DK2363140T3 - Antisekretorisk protein til anvendelse i behandlingen af kompartmentsyndrom - Google Patents
Antisekretorisk protein til anvendelse i behandlingen af kompartmentsyndrom Download PDFInfo
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- DK2363140T3 DK2363140T3 DK10188590.3T DK10188590T DK2363140T3 DK 2363140 T3 DK2363140 T3 DK 2363140T3 DK 10188590 T DK10188590 T DK 10188590T DK 2363140 T3 DK2363140 T3 DK 2363140T3
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- protein
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- homologue
- antisecretory
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000000427 trigeminal ganglion Anatomy 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 108010015385 valyl-prolyl-proline Proteins 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000028973 vesicle-mediated transport Effects 0.000 description 1
- 239000005723 virus inoculator Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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Claims (16)
1. Antisekretionsfaktor (AF) -protein, en homolog og/eller et fragment deraf med antisekretorisk aktivitet, og/eller et farmaceutisk aktivt salt deraf, til anvendelse i behandlingen og/eller forebyggelsen af et kompartmentsyndrom forårsaget af tilstedeværelsen af en godartet og/eller en ondartet tumor i et legeme.
2. Antisekretionsfaktor (AF) -protein, en homolog og/eller et fragment deraf med antisekretorisk aktivitet, og/eller et farmaceutisk aktivt salt deraf, til anvendelse ifølge krav 1, hvor kompartmentsyndromet er forårsaget af behandlingen af en tumor og/eller nærliggende strukturer.
3. Antisekretionsfaktor (AF) -protein til anvendelse ifølge krav 1, hvor antisekretionsfaktor (AF) -proteinet svarer til en aminosyresekvens som vist i SEQ ID NO 6:, eller en homolog og/eller et fragment deraf omfattende aminosyrer 38-42 af SEQ ID NO: 6, og/eller et farmaceutisk aktivt salt deraf.
4. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge krav 1, bestående af en sekvens ifølge den følgende formel
hvor XI er I, aminosyrer 1-35 af SEQ ID NO: 5, eller er fraværende, X2 er H, R eller K, X3 er S eller L, X4 er T eller A, X5 er aminosyrer 43-46, 43-51, 43-80 eller 43-163 af SEQ ID NO: 6, eller er fraværende, og/eller et farmaceutisk aktivt salt deraf.
5. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge krav 1, hvor fragmentet omfatter en aminosyresekvens som vist i SEQ ID NO:l, SEQ ID NO:2, SEQ ID NO:3, SEQ ID N0:4, eller SEQ ID NO:5, og/eller et farmaceutisk aktivt salt deraf.
6. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-4, hvor tumoren er en primær tumor eller en metastase.
7. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-6, hvor kompartmentsyndromet er forårsaget af bivirkninger forårsaget af behandling af tumoren med røntgen, højenergi stråling, lokal afkøling, lokal opvarmning, lysterapi og/eller lægemidler anvendt til behandlingen af tumoren.
8. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af de foregående krav, hvor behandlingen af kompartmentsyndromet forbedrer effektiviteten af cancerterapi ved at sænke det interstitielle tryk.
9. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af de foregående krav, hvor antisekretionsfaktor (AF) -proteinet, en homolog, og/eller fragment deraf er til stede i en farmaceutisk sammensætning og/eller en medicinsk fødevare.
10. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge krav 9, hvor den farmaceutiske sammensætning og/eller den medicinske fødevare omfatter to eller flere antisekretoriske proteiner, eller en homolog, og/eller fragment deraf ifølge et hvilket som helst af kravene 1-4.
11. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af kravene 9-10, hvor den farmaceutiske sammensætning yderligere omfatter en farmaceutisk acceptabel excipiens.
12. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af kravene 9-11, hvor den farmaceutiske sammensætning er formuleret til administration i en kropsåbning, intraokulært, intranasalt, oralt, lokalt, kutant, subkutant, intramuskulært og/eller systemisk.
13. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af kravene 9-12, hvor den farmaceutiske sammensætning er formuleret til administration som en spray, aerosol, inhalator eller ved hjælp af en forstøver.
14. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af kravene 9-13, hvor den farmaceutiske sammensætning er formuleret til systemisk administration til blodet med en indgivelsesdosis på 0,1 pg til 10 mg per kg kropsvægt og dag, fortrinsvis 1-1000 pg per kg kropsvægt og dag.
15. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af kravene 9-14, hvor administrationen udføres enten som en enkelt dosis eller som flere daglige indgivelser.
16. Antisekretionsfaktor (AF) -protein, eller en homolog og/eller et fragment deraf til anvendelse ifølge et hvilket som helst af de foregående krav, hvor det antisekretoriske protein er tilvejebragt i æggeblomme beriget med sådant antisekretorisk protein, og hvor det antisekretoriske protein fortrinsvis er tilvejebragt i æggeblommen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0600933 | 2006-04-27 | ||
| EP07748078A EP2040734B1 (en) | 2006-04-27 | 2007-04-27 | Antisecretory protein for use in the treatment of compartment syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2363140T3 true DK2363140T3 (da) | 2017-03-06 |
Family
ID=38655929
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07748080.4T DK2037950T3 (da) | 2006-04-27 | 2007-04-27 | Yderligere medicinske anvendelser af antisekretorisk protein |
| DK07748078.8T DK2040734T3 (da) | 2006-04-27 | 2007-04-27 | Antisekretorisk protein til anvendelse til behandling af kompartmentsyndrom |
| DK10188590.3T DK2363140T3 (da) | 2006-04-27 | 2007-04-27 | Antisekretorisk protein til anvendelse i behandlingen af kompartmentsyndrom |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07748080.4T DK2037950T3 (da) | 2006-04-27 | 2007-04-27 | Yderligere medicinske anvendelser af antisekretorisk protein |
| DK07748078.8T DK2040734T3 (da) | 2006-04-27 | 2007-04-27 | Antisekretorisk protein til anvendelse til behandling af kompartmentsyndrom |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8309513B2 (da) |
| EP (2) | EP2363140B1 (da) |
| JP (2) | JP5323682B2 (da) |
| KR (3) | KR101757523B1 (da) |
| CN (3) | CN104689299B (da) |
| AT (1) | ATE526031T1 (da) |
| AU (1) | AU2007244003B2 (da) |
| BR (2) | BRPI0710794A2 (da) |
| CA (1) | CA2650589C (da) |
| DK (3) | DK2037950T3 (da) |
| ES (3) | ES2472737T3 (da) |
| IL (1) | IL194774A (da) |
| MX (1) | MX2008013774A (da) |
| NZ (2) | NZ572256A (da) |
| PL (2) | PL2040734T3 (da) |
| RU (2) | RU2457853C2 (da) |
| SG (1) | SG171601A1 (da) |
| WO (1) | WO2007126363A2 (da) |
| ZA (2) | ZA200809116B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008013769A (es) * | 2006-04-27 | 2009-02-03 | Lantmaennen As Faktor Ab | Uso de factores antisecretores para el tratamiento de hipertension intraocular. |
| MX2008013777A (es) * | 2006-04-27 | 2009-02-03 | Lantmaennen As Faktor Ab | Usos medicos adicionales de la proteina antisecretora. |
| KR101757523B1 (ko) | 2006-04-27 | 2017-07-12 | 란트만넨 아스-팍토르 아베 | 구획 증후군의 치료에 사용하기 위한 항분비 단백질 |
| US9962424B2 (en) | 2007-04-27 | 2018-05-08 | Lantmännen As-Faktor Ab | Use of antisecretory factors (AF) for optimizing cellular uptake |
| WO2010093324A1 (en) * | 2009-02-11 | 2010-08-19 | Lantmännen As-Faktor Ab | Use of antisecretory factors (af) for optimizing cellular uptake |
| WO2010065342A1 (en) | 2008-11-25 | 2010-06-10 | Temple University | Angiocidin inhibition of tumor cell growth |
| US11253552B2 (en) | 2015-07-10 | 2022-02-22 | Lantmännen As-Faktor Ab | Process for producing egg yolk with high content of AF-16 |
| US11407796B2 (en) | 2016-07-18 | 2022-08-09 | Lantmännen As-Faktor Ab | Antisecretory factor 17 |
| JP7217760B2 (ja) * | 2018-06-28 | 2023-02-03 | ラントメネン・メディカル・アーベー | 急性呼吸不全の治療および／または予防の使用のための抗分泌因子 |
| CN112770643A (zh) | 2018-09-28 | 2021-05-07 | 兰特门内保健食品公司 | 包含麦芽化脱壳燕麦的可消耗产品 |
| EP3855935A1 (en) | 2018-09-28 | 2021-08-04 | Lantmännen Functional Foods AB | A consumable product comprising malted wheat |
| AU2021243735A1 (en) | 2020-03-26 | 2022-10-13 | Lantmännen Functional Foods Ab | A consumable product comprising malted cereals for promoting recovery at physical activity |
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| CH682716A5 (de) * | 1992-01-13 | 1993-11-15 | Christian Fricker | Benzo-Pyrone und/oder Dobesilat-Calcium enthaltende pharmazeutische Zusammensetzung. |
| US5585401A (en) | 1994-12-09 | 1996-12-17 | The Reents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
| SE508609C2 (sv) | 1995-08-24 | 1998-10-19 | Rural Patent Svenska Ab | Antisekretorisk faktor - dess aminosyrasekvens, nubleinsyrasekvens och användning |
| SE9604251L (sv) | 1996-11-20 | 1997-12-22 | Svenska Lantmaennen Riksfoerbu | Födoämne som vid förtäring inducerar antisekretoriska proteiner |
| SE513496C2 (sv) * | 1998-12-17 | 2000-09-18 | Rural Patent Svenska Ab | NASP-berikad äggula samt dess användning |
| US7662169B2 (en) * | 2000-09-05 | 2010-02-16 | Wittmann Dietmar H | Prosthesis and method for lowering abdominal pressure |
| GB0322645D0 (en) * | 2003-09-26 | 2003-10-29 | Melacure Therapeutics Ab | Use of antisecretory factor peptides |
| MX2008013777A (es) | 2006-04-27 | 2009-02-03 | Lantmaennen As Faktor Ab | Usos medicos adicionales de la proteina antisecretora. |
| KR101757523B1 (ko) | 2006-04-27 | 2017-07-12 | 란트만넨 아스-팍토르 아베 | 구획 증후군의 치료에 사용하기 위한 항분비 단백질 |
| US8329650B2 (en) * | 2007-10-19 | 2012-12-11 | Trustees Of Boston University | Method of treating ischemic injury with follistatin-like 1 polypeptide |
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