DK213284D0 - 5-acyl-2-(1h)-pyridinoner - Google Patents

5-acyl-2-(1h)-pyridinoner

Info

Publication number: DK213284D0
Authority: DK; Denmark
Prior art keywords: pyridinones; acyl
Prior art date: 1983-04-29

Application number

DK2132/84A

Other languages

English (en)

Other versions

DK159424C (da

DK159424B (da

DK213284A (da

Inventor

Winton D Jones

Richard A Schnettler

Richard C Dage

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-29

Filing date

1984-04-27

Publication date

1984-04-27

1984-04-27 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1984-04-27 Publication of DK213284D0 publication Critical patent/DK213284D0/da

1984-10-30 Publication of DK213284A publication Critical patent/DK213284A/da

1990-10-15 Publication of DK159424B publication Critical patent/DK159424B/da

1991-03-18 Application granted granted Critical

1991-03-18 Publication of DK159424C publication Critical patent/DK159424C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK213284A 1983-04-29 1984-04-27 5-acyl-2-(1h)-pyridinoner eller syreadditionssalte deraf DK159424C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/490,081 US4568751A (en)	1983-04-29	1983-04-29	5-Acyl-2-(1H)-pyridinones
US49008183		1983-04-29

Publications (4)

Publication Number	Publication Date
DK213284D0 true DK213284D0 (da)	1984-04-27
DK213284A DK213284A (da)	1984-10-30
DK159424B DK159424B (da)	1990-10-15
DK159424C DK159424C (da)	1991-03-18

Family

ID=23946554

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK213284A DK159424C (da)	1983-04-29	1984-04-27	5-acyl-2-(1h)-pyridinoner eller syreadditionssalte deraf
DK213584A DK159425C (da)	1983-04-29	1984-04-27	5-acyl-3-cyano-2-(1h)-pyridinoner eller syreadditionssalte deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK213584A DK159425C (da)	1983-04-29	1984-04-27	5-acyl-3-cyano-2-(1h)-pyridinoner eller syreadditionssalte deraf

Country Status (22)

Country	Link
US (1)	US4568751A (da)
EP (2)	EP0124089B1 (da)
JP (2)	JPS59206355A (da)
KR (2)	KR900005010B1 (da)
AR (1)	AR240313A1 (da)
AT (2)	ATE25678T1 (da)
AU (2)	AU571219B2 (da)
CA (2)	CA1242443A (da)
DD (1)	DD223444A5 (da)
DE (2)	DE3462889D1 (da)
DK (2)	DK159424C (da)
ES (2)	ES531911A0 (da)
GR (2)	GR81967B (da)
HU (2)	HU191928B (da)
IE (2)	IE57273B1 (da)
IL (2)	IL71649A (da)
NO (2)	NO164416C (da)
NZ (2)	NZ207961A (da)
PH (1)	PH20256A (da)
PT (2)	PT78493B (da)
SU (1)	SU1299505A3 (da)
ZA (2)	ZA843033B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5118696A (en) *	1983-04-29	1992-06-02	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure
US4568751A (en) *	1983-04-29	1986-02-04	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones
US5428045A (en) *	1983-04-29	1995-06-27	Merrell Dow Pharmaceuticals Inc.	5-acyl-2-(1H)-pyridinoes
US4992452A (en) *	1983-04-29	1991-02-12	Merrell Dow Pharmaceuticals Inc.	Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure
US4731371A (en) *	1984-03-29	1988-03-15	Merrell Dow Pharmaceuticals Inc.	Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents
US4853395A (en) *	1983-04-29	1989-08-01	Merrell Dow Pharmaceuticals Inc.	Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties
US5212314A (en) *	1983-11-03	1993-05-18	Merrell Dow Pharmaceuticals Inc.	Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US4732982A (en) *	1983-11-03	1988-03-22	Merrell Dow Pharmaceuticals Inc.	Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US4657919A (en) *	1984-08-03	1987-04-14	E. I. Du Pont De Nemours & Co.	Pyridone esters as inotropic agents
US4650806A (en) *	1985-01-14	1987-03-17	Sterling Drug Inc.	Cardiotonic 5-(heterylcarbonyl)-pyridones

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2531035A1 (de) *	1975-07-11	1977-01-27	Basf Ag	Verfahren zur herstellung von 5-cyanpyridonen-(6)
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones
GB1596887A (en) *	1977-07-15	1981-09-03	Rohm & Haas	2-pyridone derivatives and their use as plant growth regulators
DE3005069A1 (de) *	1980-02-11	1981-08-20	Cassella Ag, 6000 Frankfurt	Pyridonderivate, ihre herstellung und ihre verwendung
DE3106460A1 (de) *	1980-03-03	1982-01-28	Sandoz-Patent-GmbH, 7850 Lörrach	2(1h)-pyridinon-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen
US4412077A (en) *	1982-03-15	1983-10-25	Sterling Drug Inc.	Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone
US4524149A (en) *	1982-03-15	1985-06-18	Sterling Drug Inc.	5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use
US4568751A (en) *	1983-04-29	1986-02-04	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones
DE3406329A1 (de) *	1984-02-22	1985-08-22	Merck Patent Gmbh, 6100 Darmstadt	Pyridone

1983
- 1983-04-29 US US06/490,081 patent/US4568751A/en not_active Expired - Lifetime
1984
- 1984-04-19 AU AU27141/84A patent/AU571219B2/en not_active Ceased
- 1984-04-19 AU AU27131/84A patent/AU557543B2/en not_active Ceased
- 1984-04-24 ZA ZA843033A patent/ZA843033B/xx unknown
- 1984-04-24 AR AR296404A patent/AR240313A1/es active
- 1984-04-24 ZA ZA843034A patent/ZA843034B/xx unknown
- 1984-04-25 ES ES531911A patent/ES531911A0/es active Granted
- 1984-04-25 ES ES531910A patent/ES531910A0/es active Granted
- 1984-04-26 AT AT84104703T patent/ATE25678T1/de active
- 1984-04-26 EP EP84104703A patent/EP0124089B1/en not_active Expired
- 1984-04-26 NZ NZ207961A patent/NZ207961A/en unknown
- 1984-04-26 EP EP84104704A patent/EP0124090B1/en not_active Expired
- 1984-04-26 CA CA000452888A patent/CA1242443A/en not_active Expired
- 1984-04-26 HU HU841618A patent/HU191928B/hu not_active IP Right Cessation
- 1984-04-26 AT AT84104704T patent/ATE26262T1/de not_active IP Right Cessation
- 1984-04-26 CA CA000452889A patent/CA1256880A/en not_active Expired
- 1984-04-26 DE DE8484104704T patent/DE3462889D1/de not_active Expired
- 1984-04-26 PH PH30602A patent/PH20256A/en unknown
- 1984-04-26 IL IL71649A patent/IL71649A/xx unknown
- 1984-04-26 HU HU841619A patent/HU191753B/hu not_active IP Right Cessation
- 1984-04-26 DE DE8484104703T patent/DE3462503D1/de not_active Expired
- 1984-04-26 IL IL71648A patent/IL71648A/xx unknown
- 1984-04-26 PT PT78493A patent/PT78493B/pt not_active IP Right Cessation
- 1984-04-26 PT PT78491A patent/PT78491B/pt not_active IP Right Cessation
- 1984-04-26 NZ NZ207960A patent/NZ207960A/en unknown
- 1984-04-27 GR GR74536A patent/GR81967B/el unknown
- 1984-04-27 JP JP59084234A patent/JPS59206355A/ja active Granted
- 1984-04-27 IE IE1046/84A patent/IE57273B1/en not_active IP Right Cessation
- 1984-04-27 DD DD84262415A patent/DD223444A5/de not_active IP Right Cessation
- 1984-04-27 IE IE1047/84A patent/IE57285B1/en not_active IP Right Cessation
- 1984-04-27 NO NO841690A patent/NO164416C/no unknown
- 1984-04-27 GR GR74535A patent/GR81990B/el unknown
- 1984-04-27 NO NO841691A patent/NO164415C/no unknown
- 1984-04-27 DK DK213284A patent/DK159424C/da not_active IP Right Cessation
- 1984-04-27 JP JP59084235A patent/JPS59206356A/ja active Granted
- 1984-04-27 DK DK213584A patent/DK159425C/da not_active IP Right Cessation
- 1984-04-28 KR KR1019840002297A patent/KR900005010B1/ko not_active Expired
- 1984-04-28 SU SU843732701A patent/SU1299505A3/ru active
- 1984-04-28 KR KR1019840002298A patent/KR900005011B1/ko not_active Expired

Also Published As

Publication number	Publication date
AU557543B2 (en)	1986-12-24
ZA843033B (en)	1984-11-28
ES8505956A1 (es)	1985-06-01
IL71648A0 (en)	1984-07-31
EP0124089A1 (en)	1984-11-07
GR81967B (da)	1984-12-12
EP0124090B1 (en)	1987-04-01
GR81990B (da)	1984-12-12
PT78493B (en)	1986-05-20
NZ207961A (en)	1986-09-10
DK159425C (da)	1991-03-18
PT78493A (en)	1984-05-01
AR240313A1 (es)	1990-03-30
IE57273B1 (en)	1992-07-01
JPS59206356A (ja)	1984-11-22
AU571219B2 (en)	1988-04-14
DK159424C (da)	1991-03-18
HU191928B (en)	1987-04-28
KR900005011B1 (ko)	1990-07-16
DK213584D0 (da)	1984-04-27
IE57285B1 (en)	1992-07-15
NO841690L (no)	1984-10-30
PH20256A (en)	1986-11-14
IL71648A (en)	1987-11-30
NZ207960A (en)	1987-05-29
SU1299505A3 (ru)	1987-03-23
AU2713184A (en)	1984-11-01
NO164415C (no)	1990-10-03
DE3462503D1 (en)	1987-04-09
DE3462889D1 (de)	1987-05-07
EP0124090A1 (en)	1984-11-07
CA1242443A (en)	1988-09-27
NO841691L (no)	1984-10-30
EP0124089B1 (en)	1987-03-04
ATE26262T1 (de)	1987-04-15
US4568751A (en)	1986-02-04
JPS59206355A (ja)	1984-11-22
NO164415B (no)	1990-06-25
JPH058192B2 (da)	1993-02-01
JPH0579668B2 (da)	1993-11-04
ES531911A0 (es)	1985-06-01
HUT34006A (en)	1985-01-28
HUT34007A (en)	1985-01-28
DK159425B (da)	1990-10-15
NO164416B (no)	1990-06-25
AU2714184A (en)	1984-11-01
DK213584A (da)	1984-10-30
DK159424B (da)	1990-10-15
HU191753B (en)	1987-04-28
ES8505955A1 (es)	1985-06-01
ATE25678T1 (de)	1987-03-15
NO164416C (no)	1990-10-03
DK213284A (da)	1984-10-30
IE841047L (en)	1984-10-29
KR900005010B1 (ko)	1990-07-16
DD223444A5 (de)	1985-06-12
PT78491B (en)	1986-05-22
KR840008323A (ko)	1984-12-14
IE841046L (en)	1984-10-29
PT78491A (en)	1984-05-01
KR840008322A (ko)	1984-12-14
IL71649A0 (en)	1984-07-31
IL71649A (en)	1987-10-30
CA1256880A (en)	1989-07-04
ES531910A0 (es)	1985-06-01
ZA843034B (en)	1984-11-28

Legal Events

Date	Code	Title	Description
1994-12-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK561884D0 (da)	1984-11-27	Vaeskecarboniseringsapparat
FI830012A0 (fi)	1983-01-04	Roerbandtransportoer
FI834705A0 (fi)	1983-12-21	Oljebekaempningsfartyg
FI834224A0 (fi)	1983-11-18	Virabordselement
DE3462889D1 (de)	1987-05-07	5-acyl-2-(1h)-pyridinones
DE3463268D1 (de)	1987-05-27	3-oxaprostaglandins
DK625084D0 (da)	1984-12-21	Gonadoliberinderivater
IT1175546B (it)	1987-07-01	Insieme anaglifo
FI831461A0 (fi)	1983-04-28	Skjutdoerr foer fordon
FI834135A0 (fi)	1983-11-11	Glidlakan
FI834717A0 (fi)	1983-12-21	Nipp-pressfoerfarande och -anordning
ES273174Y (es)	1984-06-01	Ventiloconvector mejorado
FI840447A0 (fi)	1984-02-03	Foerbaettringar beroerande benzazepinderivat
KR840004859U (ko)	1984-09-22	공 구 함
FI834420A0 (fi)	1983-12-02	Fixeringsanordning
SE8403643L (sv)	1985-01-16	Tendstiftsanordning
FI832925A0 (fi)	1983-08-15	Ytbelaeggnings- och gjutanordning
FI833556A0 (fi)	1983-09-30	Baerplockningsanordning
FI833688A0 (fi)	1983-10-11	Regleringsanordning foer en svarv
FI834186A0 (fi)	1983-11-15	Skrivdonsserie
SE8306252D0 (sv)	1983-11-14	Brennare
FI830218A0 (fi)	1983-01-21	Huggkrok-drag
FI831804A0 (fi)	1983-05-20	Bittorvmaskin
FI834701A0 (fi)	1983-12-21	Byggnadspanel
DK8383D0 (da)	1983-01-11	Roeafpudser