2005-07-26 AT AT05772045T patent/ATE384802T1/de active
- 2005-07-26 HR HR20080081T patent/HRP20080081T3/xx unknown
- 2005-08-09 AR ARP050103327A patent/AR050289A1/es not_active Application Discontinuation
- 2005-08-24 TW TW094128930A patent/TWI354703B/zh not_active IP Right Cessation
-
2007
- 2007-03-27 NO NO20071602A patent/NO20071602L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101035904A (zh) | 2007-09-12 |
| CN101035904B (zh) | 2011-02-02 |
| DE602005004557T2 (de) | 2009-01-22 |
| ITMI20041703A1 (it) | 2004-12-03 |
| US20080085542A1 (en) | 2008-04-10 |
| TW200621989A (en) | 2006-07-01 |
| JP2008511309A (ja) | 2008-04-17 |
| HK1107120A1 (en) | 2008-03-28 |
| JP4880604B2 (ja) | 2012-02-22 |
| WO2006024582A1 (en) | 2006-03-09 |
| ATE384802T1 (de) | 2008-02-15 |
| NO20071602L (no) | 2007-05-30 |
| US7727751B2 (en) | 2010-06-01 |
| AR050289A1 (es) | 2006-10-11 |
| EP1784497B1 (de) | 2008-01-23 |
| EP1784497A1 (de) | 2007-05-16 |
| TWI354703B (en) | 2011-12-21 |
| DE602005004557D1 (de) | 2008-03-13 |
| HRP20080081T3 (hr) | 2008-03-31 |
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