ATE498606T1 - Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzolsulfonylamidderivate - Google Patents
Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzolsulfonylamidderivateInfo
- Publication number
- ATE498606T1 ATE498606T1 AT08749718T AT08749718T ATE498606T1 AT E498606 T1 ATE498606 T1 AT E498606T1 AT 08749718 T AT08749718 T AT 08749718T AT 08749718 T AT08749718 T AT 08749718T AT E498606 T1 ATE498606 T1 AT E498606T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- phenylbutyl
- isobutyl
- amino
- production process
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- RXZQKCYDYRLICS-UHFFFAOYSA-N [3-hydroxy-4-(2-methylpropylamino)-1-phenylbutan-2-yl]carbamic acid Chemical class CC(C)CNCC(O)C(NC(O)=O)CC1=CC=CC=C1 RXZQKCYDYRLICS-UHFFFAOYSA-N 0.000 abstract 1
- -1 p-nitrophenylsulfonyl halide Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07107177 | 2007-04-27 | ||
| PCT/EP2008/055042 WO2008132154A1 (en) | 2007-04-27 | 2008-04-25 | Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE498606T1 true ATE498606T1 (de) | 2011-03-15 |
Family
ID=38924830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08749718T ATE498606T1 (de) | 2007-04-27 | 2008-04-25 | Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzolsulfonylamidderivate |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8076513B2 (de) |
| EP (1) | EP2152667B1 (de) |
| JP (1) | JP2010525029A (de) |
| CN (1) | CN101668734A (de) |
| AT (1) | ATE498606T1 (de) |
| AU (1) | AU2008244306A1 (de) |
| BR (1) | BRPI0810609A2 (de) |
| CA (1) | CA2682616A1 (de) |
| CY (1) | CY1111457T1 (de) |
| DE (1) | DE602008005012D1 (de) |
| DK (1) | DK2152667T3 (de) |
| ES (1) | ES2360654T3 (de) |
| HR (1) | HRP20110290T1 (de) |
| IL (1) | IL200811A0 (de) |
| MX (1) | MX2009011574A (de) |
| PL (1) | PL2152667T3 (de) |
| PT (1) | PT2152667E (de) |
| RU (1) | RU2009143867A (de) |
| SI (1) | SI2152667T1 (de) |
| WO (1) | WO2008132154A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| EP2528923B1 (de) | 2010-01-28 | 2014-07-30 | Mapi Pharma Limited | Verfahren zur herstellung von darunavir und darunavir-zwischenprodukten |
| US20130211108A1 (en) * | 2010-06-18 | 2013-08-15 | Mylan Laboratories Ltd | Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts |
| PT2643326T (pt) | 2010-11-23 | 2016-12-23 | Mylan Laboratories Ltd | Processo para a preparação de (3r,3as,6ar)-hexa-hidrofuro[2,3-b]furan-3-ol |
| CN105315178B (zh) * | 2014-07-09 | 2018-07-06 | 浙江九洲药业股份有限公司 | 达芦那韦相关物质及其制备方法 |
| CN118026896A (zh) * | 2020-12-30 | 2024-05-14 | 上海飞腾医药科技有限公司 | 抗hiv类药物中间体晶体的生长方法和所得晶体 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| JPH07110846B2 (ja) * | 1987-12-23 | 1995-11-29 | アグロカネショウ株式会社 | 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤 |
| JP3657002B2 (ja) * | 1992-08-25 | 2005-06-08 | ジー．ディー．サール アンド カンパニー | レトロウイルスプロテアーゼ阻害剤として有用なα−およびβ−アミノ酸ヒドロキシエチルアミノスルホンアミド |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| AU7669794A (en) | 1993-08-24 | 1995-03-21 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
| KR100411856B1 (ko) | 1995-02-03 | 2004-05-20 | 카네카 코포레이션 | α-할로케톤,α-할로히드린및에폭사이드의제조법 |
| JP2000515488A (ja) | 1995-11-15 | 2000-11-21 | ジー．ディー．サール アンド カンパニー | 置換スルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド レトロウイルスプロテアーゼ阻害剤 |
| NZ508855A (en) | 1998-06-19 | 2003-10-31 | Vertex Pharma | Sulfonamide inhibitors of HIV aspartyl protease |
| WO1999067254A2 (en) | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| JP4776775B2 (ja) | 1998-06-23 | 2011-09-21 | アメリカ合衆国 | Ｈｉｖ感染哺乳動物を治療するための医薬組成物 |
| DE69918050T2 (de) | 1998-08-25 | 2005-06-30 | Kaneka Corp. | Verfahren zur herstellung von (2r,3s)-3-amino-1,2-oxiran |
| EP1067125B1 (de) | 1999-01-29 | 2006-07-26 | Kaneka Corporation | VERFAHREN ZUR HERSTELLUNG VON threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTAN-DERIVATEN |
| EP1159278B1 (de) | 1999-02-12 | 2005-11-30 | Vertex Pharmaceuticals Incorporated | Aspartyl-protease-inhibitoren |
| AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
| EP2319824A3 (de) * | 1999-12-23 | 2012-04-11 | Ampac Fine Chemicals LLC | Verbesserte Herstellung von 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)amin |
| KR20020046948A (ko) | 2000-12-12 | 2002-06-21 | 에가시라 구니오 | 에폭사이드 결정의 제조방법 |
| JP2002332270A (ja) * | 2001-03-07 | 2002-11-22 | Ajinomoto Co Inc | スルホンアミド誘導体の製造方法 |
| ES2338538T3 (es) | 2001-09-10 | 2010-05-10 | Tibotec Pharmaceuticals | Metodo para la preparacion de hexahidrofuro(2,3-b)furan-3-ol. |
| WO2004033462A2 (en) | 2002-10-09 | 2004-04-22 | The Board Of Trustees Of The University Of Illinois | METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS |
| WO2004060895A1 (ja) * | 2002-12-27 | 2004-07-22 | Sumitomo Chemical Company, Limited | ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法 |
| UA79404C2 (en) * | 2003-10-02 | 2007-06-11 | Basf Ag | 2-cyanobenzenesulfonamide for controlling pests |
| DE602004021640D1 (de) * | 2003-12-23 | 2009-07-30 | Tibotec Pharm Ltd | Verfahren zur herstellung von (1s,2r)-3-ää(4-aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl-2-hydroxypropylcarbamidsäure-(3r,3as,6ar)-hexahydrofuroä2,3-büfuran-3-ylester |
| TWI383975B (zh) | 2004-03-31 | 2013-02-01 | 悌柏泰克醫藥有限公司 | 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法 |
-
2008
- 2008-04-25 BR BRPI0810609-6A2A patent/BRPI0810609A2/pt not_active IP Right Cessation
- 2008-04-25 SI SI200830232T patent/SI2152667T1/sl unknown
- 2008-04-25 CA CA002682616A patent/CA2682616A1/en not_active Abandoned
- 2008-04-25 CN CN200880013559A patent/CN101668734A/zh active Pending
- 2008-04-25 WO PCT/EP2008/055042 patent/WO2008132154A1/en not_active Ceased
- 2008-04-25 DE DE602008005012T patent/DE602008005012D1/de active Active
- 2008-04-25 MX MX2009011574A patent/MX2009011574A/es active IP Right Grant
- 2008-04-25 ES ES08749718T patent/ES2360654T3/es active Active
- 2008-04-25 EP EP08749718A patent/EP2152667B1/de not_active Not-in-force
- 2008-04-25 AU AU2008244306A patent/AU2008244306A1/en not_active Abandoned
- 2008-04-25 US US12/597,088 patent/US8076513B2/en not_active Expired - Fee Related
- 2008-04-25 AT AT08749718T patent/ATE498606T1/de active
- 2008-04-25 JP JP2010504703A patent/JP2010525029A/ja active Pending
- 2008-04-25 RU RU2009143867/04A patent/RU2009143867A/ru not_active Application Discontinuation
- 2008-04-25 PL PL08749718T patent/PL2152667T3/pl unknown
- 2008-04-25 DK DK08749718.6T patent/DK2152667T3/da active
- 2008-04-25 HR HR20110290T patent/HRP20110290T1/hr unknown
- 2008-04-25 PT PT08749718T patent/PT2152667E/pt unknown
-
2009
- 2009-09-08 IL IL200811A patent/IL200811A0/en unknown
-
2011
- 2011-05-16 CY CY20111100463T patent/CY1111457T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2152667E (pt) | 2011-04-06 |
| US8076513B2 (en) | 2011-12-13 |
| IL200811A0 (en) | 2010-05-17 |
| JP2010525029A (ja) | 2010-07-22 |
| DE602008005012D1 (de) | 2011-03-31 |
| PL2152667T3 (pl) | 2011-06-30 |
| ES2360654T3 (es) | 2011-06-08 |
| HRP20110290T1 (hr) | 2011-05-31 |
| RU2009143867A (ru) | 2011-06-10 |
| SI2152667T1 (sl) | 2011-06-30 |
| AU2008244306A1 (en) | 2008-11-06 |
| EP2152667B1 (de) | 2011-02-16 |
| CY1111457T1 (el) | 2015-08-05 |
| CN101668734A (zh) | 2010-03-10 |
| CA2682616A1 (en) | 2008-11-06 |
| MX2009011574A (es) | 2009-11-09 |
| EP2152667A1 (de) | 2010-02-17 |
| DK2152667T3 (da) | 2011-05-16 |
| WO2008132154A1 (en) | 2008-11-06 |
| BRPI0810609A2 (pt) | 2014-10-21 |
| US20100121094A1 (en) | 2010-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1120660T1 (el) | Καινοφανεις υποκαταστατες toy rig-i και μεθοδοι παραγωγης αυτων | |
| DE602008005012D1 (de) | Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-rivate | |
| BR112012014683A2 (pt) | processo para a produção de derivados de ácido 1-alquil/1-aril-5-pirazolcarboxílico | |
| DE602007011250D1 (de) | Herstellungsverfahren für Drospirenon | |
| MX353581B (es) | Procesos para producir productos de fermentacion. | |
| CY1107014T1 (el) | Χρηση θρεπτικου μεσου κυτταροκαλλιεργειας ελευθερου ορου για την παραγωγη il-18bp σε κυτταρα θηλαστικων | |
| IL192847A (en) | The history of benzamide and the trower, a process for making them and their pharmaceutical preparations | |
| MX2011008946A (es) | Un complejo de haluro de hidrogeno de agomelatina y la preparacion del mismo. | |
| MX2020006387A (es) | Sintesis del cocristal 1:1:1 de 1-ciano-2-(4-ciclopropil-bencil)-4 -(beta-d-glucopiranos-1-il)-benceno, l-prolina y agua. | |
| EP4417605A3 (de) | Verfahren zur synthese von eliglustat und zwischenprodukten davon | |
| PH12012500287A1 (en) | K5 heparosan fermentation and purification | |
| NZ586187A (en) | Processes for the synthesis of sinomenine derivatives and their intermediate | |
| EP4212652A4 (de) | Verfahren zur herstellung von kristallen | |
| NZ603653A (en) | Processes for the preparation of dipyridamole | |
| BR112012013582A2 (pt) | processo para síntese de intermediários úteis para a produção de compostos de indazol e azaindazol substituídos | |
| MX2010005938A (es) | Procedimiento para la preparacion de derivados de acido 2-fluoroacil-3-amino-acrilico. | |
| BR112012014416A2 (pt) | novos derivados de dioxolanos e de dioxanos, e método para sua produção. | |
| NZ589496A (en) | Processes and compounds for the preparation of normorphinans | |
| BR112012010445A2 (pt) | processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1 h-pirrol-3-carboxamidas | |
| NZ598129A (en) | Process for the preparation of cathepsin s inhibitors | |
| WO2010110771A3 (en) | Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof | |
| MX2009001508A (es) | Un proceso novedoso para preparar ester de acido 3-amino-5-fluoro-4-dialcoxipentanoico. | |
| GB202414057D0 (en) | Large scale production of n-acetyllactos derivatives | |
| PL402306A1 (pl) | Sposób wytwarzania 3,24;16,22-O,O;O,O-diizopropylideno-protoescygeniny oraz jej postacie krystaliczne | |
| UY31936A (es) | Método para la preparación del ácido 5,6-dimetil-9-oxo-9h-xanten-4-il-acético (dmxaa) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 2152667 Country of ref document: EP |