DK1888541T3 - Benzo(d)isoxazol-3-yl-amin-forbindelser og anvendelse af disse som vanilloidreceptorligander - Google Patents

Benzo(d)isoxazol-3-yl-amin-forbindelser og anvendelse af disse som vanilloidreceptorligander

Info

Publication number: DK1888541T3
Authority: DK; Denmark
Prior art keywords: isoxazol; benzo; amine compounds; receptor ligands; vanilloid receptor
Prior art date: 2005-05-18

Application number

DK06742972T

Other languages

Danish (da)

English (en)

Inventor

Robert Frank

Beatrix Merla

Melanie Reich

Ruth Jostock

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-18

Filing date

2006-05-18

Publication date

2009-12-07

2006-05-18 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2009-12-07 Application granted granted Critical

2009-12-07 Publication of DK1888541T3 publication Critical patent/DK1888541T3/da

Links

NLMVYUBGWZWUGB-UHFFFAOYSA-N 1,2-benzoxazol-3-amine Chemical class C1=CC=C2C(N)=NOC2=C1 NLMVYUBGWZWUGB-UHFFFAOYSA-N 0.000 title abstract 2
102000011040 TRPV Cation Channels Human genes 0.000 title 1
108010062740 TRPV Cation Channels Proteins 0.000 title 1
239000003446 ligand Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Psychology (AREA)
Hematology (AREA)
Dermatology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)

DK06742972T 2005-05-18 2006-05-18 Benzo(d)isoxazol-3-yl-amin-forbindelser og anvendelse af disse som vanilloidreceptorligander DK1888541T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102005023589		2005-05-18
DE102005038947A DE102005038947A1 (de)	2005-05-18	2005-08-16	Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
PCT/EP2006/004698 WO2006122799A1 (de)	2005-05-18	2006-05-18	Benzo (d) isoxazol-3-yl-amin- verbindungen und deren verwendung als vanilloid-rezeptor liganden

Publications (1)

Publication Number	Publication Date
DK1888541T3 true DK1888541T3 (da)	2009-12-07

Family

ID=36699120

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK06742972T DK1888541T3 (da)	2005-05-18	2006-05-18	Benzo(d)isoxazol-3-yl-amin-forbindelser og anvendelse af disse som vanilloidreceptorligander
DK06753695.3T DK1881967T3 (da)	2005-05-18	2006-05-18	Substituerede benzo (D) isoaxol-3-yl-amin-forbindelser som analgetika

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK06753695.3T DK1881967T3 (da)	2005-05-18	2006-05-18	Substituerede benzo (D) isoaxol-3-yl-amin-forbindelser som analgetika

Country Status (15)

Country	Link
US (2)	US7977360B2 (pl)
EP (2)	EP1888541B1 (pl)
JP (2)	JP2008540597A (pl)
AT (2)	ATE438633T1 (pl)
AU (1)	AU2006249065B2 (pl)
CA (2)	CA2608386A1 (pl)
CY (2)	CY1109568T1 (pl)
DE (3)	DE102005038947A1 (pl)
DK (2)	DK1888541T3 (pl)
ES (2)	ES2331259T3 (pl)
PL (2)	PL1888541T3 (pl)
PT (2)	PT1881967E (pl)
RU (1)	RU2416607C2 (pl)
SI (2)	SI1881967T1 (pl)
WO (2)	WO2006122799A1 (pl)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102005038947A1 (de) *	2005-05-18	2006-11-30	Grünenthal GmbH	Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
US20100080773A1 (en)	2008-09-26	2010-04-01	Sdg, Inc.	Orally Bioavailable Lipid-Based Constructs
CN101925575B (zh)	2008-01-28	2014-06-18	株式会社爱茉莉太平洋	作为香草酸受体拮抗剂的化合物、其异构体或其药物学可接受的盐、及包含这些化合物的药物组合物
EP2307394B1 (en)	2008-07-02	2012-09-26	Amorepacific Corporation	Sulphonamides as vanilloid receptor antagonist
US8349852B2 (en)	2009-01-13	2013-01-08	Novartis Ag	Quinazolinone derivatives useful as vanilloid antagonists
TWI504395B (zh)	2009-03-10	2015-10-21		Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier
CA2754934A1 (en)	2009-03-10	2010-09-16	Gruenenthal Gmbh	Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators
TWI461197B (zh)	2009-03-12	2014-11-21		2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier
TW201038565A (en)	2009-03-12	2010-11-01	Gruenenthal Gmbh	Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators
WO2011092293A2 (en)	2010-02-01	2011-08-04	Novartis Ag	Cyclohexyl amide derivatives as crf receptor antagonists
AR080055A1 (es)	2010-02-01	2012-03-07	Novartis Ag	Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
ES2527849T3 (es)	2010-02-02	2015-01-30	Novartis Ag	Derivados de ciclohexilamida como antagonistas del receptor de CRF
RU2012139491A (ru)	2010-02-11	2014-03-20	Вандербилт Юниверсити	Бензизоксазолы и азабензизоксазолы как аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций
BR112013004690A2 (pt)	2010-08-27	2016-05-10	Gruenenthal Gmbh	2-oxo-e 2-tioxo-di-hidroquinolina-3-carboxamidas substituídas como moduladores kcnq2/3
TW201211007A (en)	2010-08-27	2012-03-16	Gruenenthal Gmbh	Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators
KR20130100300A (ko)	2010-08-27	2013-09-10	그뤼넨탈 게엠베하	Ｋｃｎｑ２／３ 조절제로서의 치환된 ２-옥시-퀴놀린-３-카복스아미드
AU2011297937B2 (en)	2010-09-01	2015-10-01	Grunenthal Gmbh	Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators
JP6014155B2 (ja)	2011-10-31	2016-10-25	ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃ．	ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
ES2586213T3 (es)	2011-10-31	2016-10-13	Xenon Pharmaceuticals Inc.	Compuestos de bencenosulfonamida y su uso como agentes terapéuticos
BR112014029161A2 (pt)	2012-05-22	2017-06-27	Genentech Inc	benzamidas n-substituídas e seu uso no tratamento de dor
BR112015000187A2 (pt)	2012-07-06	2017-06-27	Genentech Inc	benzamidas substituídas com n e métodos de uso das mesmas
BR112015022488A2 (pt)	2013-03-14	2017-07-18	Genentech Inc	triazolopiridinas substituídas e métodos de uso das mesmas
BR112015023397A2 (pt)	2013-03-15	2017-07-18	Genentech Inc	benzoxazois substituídos e métodos de uso dos mesmos
CR20160296A (es)	2013-11-27	2016-09-20	Genentech Inc	Benzamidas sustituidas y métodos para usarlas
WO2015094670A1 (en) *	2013-12-20	2015-06-25	Gilead Sciences, Inc.	Fused heterocyclic compounds as ion channel modulators
EP3166939B1 (en)	2014-07-07	2019-06-05	Genentech, Inc.	Therapeutic compounds and methods of use thereof
JP7323985B2 (ja)	2014-08-13	2023-08-09	オークランドユニサービシーズリミティド	トリプトファンジオキシゲナーゼ（ｉｄｏ１とｔｄｏ）の阻害剤及び治療におけるその使用
WO2016096709A1 (en) *	2014-12-16	2016-06-23	Eudendron S.R.L.	Heterocyclic derivatives modulating activity of certain protein kinases
EP3623371A1 (en)	2014-12-16	2020-03-18	Axovant Sciences GmbH	Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
WO2016191312A1 (en)	2015-05-22	2016-12-01	Genentech, Inc.	Substituted benzamides and methods of use thereof
CA2988968A1 (en)	2015-06-10	2016-12-15	Forum Pharmaceuticals, Inc.	Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors
WO2017027600A1 (en) *	2015-08-12	2017-02-16	Forum Pharmaceuticals, Inc.	GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS
EP3350188B1 (en)	2015-08-27	2024-03-13	Auckland Uniservices Limited	Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy
MA42683A (fr)	2015-08-27	2018-07-04	Genentech Inc	Composés thérapeutiques et leurs méthodes utilisation
PE20181003A1 (es)	2015-09-28	2018-06-26	Genentech Inc	Compuestos terapeuticos y sus metodos de uso
CN108495851A (zh)	2015-11-25	2018-09-04	基因泰克公司	取代的苯甲酰胺及其使用方法
EP3854782A1 (en)	2016-03-30	2021-07-28	Genentech, Inc.	Substituted benzamides and methods of use thereof
SG11201903348UA (en)	2016-10-17	2019-05-30	Genentech Inc	Therapeutic compounds and methods of use thereof
WO2018175707A1 (en)	2017-03-24	2018-09-27	Genentech, Inc.	4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
EP3759098A1 (en)	2018-02-26	2021-01-06	Genentech, Inc.	Pyridine-sulfonamide compounds and their use against pain and related conditions
EP3774801A1 (en)	2018-03-30	2021-02-17	F. Hoffmann-La Roche AG	Fused ring hydro-pyrido compounds as sodium channel inhibitors
TW202003490A (zh)	2018-05-22	2020-01-16	瑞士商赫孚孟拉羅股份公司	治療性化合物及其使用方法
GB201810092D0 (en)	2018-06-20	2018-08-08	Ctxt Pty Ltd	Compounds
GB201810581D0 (en)	2018-06-28	2018-08-15	Ctxt Pty Ltd	Compounds
PH12021553107A1 (en)	2019-06-18	2022-08-01	Ctxt Pty Ltd	Benzisoxazole sulfonamide derivatives
US20230053607A1 (en)	2019-12-04	2023-02-23	Syngenta Crop Protection Ag	Pesticidally active fused bicyclic heteroaromatic amino compounds
UY39006A (es) *	2019-12-31	2021-07-30	Ifm Due Inc	Compuestos y composiciones para tratar afecciones asociadas con la actividad de sting
BR112022014943A2 (pt)	2020-01-30	2022-09-20	Syngenta Crop Protection Ag	Compostos de amino heteroaromáticos bicíclicos fundidos ativos em termos pesticidas
CN112142683B (zh) *	2020-09-01	2022-05-24	成都大学	一种氮杂十一元环化合物及其制备方法、用途以及包含该化合物的药物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2076253T3 (es) *	1989-05-19	1995-11-01	Hoechst Roussel Pharma	N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
ES2188584T3 (es) *	1991-03-28	2003-07-01	Eisai Co Ltd	Derivados heterociclicos de amina.
US5328920A (en) *	1991-04-17	1994-07-12	Hoechst-Roussel Pharmaceuticals Incorporated	Substituted (pyridinylamino)-indoles
DE69332691T2 (de) *	1992-11-23	2003-12-18	Aventis Pharmaceuticals Inc., Cincinnati	Substituierte 3-(aminoalkylamino)-1,2-benzisoxazole und verwandte verbindungen
US5494908A (en) *	1992-11-23	1996-02-27	Hoechst-Roussel Pharmaceutical Incorporated	Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
JP3057763B2 (ja) *	1995-06-06	2000-07-04	ヘキスト・マリオン・ルセル・インコーポレイテツド	抗精神病薬としてのベンゾイソオキサゾール及びインダゾール誘導体
JP4590102B2 (ja) *	1998-10-06	2010-12-01	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	医薬としての三環性δ３−ピペリジン類
WO2000027199A1 (en) *	1998-11-12	2000-05-18	Eli Lilly And Company	Aminobenzisoxazole compounds and libraries thereof
WO2000027627A1 (en) *	1998-11-12	2000-05-18	Eli Lilly And Company	Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles
EP1196412B1 (en) *	1999-07-16	2004-06-09	Bristol-Myers Squibb Pharma Company	Nitrogen containing heterobicycles as factor xa inhibitors
WO2001087845A2 (en) *	2000-05-15	2001-11-22	Fujisawa Pharmaceutical Co., Ltd.	N-containing heterocyclic compounds and their use as 5-ht antagonists
MXPA03007397A (es)	2001-02-20	2003-12-04	Bristol Myers Squibb Co	Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas.
US6469042B1 (en) *	2001-02-20	2002-10-22	Bristol-Myers Squibb Company	Fluoro oxindole derivatives as modulators if KCNQ potassium channels
EP1361879A1 (en) *	2001-02-20	2003-11-19	Bristol-Myers Squibb Company	2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators
US6593349B2 (en) *	2001-03-19	2003-07-15	Icagen, Inc.	Bisarylamines as potassium channel openers
KR100789567B1 (ko) *	2001-11-06	2007-12-28	동화약품공업주식회사	3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도
DE10229070A1 (de) *	2002-06-28	2004-01-15	Merck Patent Gmbh	Phenylderivate 5
GB0217757D0 (en) *	2002-07-31	2002-09-11	Glaxo Group Ltd	Novel compounds
JO2696B1 (en) *	2002-12-23	2013-03-03	شركة جانسين فارماسوتيكا ان. في	Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
JP4810427B2 (ja) *	2003-05-22	2011-11-09	アボット・ラボラトリーズ	インダゾール、ベンズイソオキサゾールおよびベンズイソチアゾールキナーゼ阻害剤
GB0319150D0 (en)	2003-08-14	2003-09-17	Glaxo Group Ltd	Novel compounds
WO2005089753A2 (en) *	2004-03-16	2005-09-29	Janssen Pharmaceutica N.V.	Daao inhibiting bξnzisoxazoles and their use for the treatment of mental disorders
US7759337B2 (en) *	2005-03-03	2010-07-20	Amgen Inc.	Phthalazine compounds and methods of use
DE102005038947A1 (de) *	2005-05-18	2006-11-30	Grünenthal GmbH	Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
DE102005026194A1 (de) *	2005-06-06	2006-12-07	Grünenthal GmbH	Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
US7989461B2 (en) *	2005-12-23	2011-08-02	Amgen Inc.	Substituted quinazolinamine compounds for the treatment of cancer

2005
- 2005-08-16 DE DE102005038947A patent/DE102005038947A1/de not_active Withdrawn
2006
- 2006-05-18 WO PCT/EP2006/004698 patent/WO2006122799A1/de not_active Ceased
- 2006-05-18 AT AT06742972T patent/ATE438633T1/de active
- 2006-05-18 CA CA002608386A patent/CA2608386A1/en not_active Abandoned
- 2006-05-18 PL PL06742972T patent/PL1888541T3/pl unknown
- 2006-05-18 RU RU2007146385/04A patent/RU2416607C2/ru not_active IP Right Cessation
- 2006-05-18 DK DK06742972T patent/DK1888541T3/da active
- 2006-05-18 ES ES06742972T patent/ES2331259T3/es not_active Expired - Lifetime
- 2006-05-18 DK DK06753695.3T patent/DK1881967T3/da active
- 2006-05-18 JP JP2008511637A patent/JP2008540597A/ja not_active Ceased
- 2006-05-18 AU AU2006249065A patent/AU2006249065B2/en not_active Ceased
- 2006-05-18 ES ES06753695T patent/ES2344272T3/es not_active Expired - Lifetime
- 2006-05-18 EP EP06742972A patent/EP1888541B1/de not_active Expired - Lifetime
- 2006-05-18 WO PCT/EP2006/004700 patent/WO2006122800A1/de not_active Ceased
- 2006-05-18 DE DE502006004453T patent/DE502006004453D1/de not_active Expired - Lifetime
- 2006-05-18 SI SI200630725T patent/SI1881967T1/sl unknown
- 2006-05-18 EP EP06753695A patent/EP1881967B1/de not_active Expired - Lifetime
- 2006-05-18 AT AT06753695T patent/ATE466002T1/de active
- 2006-05-18 SI SI200630455T patent/SI1888541T1/sl unknown
- 2006-05-18 DE DE502006006854T patent/DE502006006854D1/de not_active Expired - Lifetime
- 2006-05-18 PT PT06753695T patent/PT1881967E/pt unknown
- 2006-05-18 CA CA002608773A patent/CA2608773A1/en not_active Abandoned
- 2006-05-18 US US11/914,636 patent/US7977360B2/en not_active Expired - Fee Related
- 2006-05-18 JP JP2008511638A patent/JP2008540598A/ja not_active Ceased
- 2006-05-18 PL PL06753695T patent/PL1881967T3/pl unknown
- 2006-05-18 PT PT06742972T patent/PT1888541E/pt unknown
2007
- 2007-11-16 US US11/941,331 patent/US7696238B2/en not_active Expired - Fee Related
2009
- 2009-11-05 CY CY20091101144T patent/CY1109568T1/el unknown
2010
- 2010-07-15 CY CY20101100664T patent/CY1110209T1/el unknown

Also Published As

Publication number	Publication date
DE502006006854D1 (de)	2010-06-10
EP1888541B1 (de)	2009-08-05
WO2006122799A1 (de)	2006-11-23
EP1881967A1 (de)	2008-01-30
PL1888541T3 (pl)	2010-01-29
PT1881967E (pt)	2010-06-30
RU2416607C2 (ru)	2011-04-20
AU2006249065B2 (en)	2011-04-21
DE102005038947A1 (de)	2006-11-30
DK1881967T3 (da)	2010-08-16
DE502006004453D1 (de)	2009-09-17
CA2608386A1 (en)	2006-11-23
AU2006249065A1 (en)	2006-11-23
US20080176915A1 (en)	2008-07-24
JP2008540597A (ja)	2008-11-20
SI1888541T1 (sl)	2010-01-29
ATE466002T1 (de)	2010-05-15
ATE438633T1 (de)	2009-08-15
EP1888541A1 (de)	2008-02-20
CY1109568T1 (el)	2014-08-13
JP2008540598A (ja)	2008-11-20
HK1112238A1 (zh)	2008-08-29
CA2608773A1 (en)	2006-11-23
PT1888541E (pt)	2009-11-10
WO2006122800A1 (de)	2006-11-23
US7696238B2 (en)	2010-04-13
CY1110209T1 (el)	2015-01-14
US7977360B2 (en)	2011-07-12
US20090042945A1 (en)	2009-02-12
PL1881967T3 (pl)	2010-10-29
SI1881967T1 (sl)	2010-08-31
EP1881967B1 (de)	2010-04-28
RU2007146385A (ru)	2009-10-27
ES2331259T3 (es)	2009-12-28
ES2344272T3 (es)	2010-08-23

Publication	Publication Date	Title
PL1888541T3 (pl)	2010-01-29	Związki benzo[d]izoksazol-3-iloaminy i ich zastosowanie jako ligandów receptora waniloidowego
NO20090295L (no)	2009-01-20	Substituerte heteroarylderivater
MX2007003108A (es)	2007-05-24	Compuestos imidazo-3-il-amina sustituidos y biciclicos.
IL190654A (en)	2013-09-30	Methods of Methyl-Sulfonamido-Propanamido, Processes for Preparation and Medicines Containing Them
MX2009003382A (es)	2009-04-08	Derivados de sulfonamidas sustituidos.
NO20081160L (no)	2008-05-29	Benzimidazoltiofen forbindelser
NO20083153L (no)	2008-09-22	Kjemiske forbindelser
DK1633697T3 (da)	2009-06-02	Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser
ES2338590T3 (es)	2010-05-10	Procedimiento regioselectivo de preparacion de benzoimidazoltiofenos.
DK1682530T3 (da)	2007-07-16	Pyrrolsubstituerede indoler som inhibitorer af PAI-1
SE0401762D0 (sv)	2004-07-05	Novel compounds
PL1891004T3 (pl)	2010-05-31	Pentafluorosulfanylo-podstawiony związek i jego zastosowanie do wytwarzania środków leczniczych
WO2009156462A3 (en)	2010-05-27	Organic compounds
MX2009011149A (es)	2009-10-30	Ligandos de receptor de vainilloide novedosos y el uso de los mismos para la produccion de sustancias farmaceuticas.
TW200740814A (en)	2007-11-01	Compounds
NO20091990L (no)	2009-06-02	Substituerte pyrazoler, sammensetninger inneholdende disse, fremgangsmate for fremstilling og anvendelse
EA200700365A1 (ru)	2007-06-29	Производные индол-2-карбоксамидина как антагонисты nmda рецептора
DE602006009789D1 (de)	2009-11-26	Acetylenderivate
ATE459620T1 (de)	2010-03-15	Benzimidazolthiophenverbindungen als plk- modulatoren
DK1756049T3 (da)	2008-02-25	Fremgangsmåde til fremstilling af 1,4-diphenylazetidinon-derivater
UY30801A1 (es)	2008-07-03	Compuestos calciliticos
NO20074528L (no)	2007-10-31	Substituerte pyrroler, sammensetninger, fremgangsmate for fremstilling og anvendelse av samme
ATE417849T1 (de)	2009-01-15	Pyrazoloä4,3-düpyrimidine
ATE542796T1 (de)	2012-02-15	N-sulfonylcarboximidamidverbindungen als apoptosepromotoren
NO20091386L (no)	2009-05-06	Fenyloksyanilinderivater