DK227186A - Profylaktisk og terapeutisk middel - Google Patents

Profylaktisk og terapeutisk middel Download PDF

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Publication number
DK227186A
DK227186A DK227186A DK227186A DK227186A DK 227186 A DK227186 A DK 227186A DK 227186 A DK227186 A DK 227186A DK 227186 A DK227186 A DK 227186A DK 227186 A DK227186 A DK 227186A
Authority
DK
Denmark
Prior art keywords
prophylactic
therapeutic agent
therapeutic
agent
Prior art date
Application number
DK227186A
Other languages
English (en)
Other versions
DK169672B1 (da
DK227186D0 (da
Inventor
Hiroyoshi Nishi
Toshiaki Watanabe
Satoshi Yuki
Yasuhiro Morinaka
Katsuhiko Iseki
Hiroko Sakurai
Original Assignee
Mitsubishi Chem Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10579885A external-priority patent/JPS61263917A/ja
Priority claimed from JP24805785A external-priority patent/JPS62108814A/ja
Application filed by Mitsubishi Chem Ind filed Critical Mitsubishi Chem Ind
Publication of DK227186D0 publication Critical patent/DK227186D0/da
Publication of DK227186A publication Critical patent/DK227186A/da
Application granted granted Critical
Publication of DK169672B1 publication Critical patent/DK169672B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK227186A 1985-05-20 1986-05-16 Farmaceutiske præparater indeholdende pyrazolonderivater som aktiv bestanddel og anvendelsen af pyrazolonderivater til fremstilling af farmaceutiske præparater DK169672B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP10579885 1985-05-20
JP10579885A JPS61263917A (ja) 1985-05-20 1985-05-20 脳機能正常化剤
JP24805785 1985-11-07
JP24805785A JPS62108814A (ja) 1985-11-07 1985-11-07 過酸化脂質生成抑制剤

Publications (3)

Publication Number Publication Date
DK227186D0 DK227186D0 (da) 1986-05-16
DK227186A true DK227186A (da) 1986-11-21
DK169672B1 DK169672B1 (da) 1995-01-09

Family

ID=26446032

Family Applications (1)

Application Number Title Priority Date Filing Date
DK227186A DK169672B1 (da) 1985-05-20 1986-05-16 Farmaceutiske præparater indeholdende pyrazolonderivater som aktiv bestanddel og anvendelsen af pyrazolonderivater til fremstilling af farmaceutiske præparater

Country Status (4)

Country Link
US (1) US4857542A (da)
EP (1) EP0208874B1 (da)
DE (1) DE3673273T2 (da)
DK (1) DK169672B1 (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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EP0235567B1 (en) * 1986-01-29 1994-01-12 Sumitomo Chemical Company, Limited Indazole compounds, their production, use and intermediates
DE3789754T2 (de) * 1986-11-20 1994-12-15 Mitsubishi Chem Ind Die Bildung von Lipid-peroxiden hemmende Zusammenstzung und dafür geeignete Verbindungen.
IL84944A (en) * 1987-01-19 1992-02-16 Ici Plc Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation
US5233044A (en) * 1989-06-08 1993-08-03 Millipore Corporation Active esters for solid phase peptide synthesis
US5264451A (en) * 1992-04-07 1993-11-23 American Home Products Corporation Process for treating hyperglycemia using trifluoromethyl substituted 3H-pyrazol-3-ones
JPH0725765A (ja) * 1993-07-07 1995-01-27 Mitsubishi Chem Corp 眼疾患用薬剤
JP3065506B2 (ja) * 1995-04-03 2000-07-17 株式会社資生堂 ピラゾリジン誘導体及びラジカルスカベンジャー、脳梗塞抑制剤、脳浮腫抑制剤
DE19518082A1 (de) * 1995-05-17 1996-11-21 Merck Patent Gmbh 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one
DE19756115A1 (de) * 1997-12-17 1999-06-24 Basf Ag Substituierte Phenylpyrazolone, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen und tierischen Schädlingen
US20030109566A1 (en) * 2000-06-29 2003-06-12 Tomiya Mano Remedial agent for optic nerve disease and the like
RU2192419C2 (ru) * 2000-08-17 2002-11-10 Открытое Акционерное Общество "Каустик" Способ получения 1-фенил-3-метил-пиразолона-5
WO2002034264A1 (en) * 2000-10-24 2002-05-02 Mitsubishi Pharma Corporation Remedies for amyotrophic lateral sclerosis (als)
KR100921199B1 (ko) 2001-05-11 2009-10-13 미쓰비시 타나베 파마 코퍼레이션 안정하고 고농도인 피라졸론 유도체를 포함하는 주사제
ES2318036T3 (es) * 2001-09-14 2009-05-01 Mitsubishi Tanabe Pharma Corporation Farmacos que comprenden una combinacion de un agente antitrombotico con un derivado de pirazolona.
JPWO2003064395A1 (ja) * 2002-01-31 2005-05-26 国立精神・神経センター総長 神経変性疾患の予防又は治療剤
JPWO2003066051A1 (ja) * 2002-02-06 2005-05-26 三菱ウェルファーマ株式会社 心筋機能障害の予防及び／又は治療剤
JP2005343789A (ja) * 2002-03-15 2005-12-15 Mitsubishi Pharma Corp 低酸素性虚血性脳障害予防・治療剤
JPWO2003105909A1 (ja) * 2002-06-13 2005-10-13 三菱ウェルファーマ株式会社 肝虚血再灌流傷害の予防及び／又は治療のための医薬並びに移植肝臓の保護剤
AU2003252397A1 (en) * 2002-08-05 2004-02-23 Mitsubishi Pharma Corporation Drugs for preventing and/or treating spinal injury
US7312239B2 (en) * 2002-09-04 2007-12-25 Mitsubishi Pharma Corporation Medicament for prevention and/or therapy of arterial wall disorder
CA2497955A1 (en) * 2002-09-09 2004-03-18 Mitsubishi Pharma Corporation Medicament for preventing and/or treating inflammatory bowel disease
JP2006504803A (ja) * 2002-09-26 2006-02-09 ファイザー・インク ピラゾール誘導体
US7230025B2 (en) 2002-09-26 2007-06-12 Pfizer, Inc. Pyrazole derivatives
AU2003282679A1 (en) * 2002-10-04 2004-05-04 Arena Pharmaceuticals, Inc. Hydroxypyrazoles for use against metabolic-related disorders
JP2006096664A (ja) * 2002-10-18 2006-04-13 Mitsubishi Pharma Corp 肝繊維化抑制剤
AU2003275707A1 (en) * 2002-10-28 2004-05-13 Mitsubishi Pharma Corporation Agent for alleviation of functional disorder after cardiopulmonary resuscitation
KR20050114606A (ko) * 2003-01-10 2005-12-06 미츠비시 웰파마 가부시키가이샤 혈액뇌관문 파탄 억제제
AU2003280739A1 (en) * 2003-11-12 2004-06-06 Lead Chemical Co., Ltd. Percutaneous absorption type cerebral protective agent
CA2555457C (en) 2004-02-09 2012-08-21 Mitsubishi Pharma Corporation A novel therapeutic agent for amyotrophic lateral sclerosis (als) or diseases caused by als
CA2576544A1 (en) 2004-08-10 2006-02-16 Mitsubishi Pharma Corporation Pyrazolone compounds useful for treatment of cerebrovascular disorders associated with ischemic stroke
US7850723B1 (en) * 2005-11-28 2010-12-14 Innercool Therapies, Inc. Method and apparatus for patient temperature control employing titration of therapy using EEG signals
CN101367763B (zh) * 2007-08-17 2012-06-27 深圳泛胜塑胶助剂有限公司 1-苯基-3-甲基-5-吡唑酮的合成工艺
WO2009066752A1 (ja) 2007-11-22 2009-05-28 Mitsubishi Tanabe Pharma Corporation 環状ポリオレフィン層を含むプラスチック容器
CN101524352A (zh) 2008-03-04 2009-09-09 江苏先声药物研究有限公司 一种含有3-甲基-1-苯基-2-吡唑啉-5-酮的组合物
CN101830852B (zh) * 2010-03-22 2012-05-09 海南美兰史克制药有限公司 一种新路线的依达拉奉化合物
CN102241631A (zh) * 2010-05-13 2011-11-16 吉林省博大制药有限责任公司 依达拉奉原料的制备方法
CN102180834B (zh) * 2011-03-24 2012-09-26 江苏正大丰海制药有限公司 一种依达拉奉的制备方法
KR20200105980A (ko) 2011-09-05 2020-09-09 미쓰비시 타나베 파마 코퍼레이션 근위축성 측색경화증의 치료 또는 병세 진전 억제를 위한 약제
CN103588709B (zh) * 2012-08-17 2015-09-09 上海医药工业研究院 一种依达拉奉的制备方法
AU2013341711A1 (en) * 2012-11-12 2015-05-21 Redwood Bioscience, Inc. Compounds and methods for producing a conjugate
JP2017222575A (ja) 2014-09-19 2017-12-21 田辺三菱製薬株式会社 眼科疾患予防治療剤
CN104326984A (zh) * 2014-10-10 2015-02-04 河南明德科润医药科技有限责任公司 一种高纯度药用注射级依达拉奉原料的合成方法
CN106117144B (zh) * 2016-06-24 2019-01-29 合肥久诺医药科技有限公司 一种高纯度依达拉奉的合成工艺
WO2019070932A1 (en) 2017-10-04 2019-04-11 Mitsubishi Tanabe Pharma Corporation METHOD OF TREATING AMYOTROPHIC LATERAL SCLEROSIS AND METHOD OF PREVENTING THE PROGRESSION OF AMYOTROPHIC LATERAL SCLEROSIS
WO2019070308A1 (en) 2017-10-04 2019-04-11 Mitsubishi Tanabe Pharma Corporation METHOD FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS AND METHOD FOR PREVENTING THE PROGRESSION OF AMYOTROPHIC LATERAL SCLEROSIS
WO2019167178A1 (ja) 2018-02-28 2019-09-06 田辺三菱製薬株式会社 ３－メチル－１－フェニル－２－ピラゾリン－５－オン原薬の分析方法、筋萎縮性側索硬化症の治療および筋萎縮性側索硬化症の進行抑制、ならびに、３－メチル－１－フェニル－２－ピラゾリン－５－オン原薬を含む薬剤の製造方法
EP4473965A4 (en) 2022-02-03 2026-01-07 Mitsubishi Tanabe Pharma Corp MEDICAL AGENT FOR THE TREATMENT OR SUPPRESSION OF THE PROGRESSION OF AMYOTROPHIC LATERAL SCLEROSIS
CN119790165A (zh) 2022-07-01 2025-04-08 田边三菱制药株式会社 用于评估依达拉奉响应性的组合物和方法

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Also Published As

Publication number Publication date
DK169672B1 (da) 1995-01-09
DE3673273T2 (de) 1993-09-09
EP0208874A1 (en) 1987-01-21
EP0208874B1 (en) 1993-03-24
DE3673273D1 (de) 1993-04-29
US4857542A (en) 1989-08-15
DK227186D0 (da) 1986-05-16

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