DK2152667T3 - Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater - Google Patents

Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater

Info

Publication number
DK2152667T3
DK2152667T3 DK08749718.6T DK08749718T DK2152667T3 DK 2152667 T3 DK2152667 T3 DK 2152667T3 DK 08749718 T DK08749718 T DK 08749718T DK 2152667 T3 DK2152667 T3 DK 2152667T3
Authority
DK
Denmark
Prior art keywords
hydroxy
phenylbutyl
isobutyl
preparation
amine
Prior art date
Application number
DK08749718.6T
Other languages
English (en)
Inventor
Hartmut Burghard Zinser
Peter Hermann Hoelzle
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of DK2152667T3 publication Critical patent/DK2152667T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK08749718.6T 2007-04-27 2008-04-25 Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater DK2152667T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07107177 2007-04-27
PCT/EP2008/055042 WO2008132154A1 (en) 2007-04-27 2008-04-25 Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives

Publications (1)

Publication Number Publication Date
DK2152667T3 true DK2152667T3 (da) 2011-05-16

Family

ID=38924830

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08749718.6T DK2152667T3 (da) 2007-04-27 2008-04-25 Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater

Country Status (20)

Country Link
US (1) US8076513B2 (da)
EP (1) EP2152667B1 (da)
JP (1) JP2010525029A (da)
CN (1) CN101668734A (da)
AT (1) ATE498606T1 (da)
AU (1) AU2008244306A1 (da)
BR (1) BRPI0810609A2 (da)
CA (1) CA2682616A1 (da)
CY (1) CY1111457T1 (da)
DE (1) DE602008005012D1 (da)
DK (1) DK2152667T3 (da)
ES (1) ES2360654T3 (da)
HR (1) HRP20110290T1 (da)
IL (1) IL200811A0 (da)
MX (1) MX2009011574A (da)
PL (1) PL2152667T3 (da)
PT (1) PT2152667E (da)
RU (1) RU2009143867A (da)
SI (1) SI2152667T1 (da)
WO (1) WO2008132154A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
US20130211108A1 (en) * 2010-06-18 2013-08-15 Mylan Laboratories Ltd Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts
DK2643326T3 (da) 2010-11-23 2017-01-09 Mylan Laboratories Ltd Fremgangsmåde til fremstilling af (3R, 3aS, 6aR)-hexahydrofuro[2,3-b]furan-3-ol
CN105315178B (zh) * 2014-07-09 2018-07-06 浙江九洲药业股份有限公司 达芦那韦相关物质及其制备方法
CN117142989A (zh) * 2020-12-30 2023-12-01 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体a的生长方法和所得晶体

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DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
JPH07110846B2 (ja) * 1987-12-23 1995-11-29 アグロカネショウ株式会社 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤
ATE218541T1 (de) 1992-08-25 2002-06-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
EP0715618B1 (en) 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
CA2186483A1 (en) 1995-02-03 1996-08-08 Akira Nishiyama Processes for producing .alpha.-halo ketones, .alpha.-halohydrins and epoxides
AU7722296A (en) 1995-11-15 1997-06-05 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
BR9912169A (pt) 1998-06-19 2001-04-10 Vertex Pharma Inibidores de sulfonamida de protease de aspartil
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
PT2336134T (pt) 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
DE69918050T2 (de) 1998-08-25 2005-06-30 Kaneka Corp. Verfahren zur herstellung von (2r,3s)-3-amino-1,2-oxiran
US6344572B1 (en) 1999-01-29 2002-02-05 Kaneka Corporation Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives
ES2254156T3 (es) 1999-02-12 2006-06-16 Vertex Pharmaceuticals Incorporated Inhibidores de aspartil-proteasa.
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
EP2314563A3 (en) 1999-12-23 2012-04-04 Ampac Fine Chemicals LLC Improved preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
KR20020046948A (ko) 2000-12-12 2002-06-21 에가시라 구니오 에폭사이드 결정의 제조방법
JP2002332270A (ja) * 2001-03-07 2002-11-22 Ajinomoto Co Inc スルホンアミド誘導体の製造方法
EA010883B1 (ru) 2001-09-10 2008-12-30 Тиботек Фармасьютикалз Лтд. Способ получения гексагидрофуро[2,3-в]фуран-3-ола
WO2004033462A2 (en) 2002-10-09 2004-04-22 The Board Of Trustees Of The University Of Illinois METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS
WO2004060895A1 (ja) 2002-12-27 2004-07-22 Sumitomo Chemical Company, Limited ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法
UA79404C2 (en) * 2003-10-02 2007-06-11 Basf Ag 2-cyanobenzenesulfonamide for controlling pests
WO2005063770A1 (en) 2003-12-23 2005-07-14 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
TWI383975B (zh) 2004-03-31 2013-02-01 悌柏泰克醫藥有限公司 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法

Also Published As

Publication number Publication date
PL2152667T3 (pl) 2011-06-30
PT2152667E (pt) 2011-04-06
HRP20110290T1 (hr) 2011-05-31
EP2152667A1 (en) 2010-02-17
JP2010525029A (ja) 2010-07-22
ES2360654T3 (es) 2011-06-08
DE602008005012D1 (de) 2011-03-31
MX2009011574A (es) 2009-11-09
ATE498606T1 (de) 2011-03-15
CN101668734A (zh) 2010-03-10
AU2008244306A1 (en) 2008-11-06
RU2009143867A (ru) 2011-06-10
EP2152667B1 (en) 2011-02-16
CA2682616A1 (en) 2008-11-06
IL200811A0 (en) 2010-05-17
WO2008132154A1 (en) 2008-11-06
US8076513B2 (en) 2011-12-13
SI2152667T1 (sl) 2011-06-30
BRPI0810609A2 (pt) 2014-10-21
US20100121094A1 (en) 2010-05-13
CY1111457T1 (el) 2015-08-05

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