DK2310012T3 - Fremgangsmåde til fremstilling af substituerede pyrimidinderivater - Google Patents

Fremgangsmåde til fremstilling af substituerede pyrimidinderivater Download PDF

Info

Publication number: DK2310012T3
Authority: DK; Denmark
Prior art keywords: procedure; pyrimidine derivatives; substituted pyrimidine; preparing substituted; preparing
Prior art date: 2008-06-30

Application number

DK09774225T

Other languages

English (en)

Inventor

Sergio Cesco-Cancian

Hongfeng Chen

Jeffrey S Grimm

Neelakandha S Mani

Christopher M Mapes

David C Palmer

Daniel J Pippel

Kirk L Sorgi

Tong Xiao

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-30

Filing date

2009-06-29

Publication date

2015-03-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2310012(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-06-29 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2015-03-30 Application granted granted Critical

2015-03-30 Publication of DK2310012T3 publication Critical patent/DK2310012T3/da

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK09774225T 2008-06-30 2009-06-29 Fremgangsmåde til fremstilling af substituerede pyrimidinderivater DK2310012T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7675208P	2008-06-30	2008-06-30
PCT/US2009/049027 WO2010002774A1 (en)	2008-06-30	2009-06-29	Process for the preparation of substituted pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
DK2310012T3 true DK2310012T3 (da)	2015-03-30

Family

ID=41464882

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09774225T DK2310012T3 (da)	2008-06-30	2009-06-29	Fremgangsmåde til fremstilling af substituerede pyrimidinderivater

Country Status (36)

Country	Link
US (6)	US8309720B2 (da)
EP (5)	EP2924025A1 (da)
JP (1)	JP5416768B2 (da)
KR (1)	KR101675354B1 (da)
CN (1)	CN102137672B (da)
AR (1)	AR072396A1 (da)
AU (1)	AU2009267156B2 (da)
BR (1)	BRPI0913644A2 (da)
CA (1)	CA2729733C (da)
CO (1)	CO6341560A2 (da)
CY (1)	CY1116134T1 (da)
DK (1)	DK2310012T3 (da)
EA (1)	EA019361B1 (da)
EC (1)	ECSP11010745A (da)
ES (1)	ES2538135T3 (da)
HK (3)	HK1201441A1 (da)
HR (1)	HRP20150576T1 (da)
HU (1)	HUE024949T2 (da)
IL (4)	IL210214A (da)
JO (1)	JO3043B1 (da)
ME (1)	ME02154B (da)
MX (1)	MX2011000080A (da)
MY (1)	MY150601A (da)
NI (1)	NI201000232A (da)
NZ (1)	NZ590170A (da)
PE (1)	PE20110163A1 (da)
PL (1)	PL2310012T3 (da)
PT (1)	PT2310012E (da)
RS (1)	RS53985B1 (da)
SI (1)	SI2310012T1 (da)
SV (1)	SV2011003788A (da)
TW (3)	TW201433568A (da)
UA (1)	UA106724C2 (da)
UY (1)	UY31949A (da)
WO (1)	WO2010002774A1 (da)
ZA (1)	ZA201100759B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007117399A2 (en)	2006-03-31	2007-10-18	Janssen Pharmaceutica N.V.	Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
EP2924025A1 (en)	2008-06-30	2015-09-30	Janssen Pharmaceutica NV	Substituted pyrimidine derivatives
US9371311B2 (en)	2008-06-30	2016-06-21	Janssen Pharmaceutica Nv	Benzoimidazol-2-yl pyrimidine derivatives
JP5574294B2 (ja) *	2010-11-04	2014-08-20	独立行政法人科学技術振興機構	光磁気記録媒体及び光磁気記録方法
RS59909B1 (sr)	2013-03-06	2020-03-31	Janssen Pharmaceutica Nv	Benzoimidazol-2-il pirimidinski modulatori histaminskog h4 receptora
CN106132926B (zh) *	2014-03-28	2019-05-21	株式会社钟化	三苄氧羰基精氨酸的制造方法
SG11201903871TA (en)	2016-11-03	2019-05-30	Bristol Myers Squibb Co	Substituted bicycle heterocyclic derivatives useful as romk channel inhibitors

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3005852A (en)	1959-12-22	1961-10-24	Gen Aniline & Film Corp	Production of sulfoxides and sulfones
US3931195A (en) *	1971-03-03	1976-01-06	Mead Johnson & Company	Substituted piperidines
US4191828A (en) *	1976-04-14	1980-03-04	Richardson-Merrell Inc.	Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
US4190601A (en) *	1978-05-31	1980-02-26	Union Carbide Corporation	Production of tertiary amines by reductive alkylation
JPS5942396A (ja) *	1982-09-02	1984-03-08	Ishihara Sangyo Kaisha Ltd	リン酸アミド誘導体およびそれらを含有する殺虫、殺ダニ、殺線虫剤
JPS6130576A (ja)	1984-07-24	1986-02-12	Ube Ind Ltd	２−アミノ−５−シアノピリミジンの製法
JP3322878B2 (ja) *	1992-10-14	2002-09-09	メルクエンドカンパニーインコーポレーテッド	フィブリノーゲンレセプターアンタゴニスト
GB9422391D0 (en)	1994-11-05	1995-01-04	Solvay Interox Ltd	Oxidation of organosulphur compounds
JP2002503662A (ja)	1998-02-17	2002-02-05	テュラリクインコーポレイテッド	抗ウイルス性ピリミジン誘導体
GB9914258D0 (en) *	1999-06-18	1999-08-18	Celltech Therapeutics Ltd	Chemical compounds
KR20020047198A (ko) *	1999-09-30	2002-06-21	해피 페너 ; 해리 에이치. 페너 2세	특정 알킬렌 디아민-치환된피라졸로[1,5-ａ]-1,5-피리미딘 및피라졸로[1,5-ａ]-1,3,5-트리아진
AU2001289701B2 (en)	2000-07-21	2004-06-24	Syngenta Participations Ag	Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine
PE20020506A1 (es) *	2000-08-22	2002-07-09	Glaxo Group Ltd	Derivados de pirazol fusionados como inhibidores de la proteina cinasa
WO2002064096A2 (en)	2001-02-16	2002-08-22	Tularik Inc.	Methods of using pyrimidine-based antiviral agents
EP1372642A1 (en) *	2001-03-30	2004-01-02	SmithKline Beecham Corporation	Use of pyrazolopyridines as therapeutic compounds
US7279473B2 (en) *	2001-12-17	2007-10-09	Smithkline Beecham Corporation	Pyrazolopyridazine derivatives
TWI270542B (en)	2002-02-07	2007-01-11	Sumitomo Chemical Co	Method for preparing sulfone or sulfoxide compound
WO2004050610A2 (en) *	2002-12-04	2004-06-17	Gene Logic Inc.	Modulators of melanocortin receptor
BRPI0409986A (pt) *	2003-05-05	2006-05-09	Hoffmann La Roche	derivados de pirimidina fundida com atividade de crf
CN101103112B (zh)	2004-10-27	2011-11-16	先灵公司	抑制Nav1.8的短干扰核酸组合物和方法
US20060281712A1 (en)	2005-06-14	2006-12-14	Chi-Feng Yen	Pyrimidine compounds
ES2608638T3 (es) *	2005-07-06	2017-04-12	Ge Healthcare Bioprocess R&D Ab	Método para preparar una matriz de separación
TW200800201A (en) *	2005-11-18	2008-01-01	Lilly Co Eli	Pyrimidinyl benzothiophene compounds
CN101032483B (zh) *	2006-03-09	2011-05-04	陈德桂	调节雄激素受体活性的乙内酰脲衍生物及其应用
WO2007117399A2 (en)	2006-03-31	2007-10-18	Janssen Pharmaceutica N.V.	Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
ATE479678T1 (de) *	2006-03-31	2010-09-15	Janssen Pharmaceutica Nv	Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors
EP2924025A1 (en)	2008-06-30	2015-09-30	Janssen Pharmaceutica NV	Substituted pyrimidine derivatives
MY157197A (en) *	2008-06-30	2016-05-13	Janssen Pharmaceutica Nv	Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives

2009
- 2009-06-29 EP EP15157463.9A patent/EP2924025A1/en not_active Withdrawn
- 2009-06-29 NZ NZ590170A patent/NZ590170A/en not_active IP Right Cessation
- 2009-06-29 UA UAA201100983A patent/UA106724C2/uk unknown
- 2009-06-29 HU HUE09774225A patent/HUE024949T2/en unknown
- 2009-06-29 EP EP15157445.6A patent/EP2924035A1/en not_active Withdrawn
- 2009-06-29 EP EP20090774225 patent/EP2310012B1/en active Active
- 2009-06-29 EP EP20140161564 patent/EP2769721A3/en not_active Withdrawn
- 2009-06-29 EP EP15157453.0A patent/EP2924023A1/en not_active Withdrawn
- 2009-06-29 RS RS20150287A patent/RS53985B1/sr unknown
- 2009-06-29 AR ARP090102405 patent/AR072396A1/es not_active Application Discontinuation
- 2009-06-29 BR BRPI0913644A patent/BRPI0913644A2/pt not_active Application Discontinuation
- 2009-06-29 ES ES09774225.8T patent/ES2538135T3/es active Active
- 2009-06-29 TW TW103118001A patent/TW201433568A/zh unknown
- 2009-06-29 SI SI200931188T patent/SI2310012T1/sl unknown
- 2009-06-29 JP JP2011516757A patent/JP5416768B2/ja not_active Expired - Fee Related
- 2009-06-29 KR KR1020117001991A patent/KR101675354B1/ko not_active Expired - Fee Related
- 2009-06-29 PT PT97742258T patent/PT2310012E/pt unknown
- 2009-06-29 JO JOP/2009/0240A patent/JO3043B1/ar active
- 2009-06-29 PL PL09774225T patent/PL2310012T3/pl unknown
- 2009-06-29 AU AU2009267156A patent/AU2009267156B2/en not_active Ceased
- 2009-06-29 ME MEP-2015-79A patent/ME02154B/me unknown
- 2009-06-29 TW TW103104509A patent/TWI481603B/zh not_active IP Right Cessation
- 2009-06-29 PE PE2010001216A patent/PE20110163A1/es not_active Application Discontinuation
- 2009-06-29 EA EA201170113A patent/EA019361B1/ru not_active IP Right Cessation
- 2009-06-29 HR HRP20150576TT patent/HRP20150576T1/hr unknown
- 2009-06-29 CN CN200980134933.7A patent/CN102137672B/zh not_active Expired - Fee Related
- 2009-06-29 CA CA2729733A patent/CA2729733C/en not_active Expired - Fee Related
- 2009-06-29 MX MX2011000080A patent/MX2011000080A/es active IP Right Grant
- 2009-06-29 US US12/459,229 patent/US8309720B2/en not_active Expired - Fee Related
- 2009-06-29 DK DK09774225T patent/DK2310012T3/da active
- 2009-06-29 MY MYPI2010006258A patent/MY150601A/en unknown
- 2009-06-29 TW TW098121755A patent/TWI498326B/zh not_active IP Right Cessation
- 2009-06-29 WO PCT/US2009/049027 patent/WO2010002774A1/en not_active Ceased
- 2009-06-30 UY UY31949A patent/UY31949A/es unknown
2010
- 2010-12-23 IL IL210214A patent/IL210214A/en active IP Right Grant
- 2010-12-23 NI NI201000232A patent/NI201000232A/es unknown
2011
- 2011-01-03 SV SV2011003788A patent/SV2011003788A/es unknown
- 2011-01-04 CO CO11000461A patent/CO6341560A2/es not_active Application Discontinuation
- 2011-01-05 EC ECSP11010745 patent/ECSP11010745A/es unknown
- 2011-01-28 ZA ZA2011/00759A patent/ZA201100759B/en unknown
2012
- 2012-10-29 US US13/663,233 patent/US9079882B2/en not_active Expired - Fee Related
2013
- 2013-03-15 US US13/844,227 patent/US9079883B2/en not_active Expired - Fee Related
- 2013-11-11 US US14/076,955 patent/US9079884B2/en not_active Expired - Fee Related
- 2013-11-12 US US14/078,153 patent/US9006432B2/en not_active Expired - Fee Related
- 2013-11-13 US US14/079,358 patent/US9359327B2/en not_active Expired - Fee Related
2014
- 2014-11-09 IL IL235572A patent/IL235572A/en active IP Right Grant
- 2014-11-09 IL IL235571A patent/IL235571A/en active IP Right Grant
- 2014-11-09 IL IL235570A patent/IL235570A/en active IP Right Grant
2015
- 2015-02-26 HK HK15101911.7A patent/HK1201441A1/en unknown
- 2015-03-23 CY CY20151100293T patent/CY1116134T1/el unknown
2016
- 2016-03-03 HK HK16102449.5A patent/HK1214590A1/en unknown
- 2016-03-23 HK HK16103405.5A patent/HK1215434A1/en unknown

Also Published As

Publication number	Publication date
IL235570A (en)	2016-08-31
EP2310012B1 (en)	2015-03-04
CN102137672B (zh)	2014-03-26
NZ590170A (en)	2012-04-27
ZA201100759B (en)	2012-07-25
US9359327B2 (en)	2016-06-07
TW201420583A (zh)	2014-06-01
IL210214A (en)	2016-07-31
EA201170113A1 (ru)	2011-08-30
HK1201441A1 (en)	2015-09-04
KR101675354B1 (ko)	2016-11-11
US9079882B2 (en)	2015-07-14
TW201012810A (en)	2010-04-01
EP2310012A1 (en)	2011-04-20
US20130053561A1 (en)	2013-02-28
HRP20150576T1 (hr)	2015-09-11
US20140073795A1 (en)	2014-03-13
CA2729733C (en)	2016-10-25
PT2310012E (pt)	2015-04-02
EP2924035A1 (en)	2015-09-30
SV2011003788A (es)	2011-02-08
EP2924023A1 (en)	2015-09-30
EP2769721A3 (en)	2015-04-01
AU2009267156B2 (en)	2015-05-28
CO6341560A2 (es)	2011-11-21
CA2729733A1 (en)	2010-01-07
EP2924025A1 (en)	2015-09-30
JP5416768B2 (ja)	2014-02-12
CY1116134T1 (el)	2017-02-08
AR072396A1 (es)	2010-08-25
US9079883B2 (en)	2015-07-14
AU2009267156A1 (en)	2010-01-07
ME02154B (me)	2015-10-20
MX2011000080A (es)	2011-03-02
RS53985B1 (sr)	2015-10-30
PL2310012T3 (pl)	2015-08-31
TWI498326B (zh)	2015-09-01
BRPI0913644A2 (pt)	2015-11-24
IL235571A (en)	2016-09-29
US9006432B2 (en)	2015-04-14
JO3043B1 (ar)	2016-09-05
PE20110163A1 (es)	2011-03-28
UY31949A (es)	2010-01-29
HK1214590A1 (en)	2016-07-29
TWI481603B (zh)	2015-04-21
JP2011526910A (ja)	2011-10-20
IL235572A (en)	2016-09-29
US20130225816A1 (en)	2013-08-29
US9079884B2 (en)	2015-07-14
WO2010002774A1 (en)	2010-01-07
SI2310012T1 (sl)	2015-06-30
EA019361B1 (ru)	2014-03-31
KR20110023901A (ko)	2011-03-08
US20100004450A1 (en)	2010-01-07
NI201000232A (es)	2011-09-07
HUE024949T2 (en)	2016-02-29
TW201433568A (zh)	2014-09-01
IL210214A0 (en)	2011-03-31
UA106724C2 (uk)	2014-10-10
US8309720B2 (en)	2012-11-13
EP2769721A2 (en)	2014-08-27
CN102137672A (zh)	2011-07-27
US20140066624A1 (en)	2014-03-06
US20140121374A1 (en)	2014-05-01
HK1215434A1 (en)	2016-08-26
HK1156857A1 (en)	2012-06-22
EP2310012A4 (en)	2012-06-20
ES2538135T3 (es)	2015-06-17
MY150601A (en)	2014-01-30
ECSP11010745A (es)	2011-02-28

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BRPI0907435A2 (pt)	2015-07-14	Derivados de 5-flúor pirimidina
DK2496562T3 (da)	2014-05-12	Fremgangsmåde til fremstilling af calcobutrol
BRPI0914544A2 (pt)	2015-12-15	derivados de pirimidona substituídos
DK2334639T3 (da)	2013-05-06	Fremgangsmåder til fremstilling af aminosulfonforbindelser
DK2300465T3 (da)	2019-06-24	Imidazopyridinderivater som hæmmere af receptortyrosinkinaser
HRP20150477T1 (xx)	2015-06-05	Postupci dobivanja derivata kinazolona
BRPI0920496A2 (pt)	2019-09-24	derivados substituídos de pirimidina etriazina
ES2465673T9 (es)	2014-11-14	Derivados de pirimidina
DK2358661T3 (da)	2014-06-30	Fremgangsmåde til fremstilling af trans-4-amino-cyclohexyl-eddikesyreethylester-hcl
BRPI0923497A2 (pt)	2019-09-24	derivados de piridazinona
EP2305514A4 (en)	2016-07-20	HEADLIGHT POINTING SYSTEM
DK2509427T3 (da)	2017-11-13	Fremgangsmåder til fremstilling af GH8-xylanasevarianter
BRPI0914662A2 (pt)	2015-10-20	derivados de triazinona substituída
DK2213654T3 (da)	2014-04-22	Fremgangsmåde til fremstilling af 2-amino-5-brombenzamid derivater
DK2167395T3 (da)	2012-09-17	Hætte til tilberedning af drikkevarer
BRPI0914301A2 (pt)	2015-10-13	derivados de pirimidin-4-ona substituída
DK2391225T3 (da)	2020-07-20	Fremgangsmåde til fremstilling af lactoferrin
BRPI1009398A2 (pt)	2016-03-08	compostos de pirimidina fundida substituída
DK2430196T3 (da)	2013-09-08	Fremgangsmåde til fremstilling af alkoholer
DK2318378T3 (da)	2013-11-18	Quinazolin-derivater
BRPI1013493A2 (pt)	2016-04-05	composto de pirimidina
DK2582673T3 (da)	2014-11-10	Fremgangsmåde til fremstilling af 2,2-difluorethylamin-derivater ved hjælp af alkylering med 2,2-difluor-1-halogenethaner
ATE545635T1 (de)	2012-03-15	Substituierte n-oxidpyrazinderivate
BRPI0820779A2 (pt)	2015-06-16	Derivados de 4-amino-pirimidina
DK2241546T3 (da)	2017-11-13	Fremgangsmåde til fremstilling af en benzaldehydforbindelse