DK1896439T3 - Krystallinsk base af escitalopram og orodispergerbare tabletter, der omfatter escitaloprambase - Google Patents

Krystallinsk base af escitalopram og orodispergerbare tabletter, der omfatter escitaloprambase

Info

Publication number
DK1896439T3
DK1896439T3 DK06742481.2T DK06742481T DK1896439T3 DK 1896439 T3 DK1896439 T3 DK 1896439T3 DK 06742481 T DK06742481 T DK 06742481T DK 1896439 T3 DK1896439 T3 DK 1896439T3
Authority
DK
Denmark
Prior art keywords
escitalopram
base
crystalline
orodispersible tablets
orodispersible
Prior art date
Application number
DK06742481.2T
Other languages
English (en)
Other versions
DK1896439T4 (da
Inventor
Hans Petersen
Ole Nielsen
Michael Harold Rock
Robert Dancer
Helle Eliasen
Ken Liljegren
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1896439(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of DK1896439T3 publication Critical patent/DK1896439T3/da
Publication of DK1896439T4 publication Critical patent/DK1896439T4/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00Purification; Separation; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK06742481.2T 2005-06-22 2006-06-22 Krystallinsk base af escitalopram og orodispergerbare tabletter, der omfatter escitaloprambase DK1896439T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500912 2005-06-22
PCT/DK2006/000366 WO2006136169A2 (en) 2005-06-22 2006-06-22 Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Publications (2)

Publication Number Publication Date
DK1896439T3 true DK1896439T3 (da) 2011-02-28
DK1896439T4 DK1896439T4 (da) 2015-01-12

Family

ID=37546630

Family Applications (3)

Application Number Title Priority Date Filing Date
DK06742481.2T DK1896439T4 (da) 2005-06-22 2006-06-22 Krystallinsk base af escitalopram og orodispergerbare tabletter, der omfatter escitaloprambase
DK200800075A DK200800075A (da) 2005-06-22 2008-01-21 Krystallinsk base af escitalopram og orodispergerbare tabletter indeholdende escitaloprambase
DKPA200900284A DK200900284A (da) 2005-06-22 2009-02-27 Krystallinsk base af escitalopram og smeltetabletter indeholdende escitalopram base

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK200800075A DK200800075A (da) 2005-06-22 2008-01-21 Krystallinsk base af escitalopram og orodispergerbare tabletter indeholdende escitaloprambase
DKPA200900284A DK200900284A (da) 2005-06-22 2009-02-27 Krystallinsk base af escitalopram og smeltetabletter indeholdende escitalopram base

Country Status (39)

Country Link
EP (3) EP2385044A1 (da)
JP (5) JP4906852B2 (da)
KR (5) KR20110084341A (da)
CN (2) CN101189220A (da)
AR (2) AR055062A1 (da)
AT (3) ATE497500T1 (da)
AU (2) AU2006261452B2 (da)
BG (1) BG66086B1 (da)
BR (1) BRPI0612295A2 (da)
CA (2) CA2646780A1 (da)
CY (1) CY1112392T1 (da)
CZ (3) CZ301286B6 (da)
DE (2) DE112006001619T5 (da)
DK (3) DK1896439T4 (da)
EA (2) EA019239B1 (da)
EE (1) EE00773U1 (da)
ES (2) ES2356838T5 (da)
FI (2) FI20077133L (da)
GB (2) GB2442160B (da)
HR (1) HRP20110093T4 (da)
HU (1) HUP0800135A3 (da)
IL (1) IL187454A0 (da)
IS (1) IS8705A (da)
LT (1) LT5550B (da)
LV (1) LV13677B (da)
MX (1) MX2007015328A (da)
MY (2) MY143239A (da)
NO (2) NO20080359L (da)
PL (2) PL1896439T5 (da)
PT (1) PT1896439E (da)
RS (1) RS51575B2 (da)
SG (1) SG169358A1 (da)
SI (1) SI1896439T2 (da)
SK (1) SK500402007A3 (da)
TR (2) TR200708792T1 (da)
TW (2) TWI347942B (da)
UA (1) UA86536C2 (da)
WO (1) WO2006136169A2 (da)
ZA (2) ZA200711066B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
EP2134325A2 (en) * 2007-03-01 2009-12-23 Aurobindo Pharma Limited Stable solid dosage forms of an antidepressant
ME02391B (me) 2010-07-23 2016-09-20 H Lundbeck As Postupak za prečišćavanje farmaceutski prihvatljivih soli escitaloprama
CN103360353A (zh) * 2013-08-07 2013-10-23 中国药科大学 草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) * 2016-07-26 2018-02-01 株式会社トクヤマ (1s)−1−[3−(ジメチルアミノ)プロピル]−1−(4−フルオロフェニル)−1,3−ジヒドロイソベンゾフラン−5−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) * 2017-04-10 2018-10-18 東和薬品株式会社 エスシタロプラム医薬組成物
CN110711198B (zh) * 2018-07-12 2022-03-15 山东大学 D-甘露糖在制备抗抑郁药物中的应用
KR102331187B1 (ko) 2019-04-09 2021-11-26 주식회사 라이트팜텍 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법
WO2022153262A1 (en) * 2021-01-18 2022-07-21 Anton Frenkel Pharmaceutical dosage form

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GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH05222041A (ja) * 1992-02-13 1993-08-31 Mitsubishi Gas Chem Co Inc アデニン誘導体の精製法
NZ279674A (en) * 1994-01-27 1997-02-24 Univ Oklahoma Rapidly dissolving oral dosage form containing a particulate support matrix
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
CA2325909C (en) 1997-06-30 2006-07-04 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
CN1206207C (zh) 1997-07-08 2005-06-15 H.隆德贝克有限公司 氰酞氟苯胺的制备方法
HUP0002953A3 (en) 1997-11-11 2002-12-28 Lundbeck & Co As H Method for preparation of citalopram and intermediates used for them
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
US20020071864A1 (en) * 1999-03-25 2002-06-13 Yuhan Corporation Rapidly disintegrable tablet for oral administration
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
US7510728B2 (en) * 2000-10-06 2009-03-31 Takeda Pharmaceutical Company Limited Solid preparations
KR20030042006A (ko) * 2000-10-16 2003-05-27 다이이찌 세이야꾸 가부시기가이샤 구강내 속붕괴성 의약 조성물 및 그의 제조방법
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
EA003581B1 (ru) * 2000-12-22 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
AU2001100399B4 (en) * 2000-12-28 2002-03-21 H Lundbeck As Process for the preparation of pure citalopram
CZ20033267A3 (en) * 2001-05-01 2004-06-16 H. Lundbeck A/S The use of enantiomeric pure escitalopram
US6872405B2 (en) * 2001-05-10 2005-03-29 Yamanouchi Pharmaceutical Co., Ltd. Quick-disintegrating tablet in buccal cavity and manufacturing method thereof
GB0113842D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
EA006213B1 (ru) * 2001-07-31 2005-10-27 Х. Лундбекк А/С Кристаллическая композиция, содержащая эсциталопрам
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
FR2834889B1 (fr) * 2002-01-18 2004-04-02 Roquette Freres Forme pharmaceutique solide orodispersible
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
JP2005535582A (ja) * 2002-05-03 2005-11-24 スカイファーマ・カナダ・インコーポレーテッド 被覆錠剤
WO2004056791A1 (en) 2002-12-23 2004-07-08 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
CN1510024A (zh) * 2002-12-24 2004-07-07 北京德众万全药物技术开发有限公司 可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
EP1620075B1 (en) * 2003-05-07 2020-06-24 Samyang Biopharmaceuticals Corporation Highly plastic granules for making fast melting tablets
EP1674083B1 (en) * 2003-10-15 2018-08-01 Fuji Chemical Industry Co., Ltd. Tablet quickly disintegrating in oral cavity
AU2003282383A1 (en) * 2003-11-20 2005-06-08 Natco Pharma Limited A process for the preparation of high purity escitalopram
HU227491B1 (en) * 2003-11-25 2011-07-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Tablet containing citalopram hydrogen bromide
BRPI0508266A (pt) * 2004-03-05 2007-07-31 Lundbeck & Co As H partìculas cristalinas de oxalato de escitalopram, forma de dosagem única sólida, e, métodos para a fabricação de partìculas cristalinas de oxalato de escitalopram e para reduzir a quantidade de hidroxila que contém impurezas no citalopram, escitalopram ou uma mistura não racêmica de r- e s-citalopram
WO2006106531A1 (en) * 2005-04-04 2006-10-12 Jubilant Organosys Ltd Process for the preparation of escitalopram or its acid addition salts

Also Published As

Publication number Publication date
EP2325177A1 (en) 2011-05-25
KR20110033310A (ko) 2011-03-30
PL1896439T3 (pl) 2011-04-29
MX2007015328A (es) 2008-02-15
AR079750A2 (es) 2012-02-15
CA2612827A1 (en) 2006-12-28
KR20120064140A (ko) 2012-06-18
SI1896439T1 (sl) 2011-03-31
DK1896439T4 (da) 2015-01-12
ZA200901698B (en) 2010-04-28
PL384185A1 (pl) 2008-06-23
FI20080548A7 (fi) 2008-10-07
ES2356838T5 (es) 2015-01-26
JP2009179635A (ja) 2009-08-13
AT11883U1 (de) 2011-06-15
JP5731957B2 (ja) 2015-06-10
KR20100133023A (ko) 2010-12-20
CZ300686B6 (cs) 2009-07-15
TWI358407B (en) 2012-02-21
JP4415056B2 (ja) 2010-02-17
JP2009046506A (ja) 2009-03-05
DE112006001619T5 (de) 2008-06-12
MY143239A (en) 2011-04-15
FI20080548L (fi) 2008-10-07
HUP0800135A3 (en) 2009-01-28
JP4906852B2 (ja) 2012-03-28
GB0811164D0 (en) 2008-07-23
JP2009179634A (ja) 2009-08-13
EA200800102A1 (ru) 2008-04-28
AU2010200844A1 (en) 2010-04-01
EA019239B1 (ru) 2014-02-28
AU2006261452A1 (en) 2006-12-28
JP2012072168A (ja) 2012-04-12
TR201000625T1 (tr) 2010-03-22
AT10983U1 (de) 2010-02-15
HRP20110093T1 (hr) 2011-03-31
GB2448834A (en) 2008-10-29
EP1896439A2 (en) 2008-03-12
ES2356838T3 (es) 2011-04-13
LT2008005A (en) 2008-10-27
WO2006136169A3 (en) 2007-10-18
FI20077133A7 (fi) 2007-12-20
BG110024A (bg) 2008-05-30
SI1896439T2 (sl) 2014-12-31
HUP0800135A2 (en) 2008-06-30
LT5550B (lt) 2009-03-25
BG66086B1 (bg) 2011-03-31
TR200708792T1 (tr) 2008-05-21
SG169358A1 (en) 2011-03-30
RS51575B2 (sr) 2018-02-28
GB2448834B (en) 2010-01-20
TW201130808A (en) 2011-09-16
ES2319073B1 (es) 2010-02-26
AU2006261452B2 (en) 2010-02-04
TW200740785A (en) 2007-11-01
KR20080018191A (ko) 2008-02-27
EP2385044A1 (en) 2011-11-09
GB0724557D0 (en) 2008-01-23
SK500402007A3 (sk) 2008-05-06
IS8705A (is) 2008-01-14
EE00773U1 (et) 2008-10-15
CZ301286B6 (cs) 2009-12-30
PT1896439E (pt) 2011-02-15
EP1896439B1 (en) 2011-02-02
UA86536C2 (ru) 2009-04-27
DK200900284A (da) 2009-02-27
MY143252A (en) 2011-04-15
LV13677B (en) 2008-05-20
BRPI0612295A2 (pt) 2011-01-04
NO20101777L (no) 2008-01-18
CA2612827C (en) 2010-11-30
IL187454A0 (en) 2008-02-09
CZ2007898A3 (cs) 2008-01-23
ATE497500T1 (de) 2011-02-15
PL1896439T5 (pl) 2016-01-29
ES2319073A1 (es) 2009-05-01
DE602006019961D1 (de) 2011-03-17
AR055062A1 (es) 2007-08-01
NO20080359L (no) 2008-01-18
WO2006136169A2 (en) 2006-12-28
EA201001108A1 (ru) 2011-02-28
ZA200711066B (en) 2009-07-29
GB2442160A (en) 2008-03-26
CN101189220A (zh) 2008-05-28
FI20077133L (fi) 2007-12-20
KR101340815B1 (ko) 2013-12-11
KR20110084341A (ko) 2011-07-21
CA2646780A1 (en) 2006-12-28
CZ299906B6 (cs) 2008-12-29
CN101928269A (zh) 2010-12-29
EP1896439B2 (en) 2014-10-15
RS51575B (sr) 2011-08-31
HRP20110093T4 (hr) 2015-02-27
CY1112392T1 (el) 2015-12-09
DK200800075A (da) 2008-03-15
JP2008546724A (ja) 2008-12-25
GB2442160B (en) 2010-01-20
TWI347942B (en) 2011-09-01

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