DK1990343T3 - Azaindoler - Google Patents

Azaindoler

Info

Publication number: DK1990343T3
Authority: DK; Denmark
Prior art keywords: ny3y4; compounds; halo; heteroaryl; cyano
Prior art date: 1999-12-24

Application number

DK08162392.8T

Other languages

English (en)

Inventor

Paul Joseph Cox

Tahir Nadeem Majid

Justine Yeun Quai Lai

Andrew David Morley

Shelley Amendola

Stephanie Deprets

Chris Edlin

Original Assignee

Aventis Pharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-24

Filing date

2000-12-27

Publication date

2012-07-23

2000-12-27 Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd

2000-12-27 Priority claimed from EP00985695A external-priority patent/EP1263759B1/en

2012-07-23 Application granted granted Critical

2012-07-23 Publication of DK1990343T3 publication Critical patent/DK1990343T3/da

Links

125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
125000004093 cyano group Chemical group *C#N 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229910014033 C-OH Inorganic materials 0.000 abstract 1
229910014570 C—OH Inorganic materials 0.000 abstract 1
102000001253 Protein Kinase Human genes 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
108060006633 protein kinase Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK08162392.8T 1999-12-24 2000-12-27 Azaindoler DK1990343T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9930698.7A GB9930698D0 (en)	1999-12-24	1999-12-24	Chemical compounds
US21581800P	2000-07-05	2000-07-05
EP00985695A EP1263759B1 (en)	1999-12-24	2000-12-27	Azaindoles

Publications (1)

Publication Number	Publication Date
DK1990343T3 true DK1990343T3 (da)	2012-07-23

Family

ID=10867079

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK00985695.6T DK1263759T3 (da)	1999-12-24	2000-12-27	Azainodoler
DK08162392.8T DK1990343T3 (da)	1999-12-24	2000-12-27	Azaindoler

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK00985695.6T DK1263759T3 (da)	1999-12-24	2000-12-27	Azainodoler

Country Status (12)

Country	Link
JP (1)	JP4871474B2 (da)
AT (2)	ATE552258T1 (da)
DE (1)	DE60044946D1 (da)
DK (2)	DK1263759T3 (da)
ES (2)	ES2382759T3 (da)
GB (1)	GB9930698D0 (da)
ME (1)	MEP49908A (da)
PL (1)	PL218884B1 (da)
PT (2)	PT1990343E (da)
RS (2)	RS20100123A (da)
UA (1)	UA76410C2 (da)
ZA (1)	ZA200204126B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0422057D0 (en) *	2004-10-05	2004-11-03	Astrazeneca Ab	Novel compounds
ES2408318T3 (es) *	2005-12-23	2013-06-20	Glaxosmithkline Llc	Inhibidores de azaindol de las cinasas Aurora
CL2007002617A1 (es) *	2006-09-11	2008-05-16	Sanofi Aventis	Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
JP5274805B2 (ja) *	2006-09-20	2013-08-28	三菱化学株式会社	フッ素化芳香族化合物の製造方法
ES2464458T3 (es) *	2008-12-05	2014-06-02	F. Hoffmann-La Roche Ag	Pirrolopirazinil-ureas como inhibidores de quinasas
US8816085B2 (en) *	2009-08-26	2014-08-26	Takeda Gmbh	Methylpyrrolopyridinecarboxamides
JP2016514113A (ja) *	2013-03-14	2016-05-19	アッヴィ・インコーポレイテッド	ピロロ［２，３−ｂ］ピリジンｃｄｋ９キナーゼ阻害剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69728688T2 (de) *	1996-11-19	2004-08-19	Amgen Inc., Thousand Oaks	Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel
WO1998047899A1 (en) *	1997-04-24	1998-10-29	Ortho-Mcneil Corporation, Inc.	Substituted pyrrolopyridines useful in the treatment of inflammatory diseases
CA2306870A1 (en) *	1997-10-20	1999-04-29	David Michael Goldstein	Bicyclic kinase inhibitors

1999
- 1999-12-24 GB GBGB9930698.7A patent/GB9930698D0/en not_active Ceased
2000
- 2000-12-27 AT AT08162392T patent/ATE552258T1/de active
- 2000-12-27 RS RSP-2010/0123A patent/RS20100123A/sr unknown
- 2000-12-27 RS YUP-462/02A patent/RS51303B/sr unknown
- 2000-12-27 ES ES08162392T patent/ES2382759T3/es not_active Expired - Lifetime
- 2000-12-27 JP JP2001549392A patent/JP4871474B2/ja not_active Expired - Fee Related
- 2000-12-27 AT AT00985695T patent/ATE480537T1/de active
- 2000-12-27 UA UA2002076056A patent/UA76410C2/uk unknown
- 2000-12-27 PT PT08162392T patent/PT1990343E/pt unknown
- 2000-12-27 PT PT00985695T patent/PT1263759E/pt unknown
- 2000-12-27 ES ES00985695T patent/ES2348861T3/es not_active Expired - Lifetime
- 2000-12-27 DK DK00985695.6T patent/DK1263759T3/da active
- 2000-12-27 ME MEP-499/08A patent/MEP49908A/xx unknown
- 2000-12-27 PL PL386205A patent/PL218884B1/pl unknown
- 2000-12-27 DE DE60044946T patent/DE60044946D1/de not_active Expired - Lifetime
- 2000-12-27 DK DK08162392.8T patent/DK1990343T3/da active
2002
- 2002-05-23 ZA ZA200204126A patent/ZA200204126B/xx unknown

Also Published As

Publication number	Publication date
MEP49908A (en)	2011-02-10
RS20100123A (sr)	2010-12-31
YU46202A (sh)	2005-06-10
GB9930698D0 (en)	2000-02-16
DE60044946D1 (de)	2010-10-21
UA76410C2 (en)	2006-08-15
ES2348861T3 (es)	2010-12-16
DK1263759T3 (da)	2011-01-10
JP2003519144A (ja)	2003-06-17
ATE552258T1 (de)	2012-04-15
ZA200204126B (en)	2003-08-25
JP4871474B2 (ja)	2012-02-08
ATE480537T1 (de)	2010-09-15
PT1263759E (pt)	2010-11-02
ES2382759T3 (es)	2012-06-13
PL218884B1 (pl)	2015-02-27
RS51303B (sr)	2010-12-31
PT1990343E (pt)	2012-05-22

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