DK1995319T3 - Forbedret bacillusværtscelle - Google Patents

Forbedret bacillusværtscelle

Info

Publication number
DK1995319T3
DK1995319T3 DK08159398.0T DK08159398T DK1995319T3 DK 1995319 T3 DK1995319 T3 DK 1995319T3 DK 08159398 T DK08159398 T DK 08159398T DK 1995319 T3 DK1995319 T3 DK 1995319T3
Authority
DK
Denmark
Prior art keywords
host cell
bacillus host
parent
enhanced
mutant
Prior art date
Application number
DK08159398.0T
Other languages
English (en)
Inventor
Jens Toenne Andersen
Steen Troels Joergensen
Michael Dolbjerg Rasmussen
Peter Bjarke Olsen
Ib Groth Clausen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of DK1995319T3 publication Critical patent/DK1995319T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/10—Bacillus licheniformis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
DK08159398.0T 2002-04-10 2003-03-25 Forbedret bacillusværtscelle DK1995319T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200200534 2002-04-10
EP03709679A EP1497429B1 (en) 2002-04-10 2003-03-25 Improved bacillus host cell

Publications (1)

Publication Number Publication Date
DK1995319T3 true DK1995319T3 (da) 2011-12-05

Family

ID=29286036

Family Applications (2)

Application Number Title Priority Date Filing Date
DK08159398.0T DK1995319T3 (da) 2002-04-10 2003-03-25 Forbedret bacillusværtscelle
DK03709679T DK1497429T3 (da) 2002-04-10 2003-03-25 Forbedret bacillusværtcelle

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK03709679T DK1497429T3 (da) 2002-04-10 2003-03-25 Forbedret bacillusværtcelle

Country Status (8)

Country Link
US (3) US7521204B2 (da)
EP (2) EP1497429B1 (da)
CN (1) CN1659283A (da)
AT (2) ATE399869T1 (da)
AU (1) AU2003214034A1 (da)
DE (1) DE60321901D1 (da)
DK (2) DK1995319T3 (da)
WO (1) WO2003093453A2 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095638A1 (en) * 2002-05-14 2003-11-20 Novozymes A/S Pectate lyase variants
CN103484486B (zh) * 2003-07-02 2018-04-24 维莱尼姆公司 葡聚糖酶，编码它们的核酸以及制备和使用它们的方法
AU2013202675A1 (en) * 2003-07-02 2013-05-02 Bp Corporation North America Inc. Glucanases, nucleic acids encoding them and methods for making and using them
WO2005069762A2 (en) * 2004-01-09 2005-08-04 Novozymes Inc. Bacillus licheniformis chromosome
EP2325318A1 (en) * 2004-02-13 2011-05-25 Novozymes A/S Protease variants
WO2005123915A1 (en) 2004-06-21 2005-12-29 Novozymes A/S Stably maintained multiple copies of at least two orf in the same orientation
EP1612267A1 (en) * 2004-07-02 2006-01-04 GBF Gesellschaft für Biotechnologische Forschung mbH Cellulases from rumen
AU2006226729B2 (en) * 2005-03-22 2012-02-16 Novozymes A/S Polypeptides and nucleic acids encoding same
EP2431470B1 (en) * 2006-11-30 2017-11-29 Novozymes A/S Dnase expression in recombinant host cells
WO2008077522A2 (en) * 2006-12-22 2008-07-03 Dsm Ip Assets B.V. Use of polypeptides as coccidiostat and /or histomonastat
CN102762723A (zh) * 2009-12-21 2012-10-31 诺维信股份有限公司 用于在巯基-二硫键氧还酶缺陷的细菌突变体细胞中产生异源多肽的方法
CN109715794A (zh) 2016-07-05 2019-05-03 诺维信公司 果胶裂解酶变体以及编码它们的多核苷酸
CN106467903B (zh) * 2016-09-18 2019-10-08 齐鲁工业大学 一种适用于制浆过程的地衣芽孢杆菌工程菌及其构建方法
CN106893736B (zh) * 2017-01-24 2020-07-07 湖北大学 一种提高地衣芽胞杆菌外源蛋白分泌水平的方法
EP3749094A2 (en) 2018-02-06 2020-12-16 Novozymes BioAG A/S Methods of protecting a plant from fungal pests
US20240052000A1 (en) 2020-12-15 2024-02-15 Novozymes A/S Mutated host cells with reduced cell motility on
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
CN117813316A (zh) 2021-06-24 2024-04-02 巴斯夫欧洲公司 用于生产纯度更高的感兴趣的化合物的地衣芽孢杆菌宿主细胞
MX2023015460A (es) 2021-06-24 2024-01-18 Basf Se Celula huesped de bacillus mejorada con proteina rema/remb alterada.
EP4387982A2 (en) * 2021-08-20 2024-06-26 Danisco US Inc. Methods and compositions for enhanced protein production in bacillus cells
WO2026009000A1 (en) 2024-07-04 2026-01-08 Solasta Bio Limited Methods for production of insecticidal neuropeptides

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Publication number Priority date Publication date Assignee Title
CA2003078A1 (en) * 1988-11-18 1990-05-18 Biotechnica International, Inc. Protease deletion
WO1991002803A1 (en) * 1989-08-25 1991-03-07 Henkel Research Corporation A method of suppressing chromosomal gene expression
DK639689D0 (da) 1989-12-18 1989-12-18 Novo Nordisk As Indfoering af dna i celler
US5294542A (en) * 1991-03-19 1994-03-15 Omnigene, Inc. Residual protease-III
IL103750A0 (en) 1991-11-14 1993-04-04 Novo Nordisk As Bacillus promoter
DK153992D0 (da) 1992-12-22 1992-12-22 Novo Nordisk As Metode
GB2279955B (en) 1993-07-15 1998-02-18 Solvay Xylanase derived from a Bacillus species, expression vectors for such xylanase and other proteins, host organisms therefor and use thereof
CA2191718A1 (en) 1994-06-03 1995-12-14 Randy M. Berka Phosphonyldipeptides useful in the treatment of cardiovascular diseases
CN1177380A (zh) 1995-01-23 1998-03-25 诺沃挪第克公司 通过转座的dna整合
DE69739121D1 (de) 1996-08-23 2009-01-02 Peter Ruhdal Jensen Künstliche promotorbibliotheken für ausgewählte organismen sowie daraus entstammende promotoren
GB9708452D0 (en) * 1997-04-26 1997-06-18 Univ Newcastle Improved prokaryotic expression of protein
US6100063A (en) 1998-02-12 2000-08-08 Novo Nordisk A/S Procaryotic cell comprising at least two copies of a gene
AU2610399A (en) 1998-02-12 1999-08-30 Novo Nordisk A/S A prokaryotic cell comprising two copies of a gene transcribed in different directions
US5955310A (en) 1998-02-26 1999-09-21 Novo Nordisk Biotech, Inc. Methods for producing a polypeptide in a bacillus cell
AU2980199A (en) * 1998-03-04 1999-09-20 Genencor International, Inc. Modified forms of pullulanase
AU2001262063A1 (en) 2000-05-24 2001-12-03 Novozymes A/S Method for increasing gene copy number in a host cell and resulting host cell
EP1297170B1 (en) * 2000-06-23 2016-03-02 Novozymes A/S Method for stable chromosomal multi-copy integration of genes
US7018794B2 (en) * 2000-10-06 2006-03-28 Novozymes, Inc. Methods for monitoring multiple gene expression

Also Published As

Publication number Publication date
EP1497429B1 (en) 2008-07-02
DE60321901D1 (de) 2008-08-14
US20050244922A1 (en) 2005-11-03
US8911969B2 (en) 2014-12-16
WO2003093453A3 (en) 2004-05-13
CN1659283A (zh) 2005-08-24
EP1995319A1 (en) 2008-11-26
ATE522614T1 (de) 2011-09-15
AU2003214034A1 (en) 2003-11-17
WO2003093453A2 (en) 2003-11-13
DK1497429T3 (da) 2008-11-03
US7521204B2 (en) 2009-04-21
AU2003214034A8 (en) 2003-11-17
ATE399869T1 (de) 2008-07-15
US20090203074A1 (en) 2009-08-13
EP1995319B1 (en) 2011-08-31
US20090176290A1 (en) 2009-07-09
EP1497429A2 (en) 2005-01-19

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