DK189686A - Carbapenemforbindelser og fremgangsmaade til fremstilling deraf samt middel indeholdende forbindelserne - Google Patents

Carbapenemforbindelser og fremgangsmaade til fremstilling deraf samt middel indeholdende forbindelserne Download PDF

Info

Publication number: DK189686A
Authority: DK; Denmark
Prior art keywords: sup; group; sub; hydrogen atom; compounds
Prior art date: 1985-04-27

Application number

DK189686A

Other languages

English (en)

Other versions

DK189686D0 (da

Inventor

Isao Kawamoto

Rokuro Endo

Masayuki Iwata

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-27

Filing date

1986-04-24

Publication date

1986-10-28

1986-04-24 Application filed by Sankyo Co filed Critical Sankyo Co

1986-04-24 Publication of DK189686D0 publication Critical patent/DK189686D0/da

1986-10-28 Publication of DK189686A publication Critical patent/DK189686A/da

Links

150000001875 compounds Chemical class 0.000 title 2
238000000034 method Methods 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract description 10
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract description 3
125000002252 acyl group Chemical group 0.000 abstract description 2
-1 carbamoyloxy group Chemical group 0.000 abstract description 2
150000002148 esters Chemical class 0.000 abstract description 2
125000005842 heteroatom Chemical group 0.000 abstract description 2
125000000623 heterocyclic group Chemical group 0.000 abstract description 2
229910052757 nitrogen Inorganic materials 0.000 abstract description 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract description 2
125000004430 oxygen atom Chemical group O* 0.000 abstract description 2
150000003839 salts Chemical class 0.000 abstract description 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Description

hvori Z betegner et oxygenatom eller to hydrogenatomer, R^· betegner et hydrogenatom, en C^^-alkylgruppe, en alkanoylgruppe eller en Cj^-alkansulfonylgruppe, 2 R betegner et hydrogenatom eller en hydroxygruppe, og R betegner en carbamoylgruppe, 2 3 eller R betegner en carbamoyloxygruppe, og R betegner et hydrogenatom eller en carbamoylgruppe, 4 r betegner et hydrogenatom eller en Cj^-alkylgruppe, og

betegner en 4-6-leddet mættet heterocyklisk gruppe hvori det angivne nitrogenatom er det eneste heteroatom, eller et farmaceutisk acceptabelt salt eller en farmaceutisk acceptabel ester deraf.

DK189686A 1985-04-27 1986-04-24 Carbapenemforbindelser og fremgangsmaade til fremstilling deraf samt middel indeholdende forbindelserne DK189686A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9198885		1985-04-27
JP9198885		1985-04-27

Publications (2)

Publication Number	Publication Date
DK189686D0 DK189686D0 (da)	1986-04-24
DK189686A true DK189686A (da)	1986-10-28

Family

ID=14041841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK189686A DK189686A (da)	1985-04-27	1986-04-24	Carbapenemforbindelser og fremgangsmaade til fremstilling deraf samt middel indeholdende forbindelserne

Country Status (17)

Country	Link
US (1)	US4771046A (da)
EP (1)	EP0202048B1 (da)
JP (1)	JPH0710868B2 (da)
KR (1)	KR920010076B1 (da)
AT (1)	ATE69053T1 (da)
AU (1)	AU583113B2 (da)
CA (1)	CA1305709C (da)
DE (1)	DE3682225D1 (da)
DK (1)	DK189686A (da)
ES (1)	ES8800952A1 (da)
FI (1)	FI81577C (da)
HU (1)	HU194882B (da)
IE (1)	IE58892B1 (da)
NO (1)	NO163452C (da)
NZ (1)	NZ215957A (da)
PH (1)	PH22555A (da)
ZA (1)	ZA863109B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0759581B2 (ja) *	1986-09-05	1995-06-28	日本レダリ−株式会社	（１ｒ）−１−メチルカルバペネム−３−カルボン酸誘導体
JPS6425780A (en) *	1987-04-28	1989-01-27	Sankyo Co	1-methylcarbapenem derivative
NZ237191A (en) *	1990-02-23	1992-12-23	Sankyo Co	2-((substituted amide) substituted heterocyclylthio) carbpen-2-em derivatives and pharmaceutical compositions
US5712267A (en) *	1991-06-04	1998-01-27	Sankyo Company,. Limited	Carbapenem derivatives, their preparation and their use as antibiotics
KR970706284A (ko)	1994-09-16	1997-11-03	나가사까 겐지로	신규의 카르바페넴 유도체(novel carbapenem deriative)
EP0781773A4 (en) *	1994-09-16	1997-12-29	Banyu Pharma Co Ltd	Novel carbapenem derivative
US5932048A (en) *	1995-04-06	1999-08-03	Komatsu Electronic Metals Co., Ltd.	Method of fabricating direct-bonded semiconductor wafers
CA2534001C (en) *	2005-01-28	2013-12-03	Ed Vaes	Multi piece curved moldings

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0017992A1 (en) *	1979-04-19	1980-10-29	Merck & Co. Inc.	2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
PT73791B (en) *	1980-10-17	1983-10-14	Merck & Co Inc	Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
EP0060612A1 (en) *	1981-02-04	1982-09-22	Beecham Group Plc	Process for the preparation of azabicyclo(3.2.0)-hept-2-ene derivatives
ES514240A0 (es) *	1981-08-03	1984-04-16	Merck & Co Inc	Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
JPS60178888A (ja) *	1984-02-22	1985-09-12	Sankyo Co Ltd	ペネムまたはカルバペネム誘導体およびその製法

1986
- 1986-04-24 DK DK189686A patent/DK189686A/da not_active Application Discontinuation
- 1986-04-24 AU AU56710/86A patent/AU583113B2/en not_active Ceased
- 1986-04-24 NZ NZ215957A patent/NZ215957A/en unknown
- 1986-04-25 NO NO861630A patent/NO163452C/no unknown
- 1986-04-25 ZA ZA863109A patent/ZA863109B/xx unknown
- 1986-04-25 HU HU861736A patent/HU194882B/hu not_active IP Right Cessation
- 1986-04-25 FI FI861763A patent/FI81577C/fi not_active IP Right Cessation
- 1986-04-25 US US06/856,696 patent/US4771046A/en not_active Expired - Fee Related
- 1986-04-26 KR KR1019860003237A patent/KR920010076B1/ko not_active Expired
- 1986-04-26 JP JP9726086A patent/JPH0710868B2/ja not_active Expired - Fee Related
- 1986-04-28 DE DE8686303193T patent/DE3682225D1/de not_active Expired - Fee Related
- 1986-04-28 PH PH33710A patent/PH22555A/en unknown
- 1986-04-28 CA CA000507751A patent/CA1305709C/en not_active Expired - Fee Related
- 1986-04-28 EP EP86303193A patent/EP0202048B1/en not_active Expired - Lifetime
- 1986-04-28 IE IE110686A patent/IE58892B1/en not_active IP Right Cessation
- 1986-04-28 ES ES554474A patent/ES8800952A1/es not_active Expired
- 1986-04-28 AT AT86303193T patent/ATE69053T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA1305709C (en)	1992-07-28
HU194882B (en)	1988-03-28
NO163452C (no)	1990-05-30
HUT40661A (en)	1987-01-28
ES8800952A1 (es)	1987-12-01
NO861630L (no)	1986-10-28
EP0202048B1 (en)	1991-10-30
KR860008178A (ko)	1986-11-12
ATE69053T1 (de)	1991-11-15
ES554474A0 (es)	1987-12-01
EP0202048A1 (en)	1986-11-20
FI861763A0 (fi)	1986-04-25
FI81577C (fi)	1990-11-12
NZ215957A (en)	1988-04-29
JPS6230781A (ja)	1987-02-09
ZA863109B (en)	1986-12-30
KR920010076B1 (ko)	1992-11-13
NO163452B (no)	1990-02-19
US4771046A (en)	1988-09-13
IE58892B1 (en)	1993-12-01
IE861106L (en)	1986-10-27
JPH0710868B2 (ja)	1995-02-08
FI81577B (fi)	1990-07-31
DE3682225D1 (de)	1991-12-05
DK189686D0 (da)	1986-04-24
AU583113B2 (en)	1989-04-20
FI861763A7 (fi)	1986-10-28
PH22555A (en)	1988-10-17
AU5671086A (en)	1986-10-30

Legal Events

Date	Code	Title	Description
1995-12-27	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
ES2033423T3 (es)	1993-03-16	Procedimientos para preparar derivados de 2-fenilpurinona.
ES503768A0 (es)	1982-11-01	Procedimiento de preparacion de derivados de 1-fenil-1-hi- droxi-etilamina
ES550907A0 (es)	1987-02-16	Un procedimiento para preparar nuevos derivados de carbapenem
ES8503667A1 (es)	1985-03-16	Un procedimiento para la preparacion de nuevos derivados de 2-oxo-imidazolina.
YU4686A (en)	1988-04-30	Process for obtaining derivatives of arylcyclobuthylalkylamine
DK189686A (da)	1986-10-28	Carbapenemforbindelser og fremgangsmaade til fremstilling deraf samt middel indeholdende forbindelserne
HU9202294D0 (en)	1992-10-28	Method for producing new medical preparatives containing diphenyl-imidazole derivatives and their active agents
DK373783A (da)	1984-02-19	Thieno-thiazol-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse
ES477517A1 (es)	1980-01-16	Procedimiento para la preparacion de nuevos derivados car- bostirilicos y oxindolicos.
ES486580A1 (es)	1980-10-01	Un procedimiento para preparar compuestos con propiedades broncodilatadoras
DK141187A (da)	1988-04-30	1-(3-(2-dialkylaminoethoxy)-2-thienyl)-3-phenyl-1-propanoner og syreadditionssalte deraf, fremgangsmaade af saadanne forbindelser samt farmaceutiske praeparater indeholdende disse
DK395584A (da)	1985-02-18	7alfa-substituerede 3-oxo-17alfa-pregn-4-en-21,17-carbolactoner og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse forbindelser
SE8103598L (sv)	1981-12-10	Antiinflammatoriska medel for yttre anvendning
ES8609288A1 (es)	1986-09-01	Un procedimiento para preparar un derivado de tiazolidina
DK215680A (da)	1981-01-20	Fremgangsmaade til fremstilling af ciavulansyrederivater
ES477742A3 (es)	1979-10-16	Un procedimiento para preparar tetrahidronaftiloxiaminopro- panoles.