DK197085A - Pyrimidinonderivater og farmaceutiske praeparater indeholdende saadanne forbindelser - Google Patents

Pyrimidinonderivater og farmaceutiske praeparater indeholdende saadanne forbindelser Download PDF

Info

Publication number: DK197085A
Authority: DK; Denmark
Prior art keywords: compounds; derivatives; pyrimidinon; pharmaceutical preparations; preparations containing
Prior art date: 1984-05-02

Application number

DK197085A

Other languages

English (en)

Other versions

DK197085D0 (da

Inventor

Kjell Undheim

Toro Benneche

Original Assignee

Nyegaard & Co As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-02

Filing date

1985-05-02

Publication date

1985-11-03

1985-05-02 Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As

1985-05-02 Publication of DK197085D0 publication Critical patent/DK197085D0/da

1985-11-03 Publication of DK197085A publication Critical patent/DK197085A/da

Links

150000001875 compounds Chemical class 0.000 title description 4
VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title description 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 description 5
-1 cyano, formyl Chemical group 0.000 description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
229910052739 hydrogen Inorganic materials 0.000 description 3
239000001257 hydrogen Substances 0.000 description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
125000002861 (C1-C4) alkanoyl group Chemical group 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
125000004414 alkyl thio group Chemical group 0.000 description 1
125000003435 aroyl group Chemical group 0.000 description 1
125000001589 carboacyl group Chemical group 0.000 description 1
230000004663 cell proliferation Effects 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
230000031864 metaphase Effects 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
239000003444 phase transfer catalyst Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

Description

substituenter udvalgt blandt halogener, alkyl, C^_4 alkanoyl, alkoxy, alkoxykarbonyl, C^_4 alkyl- tio, hydroxy, nitro, cyan, formyl, -NR7R8 (hvor R7 er g hydrogen eller C1-4 alkyl og R hydrogen eller C1-4 alkyl, alkanoyl eller aroyl) eller C^_4 alkyl substitueret med en eller flere hydroxy- eller -NR7R8 grupper og halo- 4 5 genatomer? n tallet 0 eller 1; og R og R uafhængigt af hinanden er hydrogen eller C^g alkyl, eller salte af disse addukter har metafasestandsende egenskaber og god vandopløselighed og kan være nyttige ved bekæmpelse af abnorm celleformering.

Forbindelserne kan fremstilles ved omsætning af pyrimidinonderivater med et stof der afgiver bisulfitioner, eventuelt i nærværelse af en faseoverføringskatalysator. Nyttige mellemprodukter til fremstilling af forbindelser med formel I er forbindelser med formel III

hvor R’ er en gruppe -CH2ORJ (hvor RJ er 4-formylsubsti-tueret fenyl) eller CHjOCHjR^ (hvor R^ er 3- eller 4-metylsubstitueret fenyl eller 3- og 4-klorsubstitueret fenyl) eller salte deraf.

DK197085A 1984-05-02 1985-05-02 Pyrimidinonderivater og farmaceutiske praeparater indeholdende saadanne forbindelser DK197085A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB848411291A GB8411291D0 (en)	1984-05-02	1984-05-02	Chemical compounds
GB8411291		1984-05-02

Publications (2)

Publication Number	Publication Date
DK197085D0 DK197085D0 (da)	1985-05-02
DK197085A true DK197085A (da)	1985-11-03

Family

ID=10560411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK197085A DK197085A (da)	1984-05-02	1985-05-02	Pyrimidinonderivater og farmaceutiske praeparater indeholdende saadanne forbindelser

Country Status (5)

Country	Link
EP (1)	EP0160573A3 (da)
JP (1)	JPS6110562A (da)
DK (1)	DK197085A (da)
GB (1)	GB8411291D0 (da)
NO (1)	NO851714L (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4855466A (en) *	1987-12-28	1989-08-08	E. R. Squibb & Sons, Inc.	Purinyl cyclobutanes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57136575A (en) *	1981-01-09	1982-08-23	Nyegaard & Co As	Substituted pyrimidine-2-one compound
NO161440C (no) *	1982-02-24	1989-08-16	Nyegaard & Co As	Analogifremgangsmaate for fremstilling av fysiologisk aktive pyrimidin-2-oner.

1984
- 1984-05-02 GB GB848411291A patent/GB8411291D0/en active Pending
1985
- 1985-04-30 NO NO851714A patent/NO851714L/no unknown
- 1985-05-01 EP EP85303102A patent/EP0160573A3/en not_active Withdrawn
- 1985-05-02 JP JP60093948A patent/JPS6110562A/ja active Pending
- 1985-05-02 DK DK197085A patent/DK197085A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
DK197085D0 (da)	1985-05-02
JPS6110562A (ja)	1986-01-18
EP0160573A3 (en)	1986-11-20
GB8411291D0 (en)	1984-06-06
EP0160573A2 (en)	1985-11-06
NO851714L (no)	1985-11-04

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Legal Events

Date	Code	Title	Description
1987-01-05	ATS	Application withdrawn