DK185486A - Octapeptidderivater - Google Patents

Octapeptidderivater Download PDF

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Publication number
DK185486A
DK185486A DK185486A DK185486A DK185486A DK 185486 A DK185486 A DK 185486A DK 185486 A DK185486 A DK 185486A DK 185486 A DK185486 A DK 185486A DK 185486 A DK185486 A DK 185486A
Authority
DK
Denmark
Prior art keywords
sub
trp
cys
ala
thr
Prior art date
Application number
DK185486A
Other languages
English (en)
Other versions
DK185486D0 (da
DK174920B1 (da
Inventor
Andrew V Schally
Ren Zhi Cai
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/727,105 external-priority patent/US4650787A/en
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of DK185486D0 publication Critical patent/DK185486D0/da
Publication of DK185486A publication Critical patent/DK185486A/da
Application granted granted Critical
Publication of DK174920B1 publication Critical patent/DK174920B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Description

er nyttige som midler til inhibering af frigivelsen af væksthormon, til behandling af gastrointestinale sygdomme og til terapi af visse cancere og styring af diabetes. Disse biologisk aktive octapeptider har alle et terminalt aminosyreamid i 8-stilling og fremstilles ved fastfasemetoder.
DK198601854A 1985-04-25 1986-04-22 Octapeptidsomastatinanloger, fremgangsmåde til fremstilling deraf samt en farmaceutisk præparat DK174920B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/727,105 US4650787A (en) 1985-04-25 1985-04-25 Biologically active octapeptides
US72710585 1985-04-25
US06/843,539 US4725577A (en) 1985-04-25 1986-03-28 Biologically active lysine containing octapeptides
US84353986 1986-03-28

Publications (3)

Publication Number Publication Date
DK185486D0 DK185486D0 (da) 1986-04-22
DK185486A true DK185486A (da) 1986-10-26
DK174920B1 DK174920B1 (da) 2004-02-23

Family

ID=27111452

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198601854A DK174920B1 (da) 1985-04-25 1986-04-22 Octapeptidsomastatinanloger, fremgangsmåde til fremstilling deraf samt en farmaceutisk præparat

Country Status (10)

Country Link
US (1) US4725577A (da)
EP (1) EP0203031B1 (da)
AT (1) ATE78831T1 (da)
AU (1) AU600895B2 (da)
CA (1) CA1333646C (da)
DE (1) DE3686200T2 (da)
DK (1) DK174920B1 (da)
HK (1) HK68793A (da)
IE (1) IE59621B1 (da)
SG (1) SG57793G (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
GR862206B (en) * 1985-09-12 1986-12-31 Univ Tulane Therapeutic somatostatin analogs
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
DE3726517A1 (de) * 1986-08-18 1988-03-03 Sandoz Ag Nasale zusammensetzungen, welche octreotid enthalten
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
US5068221A (en) * 1989-05-09 1991-11-26 Mathias John R Treatment of motility disorders with a gnrh analog
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
WO1991009056A1 (en) * 1989-12-08 1991-06-27 The Administrators Of The Tulane Educational Fund Octapeptide analogs of somatostatin having threonine at the sixth position
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
DK0450480T3 (da) * 1990-04-06 1995-08-14 Univ Tulane Somatostatinaloger
US5668254A (en) * 1990-05-11 1997-09-16 Romano Deghenghi D-2-alkyl-tryptophan and peptides containing same
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
US5872100A (en) * 1990-05-11 1999-02-16 Deghenghi; Romano Peptides containing D-2-Alkyl-Tryptophan
US5434136A (en) * 1990-12-14 1995-07-18 Mathias; John R. Treatment of motility disorders with a GNRH analog
HU207104B (en) * 1991-01-25 1993-03-01 Biosignal Kutato Fejlesztoe Kf Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
DK0720621T3 (da) 1992-01-14 2001-08-06 Diatide Inc Radiomærkede somatostation-afledte peptider til billeddannende og terapeutiske anvendelser
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
FR2701952B1 (fr) * 1993-02-22 1995-03-31 Adir Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6100377A (en) * 1994-06-10 2000-08-08 The Trustees Of The University Of Pennsylvania Constrained peptides
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
ATE225806T1 (de) * 1994-09-27 2002-10-15 Bioscience Limited Ardana D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
GB9513224D0 (en) * 1995-06-29 1995-09-06 Sandoz Ltd Organic compounds
IT1277391B1 (it) * 1995-07-28 1997-11-10 Romano Deghenghi Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
JPH09328499A (ja) * 1996-02-20 1997-12-22 American Cyanamid Co 純粋なソマトスタチンアンタゴニストおよびその使用方法
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
US5972895A (en) * 1996-12-11 1999-10-26 A. Glenn Braswell Composition and method for increasing growth hormone levels
EP1332762A1 (en) * 1997-05-01 2003-08-06 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
US5972893A (en) * 1997-05-06 1999-10-26 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
DE69812084T2 (de) * 1997-05-01 2003-12-24 Cedars-Sinai Medical Center, Los Angeles Verfahren zur behandlung von hyperprolaktinämia und prolaktinomen
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
WO1998051330A1 (en) * 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
AU7655098A (en) * 1997-05-13 1998-12-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin and somatostatin agonists for decreasing body weight
ES2216290T3 (es) * 1997-05-13 2004-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatina y agonistas de la somatostatina para el tratamiento de insensibilidad a la insulina y de sindrome x.
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
BR0210915A (pt) 2001-06-08 2004-06-08 Sod Conseils Rech Applic Análogos quiméricos de somatostatina-dopamina
CN101791409A (zh) 2003-04-22 2010-08-04 研究及应用科学协会股份有限公司 肽载体
US20070111930A1 (en) * 2005-11-10 2007-05-17 Palle Venkata Raghavendra A Process for preparing vapreotide
US8691761B2 (en) 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
EP2383289B1 (en) 2006-10-16 2014-10-08 The Salk Institute for Biological Studies Receptor (SSTR2)-selective somatostatin antagonists
CA2727082C (en) 2008-06-12 2019-02-26 Syntaxin Limited Fusion proteins for use in suppression of acromegaly
CN102083451A (zh) 2008-06-12 2011-06-01 赛恩泰新公司 癌症的抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
JP6869720B2 (ja) 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド 併用療法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209426A (en) * 1979-05-29 1980-06-24 American Home Products Corporation Polypeptides related to somatostatin
DE3062075D1 (en) * 1979-11-27 1983-03-24 Sandoz Ag Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone
DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
US4443434A (en) * 1982-08-18 1984-04-17 American Home Products Corporation Antiulcer agent
CH655505B (da) * 1982-08-24 1986-04-30
US4451394A (en) * 1982-10-25 1984-05-29 American Home Products Corporation Dodecapeptides preventing glucose and triglyceride assimilation
US4440904A (en) * 1983-01-31 1984-04-03 American Home Products Corporation Nonapeptide anti-secretory agents
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体

Also Published As

Publication number Publication date
DE3686200T2 (de) 1993-03-11
DK185486D0 (da) 1986-04-22
DK174920B1 (da) 2004-02-23
AU5633886A (en) 1986-10-30
EP0203031B1 (en) 1992-07-29
HK68793A (en) 1993-07-23
EP0203031A3 (en) 1988-09-21
EP0203031A2 (en) 1986-11-26
ATE78831T1 (de) 1992-08-15
IE59621B1 (en) 1994-03-09
DE3686200D1 (de) 1992-09-03
AU600895B2 (en) 1990-08-30
IE861004L (en) 1986-10-25
US4725577A (en) 1988-02-16
SG57793G (en) 1993-07-09
CA1333646C (en) 1994-12-20

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