DK1807434T3 - Thienopyridiner som allosteriske potentiatorer af M4- muscarinreceptoren - Google Patents
Thienopyridiner som allosteriske potentiatorer af M4- muscarinreceptorenInfo
- Publication number
- DK1807434T3 DK1807434T3 DK05812144.3T DK05812144T DK1807434T3 DK 1807434 T3 DK1807434 T3 DK 1807434T3 DK 05812144 T DK05812144 T DK 05812144T DK 1807434 T3 DK1807434 T3 DK 1807434T3
- Authority
- DK
- Denmark
- Prior art keywords
- thienopyridines
- muscarinic receptor
- allosteric potentiators
- potentiators
- allosteric
- Prior art date
Links
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 title abstract 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 title abstract 2
- 230000003281 allosteric effect Effects 0.000 title abstract 2
- 229940125670 thienopyridine Drugs 0.000 title 1
- 239000002175 thienopyridine Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compression, Expansion, Code Conversion, And Decoders (AREA)
- Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62178504P | 2004-10-25 | 2004-10-25 | |
| PCT/US2005/037271 WO2006047124A1 (en) | 2004-10-25 | 2005-10-18 | Thienopyridines as allosteric potentiators of the m4 muscarinic receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1807434T3 true DK1807434T3 (da) | 2010-11-22 |
Family
ID=36021809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05812144.3T DK1807434T3 (da) | 2004-10-25 | 2005-10-18 | Thienopyridiner som allosteriske potentiatorer af M4- muscarinreceptoren |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8071776B2 (da) |
| EP (1) | EP1807434B1 (da) |
| JP (1) | JP4945453B2 (da) |
| CN (1) | CN100577666C (da) |
| AT (1) | ATE478876T1 (da) |
| AU (1) | AU2005299957B2 (da) |
| BR (1) | BRPI0517438A (da) |
| CA (1) | CA2583550C (da) |
| CY (1) | CY1111477T1 (da) |
| DE (1) | DE602005023197D1 (da) |
| DK (1) | DK1807434T3 (da) |
| ES (1) | ES2349416T3 (da) |
| MX (1) | MX2007004794A (da) |
| PL (1) | PL1807434T3 (da) |
| PT (1) | PT1807434E (da) |
| WO (1) | WO2006047124A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9493481B2 (en) | 2012-02-23 | 2016-11-15 | Vanderbilt University | Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2014035829A1 (en) * | 2012-08-31 | 2014-03-06 | Vanderbilt University | Substituted 3-aminothieno[2,3-c]pyridine-2-carboxamide analogs as positive allosteric modulators |
| EA201690089A1 (ru) | 2013-06-11 | 2017-04-28 | Латвийский Институт Органического Синтеза | ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ |
| US9637498B2 (en) | 2013-08-23 | 2017-05-02 | Vanderbilt University | Substituted thieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| EP3394061B1 (en) | 2015-12-23 | 2020-03-11 | Merck Sharp & Dohme Corp. | 6,7-dihydro-5h-pyrrolo[3,4-b]pyridin-5-one allosteric modulators of the m4 muscarinic acetylcholine receptor |
| KR102474326B1 (ko) | 2016-06-22 | 2022-12-05 | 반더빌트유니버시티 | 무스카린성 아세틸콜린 수용체 m4의 양성 알로스테릭 조절제 |
| PL3478679T3 (pl) | 2016-07-01 | 2021-10-25 | Pfizer Inc. | Pochodne 5,7-dihydro-pirolopirydyny do leczenia chorób neurologicznych i neurodegeneracyjnych |
| GB201616839D0 (en) | 2016-10-04 | 2016-11-16 | Takeda Pharmaceutical Company Limited | Therapeutic compounds |
| JP7097623B2 (ja) * | 2016-11-07 | 2022-07-08 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子 |
| EP3534901B1 (en) | 2016-11-07 | 2022-06-22 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| EP3558309B1 (en) | 2016-11-07 | 2023-07-26 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| WO2018112840A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6, 5-fused heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| FI3642202T3 (fi) | 2017-06-22 | 2023-03-01 | Dihydro-pyrrolo-pyridiinijohdannaisia | |
| WO2019000236A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000237A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2019000238A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
| TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
| WO2019113174A1 (en) | 2017-12-05 | 2019-06-13 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| WO2025201078A1 (zh) * | 2024-03-25 | 2025-10-02 | 四川科伦药物研究院有限公司 | 化合物、包含其的药物组合物及其制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3430284A1 (de) * | 1984-08-17 | 1986-02-27 | Troponwerke GmbH & Co KG, 5000 Köln | Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung |
| MX9700696A (es) * | 1994-07-27 | 1997-04-30 | Sankyo Co | Compuestos heterociclicos, utiles como productores de efecto aloesterico en receptores muscarinicos. |
| US6841684B2 (en) * | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
| GB9924962D0 (en) * | 1999-10-21 | 1999-12-22 | Mrc Collaborative Centre | Allosteric sites on muscarinic receptors |
| TWI310035B (en) * | 2000-04-28 | 2009-05-21 | Acadia Pharm Inc | Muscarinic agonists |
| MXPA04007083A (es) * | 2002-02-20 | 2004-10-29 | Upjohn Co | Compuestos azabiciclicos para el tratamiento de enfermedades. |
| US6974870B2 (en) * | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
-
2005
- 2005-10-18 BR BRPI0517438-4A patent/BRPI0517438A/pt not_active IP Right Cessation
- 2005-10-18 ES ES05812144T patent/ES2349416T3/es not_active Expired - Lifetime
- 2005-10-18 AU AU2005299957A patent/AU2005299957B2/en not_active Ceased
- 2005-10-18 CA CA2583550A patent/CA2583550C/en not_active Expired - Fee Related
- 2005-10-18 EP EP05812144A patent/EP1807434B1/en not_active Expired - Lifetime
- 2005-10-18 MX MX2007004794A patent/MX2007004794A/es active IP Right Grant
- 2005-10-18 CN CN200580036624A patent/CN100577666C/zh not_active Expired - Fee Related
- 2005-10-18 JP JP2007537951A patent/JP4945453B2/ja not_active Expired - Fee Related
- 2005-10-18 WO PCT/US2005/037271 patent/WO2006047124A1/en not_active Ceased
- 2005-10-18 DE DE602005023197T patent/DE602005023197D1/de not_active Expired - Lifetime
- 2005-10-18 DK DK05812144.3T patent/DK1807434T3/da active
- 2005-10-18 US US11/577,508 patent/US8071776B2/en not_active Expired - Fee Related
- 2005-10-18 PT PT05812144T patent/PT1807434E/pt unknown
- 2005-10-18 PL PL05812144T patent/PL1807434T3/pl unknown
- 2005-10-18 AT AT05812144T patent/ATE478876T1/de active
-
2010
- 2010-10-14 CY CY20101100921T patent/CY1111477T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005023197D1 (de) | 2010-10-07 |
| US8071776B2 (en) | 2011-12-06 |
| ES2349416T3 (es) | 2011-01-03 |
| BRPI0517438A (pt) | 2008-10-07 |
| CN100577666C (zh) | 2010-01-06 |
| CA2583550C (en) | 2013-05-14 |
| EP1807434A1 (en) | 2007-07-18 |
| PT1807434E (pt) | 2010-09-22 |
| MX2007004794A (es) | 2007-07-09 |
| CY1111477T1 (el) | 2015-08-05 |
| AU2005299957B2 (en) | 2011-04-21 |
| CN101048413A (zh) | 2007-10-03 |
| JP2008517913A (ja) | 2008-05-29 |
| AU2005299957A1 (en) | 2006-05-04 |
| PL1807434T3 (pl) | 2011-02-28 |
| JP4945453B2 (ja) | 2012-06-06 |
| US20090105244A1 (en) | 2009-04-23 |
| EP1807434B1 (en) | 2010-08-25 |
| CA2583550A1 (en) | 2006-05-04 |
| ATE478876T1 (de) | 2010-09-15 |
| WO2006047124A1 (en) | 2006-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1111477T1 (el) | Θειενοπυριδινες ως αλλοστερικοι ενισχυτες του μ4 μουσκαρινικου υποδοχεα | |
| NO20075298L (no) | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists | |
| NO20083462L (no) | Nye tiofenderivater som S1P1/EDG1-reseptoragonister | |
| WO2007133802A3 (en) | Pharmaceutical formulations of pimavanserin | |
| DK1833799T3 (da) | 3-phenyl-pyrazol derivater, som modulatorer af 5-HT-2a-serotonin receptor nyttig til behandlingen af sygdomme relateret hertil | |
| WO2008040649A3 (en) | Pyrazine-2-carboxamide derivatives as cb2 receptor modulators | |
| NO20085257L (no) | Purinonderivater som HM74a-agonister | |
| NO20085099L (no) | Puritonderivativer som HM74A agonister | |
| NO20082793L (no) | Nye tiofenderivater | |
| TW200718692A (en) | Dihydrobenzofuran derivatives and uses thereof | |
| ATE399770T1 (de) | Tachykininrezeptorantagonisten | |
| EA201100612A1 (ru) | Новые производные 2-амидотиадиазола | |
| NO20091395L (no) | Nye tiofenderivater | |
| NO20093146L (no) | Amino-pyridinderivater som S1P1/EDG1-reseptoragonister | |
| WO2008012622A3 (en) | Azabenzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor | |
| WO2008077557A8 (en) | 8-ethinylxanthine derivatives as selective a2a receptor antagonists | |
| TW200600494A (en) | Bisphenyl compounds useful as vitamin d3 receptor agonists | |
| WO2007108936A3 (en) | N-substituted-azacyclylamines as histamine-3 antagonists | |
| WO2007136668A3 (en) | N-benzoyl-and n-benzylpyrrolidin-3-ylamines as histamine-3 antagonists | |
| ECSP066883A (es) | Derivados de heteroarilaminopirazol utiles para el tratamiento de la diabetes | |
| NO20084301L (no) | Tetrahydronaftalenderivater, fremgangsmate for deres fremstilling og anvendelse derav som anti-inflammatoriske midler | |
| EA200700365A1 (ru) | Производные индол-2-карбоксамидина как антагонисты nmda рецептора | |
| DK1943242T3 (da) | Piperidin-4-yl-pyridazin-3-ylamin-derivater som hurtigt opløsende antagonister af dopamin-2-receptorer | |
| CR10036A (es) | Procedimientos para la preparación de derivados de ciclopropilamida | |
| MA32834B1 (fr) | 3-aminocyclopentanecarboxamides servant de modulateurs de recepteurs de chimiokines |