DK2483271T3 - Pyrazolindionderivater som NADPH-oxidaseinhibitorer - Google Patents

Pyrazolindionderivater som NADPH-oxidaseinhibitorer

Info

Publication number: DK2483271T3
Authority: DK; Denmark
Prior art keywords: oxidase inhibitors; nadph oxidase; pyrazolinedione; derivatives; pyrazolinedione derivatives
Prior art date: 2009-09-28

Application number

DK10782688.5T

Other languages

English (en)

Inventor

Patrick Page

Benoît Laleu

Francesca Gaggini

Original Assignee

Genkyotex Suisse Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-09-28

Filing date

2010-09-27

Publication date

2017-11-27

2010-09-27 Application filed by Genkyotex Suisse Sa filed Critical Genkyotex Suisse Sa

2017-11-27 Application granted granted Critical

2017-11-27 Publication of DK2483271T3 publication Critical patent/DK2483271T3/da

Links

102000004722 NADPH Oxidases Human genes 0.000 title 1
108010002998 NADPH Oxidases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
CYMJPJKHCSDSRG-UHFFFAOYSA-N pyrazolidine-3,4-dione Chemical class O=C1CNNC1=O CYMJPJKHCSDSRG-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Obesity (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)

DK10782688.5T 2009-09-28 2010-09-27 Pyrazolindionderivater som NADPH-oxidaseinhibitorer DK2483271T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP09171466A EP2305679A1 (en)	2009-09-28	2009-09-28	Pyrazoline dione derivatives as nadph oxidase inhibitors
PCT/IB2010/054329 WO2011036651A1 (en)	2009-09-28	2010-09-27	Pyrazoline dione derivatives as nadph oxidase inhibitors

Publications (1)

Publication Number	Publication Date
DK2483271T3 true DK2483271T3 (da)	2017-11-27

Family

ID=41347804

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK10782688.5T DK2483271T3 (da)	2009-09-28	2010-09-27	Pyrazolindionderivater som NADPH-oxidaseinhibitorer

Country Status (24)

Country	Link
US (1)	US9394306B2 (da)
EP (2)	EP2305679A1 (da)
JP (1)	JP5707406B2 (da)
KR (1)	KR101791273B1 (da)
CN (1)	CN102686590B (da)
AU (1)	AU2010299487B2 (da)
BR (1)	BR112012004208A2 (da)
CA (1)	CA2770278C (da)
CY (1)	CY1119780T1 (da)
DK (1)	DK2483271T3 (da)
ES (1)	ES2644857T3 (da)
HR (1)	HRP20171638T1 (da)
HU (1)	HUE035058T2 (da)
IL (1)	IL218814A0 (da)
LT (1)	LT2483271T (da)
ME (1)	ME03040B (da)
NO (1)	NO2483271T3 (da)
PL (1)	PL2483271T3 (da)
PT (1)	PT2483271T (da)
RS (1)	RS56542B1 (da)
RU (1)	RU2569855C2 (da)
SI (1)	SI2483271T1 (da)
SM (1)	SMT201700541T1 (da)
WO (1)	WO2011036651A1 (da)

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EP2002835A1 (en)	2007-06-04	2008-12-17	GenKyo Tex	Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166010A1 (en)	2008-09-23	2010-03-24	Genkyo Tex Sa	Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en)	2008-09-23	2010-03-24	Genkyo Tex Sa	Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en)	2008-09-23	2010-03-24	Genkyo Tex Sa	Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2361911A1 (en)	2010-02-18	2011-08-31	GenKyoTex SA	Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
WO2013078261A1 (en)	2011-11-22	2013-05-30	The University Of Maryland, Baltimore	Treatment of muscular conditions and muscular dystrophies
JP2015509969A (ja) *	2012-03-16	2015-04-02	グルソックス・バイオテック・アーベー	Ｎｏｘ４阻害活性を示すチオフェン−ベースの化合物および療法におけるその使用
EP2911667B1 (en)	2012-10-24	2017-02-22	Glucox Biotech AB	Triazine derivatives for the treatment of conditions associated with nicotinamide adenine dinucleotide phosphate oxidase
EP2857399A1 (en)	2013-10-03	2015-04-08	GenKyoTex SA	Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction
US10173988B2 (en)	2015-02-16	2019-01-08	Glucox Biotech Ab	N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine
EP3098220A1 (en)	2015-05-28	2016-11-30	GenKyoTex SA	Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof
JP7312749B2 (ja)	2017-08-04	2023-07-21	スカイホーク・セラピューティクス・インコーポレーテッド	スプライシングをモジュレートする方法および組成物
EP3479843A1 (en)	2017-11-01	2019-05-08	GenKyoTex Suisse SA	Use of nox inhibitors for treatment of cancer
JP7551629B2 (ja)	2019-02-05	2024-09-17	スカイホーク・セラピューティクス・インコーポレーテッド	スプライシングを調節するための方法および組成物
WO2020163405A1 (en)	2019-02-05	2020-08-13	Skyhawk Therapeutics, Inc.	Methods and compositions for modulating splicing
JP7603594B2 (ja)	2019-02-06	2024-12-20	スカイホーク・セラピューティクス・インコーポレーテッド	スプライシングを調節するための方法および組成物
JP7603595B2 (ja)	2019-02-06	2024-12-20	スカイホーク・セラピューティクス・インコーポレーテッド	スプライシングを調節するための方法および組成物
KR20230084419A (ko) *	2021-12-03	2023-06-13	(주)인비보텍	난청 또는 이명의 예방 또는 치료용 조성물

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EP2002835A1 (en)	2007-06-04	2008-12-17	GenKyo Tex	Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
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TW200930713A (en)	2007-12-03	2009-07-16	Takeda Pharmaceutical	Nitrogen-containing heterocyclic compound and use thereof
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EP2166008A1 (en)	2008-09-23	2010-03-24	Genkyo Tex Sa	Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en)	2008-09-23	2010-03-24	Genkyo Tex Sa	Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2165707A1 (en)	2008-09-23	2010-03-24	Genkyo Tex Sa	Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166010A1 (en)	2008-09-23	2010-03-24	Genkyo Tex Sa	Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2361912A1 (en)	2010-02-18	2011-08-31	GenKyoTex SA	Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
EP2361911A1 (en)	2010-02-18	2011-08-31	GenKyoTex SA	Pyrazolo piperidine derivatives as NADPH oxidase inhibitors

2009
- 2009-09-28 EP EP09171466A patent/EP2305679A1/en not_active Withdrawn
2010
- 2010-09-27 PL PL10782688T patent/PL2483271T3/pl unknown
- 2010-09-27 SI SI201031580T patent/SI2483271T1/en unknown
- 2010-09-27 HR HRP20171638TT patent/HRP20171638T1/hr unknown
- 2010-09-27 JP JP2012530402A patent/JP5707406B2/ja not_active Expired - Fee Related
- 2010-09-27 HU HUE10782688A patent/HUE035058T2/en unknown
- 2010-09-27 US US13/394,904 patent/US9394306B2/en not_active Expired - Fee Related
- 2010-09-27 DK DK10782688.5T patent/DK2483271T3/da active
- 2010-09-27 ME MEP-2017-258A patent/ME03040B/me unknown
- 2010-09-27 LT LTEP10782688.5T patent/LT2483271T/lt unknown
- 2010-09-27 KR KR1020127007664A patent/KR101791273B1/ko not_active Expired - Fee Related
- 2010-09-27 RS RS20171071A patent/RS56542B1/sr unknown
- 2010-09-27 RU RU2012117796/04A patent/RU2569855C2/ru not_active IP Right Cessation
- 2010-09-27 CN CN201080041718.5A patent/CN102686590B/zh not_active Expired - Fee Related
- 2010-09-27 CA CA2770278A patent/CA2770278C/en not_active Expired - Fee Related
- 2010-09-27 PT PT107826885T patent/PT2483271T/pt unknown
- 2010-09-27 ES ES10782688.5T patent/ES2644857T3/es active Active
- 2010-09-27 WO PCT/IB2010/054329 patent/WO2011036651A1/en not_active Ceased
- 2010-09-27 BR BR112012004208A patent/BR112012004208A2/pt not_active Application Discontinuation
- 2010-09-27 NO NO10782688A patent/NO2483271T3/no unknown
- 2010-09-27 SM SM20170541T patent/SMT201700541T1/it unknown
- 2010-09-27 AU AU2010299487A patent/AU2010299487B2/en not_active Ceased
- 2010-09-27 EP EP10782688.5A patent/EP2483271B1/en active Active
2012
- 2012-03-25 IL IL218814A patent/IL218814A0/en unknown
2017
- 2017-11-03 CY CY20171101161T patent/CY1119780T1/el unknown

Also Published As

Publication number	Publication date
NO2483271T3 (da)	2018-01-13
US20120172352A1 (en)	2012-07-05
RS56542B1 (sr)	2018-02-28
RU2012117796A (ru)	2013-11-20
SI2483271T1 (en)	2018-01-31
EP2483271B1 (en)	2017-08-16
CY1119780T1 (el)	2018-09-05
EP2305679A1 (en)	2011-04-06
JP2013505930A (ja)	2013-02-21
HK1171748A1 (zh)	2013-04-05
KR20120090998A (ko)	2012-08-17
LT2483271T (lt)	2017-11-10
PL2483271T3 (pl)	2018-02-28
ME03040B (me)	2018-10-20
HUE035058T2 (en)	2018-05-02
CN102686590B (zh)	2015-09-16
CA2770278C (en)	2018-08-14
PT2483271T (pt)	2017-11-15
US9394306B2 (en)	2016-07-19
EP2483271A1 (en)	2012-08-08
SMT201700541T1 (it)	2018-01-11
WO2011036651A1 (en)	2011-03-31
BR112012004208A2 (pt)	2016-03-29
HRP20171638T1 (hr)	2017-12-01
ES2644857T3 (es)	2017-11-30
IL218814A0 (en)	2012-06-28
AU2010299487B2 (en)	2016-03-24
CN102686590A (zh)	2012-09-19
AU2010299487A1 (en)	2012-03-29
RU2569855C2 (ru)	2015-11-27
KR101791273B1 (ko)	2017-10-27
CA2770278A1 (en)	2011-03-31
JP5707406B2 (ja)	2015-04-30

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