ATE507292T1 - Verfahren zur synthese codierter bibliotheken - Google Patents

Verfahren zur synthese codierter bibliotheken

Info

Publication number: ATE507292T1
Authority: AT; Austria
Prior art keywords: synthesis; coded libraries; libraries; coded; tag
Prior art date: 2005-06-09

Application number

AT06784718T

Other languages

English (en)

Inventor

Barry Morgan

Stephen Hale

Christopher C Arico-Muendel

Matthew Clark

Richard Wagner

Malcolm J Kavarana

Steffen Creaser

George J Franklin

Paolo A Centrella

David I Israel

Malcolm L Gefter

Dennis Benjamin

Nils Jakob Vest Hansen

Raksha A Acharya

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-09

Publication date

2011-05-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36930432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE507292(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-09 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2011-05-15 Application granted granted Critical

2011-05-15 Publication of ATE507292T1 publication Critical patent/ATE507292T1/de

Links

238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Computational Biology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Saccharide Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polyurethanes Or Polyureas (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

AT06784718T 2005-06-09 2006-06-09 Verfahren zur synthese codierter bibliotheken ATE507292T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68946605P	2005-06-09	2005-06-09
US73104105P	2005-10-28	2005-10-28
PCT/US2006/022555 WO2006135786A2 (en)	2005-06-09	2006-06-09	Methods for synthesis of encoded libraries

Publications (1)

Publication Number	Publication Date
ATE507292T1 true ATE507292T1 (de)	2011-05-15

Family

ID=36930432

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06784718T ATE507292T1 (de)	2005-06-09	2006-06-09	Verfahren zur synthese codierter bibliotheken

Country Status (23)

Country	Link
EP (4)	EP2338990A3 (de)
JP (2)	JP5508711B2 (de)
KR (1)	KR101346432B1 (de)
CN (2)	CN102392014A (de)
AT (1)	ATE507292T1 (de)
AU (1)	AU2006257915B2 (de)
BR (1)	BRPI0613566B1 (de)
CA (1)	CA2611512C (de)
CY (1)	CY1112036T1 (de)
DE (1)	DE602006021580D1 (de)
DK (4)	DK2258870T3 (de)
ES (2)	ES2401485T3 (de)
HR (1)	HRP20110528T1 (de)
IL (1)	IL187977A (de)
NO (1)	NO343698B1 (de)
NZ (1)	NZ564545A (de)
PL (2)	PL1910538T3 (de)
PT (2)	PT2258870E (de)
RS (1)	RS51868B (de)
RU (2)	RU2459869C2 (de)
SI (1)	SI1910538T1 (de)
WO (1)	WO2006135786A2 (de)
ZA (2)	ZA200800190B (de)

Families Citing this family (22)

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EP1401850A1 (de)	2001-06-20	2004-03-31	Nuevolution A/S	Nukleosidderivate zur herstellung einer verbindungsbibliothek
IL163822A0 (en)	2002-03-15	2005-12-18	Nuevolution As	An improved method for synthesising templated molecules
AU2003247266A1 (en)	2002-08-01	2004-02-23	Nuevolution A/S	Multi-step synthesis of templated molecules
PT1558744E (pt)	2002-10-30	2011-09-22	Nuevolution As	Codificação enzimática
WO2004056994A2 (en)	2002-12-19	2004-07-08	Nuevolution A/S	Quasirandom structure and function guided synthesis methods
EP1597395A2 (de)	2003-02-21	2005-11-23	Nuevolution A/S	Methode zur herstellung einer bibliothek der zweiten generation
DE602004023960D1 (de)	2003-09-18	2009-12-17	Nuevolution As	Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
PL1910538T3 (pl)	2005-06-09	2011-12-30	Praecis Pharm Inc	Sposób syntezy kodowanych bibliotek
US9574189B2 (en) *	2005-12-01	2017-02-21	Nuevolution A/S	Enzymatic encoding methods for efficient synthesis of large libraries
EP3653763A1 (de) *	2009-02-13	2020-05-20	X-Chem, Inc.	Verfahren zur erstellung und durchsuchung von dna-codierten bibliotheken
ES2713873T3 (es)	2010-04-16	2019-05-24	Nuevolution As	Complejos bifuncionales y métodos para hacer y utilizar tales complejos
DK2748357T3 (en) *	2011-09-07	2018-07-16	X Chem Inc	Methods for labeling DNA-encoded libraries
CA2879018A1 (en)	2012-07-13	2014-01-16	X-Chem, Inc.	Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
US20200149034A1 (en) *	2017-03-17	2020-05-14	Hitgen Ltd.	Methods and Compositions for Synthesis of Encoded Libraries
WO2019149198A1 (zh) *	2018-01-31	2019-08-08	成都先导药物开发股份有限公司	一种dna编码化合物库及化合物筛选方法
GB201821109D0 (en) *	2018-12-21	2019-02-06	Philochem Ag	Nucleic acid encoded chemical libraries
CN110041390B (zh) *	2019-04-26	2022-05-27	上海药明康德新药开发有限公司	DNA编码化合物库中On-DNA的1,2,3-三氮唑化合物的合成方法
CN112779606A (zh) *	2019-11-06	2021-05-11	成都先导药物开发股份有限公司	一种On-DNA曼尼希反应的方法
CN113089104B (zh) *	2019-12-23	2023-03-28	成都先导药物开发股份有限公司	一种On-DNA二胺化合物关环反应的合成方法
CN115506036B (zh) *	2021-06-22	2024-07-02	中国科学院上海药物研究所	Dna编码化合物文库起始片段及其制备和应用
EP4201951B1 (de) *	2021-12-21	2023-11-22	Bachem Holding AG	Verfahren zur peptidsynthese
CN114920791B (zh) *	2022-04-28	2024-06-18	康龙化成(宁波)科技发展有限公司	一种寡聚核酸-琥珀酰亚胺化合物的合成方法

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DE602004023960D1 (de) *	2003-09-18	2009-12-17	Nuevolution As	Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
EP1694693A2 (de) *	2003-12-17	2006-08-30	Praecis Pharmaceuticals Inc.	Verfahren zur synthese codierter bibliotheken
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PL1910538T3 (pl)	2005-06-09	2011-12-30	Praecis Pharm Inc	Sposób syntezy kodowanych bibliotek

2006
- 2006-06-09 PL PL06784718T patent/PL1910538T3/pl unknown
- 2006-06-09 PT PT100752955T patent/PT2258870E/pt unknown
- 2006-06-09 JP JP2008515983A patent/JP5508711B2/ja not_active Expired - Fee Related
- 2006-06-09 CA CA2611512A patent/CA2611512C/en active Active
- 2006-06-09 EP EP10012326A patent/EP2338990A3/de not_active Withdrawn
- 2006-06-09 AT AT06784718T patent/ATE507292T1/de active
- 2006-06-09 KR KR1020087000511A patent/KR101346432B1/ko active Active
- 2006-06-09 BR BRPI0613566-8A patent/BRPI0613566B1/pt active IP Right Grant
- 2006-06-09 EP EP10075295A patent/EP2258870B1/de active Active
- 2006-06-09 WO PCT/US2006/022555 patent/WO2006135786A2/en not_active Ceased
- 2006-06-09 AU AU2006257915A patent/AU2006257915B2/en not_active Ceased
- 2006-06-09 DK DK10075295.5T patent/DK2258870T3/da active
- 2006-06-09 RU RU2008100035/10A patent/RU2459869C2/ru active
- 2006-06-09 PL PL10075295T patent/PL2258870T3/pl unknown
- 2006-06-09 RS RS20110327A patent/RS51868B/sr unknown
- 2006-06-09 EP EP10075296.3A patent/EP2311786A3/de not_active Withdrawn
- 2006-06-09 EP EP06784718A patent/EP1910538B1/de active Active
- 2006-06-09 DK DK06784718.6T patent/DK1910538T3/da active
- 2006-06-09 ES ES10075295T patent/ES2401485T3/es active Active
- 2006-06-09 PT PT06784718T patent/PT1910538E/pt unknown
- 2006-06-09 ES ES06784718T patent/ES2365534T3/es active Active
- 2006-06-09 CN CN2011102198704A patent/CN102392014A/zh active Pending
- 2006-06-09 CN CN2006800276157A patent/CN101233235B/zh active Active
- 2006-06-09 NZ NZ564545A patent/NZ564545A/en not_active IP Right Cessation
- 2006-06-09 SI SI200631057T patent/SI1910538T1/sl unknown
- 2006-06-09 HR HR20110528T patent/HRP20110528T1/hr unknown
- 2006-06-09 DE DE602006021580T patent/DE602006021580D1/de active Active
2007
- 2007-12-06 IL IL187977A patent/IL187977A/en active IP Right Grant
- 2007-12-12 NO NO20076362A patent/NO343698B1/no unknown
2008
- 2008-01-03 DK DKPA200800005A patent/DK177345B1/da not_active IP Right Cessation
- 2008-01-08 ZA ZA2008/00190A patent/ZA200800190B/en unknown
2010
- 2010-07-07 ZA ZA2010/04791A patent/ZA201004791B/en unknown
2011
- 2011-01-19 RU RU2011101778/10A patent/RU2011101778A/ru not_active Application Discontinuation
- 2011-07-14 CY CY20111100688T patent/CY1112036T1/el unknown
- 2011-12-20 DK DKPA201170734A patent/DK179064B1/da not_active IP Right Cessation
2013
- 2013-09-19 JP JP2013194319A patent/JP2014039550A/ja active Pending

Also Published As

Publication number	Publication date
EP1910538B1 (de)	2011-04-27
CN102392014A (zh)	2012-03-28
DK179064B1 (da)	2017-10-02
JP5508711B2 (ja)	2014-06-04
EP2338990A3 (de)	2011-10-19
HRP20110528T1 (hr)	2011-09-30
ES2401485T3 (es)	2013-04-22
ZA201004791B (en)	2012-06-27
DK1910538T3 (da)	2011-08-08
JP2008543289A (ja)	2008-12-04
HK1150454A1 (en)	2011-12-30
WO2006135786A3 (en)	2007-06-21
NZ564545A (en)	2011-03-31
RU2011101778A (ru)	2012-07-27
EP2258870B1 (de)	2013-01-02
CA2611512A1 (en)	2006-12-21
KR20080036577A (ko)	2008-04-28
EP2311786A2 (de)	2011-04-20
PL2258870T3 (pl)	2013-05-31
RU2008100035A (ru)	2009-07-20
AU2006257915A1 (en)	2006-12-21
ES2365534T3 (es)	2011-10-06
CN101233235A (zh)	2008-07-30
EP2311786A3 (de)	2014-04-02
JP2014039550A (ja)	2014-03-06
KR101346432B1 (ko)	2014-02-14
RS51868B (sr)	2012-02-29
BRPI0613566A2 (pt)	2011-01-18
NO20076362L (no)	2008-03-07
DK2258870T3 (da)	2013-03-18
RU2459869C2 (ru)	2012-08-27
CY1112036T1 (el)	2015-11-04
DE602006021580D1 (de)	2011-06-09
PT2258870E (pt)	2013-04-01
SI1910538T1 (sl)	2011-09-30
IL187977A (en)	2013-02-28
PL1910538T3 (pl)	2011-12-30
NO343698B1 (no)	2019-05-13
IL187977A0 (en)	2008-03-20
CN101233235B (zh)	2012-10-03
BRPI0613566B1 (pt)	2020-01-07
CA2611512C (en)	2018-05-22
DK177345B1 (da)	2013-01-28
EP2258870A3 (de)	2011-11-30
DK201170734A (en)	2011-12-20
ZA200800190B (en)	2010-11-24
DK200800005A (da)	2008-03-04
HK1120546A1 (en)	2009-04-03
AU2006257915B2 (en)	2011-09-08
EP1910538A2 (de)	2008-04-16
EP2338990A2 (de)	2011-06-29
PT1910538E (pt)	2011-07-28
EP2258870A2 (de)	2010-12-08
WO2006135786A2 (en)	2006-12-21

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2011-12-15

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Publication	Publication Date	Title
ATE507292T1 (de)	2011-05-15	Verfahren zur synthese codierter bibliotheken
BRPI0417830A (pt)	2007-04-17	métodos para a sìntese de bibliotecas codificadas
WO2007053358A3 (en)	2007-11-01	Methods for identifying compounds of interest using encoded libraries
ATE540931T1 (de)	2012-01-15	Verfahren zur synthese organischer verbindungen
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