DK185486D0 - Octapeptidderivater - Google Patents

Octapeptidderivater

Info

Publication number: DK185486D0
Authority: DK; Denmark
Prior art keywords: sub; trp; cys; ala; thr
Prior art date: 1985-04-25

Application number

DK185486A

Other languages

English (en)

Other versions

DK174920B1 (da

DK185486A (da

Inventor

Andrew V Schally

Ren Zhi Cai

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-25

Filing date

1986-04-22

Publication date

1986-04-22

1985-04-25 Priority claimed from US06/727,105 external-priority patent/US4650787A/en

1986-04-22 Application filed by Univ Tulane filed Critical Univ Tulane

1986-04-22 Publication of DK185486D0 publication Critical patent/DK185486D0/da

1986-10-26 Publication of DK185486A publication Critical patent/DK185486A/da

2004-02-23 Application granted granted Critical

2004-02-23 Publication of DK174920B1 publication Critical patent/DK174920B1/da

Links

AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
101100379081 Emericella variicolor andC gene Proteins 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
102000018997 Growth Hormone Human genes 0.000 abstract 1
108010051696 Growth Hormone Proteins 0.000 abstract 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK198601854A 1985-04-25 1986-04-22 Octapeptidsomastatinanloger, fremgangsmåde til fremstilling deraf samt en farmaceutisk præparat DK174920B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US06/727,105 US4650787A (en)	1985-04-25	1985-04-25	Biologically active octapeptides
US72710585		1985-04-25
US06/843,539 US4725577A (en)	1985-04-25	1986-03-28	Biologically active lysine containing octapeptides
US84353986		1986-03-28

Publications (3)

Publication Number	Publication Date
DK185486D0 true DK185486D0 (da)	1986-04-22
DK185486A DK185486A (da)	1986-10-26
DK174920B1 DK174920B1 (da)	2004-02-23

Family

ID=27111452

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198601854A DK174920B1 (da)	1985-04-25	1986-04-22	Octapeptidsomastatinanloger, fremgangsmåde til fremstilling deraf samt en farmaceutisk præparat

Country Status (10)

Country	Link
US (1)	US4725577A (da)
EP (1)	EP0203031B1 (da)
AT (1)	ATE78831T1 (da)
AU (1)	AU600895B2 (da)
CA (1)	CA1333646C (da)
DE (1)	DE3686200T2 (da)
DK (1)	DK174920B1 (da)
HK (1)	HK68793A (da)
IE (1)	IE59621B1 (da)
SG (1)	SG57793G (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH085913B2 (ja) *	1985-09-12	1996-01-24	ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド	治療用ソマトスタチン同族体
US4904642A (en) *	1985-09-12	1990-02-27	The Administrators Of The Tulane Educational Fund	Therapeutic somatostatin analogs
GR862206B (en) *	1985-09-12	1986-12-31	Univ Tulane	Therapeutic somatostatin analogs
US4853371A (en) *	1986-06-17	1989-08-01	The Administrators Of The Tulane Educational Fund	Therapeutic somatostatin analogs
DE3726517A1 (de) *	1986-08-18	1988-03-03	Sandoz Ag	Nasale zusammensetzungen, welche octreotid enthalten
AU639371B2 (en) *	1987-07-10	1993-07-22	Novartis Ag	Method of treating breast cancer
DE3822557C2 (de) *	1987-07-10	1998-07-02	Ciba Geigy Ag	Arzneimittel, enthaltend Somatostatine
US5073541A (en) *	1987-11-18	1991-12-17	Administrators Of The Tulane Educational Fund	Treatment of small cell lung cancer with somatostatin analogs
US5068221A (en) *	1989-05-09	1991-11-26	Mathias John R	Treatment of motility disorders with a gnrh analog
HU221294B1 (en) *	1989-07-07	2002-09-28	Novartis Ag	Process for producing retarde compositions containing the active ingredient in a polymeric carrier
PH30995A (en) *	1989-07-07	1997-12-23	Novartis Inc	Sustained release formulations of water soluble peptides.
US5538739A (en) *	1989-07-07	1996-07-23	Sandoz Ltd.	Sustained release formulations of water soluble peptides
WO1991009056A1 (en) *	1989-12-08	1991-06-27	The Administrators Of The Tulane Educational Fund	Octapeptide analogs of somatostatin having threonine at the sixth position
GB9004017D0 (en) *	1990-02-22	1990-04-18	Krenning Eric P	Improvements in or relating to organic compounds
DK0450480T3 (da) *	1990-04-06	1995-08-14	Univ Tulane	Somatostatinaloger
US5668254A (en) *	1990-05-11	1997-09-16	Romano Deghenghi	D-2-alkyl-tryptophan and peptides containing same
IT1240643B (it) *	1990-05-11	1993-12-17	Mediolanum Farmaceutici Spa	Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
US5872100A (en) *	1990-05-11	1999-02-16	Deghenghi; Romano	Peptides containing D-2-Alkyl-Tryptophan
US5434136A (en) *	1990-12-14	1995-07-18	Mathias; John R.	Treatment of motility disorders with a GNRH analog
HU207104B (en) *	1991-01-25	1993-03-01	Biosignal Kutato Fejlesztoe Kf	Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
US5443815A (en) *	1991-11-27	1995-08-22	Diatech, Inc.	Technetium-99m labeled peptides for imaging
DK0720621T3 (da)	1992-01-14	2001-08-06	Diatide Inc	Radiomærkede somatostation-afledte peptider til billeddannende og terapeutiske anvendelser
US5620675A (en)	1992-06-23	1997-04-15	Diatech, Inc.	Radioactive peptides
US6017512A (en) *	1992-06-23	2000-01-25	Diatide, Inc.	Radiolabeled peptides
US5504069A (en) *	1993-02-11	1996-04-02	Biomeasure, Inc.	Inhibition of trauma-induced tumor growth
FR2701952B1 (fr) *	1993-02-22	1995-03-31	Adir	Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6051206A (en) *	1994-06-03	2000-04-18	Diatide, Inc	Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6100377A (en) *	1994-06-10	2000-08-08	The Trustees Of The University Of Pennsylvania	Constrained peptides
GB9417873D0 (en) *	1994-09-06	1994-10-26	Sandoz Ltd	Organic compounds
ATE225806T1 (de) *	1994-09-27	2002-10-15	Bioscience Limited Ardana	D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
US5597894A (en) *	1995-06-05	1997-01-28	The Louisiana State University Medical Center Foundation	Multi-tyrosinated somatostatin analogs
US5830431A (en) *	1995-06-07	1998-11-03	Mallinckrodt Medical, Inc.	Radiolabeled peptide compositions for site-specific targeting
US5770687A (en) *	1995-06-07	1998-06-23	Peptor Limited	Comformationally constrained backbone cyclized somatostatin analogs
GB9513224D0 (en) *	1995-06-29	1995-09-06	Sandoz Ltd	Organic compounds
IT1277391B1 (it) *	1995-07-28	1997-11-10	Romano Deghenghi	Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
JPH09328499A (ja) *	1996-02-20	1997-12-22	American Cyanamid Co	純粋なソマトスタチンアンタゴニストおよびその使用方法
US6262229B1 (en)	1996-12-04	2001-07-17	Biomeasure Incorporated	Somatostatin antagonists
US5972895A (en) *	1996-12-11	1999-10-26	A. Glenn Braswell	Composition and method for increasing growth hormone levels
EP1332762A1 (en) *	1997-05-01	2003-08-06	Cedars-Sinai Medical Center	Method of treating hyperprolactinemia and prolactinomas
US5972893A (en) *	1997-05-06	1999-10-26	Cedars-Sinai Medical Center	Method of treating hyperprolactinemia and prolactinomas
DE69812084T2 (de) *	1997-05-01	2003-12-24	Cedars-Sinai Medical Center, Los Angeles	Verfahren zur behandlung von hyperprolaktinämia und prolaktinomen
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
WO1998051330A1 (en) *	1997-05-13	1998-11-19	Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.)	Method and compositions for treating hyperlipidemia and other conditions
AU7655098A (en) *	1997-05-13	1998-12-08	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Somatostatin and somatostatin agonists for decreasing body weight
ES2216290T3 (es) *	1997-05-13	2004-10-16	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Somatostatina y agonistas de la somatostatina para el tratamiento de insensibilidad a la insulina y de sindrome x.
US5968903A (en) *	1998-05-07	1999-10-19	Biomeasure, Incorporated	Inhibition of H. pylori proliferation
BR0210915A (pt)	2001-06-08	2004-06-08	Sod Conseils Rech Applic	Análogos quiméricos de somatostatina-dopamina
CN101791409A (zh)	2003-04-22	2010-08-04	研究及应用科学协会股份有限公司	肽载体
US20070111930A1 (en) *	2005-11-10	2007-05-17	Palle Venkata Raghavendra A	Process for preparing vapreotide
US8691761B2 (en)	2006-10-16	2014-04-08	Jean E. F. Rivier	Somatostatin receptor 2 antagonists
EP2383289B1 (en)	2006-10-16	2014-10-08	The Salk Institute for Biological Studies	Receptor (SSTR2)-selective somatostatin antagonists
CA2727082C (en)	2008-06-12	2019-02-26	Syntaxin Limited	Fusion proteins for use in suppression of acromegaly
CN102083451A (zh)	2008-06-12	2011-06-01	赛恩泰新公司	癌症的抑制
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
JP6869720B2 (ja)	2013-06-13	2021-05-12	アンチセンスセラピューティクスリミテッド	併用療法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4209426A (en) *	1979-05-29	1980-06-24	American Home Products Corporation	Polypeptides related to somatostatin
DE3062075D1 (en) *	1979-11-27	1983-03-24	Sandoz Ag	Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
US4282143A (en) *	1980-06-13	1981-08-04	American Home Products Corporation	Octapeptides lowering growth hormone
DK81082A (da) *	1981-03-06	1982-09-07	Sandoz Ag	Fremgangsmaade til fremstilling af polypeptider
US4443434A (en) *	1982-08-18	1984-04-17	American Home Products Corporation	Antiulcer agent
CH655505B (da) *	1982-08-24	1986-04-30
US4451394A (en) *	1982-10-25	1984-05-29	American Home Products Corporation	Dodecapeptides preventing glucose and triglyceride assimilation
US4440904A (en) *	1983-01-31	1984-04-03	American Home Products Corporation	Nonapeptide anti-secretory agents
US4684620A (en) *	1984-09-04	1987-08-04	Gibson-Stephens Neuropharmaceuticals, Inc.	Cyclic polypeptides having mu-receptor specificity
JPH085913B2 (ja) *	1985-09-12	1996-01-24	ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド	治療用ソマトスタチン同族体

1986
- 1986-03-28 US US06/843,539 patent/US4725577A/en not_active Expired - Lifetime
- 1986-04-15 AT AT86810174T patent/ATE78831T1/de not_active IP Right Cessation
- 1986-04-15 EP EP86810174A patent/EP0203031B1/en not_active Expired
- 1986-04-15 DE DE8686810174T patent/DE3686200T2/de not_active Expired - Lifetime
- 1986-04-16 IE IE100486A patent/IE59621B1/en not_active IP Right Cessation
- 1986-04-17 AU AU56338/86A patent/AU600895B2/en not_active Expired
- 1986-04-22 DK DK198601854A patent/DK174920B1/da not_active IP Right Cessation
- 1986-04-24 CA CA000507490A patent/CA1333646C/en not_active Expired - Lifetime
1993
- 1993-05-04 SG SG577/93A patent/SG57793G/en unknown
- 1993-07-15 HK HK687/93A patent/HK68793A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3686200T2 (de)	1993-03-11
DK174920B1 (da)	2004-02-23
AU5633886A (en)	1986-10-30
EP0203031B1 (en)	1992-07-29
HK68793A (en)	1993-07-23
DK185486A (da)	1986-10-26
EP0203031A3 (en)	1988-09-21
EP0203031A2 (en)	1986-11-26
ATE78831T1 (de)	1992-08-15
IE59621B1 (en)	1994-03-09
DE3686200D1 (de)	1992-09-03
AU600895B2 (en)	1990-08-30
IE861004L (en)	1986-10-25
US4725577A (en)	1988-02-16
SG57793G (en)	1993-07-09
CA1333646C (en)	1994-12-20

Legal Events

Date	Code	Title	Description
2006-05-08	PUP	Patent expired

Publication	Publication Date	Title
DK185486D0 (da)	1986-04-22	Octapeptidderivater
EP0142272B1 (en)	1988-01-13	Peptides and their use in therapy
EP0528312A3 (en)	1993-04-14	Cyclic peptides and use thereof
WO1998021237A3 (en)	1998-07-30	Peptide compounds useful for modulating FGF receptor activity
AU633913B2 (en)	1993-02-11	Novel tnf-inhibit proteins and their preparation
KR960703015A (ko)	1996-06-19	후천성 면역결핍증 치료용 약물의 제조시 노나- 및 데카펩타이드의 용도(Use of nona-and decapeptides in the preparation of a durg for the treatment of AIDS)
AU6819294A (en)	1994-11-08	Oral drug delivery compositions and methods
CA2207078A1 (en)	1998-01-26	Insulin derivatives with increased zinc binding
AU559914B2 (en)	1987-03-26	Peptide compounds
CA2097192A1 (en)	1992-05-30	Bombesin antagonists
US7189692B2 (en)	2007-03-13	Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
KR880011198A (ko)	1988-10-27	사이클릭 펩타이드 및 이의 제조방법
MX9702275A (es)	1997-06-28	Compuestos polipectidicos que contienen d-2 alquiltriptofano capaces de promover la liberacion de hormona del crecimiento.
BG97123A (bg)	1993-12-24	Производни на човешка, стимулирана от жлъчните соли, липаза и фармацевтични състави на тяхна основа
NZ335879A (en)	2000-11-24	Somatostatin antagonist peptides having a D-amino acid at the second residue
ATE124955T1 (de)	1995-07-15	Substrat-peptide.
ES8701784A1 (es)	1986-12-01	Un procedimiento para preparar un peptido ciclico con acti- vidad antagonista de vasopresina
AU2002351536A1 (en)	2003-05-12	Analogs of human growth hormone-releasing hormone, their preparation and use
CA2257973A1 (en)	1997-12-18	T cell antigen receptor peptides
KR890009974A (ko)	1989-08-05	신규 화합물들
EP0346068A3 (en)	1991-01-30	D-cys6 vasopressin antagonists
GB1425099A (en)	1976-02-18	Psychopharmacologically active peptides
CA2216704A1 (en)	1996-10-10	Novel peptides and remedy for bone diseases containing the same as active ingredient
Kozono et al.	1983	Synthesis of a Lactam Analog of AM-Toxin I
TH35998A (th)	1999-11-30	Lh-rh เป็ปไทด์ อะนาล็อก ประโยชน์ของสิ่งเหล่านั้นและองค์ประกอบทางเภสัชกรรมซึ่งประกอบด้วยสิ่งเหล่านั้น