DK2247558T4 - Nye billeddannelsesmidler til detektering af neurologisk dysfunktion - Google Patents

Nye billeddannelsesmidler til detektering af neurologisk dysfunktion Download PDF

Info

Publication number
DK2247558T4
DK2247558T4 DK09711194.2T DK09711194T DK2247558T4 DK 2247558 T4 DK2247558 T4 DK 2247558T4 DK 09711194 T DK09711194 T DK 09711194T DK 2247558 T4 DK2247558 T4 DK 2247558T4
Authority
DK
Denmark
Prior art keywords
detection
imaging agents
neurological dysfunction
new imaging
neurological
Prior art date
Application number
DK09711194.2T
Other languages
English (en)
Other versions
DK2247558T3 (da
Inventor
Zhiyong Gao
Eric Wang
Anjana Sinha
Chunfang Xia
Henry Clifton Padgett
Hartmuth C Kolb
Joseph C Walsh
Qianwa Liang
Brian A Duclos
Peter J H Scott
Kai Chen
Tieming Zhao
Dhanalakshmi Kasi
Gang Chen
Wei Zhang
Vani P Mocharla
Farhad Karimi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40627498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2247558(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK2247558T3 publication Critical patent/DK2247558T3/da
Publication of DK2247558T4 publication Critical patent/DK2247558T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK09711194.2T 2008-02-14 2009-02-17 Nye billeddannelsesmidler til detektering af neurologisk dysfunktion DK2247558T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6610108P 2008-02-14 2008-02-14
PCT/US2009/000961 WO2009102498A1 (en) 2008-02-14 2009-02-17 Novel imaging agents for detecting neurological dysfunction

Publications (2)

Publication Number Publication Date
DK2247558T3 DK2247558T3 (da) 2022-02-21
DK2247558T4 true DK2247558T4 (da) 2024-07-29

Family

ID=40627498

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09711194.2T DK2247558T4 (da) 2008-02-14 2009-02-17 Nye billeddannelsesmidler til detektering af neurologisk dysfunktion

Country Status (16)

Country Link
US (2) US8318132B2 (da)
EP (2) EP2599763A1 (da)
JP (1) JP2011512354A (da)
KR (1) KR20100135235A (da)
CA (1) CA2715390A1 (da)
CY (1) CY1125258T1 (da)
DK (1) DK2247558T4 (da)
ES (1) ES2907992T5 (da)
FI (1) FI2247558T4 (da)
HR (1) HRP20220401T4 (da)
HU (1) HUE058352T2 (da)
LT (1) LT2247558T (da)
PL (1) PL2247558T5 (da)
PT (1) PT2247558T (da)
SI (1) SI2247558T2 (da)
WO (1) WO2009102498A1 (da)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2599763A1 (en) 2008-02-14 2013-06-05 Siemens Molecular Imaging, Inc. Novel imaging agents for detecting neurological dysfunction
US8932557B2 (en) * 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
EP2313378A1 (en) * 2008-08-08 2011-04-27 NeuroSearch A/S Novel diphenyl 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors
WO2010033861A1 (en) * 2008-09-18 2010-03-25 Cedars-Sinai Medical Center Optical method for the detection of alzheimer's disease
US8691187B2 (en) * 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
GB201016038D0 (en) 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
CA2815960C (en) * 2010-10-29 2019-01-22 Clino Ltd. Tau imaging probe
WO2013020184A1 (en) * 2011-08-11 2013-02-14 Neuprotect Pty Ltd Flavonoid compounds, and methods of use thereof
US20130315825A1 (en) * 2012-05-03 2013-11-28 Washington University Tricyclic heteroaromatic compounds as alpha-synuclein ligands
JP5976206B2 (ja) * 2012-05-22 2016-08-23 イーライ リリー アンド カンパニー 神経機能障害を検出するための造影剤
JP5422782B1 (ja) 2012-12-21 2014-02-19 独立行政法人放射線医学総合研究所 脳内に蓄積したタウタンパク質をイメージングするための新規化合物
WO2014194169A1 (en) * 2013-05-31 2014-12-04 The General Hospital Corporation Radiosynthesis of tau radiopharmaceuticals
KR102345381B1 (ko) 2013-06-25 2021-12-29 브리스톨-마이어스 스큅 컴퍼니 키나제 억제제로서 유용한 카르바졸 카르복스아미드 화합물
AR096721A1 (es) 2013-06-25 2016-01-27 Bristol Myers Squibb Co Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos
AU2014333996B2 (en) 2013-10-08 2018-03-15 F. Hoffmann-La Roche Ag Diazacarbazole derivatives as tau-pet-ligands
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
US10662193B2 (en) 2014-01-21 2020-05-26 Ac Immune Sa Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins
MX376163B (es) 2014-05-13 2025-03-07 Hoffmann La Roche Compuestos heterocíclicos deuterados y su uso como agentes formadores de imágenes.
JP6487534B2 (ja) 2014-09-05 2019-03-20 シンビオミックス セラピューティクス、エルエルシー 細菌性膣炎の治療に使用するためのセクニダゾール
CA2960101C (en) * 2014-09-05 2024-05-21 Allosteros Therapeutics, Inc. Substituted carboline derivative and compositions thereof useful as camkii inhibitors
MX393057B (es) 2014-10-24 2025-03-24 Bristol Myers Squibb Co Compuestos de indol carboxamida útiles como inhibidores de cinasas.
CN107108555B (zh) 2014-10-24 2020-12-01 百时美施贵宝公司 三环阻转异构体化合物
TWI676618B (zh) 2014-10-24 2019-11-11 美商必治妥美雅史谷比公司 三環化合物
US20180022748A1 (en) * 2015-02-02 2018-01-25 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
CN105524034B (zh) * 2015-03-27 2018-08-17 北京大学 香豆素衍生物的制备、药理作用及治疗脑缺血的应用
CN105566269B (zh) * 2015-03-27 2018-07-10 北京大学 香豆素衍生物的制备、药理作用及治疗瘙痒的应用
US11253501B2 (en) 2015-06-01 2022-02-22 Lupin Inc. Secnidazole formulations and use in treating bacterial vaginosis
EP3118202A1 (en) 2015-07-15 2017-01-18 AC Immune S.A. Dihydropyridopyrrole derivatives as tau-pet-ligands
US20180264146A1 (en) 2015-07-15 2018-09-20 Ac Immune S.A. Novel imaging compounds
ES2864825T3 (es) 2015-11-13 2021-10-14 Lilly Co Eli Derivados de azetidina para la obtención de imágenes Tau
WO2017134098A1 (en) * 2016-02-03 2017-08-10 Janssen Pharmaceutica Nv Tau pet imaging ligands
WO2018015549A1 (en) 2016-07-22 2018-01-25 Ac Immune S.A. Compounds for imaging tau protein aggregates
EP3487545A1 (en) 2016-07-22 2019-05-29 AC Immune S.A. Compounds for imaging tau protein aggregates
WO2018024643A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
WO2018024642A1 (en) 2016-08-02 2018-02-08 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives
WO2018046428A1 (en) 2016-09-09 2018-03-15 F. Hoffmann-La Roche Ag Process for preparation of 2-(6-nitropyridin-3-yl)-9h-dipyrido[2,3-b;3',4'-d]pyrrole
TW201906818A (zh) * 2017-05-31 2019-02-16 美商511製藥公司 新穎氘取代之正子發射斷層掃描(pet)顯影劑及其藥理應用
WO2019145291A1 (en) 2018-01-24 2019-08-01 Ac Immune Sa Gamma-carboline compounds for the detection of tau aggregates
EP3743426A1 (en) 2018-01-24 2020-12-02 AC Immune SA Azacarboline compounds for the detection of tau aggregates
JPWO2019168170A1 (ja) * 2018-03-02 2021-03-04 国立大学法人 長崎大学 クロモン誘導体及びアミロイド関連疾患診断用組成物
CN112384517B (zh) 2018-05-09 2023-07-14 新旭生技股份有限公司 杂芳基化合物及其用途
US12352719B2 (en) 2019-09-20 2025-07-08 KYCERA AVX Components Corporation Somatic cell-based electrical biosensor
CA3161455A1 (en) 2019-11-13 2021-05-20 Aprinoia Therapeutics Limited Compounds for degrading tau protein aggregates and uses thereof
US12280037B2 (en) 2020-09-22 2025-04-22 Evofem Biosciences, Inc. Method and pharmaceutical composition for treating or preventing trichomoniasis and uses thereof
US20250326732A1 (en) * 2021-08-30 2025-10-23 Pretzel Therapeutics, Inc. Chromen-2-one modulators of polrmt
WO2023034340A1 (en) * 2021-08-30 2023-03-09 Pretzel Therapeutics, Inc. Hydroxy and alkoxy coumarins as modulators of polrmt
US11938127B2 (en) 2021-09-28 2024-03-26 Wayne State University Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders
SMT202500447T1 (it) 2021-11-02 2026-01-12 Flare Therapeutics Inc Agonisti inversi di pparg e loro usi
US20250243172A1 (en) * 2022-04-21 2025-07-31 Virginia Commonwealth University Nlrp3 inflammasome inhibitors and compositions and uses thereof
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
WO2024163546A1 (en) 2023-02-02 2024-08-08 Eli Lilly And Company Novel compounds for tau imaging
WO2025155625A1 (en) 2024-01-16 2025-07-24 Eli Lilly And Company Novel compounds for tau imaging

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0674530B1 (en) * 1992-12-21 2004-09-01 Mallinckrodt Inc. Radiolabeled polyhydric phenol compounds
US5871934A (en) 1993-09-17 1999-02-16 Smithkline Beecham Corporation Screening methods using cytokine suppressive anti-inflammatory drug (CSAID) binding proteins
US6417178B1 (en) 1994-07-19 2002-07-09 University Of Pittsburgh Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
BR9611047A (pt) * 1995-10-17 2000-03-08 Searle & Co Processo de deteção de ciclo oxigenase-2
JPH09165378A (ja) * 1995-12-15 1997-06-24 Seitai Kinou Kenkyusho:Kk N1−[18f]フルオロベンジル複素環化合物およびそれらの製造法
ZA989365B (en) 1997-10-15 1999-04-15 Boehringer Mannheim Pharm Corp Preparation for treating alzheimer's disease
JP2001048786A (ja) 1999-08-05 2001-02-20 Yamanouchi Pharmaceut Co Ltd 三環式ヘテロアリール誘導体
US20020115717A1 (en) 2000-07-25 2002-08-22 Francine Gervais Amyloid targeting imaging agents and uses thereof
CA2444214A1 (en) 2001-04-23 2002-10-31 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
AU2002323417B2 (en) 2001-08-27 2008-05-15 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US20040006092A1 (en) * 2001-08-31 2004-01-08 Neurochem, Inc. Amidine derivatives for treating amyloidosis
CA2464934A1 (en) 2001-10-31 2003-05-08 Bayer Healthcare Ag Pyrimido [4,5-b] indole derivatives
EP1572129A4 (en) * 2002-06-07 2007-03-28 Univ North Carolina AMIDINE DERIVATIVES FOR THE TREATMENT OF AMYLOIDOSE
JP2006513996A (ja) 2002-10-24 2006-04-27 メルク エンド カムパニー インコーポレーテッド 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
WO2004043496A1 (de) 2002-11-11 2004-05-27 Austria Wirtschaftsservice Gesellschaft M.B.H. Fluor-18-markierte fluorchinolone
GB0229686D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
AU2003300522A1 (en) 2002-12-27 2004-07-22 Bayer Healthcare Ag 4-phenyl-pyrimido (4,5-b) indole derivatives
AU2004249529A1 (en) 2003-06-23 2004-12-29 Bellus Health (International) Limited Methods and compositions for treating amyloid-related diseases
EP1655287A1 (en) 2003-08-13 2006-05-10 BF Research Institute, Inc. Probe for diseases with amyloid accumulation, amyloid-staining agent, remedy and preventive for diseases with amyloid accumulation and diagnostic probe and staining agent for neurofibrillary change
JP2006100537A (ja) 2004-09-29 2006-04-13 Konica Minolta Holdings Inc 有機エレクトロルミネッセンス素子、照明装置及び表示装置
US20060110787A1 (en) 2004-11-19 2006-05-25 The Board Trustees Of The University Of Arkansas Use of fluorine-18-labeled fluoroquinolone antibiotics for diagnosing and monitoring bacterial infection
JP2007084526A (ja) * 2004-11-26 2007-04-05 Nagasaki Univ アミロイド関連疾患診断用組成物
EP1815872A4 (en) * 2004-11-26 2011-06-15 Univ Nagasaki COMPOSITION FOR THE DIAGNOSIS OF AMYLOID ASSOCIATED DISEASE
CA2591534C (en) * 2004-12-17 2013-08-06 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
FR2885905A1 (fr) 2005-05-23 2006-11-24 Trophos Sa Nouveaux composes chimiques et leurs utilisations comme medicament
US20070031328A1 (en) * 2005-06-24 2007-02-08 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
WO2007014467A1 (en) 2005-08-03 2007-02-08 Centre For Addiction And Mental Health DlAGNOSIS AND TREATMENT OF MOOD DISORDERS
GB0523506D0 (en) * 2005-11-18 2005-12-28 Hammersmith Imanet Ltd Novel in vivo imaging compounds
EP1954290B1 (en) * 2005-11-22 2012-07-25 Merck Sharp & Dohme Corp. Tricyclic compounds useful as inhibitors of kinases
US8022075B2 (en) 2005-11-30 2011-09-20 Fujifilm Ri Pharma Co., Ltd. Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition
AR059356A1 (es) * 2006-02-14 2008-03-26 Astrazeneca Ab Nuevos radioligandos
JP2007223952A (ja) 2006-02-23 2007-09-06 Tohoku Univ アミロイドβ蛋白が蓄積する疾患の画像診断プローブ
EP2023919A4 (en) 2006-05-08 2010-12-22 Molecular Neuroimaging Llc COMPOUNDS AND AMYLOID PROBES FOR THERAPY AND IMAGING USES
US7678819B2 (en) 2006-12-07 2010-03-16 The Trustees Of The University Of Pennsylvania Acetylene derivatives and their use for binding and imaging amyloid plaques
ES2415863T3 (es) 2006-12-22 2013-07-29 Incyte Corporation Heterociclos sustituidos como inhibidores de Janus Quinasas
EP1944281A1 (en) 2007-01-09 2008-07-16 Technische Universität München 18F-labeled compounds, method for the preparation and use thereof
BRPI0702640A (pt) 2007-01-10 2008-08-26 Comissao Nac Energia Nuclear processo de radiomarcação de flavonóides e sua aplicação em diagnóstico in vivo de disfunções cerebrais relacionadas aos sìtios receptores benzodiazepìnicos
WO2008124812A1 (en) 2007-04-10 2008-10-16 The Trustees Of The University Of Pennsylvania Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques
WO2008131148A1 (en) * 2007-04-19 2008-10-30 The Trustees Of The University Of Pennsylvania Diphenyl-heteroaryl derivatives and their use for binding and imaging amyloid plaques
WO2008132454A1 (en) 2007-04-26 2008-11-06 Ge Healthcare Limited Carbolines and their use as imaging agents
US8942164B2 (en) 2007-10-22 2015-01-27 Texas Instruments Incorporated Differential CQI for OFDMA systems
CA2699965A1 (en) 2007-07-04 2009-01-08 Tohoku University Pet probe having an alkoxy group substituted by fluorine and hydroxy group
WO2009045535A2 (en) 2007-10-04 2009-04-09 Sloan-Kettering Institute For Cancer Research Fluorine-18 derivative of dasatinib and uses thereof
EP2599763A1 (en) 2008-02-14 2013-06-05 Siemens Molecular Imaging, Inc. Novel imaging agents for detecting neurological dysfunction
WO2010011964A2 (en) 2008-07-24 2010-01-28 Siemens Medical Solutions Usa, Inc. Imaging agents useful for identifying ad pathology
JP2012051804A (ja) 2008-12-26 2012-03-15 Kyoto Univ Eg5阻害剤
EP2218464A1 (en) 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
AU2014333996B2 (en) 2013-10-08 2018-03-15 F. Hoffmann-La Roche Ag Diazacarbazole derivatives as tau-pet-ligands
US20180022748A1 (en) 2015-02-02 2018-01-25 Ucb Biopharma Sprl 9h-pyrrolo-dipyridine derivatives

Also Published As

Publication number Publication date
PL2247558T5 (pl) 2024-10-14
ES2907992T5 (en) 2025-03-19
US8318132B2 (en) 2012-11-27
EP2247558B2 (en) 2024-07-03
EP2247558B1 (en) 2022-02-02
WO2009102498A1 (en) 2009-08-20
FI2247558T4 (fi) 2024-09-19
HUE058352T2 (hu) 2022-07-28
DK2247558T3 (da) 2022-02-21
PL2247558T3 (pl) 2022-05-02
SI2247558T2 (sl) 2024-10-30
EP2247558A1 (en) 2010-11-10
SI2247558T1 (sl) 2022-07-29
ES2907992T3 (es) 2022-04-27
US20110046378A1 (en) 2011-02-24
EP2599763A1 (en) 2013-06-05
CY1125258T1 (el) 2024-02-16
LT2247558T (lt) 2022-04-11
PT2247558T (pt) 2022-03-21
HRP20220401T4 (hr) 2024-09-27
KR20100135235A (ko) 2010-12-24
CA2715390A1 (en) 2009-08-20
JP2011512354A (ja) 2011-04-21
HRP20220401T3 (hr) 2022-05-27
US20110091382A1 (en) 2011-04-21

Similar Documents

Publication Publication Date Title
DK2247558T3 (da) Nye billeddannelsesmidler til detektering af neurologisk dysfunktion
DK2853265T3 (da) Fremgangsmåder til at øge stabiliseringen af hypoxi-inducerbar faktor-1-alpha
DK2346321T4 (da) Sammensætning til forbedring af effektiviteten af herbicider
BR112012008061A2 (pt) compostos de oxima heterocíclica
BR112012006686A2 (pt) composto amida substituído
DE602008003015D1 (de) Heterocyclische spiroverbindungen
BRPI0912778A2 (pt) composto de amida
DK3192520T3 (da) Terapeutiske midler til reducering af niveauerne af parathyreoideahormon
DK2313364T3 (da) Fremgangsmåder til detektering af symmetrisk demethylarginin
BRPI1016189A2 (pt) compostos de 4-azetidinil-1-fenil-ciclohexano antagonistas de ccr2
DK3111764T3 (da) Tensider af amin-typen til styring af herbicid spraydrift
BRPI1016125A2 (pt) meio de ancoragem
DK2467220T3 (da) Anordning til udvidelse af hullegemer
DK2557988T3 (da) System til forudsigelse af gastrointestinal dysfunktion
EP2293092A4 (en) MAGNETIC SENSOR ELEMENT IMPEDANCE
BR112012003701A2 (pt) "novos antagonistas de quinolina-hepcidina"
DK2074123T3 (da) Nye anxiolytiske forbindelser
BRPI0813681A2 (pt) Detecção de coproantígeno de nematelminto
EP2254413A4 (en) IMIDAZOBENZAZEPIN-CGRP receptor antagonists
EP2413941A4 (en) Renin Inhibitors
BRPI0923237A2 (pt) compostos de 4-azetidinil-1-heteroaril-ciclohexanol antagonistas de ccr2
BRPI1007350A2 (pt) compostos espiro heterocíclicos bicíclicos
DK2408468T3 (da) Anvendelse af NKp46 til forebyggelse af type 1-diabetes
BRPI1016207A2 (pt) compostos de 4-azetidinil-1-heteroaril-ciclohexano antagonistas de ccr2
DK2462108T3 (da) Fremgangsmåde til fremstilling af pyrazolcarboxylsyreamider