DK2418201T3 - Polymorfe former af (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin) yl]-4-penten-2-amin p-hydroxybenzoat til behandling af centralnervesystemlidelser - Google Patents

Polymorfe former af (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin) yl]-4-penten-2-amin p-hydroxybenzoat til behandling af centralnervesystemlidelser

Info

Publication number
DK2418201T3
DK2418201T3 DK11167528.6T DK11167528T DK2418201T3 DK 2418201 T3 DK2418201 T3 DK 2418201T3 DK 11167528 T DK11167528 T DK 11167528T DK 2418201 T3 DK2418201 T3 DK 2418201T3
Authority
DK
Denmark
Prior art keywords
isopropoxypyridin
penten
hydroxybenzoate
amine
methyl
Prior art date
Application number
DK11167528.6T
Other languages
English (en)
Inventor
Julio A Munoz
Gary Maurice Dull
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Application granted granted Critical
Publication of DK2418201T3 publication Critical patent/DK2418201T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK11167528.6T 2006-05-09 2007-05-08 Polymorfe former af (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin) yl]-4-penten-2-amin p-hydroxybenzoat til behandling af centralnervesystemlidelser DK2418201T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74682106P 2006-05-09 2006-05-09
EP07783431A EP2021326A1 (en) 2006-05-09 2007-05-08 Polymorph forms of (2s) - (4e) -n-methyl-5- (3-isopropoxypyridin) yl]-4-penten-2-amine for the treatment of central nervous system disorders

Publications (1)

Publication Number Publication Date
DK2418201T3 true DK2418201T3 (da) 2014-05-12

Family

ID=38441430

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11167528.6T DK2418201T3 (da) 2006-05-09 2007-05-08 Polymorfe former af (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin) yl]-4-penten-2-amin p-hydroxybenzoat til behandling af centralnervesystemlidelser

Country Status (29)

Country Link
US (3) US8461344B2 (da)
EP (2) EP2418201B1 (da)
JP (1) JP4477097B2 (da)
KR (1) KR20090005369A (da)
CN (1) CN101472893A (da)
AR (1) AR060786A1 (da)
AU (1) AU2007249485B2 (da)
BR (1) BRPI0709781A2 (da)
CA (1) CA2649961A1 (da)
DK (1) DK2418201T3 (da)
EC (1) ECSP088876A (da)
ES (1) ES2460919T3 (da)
HR (1) HRP20140385T1 (da)
IL (1) IL194833A0 (da)
MX (1) MX2008013982A (da)
MY (1) MY144132A (da)
NO (1) NO20084567L (da)
NZ (1) NZ597177A (da)
PL (1) PL2418201T3 (da)
PT (1) PT2418201E (da)
RS (1) RS53286B (da)
RU (1) RU2440984C2 (da)
SA (1) SA07280230B1 (da)
SI (1) SI2418201T1 (da)
TW (1) TWI389889B (da)
UA (1) UA96447C2 (da)
UY (1) UY30330A1 (da)
WO (1) WO2007134034A1 (da)
ZA (1) ZA200809284B (da)

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UA88792C2 (ru) * 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
EP2021325A2 (en) 2006-05-09 2009-02-11 AstraZeneca AB Salt forms of (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine
TWI389889B (zh) 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
AR062860A1 (es) * 2006-09-15 2008-12-10 Astrazeneca Ab Combinaciones terapeuticas 482
WO2008091588A1 (en) * 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
BRPI0815070A2 (pt) * 2007-07-31 2018-07-31 Astrazeneca Ab Administração transdérmica de (2s)-(4e)-n-metil-5-(3- (5-isopropoxipiridin) il-4-penten-2-amina
JP2011522886A (ja) * 2008-06-11 2011-08-04 アストラゼネカ・アクチエボラーグ （２ｓ）−（４ｅ）−ｎ−メチル−５−（３−（５−イソプロポキシピリジン）イル）−４−ペンテン−２−アミンを含む舌下組成物
WO2010080757A2 (en) * 2009-01-07 2010-07-15 Astrazeneca Ab Combinations with an alpha-4beta-2 nicotinic agonist
FR2959107B1 (fr) 2010-04-23 2015-03-27 Oreal Unite d'application d'un produit cosmetique
CN103180277A (zh) * 2010-05-20 2013-06-26 塔格塞普特股份有限公司 制备芳基取代的烯属胺的新方法
WO2013184732A1 (en) * 2012-06-06 2013-12-12 Targacept, Inc. Crystalline (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]4-penten-2-amine 1,5-naphthalenedisulfonate
KR101579904B1 (ko) 2014-09-05 2016-01-05 동신대학교산학협력단 마스카라

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Also Published As

Publication number Publication date
US20070265314A1 (en) 2007-11-15
PT2418201E (pt) 2014-04-14
RU2008148325A (ru) 2010-06-20
IL194833A0 (en) 2009-08-03
HRP20140385T1 (hr) 2014-06-06
TW200808726A (en) 2008-02-16
SI2418201T1 (sl) 2014-06-30
TWI389889B (zh) 2013-03-21
NO20084567L (no) 2008-12-04
US8461344B2 (en) 2013-06-11
SA07280230B1 (ar) 2010-08-20
ES2460919T3 (es) 2014-05-16
CA2649961A1 (en) 2007-11-22
EP2418201A1 (en) 2012-02-15
MY144132A (en) 2011-08-15
US20130310425A1 (en) 2013-11-21
RS53286B (sr) 2014-08-29
ZA200809284B (en) 2009-08-26
AR060786A1 (es) 2008-07-10
MX2008013982A (es) 2009-03-13
AU2007249485A1 (en) 2007-11-22
EP2021326A1 (en) 2009-02-11
JP2009531465A (ja) 2009-09-03
WO2007134034A1 (en) 2007-11-22
UA96447C2 (ru) 2011-11-10
CN101472893A (zh) 2009-07-01
AU2007249485B2 (en) 2012-11-01
UY30330A1 (es) 2008-10-31
NZ597177A (en) 2013-06-28
JP4477097B2 (ja) 2010-06-09
PL2418201T3 (pl) 2014-07-31
KR20090005369A (ko) 2009-01-13
ECSP088876A (es) 2009-02-27
BRPI0709781A2 (pt) 2011-07-26
RU2440984C2 (ru) 2012-01-27
EP2418201B1 (en) 2014-02-12
US20100048643A1 (en) 2010-02-25

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