NO841691L - Fremgangsmaate ved fremstilling av nye 5-acyl-2-(1h)-pyridinoner - Google Patents

Fremgangsmaate ved fremstilling av nye 5-acyl-2-(1h)-pyridinoner

Info

Publication number: NO841691L
Authority: NO; Norway
Prior art keywords: pyridinones; acyl; procedure; preparation; new
Prior art date: 1983-04-29

Application number

NO841691A

Other languages

English (en)

Other versions

NO164415B (no

NO164415C (no

Inventor

Winton D Jones

Richard A Schnettler

Richard C Dage

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-29

Filing date

1984-04-27

Publication date

1984-10-30

1984-04-27 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1984-10-30 Publication of NO841691L publication Critical patent/NO841691L/no

1990-06-25 Publication of NO164415B publication Critical patent/NO164415B/no

1990-10-03 Publication of NO164415C publication Critical patent/NO164415C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO841691A 1983-04-29 1984-04-27 Analogifremgangsmaate ved fremstilling av terapeutisk aktive 5-acyl-2-(1h)-pyridinoner. NO164415C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/490,081 US4568751A (en)	1983-04-29	1983-04-29	5-Acyl-2-(1H)-pyridinones

Publications (3)

Publication Number	Publication Date
NO841691L true NO841691L (no)	1984-10-30
NO164415B NO164415B (no)	1990-06-25
NO164415C NO164415C (no)	1990-10-03

Family

ID=23946554

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO841691A NO164415C (no)	1983-04-29	1984-04-27	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 5-acyl-2-(1h)-pyridinoner.
NO841690A NO164416C (no)	1983-04-29	1984-04-27	Analogiremgangsmaate ved fremstilling av terapeutisk aktive 5-acyl-2-(1h)-pyridinoner.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO841690A NO164416C (no)	1983-04-29	1984-04-27	Analogiremgangsmaate ved fremstilling av terapeutisk aktive 5-acyl-2-(1h)-pyridinoner.

Country Status (22)

Country	Link
US (1)	US4568751A (no)
EP (2)	EP0124089B1 (no)
JP (2)	JPS59206356A (no)
KR (2)	KR900005010B1 (no)
AR (1)	AR240313A1 (no)
AT (2)	ATE26262T1 (no)
AU (2)	AU557543B2 (no)
CA (2)	CA1256880A (no)
DD (1)	DD223444A5 (no)
DE (2)	DE3462503D1 (no)
DK (2)	DK159425C (no)
ES (2)	ES8505956A1 (no)
GR (2)	GR81990B (no)
HU (2)	HU191928B (no)
IE (2)	IE57285B1 (no)
IL (2)	IL71648A (no)
NO (2)	NO164415C (no)
NZ (2)	NZ207961A (no)
PH (1)	PH20256A (no)
PT (2)	PT78491B (no)
SU (1)	SU1299505A3 (no)
ZA (2)	ZA843033B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4992452A (en) *	1983-04-29	1991-02-12	Merrell Dow Pharmaceuticals Inc.	Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure
US4568751A (en) *	1983-04-29	1986-02-04	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones
US5428045A (en) *	1983-04-29	1995-06-27	Merrell Dow Pharmaceuticals Inc.	5-acyl-2-(1H)-pyridinoes
US4731371A (en) *	1984-03-29	1988-03-15	Merrell Dow Pharmaceuticals Inc.	Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents
US4853395A (en) *	1983-04-29	1989-08-01	Merrell Dow Pharmaceuticals Inc.	Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties
US5118696A (en) *	1983-04-29	1992-06-02	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure
US5212314A (en) *	1983-11-03	1993-05-18	Merrell Dow Pharmaceuticals Inc.	Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US4732982A (en) *	1983-11-03	1988-03-22	Merrell Dow Pharmaceuticals Inc.	Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
US4657919A (en) *	1984-08-03	1987-04-14	E. I. Du Pont De Nemours & Co.	Pyridone esters as inotropic agents
US4650806A (en) *	1985-01-14	1987-03-17	Sterling Drug Inc.	Cardiotonic 5-(heterylcarbonyl)-pyridones

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2531035A1 (de) *	1975-07-11	1977-01-27	Basf Ag	Verfahren zur herstellung von 5-cyanpyridonen-(6)
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones
GB1596887A (en) *	1977-07-15	1981-09-03	Rohm & Haas	2-pyridone derivatives and their use as plant growth regulators
DE3005069A1 (de) *	1980-02-11	1981-08-20	Cassella Ag, 6000 Frankfurt	Pyridonderivate, ihre herstellung und ihre verwendung
DE3106460A1 (de) *	1980-03-03	1982-01-28	Sandoz-Patent-GmbH, 7850 Lörrach	2(1h)-pyridinon-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen
US4524149A (en) *	1982-03-15	1985-06-18	Sterling Drug Inc.	5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use
US4412077A (en) *	1982-03-15	1983-10-25	Sterling Drug Inc.	Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone
US4568751A (en) *	1983-04-29	1986-02-04	Merrell Dow Pharmaceuticals Inc.	5-Acyl-2-(1H)-pyridinones
DE3406329A1 (de) *	1984-02-22	1985-08-22	Merck Patent Gmbh, 6100 Darmstadt	Pyridone

1983
- 1983-04-29 US US06/490,081 patent/US4568751A/en not_active Expired - Lifetime
1984
- 1984-04-19 AU AU27131/84A patent/AU557543B2/en not_active Ceased
- 1984-04-19 AU AU27141/84A patent/AU571219B2/en not_active Ceased
- 1984-04-24 ZA ZA843033A patent/ZA843033B/xx unknown
- 1984-04-24 AR AR296404A patent/AR240313A1/es active
- 1984-04-24 ZA ZA843034A patent/ZA843034B/xx unknown
- 1984-04-25 ES ES531911A patent/ES8505956A1/es not_active Expired
- 1984-04-25 ES ES531910A patent/ES531910A0/es active Granted
- 1984-04-26 PH PH30602A patent/PH20256A/en unknown
- 1984-04-26 IL IL71648A patent/IL71648A/xx unknown
- 1984-04-26 AT AT84104704T patent/ATE26262T1/de not_active IP Right Cessation
- 1984-04-26 NZ NZ207961A patent/NZ207961A/en unknown
- 1984-04-26 HU HU841618A patent/HU191928B/hu not_active IP Right Cessation
- 1984-04-26 PT PT78491A patent/PT78491B/pt not_active IP Right Cessation
- 1984-04-26 NZ NZ207960A patent/NZ207960A/en unknown
- 1984-04-26 AT AT84104703T patent/ATE25678T1/de active
- 1984-04-26 IL IL71649A patent/IL71649A/xx unknown
- 1984-04-26 CA CA000452889A patent/CA1256880A/en not_active Expired
- 1984-04-26 CA CA000452888A patent/CA1242443A/en not_active Expired
- 1984-04-26 HU HU841619A patent/HU191753B/hu not_active IP Right Cessation
- 1984-04-26 DE DE8484104703T patent/DE3462503D1/de not_active Expired
- 1984-04-26 EP EP84104703A patent/EP0124089B1/en not_active Expired
- 1984-04-26 EP EP84104704A patent/EP0124090B1/en not_active Expired
- 1984-04-26 DE DE8484104704T patent/DE3462889D1/de not_active Expired
- 1984-04-26 PT PT78493A patent/PT78493B/pt not_active IP Right Cessation
- 1984-04-27 JP JP59084235A patent/JPS59206356A/ja active Granted
- 1984-04-27 GR GR74535A patent/GR81990B/el unknown
- 1984-04-27 DK DK213584A patent/DK159425C/da not_active IP Right Cessation
- 1984-04-27 IE IE1047/84A patent/IE57285B1/en not_active IP Right Cessation
- 1984-04-27 DK DK213284A patent/DK159424C/da not_active IP Right Cessation
- 1984-04-27 GR GR74536A patent/GR81967B/el unknown
- 1984-04-27 IE IE1046/84A patent/IE57273B1/en not_active IP Right Cessation
- 1984-04-27 JP JP59084234A patent/JPS59206355A/ja active Granted
- 1984-04-27 NO NO841691A patent/NO164415C/no unknown
- 1984-04-27 DD DD84262415A patent/DD223444A5/de not_active IP Right Cessation
- 1984-04-27 NO NO841690A patent/NO164416C/no unknown
- 1984-04-28 SU SU843732701A patent/SU1299505A3/ru active
- 1984-04-28 KR KR1019840002297A patent/KR900005010B1/ko not_active Expired
- 1984-04-28 KR KR1019840002298A patent/KR900005011B1/ko not_active Expired

Also Published As

Publication number	Publication date
HU191928B (en)	1987-04-28
GR81967B (no)	1984-12-12
IL71648A (en)	1987-11-30
NO841690L (no)	1984-10-30
KR840008323A (ko)	1984-12-14
DK213584D0 (da)	1984-04-27
NO164416C (no)	1990-10-03
US4568751A (en)	1986-02-04
AU2714184A (en)	1984-11-01
HUT34007A (en)	1985-01-28
IE57273B1 (en)	1992-07-01
PT78491B (en)	1986-05-22
DK213284D0 (da)	1984-04-27
JPH0579668B2 (no)	1993-11-04
DK159425C (da)	1991-03-18
HU191753B (en)	1987-04-28
ES531911A0 (es)	1985-06-01
ES8505955A1 (es)	1985-06-01
EP0124090A1 (en)	1984-11-07
DK159424C (da)	1991-03-18
IE841047L (en)	1984-10-29
JPS59206356A (ja)	1984-11-22
DK213584A (da)	1984-10-30
ES8505956A1 (es)	1985-06-01
NO164415B (no)	1990-06-25
PT78493B (en)	1986-05-20
DD223444A5 (de)	1985-06-12
NZ207961A (en)	1986-09-10
NZ207960A (en)	1987-05-29
NO164416B (no)	1990-06-25
PT78491A (en)	1984-05-01
SU1299505A3 (ru)	1987-03-23
CA1256880A (en)	1989-07-04
JPH058192B2 (no)	1993-02-01
ZA843033B (en)	1984-11-28
EP0124089A1 (en)	1984-11-07
CA1242443A (en)	1988-09-27
DK159424B (da)	1990-10-15
DK213284A (da)	1984-10-30
IE57285B1 (en)	1992-07-15
KR840008322A (ko)	1984-12-14
GR81990B (no)	1984-12-12
ES531910A0 (es)	1985-06-01
ATE25678T1 (de)	1987-03-15
ATE26262T1 (de)	1987-04-15
HUT34006A (en)	1985-01-28
JPS59206355A (ja)	1984-11-22
KR900005010B1 (ko)	1990-07-16
ZA843034B (en)	1984-11-28
EP0124089B1 (en)	1987-03-04
IL71648A0 (en)	1984-07-31
KR900005011B1 (ko)	1990-07-16
AR240313A1 (es)	1990-03-30
AU557543B2 (en)	1986-12-24
NO164415C (no)	1990-10-03
IL71649A0 (en)	1984-07-31
DE3462889D1 (de)	1987-05-07
DK159425B (da)	1990-10-15
PH20256A (en)	1986-11-14
DE3462503D1 (en)	1987-04-09
IL71649A (en)	1987-10-30
AU571219B2 (en)	1988-04-14
PT78493A (en)	1984-05-01
EP0124090B1 (en)	1987-04-01
AU2713184A (en)	1984-11-01
IE841046L (en)	1984-10-29

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