ATE497500T1 - Kristalline base von escitalopram und orodispergierbare tabletten, die escitaloprambase enthalten - Google Patents

Kristalline base von escitalopram und orodispergierbare tabletten, die escitaloprambase enthalten

Info

Publication number: ATE497500T1
Authority: AT; Austria
Prior art keywords: escitalopram; base; tablets containing; orodispersible tablets; crystalline
Prior art date: 2005-06-22

Application number

AT06742481T

Other languages

English (en)

Inventor

Robert Dancer

Hans Petersen

Ole Nielsen

Michael Rock

Helle Eliasen

Ken Liljegren

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-22

Filing date

2006-06-22

Publication date

2011-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE497500(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-22 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE497500T1 publication Critical patent/ATE497500T1/de

Links

WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title 2
229960004341 escitalopram Drugs 0.000 title 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT06742481T 2005-06-22 2006-06-22 Kristalline base von escitalopram und orodispergierbare tabletten, die escitaloprambase enthalten ATE497500T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200500912		2005-06-22
PCT/DK2006/000366 WO2006136169A2 (en)	2005-06-22	2006-06-22	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Publications (1)

Publication Number	Publication Date
ATE497500T1 true ATE497500T1 (de)	2011-02-15

Family

ID=37546630

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT0900506U AT10983U1 (de)	2005-06-22	2006-06-22	Kristalline base von escitalopram und orodispersible tabletten, die escitalopram-base umfassen
AT06742481T ATE497500T1 (de)	2005-06-22	2006-06-22	Kristalline base von escitalopram und orodispergierbare tabletten, die escitaloprambase enthalten
AT0041709U AT11883U1 (de)	2005-06-22	2009-07-07	Kristalline base von escitalopram und orodispersible tabletten, die escitalopram-base umfassen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT0900506U AT10983U1 (de)	2005-06-22	2006-06-22	Kristalline base von escitalopram und orodispersible tabletten, die escitalopram-base umfassen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT0041709U AT11883U1 (de)	2005-06-22	2009-07-07	Kristalline base von escitalopram und orodispersible tabletten, die escitalopram-base umfassen

Country Status (39)

Country	Link
EP (3)	EP1896439B2 (de)
JP (5)	JP4906852B2 (de)
KR (5)	KR20110084341A (de)
CN (2)	CN101189220A (de)
AR (2)	AR055062A1 (de)
AT (3)	AT10983U1 (de)
AU (2)	AU2006261452B2 (de)
BG (1)	BG66086B1 (de)
BR (1)	BRPI0612295A2 (de)
CA (2)	CA2612827C (de)
CY (1)	CY1112392T1 (de)
CZ (3)	CZ299906B6 (de)
DE (2)	DE602006019961D1 (de)
DK (3)	DK1896439T4 (de)
EA (2)	EA201001108A1 (de)
EE (1)	EE00773U1 (de)
ES (2)	ES2319073B1 (de)
FI (2)	FI20080548A7 (de)
GB (2)	GB2442160B (de)
HR (1)	HRP20110093T4 (de)
HU (1)	HUP0800135A3 (de)
IL (1)	IL187454A0 (de)
IS (1)	IS8705A (de)
LT (1)	LT5550B (de)
LV (1)	LV13677B (de)
MX (1)	MX2007015328A (de)
MY (2)	MY143239A (de)
NO (2)	NO20080359L (de)
PL (2)	PL1896439T5 (de)
PT (1)	PT1896439E (de)
RS (1)	RS51575B2 (de)
SG (1)	SG169358A1 (de)
SI (1)	SI1896439T2 (de)
SK (1)	SK500402007A3 (de)
TR (2)	TR201000625T1 (de)
TW (2)	TWI347942B (de)
UA (1)	UA86536C2 (de)
WO (1)	WO2006136169A2 (de)
ZA (2)	ZA200711066B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0123400D0 (en)	2001-09-28	2001-11-21	Novartis Ag	Organic compounds
WO2008059514A2 (en) *	2006-07-31	2008-05-22	Cadila Healthcare Limited	Process for preparing escitalopram
WO2008104880A2 (en) *	2007-03-01	2008-09-04	Aurobindo Pharma Limited	Stable solid dosage forms of an antidepressant
EP2595979B1 (de)	2010-07-23	2016-04-06	H. Lundbeck A/S	Verfahren zur reinigung pharmazeutisch zulässiger salze
CN103360353A (zh) *	2013-08-07	2013-10-23	中国药科大学	草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) *	2016-07-26	2018-02-01	株式会社トクヤマ	（１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) *	2017-04-10	2018-10-18	東和薬品株式会社	エスシタロプラム医薬組成物
CN110711198B (zh) *	2018-07-12	2022-03-15	山东大学	D-甘露糖在制备抗抑郁药物中的应用
KR102331187B1 (ko)	2019-04-09	2021-11-26	주식회사 라이트팜텍	에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법
US20240100012A1 (en) *	2021-01-18	2024-03-28	Mark Hasleton	Pharmaceutical dosage form

Family Cites Families (39)

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GB1526331A (en)	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8814057D0 (en)	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
JPH05222041A (ja) *	1992-02-13	1993-08-31	Mitsubishi Gas Chem Co Inc	アデニン誘導体の精製法
WO1995020377A1 (en) *	1994-01-27	1995-08-03	The Board Of Regents Of The University Of Oklahoma	Rapidly dissolving oral dosage form
US5607697A (en) *	1995-06-07	1997-03-04	Cima Labs, Incorporated	Taste masking microparticles for oral dosage forms
EP0993524B1 (de)	1997-06-30	2002-11-20	Beloit Technologies, Inc.	Verfahren und vorrichtung zum auftragen einer beschichtung auf eine bei hoher geschwindigkeit laufende papierbahn
ES2148120T3 (es)	1997-07-08	2002-01-16	Lundbeck & Co As H	Metodo para la preparacion de citalopram.
EA002770B1 (ru)	1997-11-11	2002-08-29	Х.Лундбекк А/С	Способ получения циталопрама
FR2785538B1 (fr) *	1998-11-06	2004-04-09	Prographarm Laboratoires	Comprime a delitement rapide perfectionne
US20020071864A1 (en) *	1999-03-25	2002-06-13	Yuhan Corporation	Rapidly disintegrable tablet for oral administration
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
JP2001226372A (ja) *	1999-12-06	2001-08-21	Sumika Fine Chemicals Co Ltd	ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
GB2357762B (en) *	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
WO2002030400A1 (fr) *	2000-10-06	2002-04-18	Takeda Chemical Industries, Ltd.	Preparations solides
KR20030042006A (ko) *	2000-10-16	2003-05-27	다이이찌 세이야꾸 가부시기가이샤	구강내 속붕괴성 의약 조성물 및 그의 제조방법
US7799342B2 (en) *	2000-12-06	2010-09-21	Wyeth Llc	Fast dissolving tablet
WO2001045483A2 (en) *	2000-12-22	2001-06-28	H. Lundbeck A/S	Method for the preparation of pure citalopram
JP2003519121A (ja) *	2000-12-28	2003-06-17	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法
WO2002087566A1 (en) *	2001-05-01	2002-11-07	H. Lundbeck A/S	The use of enantiomeric pure escitalopram
US6872405B2 (en) *	2001-05-10	2005-03-29	Yamanouchi Pharmaceutical Co., Ltd.	Quick-disintegrating tablet in buccal cavity and manufacturing method thereof
GB0113842D0 (en) *	2001-06-07	2001-08-01	Boots Co Plc	Therapeutic agents
AR034612A1 (es) *	2001-06-25	2004-03-03	Lundbeck & Co As H	Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es)	2001-07-13	2004-03-17	Lundbeck & Co As H	Metodo para la preparacion de escitalopram
IL159326A0 (en) *	2001-07-31	2004-06-01	Lundbeck & Co As H	Crystalline composition containing escitalopram
IS7239A (is)	2001-12-14	2004-04-29	H. Lundbeck A/S	Aðferð til framleiðslu á essítalóprami
US7148364B2 (en) *	2002-01-07	2006-12-12	Sun Pharmaceutical Industries	Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
FR2834889B1 (fr) *	2002-01-18	2004-04-02	Roquette Freres	Forme pharmaceutique solide orodispersible
GB0204607D0 (en) *	2002-02-27	2002-04-10	Matrix Lab Ltd	Process
EP1517676A1 (de) *	2002-05-03	2005-03-30	Skyepharma Canada Inc.	Orale darreichungsformen mit fenofibrat
AU2003287919B2 (en)	2002-12-23	2009-11-12	H. Lundbeck A/S	Escitalopram hydrobromide and a method for the preparation thereof
CN1510024A (zh) *	2002-12-24	2004-07-07	北京德众万全药物技术开发有限公司	可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法
DE10305984A1 (de) *	2003-02-13	2004-09-02	Helm Ag	Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
JP4739217B2 (ja) *	2003-05-07	2011-08-03	サムヤンコーポレイション	速く溶ける錠剤を製造するための高可塑性顆粒
US8647668B2 (en) *	2003-10-15	2014-02-11	Fuji Chemical Industry Co., Ltd.	Tablet quickly disintegrating in oral cavity
WO2005049596A1 (en) *	2003-11-20	2005-06-02	Natco Pharma Limited	A process for the preparation of high purity escitalopram
HU227491B1 (en) *	2003-11-25	2011-07-28	Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag	Tablet containing citalopram hydrogen bromide
WO2005084643A1 (en) *	2004-03-05	2005-09-15	H. Lundbeck A/S	Crystalline composition containing escitalopram oxalate
EP1877394A1 (de) *	2005-04-04	2008-01-16	Jubilant Organosys Limited	Verfahren zur herstellung von escitalopram oder seinen säureadditionssalzen

2006
- 2006-06-15 TW TW095121358A patent/TWI347942B/zh not_active IP Right Cessation
- 2006-06-15 TW TW100102601A patent/TWI358407B/zh not_active IP Right Cessation
- 2006-06-21 AR ARP060102654A patent/AR055062A1/es not_active Application Discontinuation
- 2006-06-21 MY MYPI2010000618A patent/MY143239A/en unknown
- 2006-06-21 MY MYPI20062933A patent/MY143252A/en unknown
- 2006-06-22 ZA ZA200711066A patent/ZA200711066B/xx unknown
- 2006-06-22 KR KR1020117015711A patent/KR20110084341A/ko not_active Ceased
- 2006-06-22 KR KR1020107026804A patent/KR20100133023A/ko not_active Ceased
- 2006-06-22 DE DE602006019961T patent/DE602006019961D1/de active Active
- 2006-06-22 CZ CZ20070898A patent/CZ299906B6/cs not_active IP Right Cessation
- 2006-06-22 CZ CZ20080429A patent/CZ301286B6/cs not_active IP Right Cessation
- 2006-06-22 KR KR1020077028918A patent/KR20080018191A/ko not_active Ceased
- 2006-06-22 DE DE112006001619T patent/DE112006001619T5/de not_active Withdrawn
- 2006-06-22 CN CNA2006800200393A patent/CN101189220A/zh active Pending
- 2006-06-22 DK DK06742481.2T patent/DK1896439T4/en active
- 2006-06-22 KR KR1020127014205A patent/KR20120064140A/ko not_active Ceased
- 2006-06-22 EA EA201001108A patent/EA201001108A1/ru unknown
- 2006-06-22 CA CA2612827A patent/CA2612827C/en not_active Expired - Fee Related
- 2006-06-22 PL PL06742481T patent/PL1896439T5/pl unknown
- 2006-06-22 KR KR1020117005777A patent/KR101340815B1/ko active Active
- 2006-06-22 WO PCT/DK2006/000366 patent/WO2006136169A2/en not_active Ceased
- 2006-06-22 EP EP06742481.2A patent/EP1896439B2/de active Active
- 2006-06-22 EP EP10179395A patent/EP2325177A1/de not_active Withdrawn
- 2006-06-22 JP JP2008517323A patent/JP4906852B2/ja active Active
- 2006-06-22 MX MX2007015328A patent/MX2007015328A/es active IP Right Grant
- 2006-06-22 EA EA200800102A patent/EA019239B1/ru not_active IP Right Cessation
- 2006-06-22 CA CA002646780A patent/CA2646780A1/en not_active Abandoned
- 2006-06-22 EP EP10179318A patent/EP2385044A1/de not_active Withdrawn
- 2006-06-22 PL PL384185A patent/PL384185A1/pl unknown
- 2006-06-22 FI FI20080548A patent/FI20080548A7/fi unknown
- 2006-06-22 SK SK50040-2007A patent/SK500402007A3/sk unknown
- 2006-06-22 HR HRP20110093TT patent/HRP20110093T4/hr unknown
- 2006-06-22 GB GB0724557A patent/GB2442160B/en not_active Expired - Fee Related
- 2006-06-22 PT PT06742481T patent/PT1896439E/pt unknown
- 2006-06-22 CZ CZ20080430A patent/CZ300686B6/cs not_active IP Right Cessation
- 2006-06-22 AT AT0900506U patent/AT10983U1/de not_active IP Right Cessation
- 2006-06-22 AT AT06742481T patent/ATE497500T1/de active
- 2006-06-22 CN CN201010286088XA patent/CN101928269A/zh active Pending
- 2006-06-22 ES ES200750085A patent/ES2319073B1/es not_active Expired - Fee Related
- 2006-06-22 FI FI20077133A patent/FI20077133A7/fi unknown
- 2006-06-22 GB GB0811164A patent/GB2448834B/en not_active Expired - Fee Related
- 2006-06-22 HU HU0800135A patent/HUP0800135A3/hu unknown
- 2006-06-22 SI SI200630923T patent/SI1896439T2/sl unknown
- 2006-06-22 UA UAA200800362A patent/UA86536C2/ru unknown
- 2006-06-22 SG SG201100648-3A patent/SG169358A1/en unknown
- 2006-06-22 ES ES06742481.2T patent/ES2356838T5/es active Active
- 2006-06-22 RS RS20110057A patent/RS51575B2/sr unknown
- 2006-06-22 TR TR2010/00625T patent/TR201000625T1/xx unknown
- 2006-06-22 TR TR2007/08792T patent/TR200708792T1/xx unknown
- 2006-06-22 AU AU2006261452A patent/AU2006261452B2/en not_active Withdrawn - After Issue
- 2006-06-22 EE EEU200800003U patent/EE00773U1/xx not_active IP Right Cessation
- 2006-06-22 BR BRPI0612295-7A patent/BRPI0612295A2/pt not_active IP Right Cessation
2007
- 2007-11-18 IL IL187454A patent/IL187454A0/en unknown
- 2007-12-19 BG BG10110024A patent/BG66086B1/bg unknown
- 2007-12-21 LV LVP-07-157A patent/LV13677B/lv unknown
2008
- 2008-01-14 IS IS8705A patent/IS8705A/is unknown
- 2008-01-18 NO NO20080359A patent/NO20080359L/no unknown
- 2008-01-21 LT LT2008005A patent/LT5550B/lt not_active IP Right Cessation
- 2008-01-21 DK DK200800075A patent/DK200800075A/da not_active Application Discontinuation
- 2008-10-07 JP JP2008260742A patent/JP4415056B2/ja active Active
2009
- 2009-02-27 DK DKPA200900284A patent/DK200900284A/da not_active Application Discontinuation
- 2009-03-10 ZA ZA200901698A patent/ZA200901698B/en unknown
- 2009-05-12 JP JP2009115280A patent/JP2009179635A/ja active Pending
- 2009-05-12 JP JP2009115279A patent/JP2009179634A/ja active Pending
- 2009-07-07 AT AT0041709U patent/AT11883U1/de not_active IP Right Cessation
2010
- 2010-03-05 AU AU2010200844A patent/AU2010200844A1/en not_active Withdrawn
- 2010-12-20 NO NO20101777A patent/NO20101777L/no not_active Application Discontinuation
- 2010-12-27 AR ARP100104958A patent/AR079750A2/es not_active Application Discontinuation
2011
- 2011-02-03 CY CY20111100116T patent/CY1112392T1/el unknown
- 2011-11-24 JP JP2011255804A patent/JP5731957B2/ja active Active

Also Published As

Publication number	Publication date
IL187454A0 (en)	2008-02-09
SG169358A1 (en)	2011-03-30
SK500402007A3 (sk)	2008-05-06
ZA200901698B (en)	2010-04-28
CA2612827C (en)	2010-11-30
GB2448834B (en)	2010-01-20
TR200708792T1 (tr)	2008-05-21
LT2008005A (en)	2008-10-27
FI20077133L (fi)	2007-12-20
AR079750A2 (es)	2012-02-15
TR201000625T1 (tr)	2010-03-22
AT11883U1 (de)	2011-06-15
JP4415056B2 (ja)	2010-02-17
NO20080359L (no)	2008-01-18
DK1896439T4 (en)	2015-01-12
GB2442160A (en)	2008-03-26
AT10983U1 (de)	2010-02-15
CZ2007898A3 (cs)	2008-01-23
KR20100133023A (ko)	2010-12-20
RS51575B2 (sr)	2018-02-28
IS8705A (is)	2008-01-14
FI20080548L (fi)	2008-10-07
GB0811164D0 (en)	2008-07-23
EP2385044A1 (de)	2011-11-09
UA86536C2 (ru)	2009-04-27
EP1896439B2 (de)	2014-10-15
KR101340815B1 (ko)	2013-12-11
WO2006136169A2 (en)	2006-12-28
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