DK182783A - Fremgangsmaade til fremstilling af 1-carboxy-(alkanoyl eller aralkanoyl)-indolin-2-carboxylsyreestere eller salte deraf - Google Patents

Fremgangsmaade til fremstilling af 1-carboxy-(alkanoyl eller aralkanoyl)-indolin-2-carboxylsyreestere eller salte deraf Download PDF

Info

Publication number
DK182783A
DK182783A DK182783A DK182783A DK182783A DK 182783 A DK182783 A DK 182783A DK 182783 A DK182783 A DK 182783A DK 182783 A DK182783 A DK 182783A DK 182783 A DK182783 A DK 182783A
Authority
DK
Denmark
Prior art keywords
salts
aralkanoyl
indoline
alkanoyl
carboxy
Prior art date
Application number
DK182783A
Other languages
English (en)
Other versions
DK182783D0 (da
Inventor
Norbert Gruenfeld
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK182783D0 publication Critical patent/DK182783D0/da
Publication of DK182783A publication Critical patent/DK182783A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/89—Benzo [c] furans; Hydrogenated benzo [c] furans with two oxygen atoms directly attached in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

hvor aryl er eventuelt med alkyl, alkoxy eller halogen substitueret phenyl, eller pyridyl, alkanoyloxyalkyl, eventuelt med alkyl, alkoxy eller halogen substitueret phthalidyl, (hydroxy, alkanoyloxy eller alkoxy)-substitueret alkoxymethyl, bicycloalkyloxycarbonyl-alkyl, hvor bicycloalkyl eventuelt er substitueret med alkyl, eller 1-(alkoxycarbonyloxy)-alkyl, eller et af symbolerne er H og det andet en ovennævnt gruppe, eller salte deraf fremstilles på i og for sig kendt måde.
Forbindelserne (I) har blodtrykssænkende virkning.
DK182783A 1982-04-26 1983-04-25 Fremgangsmaade til fremstilling af 1-carboxy-(alkanoyl eller aralkanoyl)-indolin-2-carboxylsyreestere eller salte deraf DK182783A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37170082 1982-04-26
US06/371,700 US4479963A (en) 1981-02-17 1982-04-26 1-Carboxyalkanoylindoline-2-carboxylic acids

Publications (2)

Publication Number Publication Date
DK182783D0 DK182783D0 (da) 1983-04-25
DK182783A true DK182783A (da) 1983-10-27

Family

ID=23465059

Family Applications (1)

Application Number Title Priority Date Filing Date
DK182783A DK182783A (da) 1982-04-26 1983-04-25 Fremgangsmaade til fremstilling af 1-carboxy-(alkanoyl eller aralkanoyl)-indolin-2-carboxylsyreestere eller salte deraf

Country Status (11)

Country Link
US (1) US4479963A (da)
EP (2) EP0093084B1 (da)
JP (1) JPS58194859A (da)
AT (1) ATE18549T1 (da)
AU (1) AU1395283A (da)
CA (1) CA1199911A (da)
DE (2) DE3362504D1 (da)
DK (1) DK182783A (da)
FI (1) FI834730A7 (da)
WO (1) WO1983003828A1 (da)
ZA (1) ZA832887B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0798802B2 (ja) * 1984-07-13 1995-10-25 東レ株式会社 光学活性インドリン―２―カルボン酸の製造法
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2665441B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
FR2679903B1 (fr) * 1991-08-02 1993-12-03 Elf Sanofi Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.
US5338755A (en) * 1990-07-31 1994-08-16 Elf Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
US5481005A (en) * 1990-07-31 1996-01-02 Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
AU654331B2 (en) * 1991-03-30 1994-11-03 Kissei Pharmaceutical Co. Ltd. Succinic acid compounds
WO1997011936A1 (en) * 1995-09-28 1997-04-03 Merck & Co., Inc. Preparation of carboxyalkyl derivatives
US5939455A (en) * 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
US6043389A (en) 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
JP6487752B2 (ja) * 2015-03-31 2019-03-20 大阪瓦斯株式会社 ジカルボン酸又はエステル及びそれを用いた樹脂並びにそれらの製造方法
CN117919232B (zh) * 2023-11-30 2024-10-25 上海市东方医院（同济大学附属东方医院） 吲哚丙酸在治疗肝硬化以及免疫性肝损伤的应用
CN119586613B (zh) * 2025-02-08 2025-04-29 浙江大学 多元醇乙二酸酯聚合物载药缓控释微球的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3974145A (en) * 1970-08-26 1976-08-10 Sumitomo Chemical Company, Limited Novel N'-acylated phenyl-hydrazine and hydrozone derivatives
CH547799A (de) * 1970-10-30 1974-04-11 Hoffmann La Roche Verfahren zur herstellung von indolinderivaten.
CH555825A (de) * 1970-10-30 1974-11-15 Hoffmann La Roche Verfahren zur herstellung von indolinderivaten.
US4052511A (en) * 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4154937A (en) * 1977-02-11 1979-05-15 E. R. Squibb & Sons, Inc. Hydroxycarbamoylalkylacylpipecolic acid compounds
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2470767A1 (fr) * 1979-12-07 1981-06-12 Science Union & Cie Nouveaux iminoacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzymes
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350633A (en) * 1980-07-01 1982-09-21 American Home Products Corporation N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
EP0046953B1 (de) * 1980-08-30 1989-12-06 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4724265A (en) * 1986-05-15 1988-02-09 Stauffer Chemical Company Process for preparing liquid triaryl thiophosphate mixtures

Also Published As

Publication number Publication date
FI834730L (fi) 1983-12-22
EP0105919B1 (en) 1987-07-08
FI834730A0 (fi) 1983-12-22
ZA832887B (en) 1983-12-28
AU1395283A (en) 1983-11-03
WO1983003828A1 (en) 1983-11-10
EP0093084A1 (de) 1983-11-02
DE3372364D1 (en) 1987-08-13
JPS58194859A (ja) 1983-11-12
FI834730A7 (fi) 1983-12-22
US4479963A (en) 1984-10-30
EP0105919A1 (en) 1984-04-25
CA1199911A (en) 1986-01-28
ATE18549T1 (de) 1986-03-15
DK182783D0 (da) 1983-04-25
EP0093084B1 (de) 1986-03-12
DE3362504D1 (en) 1986-04-17

Similar Documents

Publication Publication Date Title
DK182783A (da) Fremgangsmaade til fremstilling af 1-carboxy-(alkanoyl eller aralkanoyl)-indolin-2-carboxylsyreestere eller salte deraf
ES520441A0 (es) Procedimiento para la obtencion de derivados de piridina.
KR850002269A (ko) 피리도인돌 유도체의 제조방법
GB1252341A (da)
DK188183A (da) Thiomethylpyridinderivater, fremgangsmaade til deres fremstilling og laegemidler indeholdende disse forbindelser
ES8306374A1 (es) "procedimiento para la preparacion de nuevos derivados de acidos 4-fenoxialcarboxilicos sustituidos con radicales haterociclicos".
ZA833849B (en) Novel sulfonylureas and sulfonylthioureas,the preparation thereof,and method of use thereof as herbicides and/or growth regulators
DE3572808D1 (en) 4-(nitrophenyl)-tetrahydropyridines, process for their preparation and their application as pharmaceutical compounds
FR2529891B1 (da)
DK156563C (da) Analogifremgangsmaade til fremstilling af carbacyklinderivater
DK133083A (da) Fremgangsmaade til fremstilling af phenylalkyloxirancarboxylsyrer
DK0516486T3 (da) Azetidinonderivater egnede til fremstilling af carbapenemantibiotika
ATE29490T1 (de) Chloracetanilide, ihre herstellung, ihre verwendung, diese enthaltende zusammenstellungen und mittel zur bekaempfung von unerwuenschtem pflanzenwachstum.
MY110940A (en) Substituted pyridinesulfonamide compounds,herbicidal composition containing them, and method of preparing these compounds.

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment