DK2261335T3 - Sammensætninger og fremgangsmåder til forøgelse af knoglemineralisering - Google Patents

Sammensætninger og fremgangsmåder til forøgelse af knoglemineralisering Download PDF

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DK2261335T3
DK2261335T3 DK10008049.8T DK10008049T DK2261335T3 DK 2261335 T3 DK2261335 T3 DK 2261335T3 DK 10008049 T DK10008049 T DK 10008049T DK 2261335 T3 DK2261335 T3 DK 2261335T3
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antibody
fragment
protein
tgf
binding
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Mary E Brunkow
David J Galas
Brian Kovacevich
John T Mulligan
Bryan W Paeper
Ness Jeffrey Van
David G Winkler
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Ucb Pharma Sa
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Claims (42)

1. Antistof eller fragment deraf, der binder til et protein kodet af SEQ ID NO: 1.
2. Antistof eller fragment ifølge krav 1, hvor det kodede protein har sekvensen SEQ ID NO: 2.
3. Antistof eller fragment ifølge krav 1, hvor antistoffet eller fragmentet binder proteinet, når det er udtrykt af insektceller.
4. Antistof eller fragment ifølge krav 3, hvor antistoffet eller fragmentet binder proteinet, når det er udtrykt under anvendelse af et baculovirussystem i Sf9-celler.
5. Antistof eller fragment ifølge krav 1 eller 2, hvor antistoffet eller fragmentet binder proteinet, når det er udtrykt af pattedyrsceller.
6. Antistof eller fragment ifølge krav 1 eller 2, hvor antistoffet eller fragmentet binder proteinet, når det er udtrykt af humane embryoniske nyreceller, eller primære osteoblaster.
7. Antistof eller fragment ifølge krav 6, hvor de humane embryoniske nyreceller er 293-HEK-celler.
8. Antistof eller fragment deraf, som binder til et protein med i det mindste 80% aminosyreidentitet med SEQ ID NO: 2, og som forøger knoglemineralindhold.
9. Antistoffragment ifølge ethvert af de foregående krav, der er en F(ab')2, F(ab)2, Fab', Fab eller Fv.
10. Antistof eller fragment ifølge ethvert af de foregående krav, der er monoklonalt.
11. Antistof eller fragment ifølge krav 10, der er murint eller humant.
12. Antistof eller fragment ifølge ethvert af kravene 1-10, der er humaniseret.
13. Antistof eller fragment ifølge ethvert af kravene 1-8, der er polyklonalt.
14. Antistof eller fragment ifølge ethvert af de foregående krav, der er et antistof eller fragment af IgG-klasse.
15. Antistof eller fragment ifølge krav 14, hvor IgG-klassen er IgGi eller lgG4.
16. Antistof eller fragment ifølge ethvert af kravene 1-13, hvor antistoffet eller fragmentet er et IgE-, IgM- eller IgA-antistof- eller fragment.
17. Antistof eller fragment ifølge ethvert af de foregående krav, der er konjugeret til et effektor- eller reportermolekyle.
18. Antistof ifølge krav 17, hvor antistoffet eller fragmentet er konjugeret til en polymer.
19. Antistof ifølge krav 18, hvor antistoffet eller fragment er konjugeret til polyethylen-glycol.
20. Nukleinsyremolekyle, der koder for et antistof eller fragment ifølge ethvert af kravene 1-12.
21. Ekspressionsvektor indeholdende et nukleinsyremolekyle ifølge krav 20.
22. Celle, der producerer et antistof eller fragment ifølge ethvert af kravene 1-12.
23. Celle ifølge krav 22, der er et hybridoma.
24. Fremgangsmåde til fremstilling af et hybridoma, der producerer et monoklonalt antistof som defineret i krav 10, hvilken fremgangsmåde omfatter: (i) immunisering af en rotte eller mus med et protein kodet af sekvensen i SEQ ID NO: 1 eller en del deraf; (ii) aflivning af rotten eller musen og indhøstning af milten og/eller lymfeknuder fra rotten eller musen; og (iii) fusionering af milt- eller lymfeknudecellesuspensioner med myelomaceller til dannelse af hybridomaer.
25. Fremgangsmåde ifølge krav 24, hvor fremgangsmåden yderligere omfatter screening af hybridomaerne til identifikation af et hybridoma, der producerer et antistof mod proteinet.
26. Fremgangsmåde ifølge krav 24, ved hvilken musen er blevet manipuleret til at producere humane antistoffer.
27. Fremgangsmåde til produktion af et monoklonalt antistof eller antistoffragment ifølge krav 10, hvilken fremgangsmåde omfatter isolering og rensning af antistoffet eller fragmentet fra et hybridoma som defineret i krav 23 eller tilvejebringelse af én eller flere replicerbare DNA indeholdende ekspressionsvektorer, som koder de variable og/eller konstante regioner for antistoffet og transformerer en egnet cellelinie, i hvilken produktionen af antistoffet finder sted.
28. Antistof eller fragment som defineret i ethvert af kravene 1-19 til anvendelse ved en fremgangsmåde til forøgelse af knoglemineralisering hos et varmblodet dyr.
29. Antistof eller fragment til anvendelse ifølge krav 28, hvor det varmblodede dyr har osteopeni eller en knoglefraktur.
30. Antistof eller fragment til anvendelse ifølge krav 29, hvor osteopenien er forårsaget af en anæmisk tilstand, steroider, heparin, en knoglemarvslidelse, skørbug, fejlernæring, calciumdeficiens, idiopatisk osteoporose, kongenital osteopeni eller osteoporose, alkoholisme, kronisk leversygdom, senilitet, postmenopausal tilstand, oligomenorrhea, amenorrhea, graviditet, diabetes mellitus, hyperthyroidisme, Cushing's sygdom, akromegali, hypogonadisme, immobilisering eller inaktivitet, refleks-sympatetisk dystrofi-syndrom, forbigående regional osteoporose eller osteomalaki.
31. Antistof eller fragment til anvendelse ifølge krav 28, hvor dyret har osteoporose.
32. Antistof eller fragment til anvendelse ifølge krav 28, hvor dyret har achondroplasi.
33. Fragment eller antistof til anvendelse ifølge ethvert af kravene 28-32, hvor det varmblodede dyr er et menneske.
34. Farmaceutisk sammensætning indeholdende et antistof eller antistoffragment ifølge ethvert af kravene 1-19 samt et farmaceutisk acceptabelt bærestof eller fortyndingsmiddel.
35. In vitro-fremgangsmåde til detektering af et protein kodet af sekvensen SEQ ID NO: 1, hvilken fremgangsmåde omfatter inkubering af et antistof eller fragment ifølge ethvert af kravene 1-19 under sådanne betingelser og i et tidsrum tilstrækkeligt til at tillade, at antistoffet eller fragmentet binder til proteinet, hvorefter bindingen detekteres.
36. Fremgangsmåde ifølge krav 35, ved hvilken antistoffet eller fragmentet er bundet til en fast understøtning.
37. Fremgangsmåde ifølge krav 36, ved hvilken antistoffet eller fragmentet er mærket.
38. Fremgangsmåde ifølge krav 37, ved hvilken antistoffet eller fragmentet er mærket med en markør valgt fra et enzym, et fluorescerende protein og en radioisotop.
39. Kit til detektering af et protein kodet af SEQ ID NO: 1, indeholdende en beholder, der indeholder et antistof eller fragment ifølge ethvert af kravene 1-19.
40. Anvendelse af et antistof eller fragment som defineret i ethvert af kravene 1-19 til fremstilling af et lægemiddel til forøgelse af knoglemineralisering hos et varmblodet pattedyr.
41. Anvendelse ifølge krav 40, ved hvilken pattedyret har osteopeni eller en knogle-fraktur.
42. Anvendelse ifølge krav 41, ved hvilken pattedyret har osteoporose.
DK10008049.8T 1998-11-27 1999-11-24 Sammensætninger og fremgangsmåder til forøgelse af knoglemineralisering DK2261335T3 (da)

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US11028398P 1998-11-27 1998-11-27
EP06011535A EP1721979B1 (en) 1998-11-27 1999-11-24 Compositions and methods for increasing bone mineralisation

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DK2261335T3 true DK2261335T3 (da) 2017-09-18

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DK06011535.9T DK1721979T3 (da) 1998-11-27 1999-11-24 Sammensætninger og fremgangsmåder til forøgelse af knoglemineralisering
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DK99963986.7T DK1133558T4 (da) 1998-11-27 1999-11-24 Sammensætninger og fremgangsmåder til forøgelse af knoglemineralisering

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CY1110982T1 (el) 2015-06-11

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