DK2343275T3 - Krystallinsk form af optiske enantiomerer af modafinil - Google Patents

Krystallinsk form af optiske enantiomerer af modafinil

Info

Publication number: DK2343275T3
Authority: DK; Denmark
Prior art keywords: modafinil; crystalline form; optical enantiomers; enantiomers; optical
Prior art date: 2002-12-20

Application number

DK11163602.3T

Other languages

English (en)

Inventor

Gilles Serrure

Franck Mallet

Sebastien Rose

Olivier Neckebrock

Laurent Courvoisier

Stephanie Graf

Gerard Coquerel

Christine Besselievre

Langevelde Adriaan Jan Van

Pierre Leproust

Original Assignee

Teva Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-20

Filing date

2003-12-18

Publication date

2013-07-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32406320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2343275(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-12-18 Application filed by Teva Sante filed Critical Teva Sante

2013-07-01 Application granted granted Critical

2013-07-01 Publication of DK2343275T3 publication Critical patent/DK2343275T3/da

Links

YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
229960001165 modafinil Drugs 0.000 title 1
230000003287 optical effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/06—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Psychology (AREA)
Nutrition Science (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK11163602.3T 2002-12-20 2003-12-18 Krystallinsk form af optiske enantiomerer af modafinil DK2343275T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0216412A FR2849029B1 (fr)	2002-12-20	2002-12-20	Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP03799631.1A EP1572635B1 (fr)	2002-12-20	2003-12-18	Procede de preparation et formes cristallines des enantiomeres optiques du modafinil

Publications (1)

Publication Number	Publication Date
DK2343275T3 true DK2343275T3 (da)	2013-07-01

Family

ID=32406320

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK11163602.3T DK2343275T3 (da)	2002-12-20	2003-12-18	Krystallinsk form af optiske enantiomerer af modafinil

Country Status (30)

Country	Link
US (10)	US7132570B2 (da)
EP (6)	EP2679578B1 (da)
JP (2)	JP4719471B2 (da)
KR (1)	KR101050565B1 (da)
CN (5)	CN106065007A (da)
AR (1)	AR042546A1 (da)
AU (2)	AU2003299349C1 (da)
BR (1)	BRPI0316916B1 (da)
CA (2)	CA2510096C (da)
CL (2)	CL2007002450A1 (da)
CY (1)	CY1114291T1 (da)
DK (1)	DK2343275T3 (da)
EA (1)	EA009592B1 (da)
EG (1)	EG24849A (da)
ES (3)	ES2627808T3 (da)
FR (1)	FR2849029B1 (da)
HK (1)	HK1225371A1 (da)
IL (1)	IL169205A (da)
IS (1)	IS7947A (da)
MX (1)	MXPA05006525A (da)
MY (1)	MY142926A (da)
NO (1)	NO335724B1 (da)
NZ (2)	NZ540733A (da)
PL (1)	PL377196A1 (da)
PT (1)	PT2343275E (da)
SI (1)	SI2343275T1 (da)
TW (1)	TWI344952B (da)
UA (1)	UA100964C2 (da)
WO (1)	WO2004060858A1 (da)
ZA (1)	ZA200504805B (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7790905B2 (en)	2002-02-15	2010-09-07	Mcneil-Ppc, Inc.	Pharmaceutical propylene glycol solvate compositions
WO2003074474A2 (en)	2002-03-01	2003-09-12	University Of South Florida	Multiple-component solid phases containing at least one active pharmaceutical ingredient
US20050025791A1 (en)	2002-06-21	2005-02-03	Julius Remenar	Pharmaceutical compositions with improved dissolution
US7927613B2 (en)	2002-02-15	2011-04-19	University Of South Florida	Pharmaceutical co-crystal compositions
FR2849029B1 (fr)	2002-12-20	2005-03-18	Lafon Labor	Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
US8183290B2 (en)	2002-12-30	2012-05-22	Mcneil-Ppc, Inc.	Pharmaceutically acceptable propylene glycol solvate of naproxen
WO2004082630A2 (en) *	2003-03-17	2004-09-30	Neurohealing Pharmaceuticals, Inc.	High potency dopaminergic treatment of neurological impairment associated with brain injury
EP1603889A1 (en)	2003-03-17	2005-12-14	Hetero Drugs Limited	Novel crystalline forms of lamotrigine
JP4842819B2 (ja) *	2003-09-04	2011-12-21	セフアロン・インコーポレーテツド	モダフィニル組成物
EP1516869A1 (en)	2003-09-19	2005-03-23	Cephalon France	Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7368591B2 (en)	2003-09-19	2008-05-06	Cephalon France	Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP2292213A1 (en) *	2004-02-06	2011-03-09	Cephalon, Inc.	Compositions comprising a polymorphic form of armodafinil
US20090018202A1 (en)	2004-02-06	2009-01-15	Cephalon, Inc.	Modafinil compositions
EP1718607A4 (en) *	2004-02-06	2008-05-28	Cephalon Inc	COMPOSITIONS BASED ON MODAFINIL
JP2008506764A (ja)	2004-07-20	2008-03-06	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	［Ｒ−（Ｒ＊，Ｒ＊）］−２−（４−フルオロフェニル）−β、δ−ジヒドロキシ−５−（１−メチルエチル）−３−フェニル−４−［（フェニルアミノ）カルボニル］−１Ｈ−ピロール−１−ヘプタン酸カルシウム塩（２：１）の新規形態
US20060086667A1 (en) *	2004-09-13	2006-04-27	Cephalon, Inc., U.S. Corporation	Methods for the separation of enantiomeric sulfinylacetamides
EP1702915A1 (en) *	2005-03-14	2006-09-20	Cephalon France	Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
US20090123545A1 (en) *	2005-07-21	2009-05-14	Ron Eyal S	Rapid Onset and Short Term Modafinil Compositions and Methods of Use Thereof
JP2009508880A (ja) *	2006-02-21	2009-03-05	テバファーマシューティカルインダストリーズリミティド	アルモダフィニルの新規な結晶形とその調製方法
WO2007103221A2 (en) *	2006-03-01	2007-09-13	Teva Pharmaceutical Industries Ltd.	An improved process for the preparation of armodafinil
MX2009000391A (es) *	2006-07-12	2009-06-30	Elan Pharma Int Ltd	Formulación de modafinilo en forma de nano-partículas.
CA2660565C (en) *	2006-08-14	2012-10-09	Neurohealing Pharmaceuticals, Inc.	Modafinil-based treatment for premature ejaculation
US20080214862A1 (en) *	2006-12-06	2008-09-04	Ben-Zion Dolitzky	Processes for preparing armodafinil intermediate
CN101641090B (zh) *	2006-12-19	2012-12-05	亚勒斯有限公司	莫达非尼在制备治疗多动腿综合征的药物中的应用
AU2008259588A1 (en) *	2007-06-04	2008-12-11	Generics [Uk] Limited	Novel process
WO2009024863A2 (en) *	2007-06-26	2009-02-26	Actavis Group Ptc Ehf	Process for the preparation of modafinil enantiomers
US7960586B2 (en)	2007-08-16	2011-06-14	Teva Pharmaceutical Industries Ltd.	Purification of armodafinil
US20090082462A1 (en) *	2007-09-25	2009-03-26	Protia, Llc	Deuterium-enriched armodafinil
US20090105346A1 (en) *	2007-10-02	2009-04-23	Alexandr Jegorov	Novel crystalline forms of armodafinil and preparation thereof
WO2009090663A1 (en) *	2008-01-15	2009-07-23	Lupin Limited	Novel crystalline polymorph of armodafinil and an improved process for preparation thereof
US20090325999A1 (en) *	2008-06-27	2009-12-31	Jie Du	Personalized pharmaceutical kits, packaging and compositions for the treatment of allergic conditions
US20100036164A1 (en) *	2008-08-06	2010-02-11	Srinivas Areveli	Preparation of armodafinil form i
EP2292306B1 (en)	2009-09-02	2013-05-01	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Method for separation of racemic compound-forming chiral substances by a cyclic crystallization process and a crystallization device
WO2011061610A2 (en) *	2009-11-19	2011-05-26	Ranbaxy Laboratories Limited	Processes for preparation of polymorphic forms of lacosamide
US20110224196A1 (en) *	2010-01-07	2011-09-15	Vivus, Inc.	Treatment of obstructive sleep apnea syndrome with a combination of a carbonic anhydrase inhibitor and an additional active agent
HUE037616T2 (hu)	2010-12-08	2018-09-28	Codexis Inc	Biokatalizátorok és eljárások armodafinil szintéziséhez
JP6116847B2 (ja) *	2012-10-01	2017-04-19	アムビトバイオサイエンシスコーポレーションＡｍｂｉｔＢｉｏｓｃｉｅｎｃｅｓＣｏｒｐｏｒａｔｉｏｎ	シクロデキストリンとの混合体を含有する錠剤
US10466776B2 (en) *	2014-06-24	2019-11-05	Paypal, Inc.	Surfacing related content based on user interaction with currently presented content
WO2016012865A2 (en) *	2014-07-23	2016-01-28	Yonatan Wexler	Wearable apparatus and methods for processing image data
KR20180123194A (ko) *	2014-11-27	2018-11-14	가부시키가이샤 지씨	왁스 패턴용 표면처리제 및 치과용 보철물을 제조하기 위한 방법
WO2017064723A1 (en) *	2015-10-12	2017-04-20	Natco Pharma Ltd	An improved process for the preparation of armodafinil

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1905990A (en)	1931-01-02	1933-04-25	Hoffmann La Roche	Disubstituted carbamic acid esters of phenols containing a basic constituent
GB1197809A (en)	1968-02-13	1970-07-08	Inst Noguchi	Method for Continuous Optical Resolution of Organic Racemates.
GB1584462A (en)	1977-03-31	1981-02-11	Lafon Labor	N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2593809B1 (fr) *	1986-01-31	1988-07-22	Lafon Labor	Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
FR2597864B1 (fr)	1986-04-28	1990-11-16	Lafon Labor	Nouveaux derives de la n-((trimethoxy-2,4,6-benzoyl)-3 propyl) piperidine, leurs procedes de preparation et leur application en therapeutique
FR2626881B1 (fr)	1988-02-10	1990-07-27	Lafon Labor	1-(4-aminophenyl)-2-hexamethyleneiminopropanone, procede de preparation et utilisation en therapeutique
FR2663225B1 (fr) *	1990-06-14	1994-11-04	Lafon Labor	Nouvelle utilisation du modafinil.
FR2671349B1 (fr)	1991-01-09	1993-04-23	Lafon Labor	Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
FR2710337B1 (fr) *	1993-09-23	1995-12-08	Gerard Coquerel	Procédé de dédoublement de deux antipodes optiques par entraînement polythermique programmé et autoensemencé.
US6894171B1 (en)	1998-07-20	2005-05-17	Abbott Laboratories	Polymorph of a pharmaceutical
CN1249932A (zh)	1999-09-29	2000-04-12	付俊昌	一种莫达芬尼及其光学对映体l及d异构体的新用途
SK9742002A3 (en)	2000-01-07	2003-02-04	Transform Pharmaceuticals Inc	High-throughput formation, identification, and analysis of diverse solid-forms
US20010036640A1 (en)	2000-04-25	2001-11-01	D'amico Kevin L.	System and methods for the high throughput screening of polymorphs
US6492396B2 (en) *	2000-05-16	2002-12-10	Cephalon, Inc.	Substituted thioacetamides
US6670358B2 (en)	2000-05-16	2003-12-30	Cephalon, Inc.	Substituted thioacetamides
DE10025756C2 (de) *	2000-05-25	2003-02-20	Cognis Deutschland Gmbh	Lösungsvermittler
DK1787980T3 (da) *	2000-07-27	2010-04-26	Teva Pharma	Krystallint og rent modafinil og fremgangsmåde til atfremstille dette
US6835307B2 (en) *	2000-08-04	2004-12-28	Battelle Memorial Institute	Thermal water treatment
US6489363B2 (en)	2000-10-11	2002-12-03	Cephalon, Inc.	Pharmaceutical solutions of modafinil compounds
US6919378B2 (en)	2000-10-11	2005-07-19	Cephalon, Inc.	Pharmaceutical solutions of modafinil compounds
CZ20031495A3 (cs)	2000-11-03	2004-01-14	Teva Pharmaceutical Industries Ltd.	Forma VII hemi-kalcium atorvastatinu
IL158959A (en)	2001-05-25	2010-06-30	Cephalon Inc	Solid pharmaceutical formulations comprising modafinil
EP1425577A4 (en)	2001-08-10	2004-12-29	Symyx Technologies Inc	APPARATUSES AND METHODS FOR PREPARING AND TESTING PRE-FORMULATIONS AND CORRESPONDING SYSTEMS
WO2003060497A1 (en)	2002-01-15	2003-07-24	Avantium International B.V.	Method for performing powder diffraction analysis
US6875893B2 (en) *	2002-05-23	2005-04-05	Cephalon, Inc.	Preparations of a sulfinyl acetamide
US7229644B2 (en)	2002-05-23	2007-06-12	Cephalon, Inc.	Pharmaceutical formulations of modafinil
US20040048931A1 (en)	2002-07-12	2004-03-11	Craig Heacock	Modafinil pharmaceutical compositions
ATE366137T1 (de)	2002-08-02	2007-07-15	Avantium Int Bv	Vorrichtung und verfahren zur parallelen durchführung chemischer experimente, insbesondere kristallisationsexperimente
US6992219B2 (en) *	2002-08-09	2006-01-31	Cephalon France	Modafinil polymorphic forms
EP1567497B1 (en)	2002-12-06	2009-09-23	Purdue Research Foundation	Pyridines for treating injured mammalian nerve tissue
FR2849029B1 (fr)	2002-12-20	2005-03-18	Lafon Labor	Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
AU2004270238B2 (en)	2003-09-04	2010-07-29	Cephalon, Inc.	Modafinil compositions
US7566805B2 (en) *	2003-09-04	2009-07-28	Cephalon, Inc.	Modafinil compositions
EP1718607A4 (en)	2004-02-06	2008-05-28	Cephalon Inc	COMPOSITIONS BASED ON MODAFINIL
US20090018202A1 (en) *	2004-02-06	2009-01-15	Cephalon, Inc.	Modafinil compositions
CA2584246C (en)	2004-10-13	2011-08-09	Pharmacia & Upjohn Company Llc	Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6h)-yl]-n-(2-hydroxyethyl)-4-methylbenzamide
US20090123545A1 (en) *	2005-07-21	2009-05-14	Ron Eyal S	Rapid Onset and Short Term Modafinil Compositions and Methods of Use Thereof
JP2009508880A (ja)	2006-02-21	2009-03-05	テバファーマシューティカルインダストリーズリミティド	アルモダフィニルの新規な結晶形とその調製方法
WO2007103221A2 (en)	2006-03-01	2007-09-13	Teva Pharmaceutical Industries Ltd.	An improved process for the preparation of armodafinil
AU2008259588A1 (en)	2007-06-04	2008-12-11	Generics [Uk] Limited	Novel process
WO2009024863A2 (en)	2007-06-26	2009-02-26	Actavis Group Ptc Ehf	Process for the preparation of modafinil enantiomers
US7960586B2 (en)	2007-08-16	2011-06-14	Teva Pharmaceutical Industries Ltd.	Purification of armodafinil
US20090105346A1 (en) *	2007-10-02	2009-04-23	Alexandr Jegorov	Novel crystalline forms of armodafinil and preparation thereof
EP1911739A3 (en) *	2007-11-05	2008-09-17	Dipharma Francis S.r.l.	Crystalline form of (S)-2-phenylethylammonium (R)-diphenyl-methanesulphinyl-acetate
WO2009090663A1 (en)	2008-01-15	2009-07-23	Lupin Limited	Novel crystalline polymorph of armodafinil and an improved process for preparation thereof

2002
- 2002-12-20 FR FR0216412A patent/FR2849029B1/fr not_active Expired - Fee Related
2003
- 2003-12-18 ES ES03799631.1T patent/ES2627808T3/es not_active Expired - Lifetime
- 2003-12-18 ES ES11163602T patent/ES2425023T3/es not_active Expired - Lifetime
- 2003-12-18 BR BRPI0316916-2A patent/BRPI0316916B1/pt not_active IP Right Cessation
- 2003-12-18 CN CN201610461501.9A patent/CN106065007A/zh active Pending
- 2003-12-18 CN CN2010101503175A patent/CN101914044A/zh active Pending
- 2003-12-18 EP EP13177660.1A patent/EP2679578B1/fr not_active Expired - Lifetime
- 2003-12-18 ES ES13177660.1T patent/ES2575018T3/es not_active Expired - Lifetime
- 2003-12-18 PT PT111636023T patent/PT2343275E/pt unknown
- 2003-12-18 CA CA2510096A patent/CA2510096C/fr not_active Expired - Lifetime
- 2003-12-18 CN CN200910152177A patent/CN101654423A/zh active Pending
- 2003-12-18 EP EP11163602.3A patent/EP2343275B1/fr not_active Expired - Lifetime
- 2003-12-18 SI SI200332281T patent/SI2343275T1/sl unknown
- 2003-12-18 WO PCT/FR2003/003799 patent/WO2004060858A1/fr not_active Ceased
- 2003-12-18 JP JP2004564285A patent/JP4719471B2/ja not_active Expired - Fee Related
- 2003-12-18 EP EP13177658.5A patent/EP2679577A3/fr not_active Withdrawn
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- 2003-12-18 EA EA200501016A patent/EA009592B1/ru not_active IP Right Cessation
- 2003-12-18 EP EP13177648.6A patent/EP2679576A3/fr not_active Withdrawn
- 2003-12-18 EP EP03799631.1A patent/EP1572635B1/fr not_active Expired - Lifetime
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- 2003-12-18 CA CA2724305A patent/CA2724305A1/fr not_active Abandoned
- 2003-12-18 DK DK11163602.3T patent/DK2343275T3/da active
- 2003-12-18 EP EP13177661.9A patent/EP2676952A3/fr not_active Withdrawn
- 2003-12-18 US US10/539,918 patent/US7132570B2/en not_active Expired - Fee Related
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2007
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Also Published As

Publication number	Publication date
EP2343275B1 (fr)	2013-04-24
CN100540533C (zh)	2009-09-16
FR2849029A1 (fr)	2004-06-25
CN1751021A (zh)	2006-03-22
US20100048718A1 (en)	2010-02-25
EP2679576A2 (fr)	2014-01-01
US9382200B2 (en)	2016-07-05
US20060241320A1 (en)	2006-10-26
US8975442B2 (en)	2015-03-10
BR0316916A (pt)	2005-10-18
CL2016002640A1 (es)	2017-03-24
HK1192222A1 (zh)	2014-08-15
IL169205A (en)	2013-11-28
IS7947A (is)	2005-07-19
CN101654423A (zh)	2010-02-24
US20100048719A1 (en)	2010-02-25
EP1572635A1 (fr)	2005-09-14
JP2006511588A (ja)	2006-04-06
ZA200504805B (en)	2006-07-26
EA009592B1 (ru)	2008-02-28
TWI344952B (en)	2011-07-11
NZ540733A (en)	2008-10-31
US20100022653A1 (en)	2010-01-28
US20140031589A1 (en)	2014-01-30
NO20052912L (no)	2005-07-19
JP2011102330A (ja)	2011-05-26
KR20050085847A (ko)	2005-08-29
JP5497680B2 (ja)	2014-05-21
BRPI0316916B1 (pt)	2021-11-30
US20090281193A1 (en)	2009-11-12
NZ571235A (en)	2010-01-29
CA2724305A1 (fr)	2004-07-22
TW200419175A (en)	2004-10-01
BRPI0316916A8 (pt)	2015-09-22
US20100048720A1 (en)	2010-02-25
AU2010212462A1 (en)	2010-09-16
EP2679577A3 (fr)	2014-02-12
CN101012189A (zh)	2007-08-08
US20090281192A1 (en)	2009-11-12
CA2510096C (fr)	2011-02-22
UA100964C2 (ru)	2013-02-25
CN101914044A (zh)	2010-12-15
US20060135621A1 (en)	2006-06-22
EP1572635B1 (fr)	2017-04-12
FR2849029B1 (fr)	2005-03-18
CN106065007A (zh)	2016-11-02
EP2679576A3 (fr)	2014-02-12
AU2003299349A1 (en)	2004-07-29
PT2343275E (pt)	2013-07-30
EP2343275A2 (fr)	2011-07-13
EP2679578A3 (fr)	2014-03-19
ES2627808T3 (es)	2017-07-31
EP2679578A2 (fr)	2014-01-01
EP2343275A3 (fr)	2011-08-17
AU2003299349A8 (en)	2004-07-29
MXPA05006525A (es)	2005-12-05
WO2004060858A1 (fr)	2004-07-22
ES2575018T3 (es)	2016-06-23
EA200501016A1 (ru)	2005-12-29
AR042546A1 (es)	2005-06-22
EP2679578B1 (fr)	2016-03-09
CL2007002450A1 (es)	2009-01-16
CN101012189B (zh)	2013-03-13
CY1114291T1 (el)	2016-08-31
KR101050565B1 (ko)	2011-07-19
CA2510096A1 (fr)	2004-07-22
SI2343275T1 (sl)	2013-10-30
PL377196A1 (pl)	2006-01-23
HK1225371A1 (zh)	2017-09-08
US20130274521A1 (en)	2013-10-17
MY142926A (en)	2011-01-31
EP2676952A2 (fr)	2013-12-25
JP4719471B2 (ja)	2011-07-06
ES2425023T3 (es)	2013-10-10
EP2679577A2 (fr)	2014-01-01
US7132570B2 (en)	2006-11-07
AU2003299349B2 (en)	2010-06-03
US8729305B2 (en)	2014-05-20
NO335724B1 (no)	2015-02-02
EG24849A (en)	2010-10-27
EP2676952A3 (fr)	2014-02-12
NO20052912D0 (no)	2005-06-15
AU2003299349C1 (en)	2011-01-20

Publication	Publication Date	Title
SI2343275T1 (sl)	2013-10-30	Kristaliniäśna oblika optiäśnih enantiomerov modafinila
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