DK256977A - Fremgangsmaade til fremstilling af flerdobbelt halogenerede steroider - Google Patents

Fremgangsmaade til fremstilling af flerdobbelt halogenerede steroider

Info

Publication number: DK256977A
Authority: DK; Denmark
Prior art keywords: procedure; production; double halogenated; halogenated steroids; steroids
Prior art date: 1976-09-29

Application number

DK256977A

Other languages

English (en)

Other versions

DK146017B (da

DK146017C (da

Inventor

J Kalvoda

G Anner

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-29

Filing date

1977-06-09

Publication date

1978-03-30

1977-06-09 Application filed by Ciba Geigy filed Critical Ciba Geigy

1978-03-30 Publication of DK256977A publication Critical patent/DK256977A/da

1983-05-24 Publication of DK146017B publication Critical patent/DK146017B/da

1983-10-24 Application granted granted Critical

1983-10-24 Publication of DK146017C publication Critical patent/DK146017C/da

Links

150000003431 steroids Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK256977A 1976-09-29 1977-06-09 Analogifremgangsmaade til fremstilling af 17alfa-acyloxy-9alfa,21-dihalogen-11beta-hydroxy-6alfa-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-forbindelser DK146017C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU75903A LU75903A1 (da)	1976-09-29	1976-09-29
LU75903		1976-09-29

Publications (3)

Publication Number	Publication Date
DK256977A true DK256977A (da)	1978-03-30
DK146017B DK146017B (da)	1983-05-24
DK146017C DK146017C (da)	1983-10-24

Family

ID=19728370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK256977A DK146017C (da)	1976-09-29	1977-06-09	Analogifremgangsmaade til fremstilling af 17alfa-acyloxy-9alfa,21-dihalogen-11beta-hydroxy-6alfa-fluor-16beta-methyl-pregna-1,4-dien-3,20-dion-forbindelser

Country Status (24)

Country	Link
JP (1)	JPS5356652A (da)
AT (3)	AT363197B (da)
AU (1)	AU514200B2 (da)
BE (1)	BE859120A (da)
CA (1)	CA1101410A (da)
CH (9)	CH624967A5 (da)
CY (1)	CY1178A (da)
DD (1)	DD133150A5 (da)
DE (1)	DE2743069C2 (da)
DK (1)	DK146017C (da)
ES (1)	ES462763A1 (da)
FR (1)	FR2366311A1 (da)
GB (1)	GB1563638A (da)
HK (1)	HK16683A (da)
HU (1)	HU175218B (da)
IE (1)	IE46047B1 (da)
IL (1)	IL53012A (da)
KE (1)	KE3258A (da)
LU (1)	LU75903A1 (da)
MY (1)	MY8400092A (da)
NL (1)	NL7710089A (da)
SE (1)	SE436751B (da)
SG (1)	SG3383G (da)
ZA (1)	ZA775800B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL187577C (nl) *	1978-04-05	1991-11-18	Sibla Srl	3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
DE3227312A1 (de) *	1982-07-19	1984-01-19	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
JPH05501115A (ja) *	1990-03-27	1993-03-04	シェリング・コーポレーション	９α―ヒドロキシ　ステロイドの脱水法
US5972922A (en) *	1990-06-11	1999-10-26	Alcon Laboratories, Inc.	Steroids which inhibit angiogenesis
CA2473471A1 (en)	2001-11-29	2003-06-12	Taro Pharmaceuticals U.S.A., Inc.	Method for the preparation of 6-alpha-fluoro corticosteroids
US8809307B2 (en)	2010-11-22	2014-08-19	Dow Pharmaceutical Sciences, Inc.	Pharmaceutical formulations containing corticosteroids for topical administration
US11957753B2 (en)	2010-11-22	2024-04-16	Bausch Health Ireland Limited	Pharmaceutical formulations containing corticosteroids for topical administration
HUE050603T2 (hu)	2015-06-18	2020-12-28	Bausch Health Ireland Ltd	Egy kortikoszteroidot és egy retinoidot tartalmazó topikális készítmények psoriasis kezelésére
US11311482B2 (en)	2017-05-12	2022-04-26	Bausch Health Us, Llc	Topical compositions and methods for treating skin diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB898292A (en) *	1959-03-18	1962-06-06	Upjohn Co	Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) *	1970-03-19	1972-02-22	Syntex Corp	Preparation of 21-chloro steroids
US3992422A (en) *	1975-08-14	1976-11-16	Schering Corporation	Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

1976
- 1976-09-29 LU LU75903A patent/LU75903A1/xx unknown
- 1976-12-09 CH CH1549976A patent/CH624967A5/de not_active IP Right Cessation
1977
- 1977-06-08 SE SE7706673A patent/SE436751B/xx not_active IP Right Cessation
- 1977-06-09 DK DK256977A patent/DK146017C/da not_active IP Right Cessation
- 1977-09-14 NL NL7710089A patent/NL7710089A/xx not_active Application Discontinuation
- 1977-09-24 DE DE2743069A patent/DE2743069C2/de not_active Expired
- 1977-09-26 CH CH1172177A patent/CH632279A5/de not_active IP Right Cessation
- 1977-09-27 GB GB40131/77A patent/GB1563638A/en not_active Expired
- 1977-09-27 CY CY1178A patent/CY1178A/xx unknown
- 1977-09-27 FR FR7729043A patent/FR2366311A1/fr active Granted
- 1977-09-27 CA CA287,560A patent/CA1101410A/en not_active Expired
- 1977-09-27 DD DD7700201226A patent/DD133150A5/xx unknown
- 1977-09-27 AU AU29148/77A patent/AU514200B2/en not_active Expired
- 1977-09-28 IE IE1979/77A patent/IE46047B1/en not_active IP Right Cessation
- 1977-09-28 IL IL53012A patent/IL53012A/xx unknown
- 1977-09-28 AT AT0691077A patent/AT363197B/de not_active IP Right Cessation
- 1977-09-28 ZA ZA00775800A patent/ZA775800B/xx unknown
- 1977-09-28 BE BE181243A patent/BE859120A/xx not_active IP Right Cessation
- 1977-09-28 HU HU77CI1774A patent/HU175218B/hu unknown
- 1977-09-29 JP JP11619377A patent/JPS5356652A/ja active Granted
- 1977-09-29 ES ES462763A patent/ES462763A1/es not_active Expired
1979
- 1979-02-28 AT AT0151279A patent/AT363202B/de not_active IP Right Cessation
- 1979-02-28 AT AT0151379A patent/AT363203B/de not_active IP Right Cessation
1980
- 1980-11-18 CH CH853780A patent/CH625808A5/de not_active IP Right Cessation
- 1980-11-18 CH CH853980A patent/CH625810A5/de not_active IP Right Cessation
- 1980-11-18 CH CH853880A patent/CH625809A5/de not_active IP Right Cessation
1981
- 1981-10-26 CH CH683281A patent/CH632000A5/de not_active IP Right Cessation
- 1981-10-26 CH CH683081A patent/CH631998A5/de not_active IP Right Cessation
- 1981-10-26 CH CH683181A patent/CH631999A5/de not_active IP Right Cessation
1982
- 1982-01-06 CH CH4682A patent/CH632521A5/de not_active IP Right Cessation
1983
- 1983-01-20 SG SG33/83A patent/SG3383G/en unknown
- 1983-01-21 KE KE3258A patent/KE3258A/xx unknown
- 1983-05-19 HK HK166/83A patent/HK16683A/en not_active IP Right Cessation
1984
- 1984-12-30 MY MY92/84A patent/MY8400092A/xx unknown

Also Published As

Publication number	Publication date
LU75903A1 (da)	1978-05-16
CH632521A5 (en)	1982-10-15
CH625810A5 (en)	1981-10-15
FR2366311A1 (fr)	1978-04-28
JPS6214557B2 (da)	1987-04-02
IL53012A0 (en)	1977-11-30
NL7710089A (nl)	1978-03-31
CH631998A5 (en)	1982-09-15
DE2743069C2 (de)	1987-03-05
JPS5356652A (en)	1978-05-23
ZA775800B (en)	1978-08-30
CH632279A5 (en)	1982-09-30
CH625809A5 (en)	1981-10-15
IE46047L (en)	1978-03-29
DE2743069A1 (de)	1978-03-30
CH625808A5 (en)	1981-10-15
CH632000A5 (en)	1982-09-15
ES462763A1 (es)	1978-05-16
CY1178A (en)	1983-06-10
ATA151279A (de)	1980-12-15
AT363197B (de)	1981-07-10
DK146017B (da)	1983-05-24
CA1101410A (en)	1981-05-19
HU175218B (hu)	1980-06-28
ATA151379A (de)	1980-12-15
BE859120A (fr)	1978-03-28
AT363203B (de)	1981-07-27
CH631999A5 (en)	1982-09-15
IE46047B1 (en)	1983-02-09
FR2366311B1 (da)	1982-12-03
DD133150A5 (de)	1978-12-13
MY8400092A (en)	1984-12-31
DK146017C (da)	1983-10-24
SG3383G (en)	1983-09-09
HK16683A (en)	1983-05-27
KE3258A (en)	1983-03-04
SE436751B (sv)	1985-01-21
AU2914877A (en)	1979-04-05
ATA691077A (de)	1980-12-15
AT363202B (de)	1981-07-27
AU514200B2 (en)	1981-01-29
CH624967A5 (en)	1981-08-31
GB1563638A (en)	1980-03-26
SE7706673L (sv)	1978-03-30
IL53012A (en)	1982-05-31

Legal Events

Date	Code	Title	Description
1997-07-14	PUP	Patent expired

Publication	Publication Date	Title
DK492677A (da)	1978-05-06	Fremgangsmaade til fremstilling af substituerede benzam9der
DK399577A (da)	1978-03-10	Fremgangsmaade til fremstilling af urinstof
DK377A (da)	1977-07-06	Fremgangsmade til fremstilling af n-phosphonomethyl-glycin
DK354678A (da)	1979-02-20	Fremgangsmaade til fremstilling af propenylaminer
DK207178A (da)	1978-11-18	Fremgangsmaade til fremstilling af sojaskraa
DK244577A (da)	1977-12-04	Fremgangsmade til fremstilling af hydantoinderivater
DK31377A (da)	1977-08-14	Fremgangsmade til fremstilling af et antihypertensivt middel
DK339677A (da)	1978-01-29	Fremgangsmade til fremstilling af 2-benzylpyrrolidiner
DK452578A (da)	1979-04-12	Fremgangsmaade til fremstilling af furanderivater
DK144377A (da)	1977-10-03	Fremgangsmade til fremstilling af acylcyanider
DK377978A (da)	1979-02-28	Fremgangsmaade til fremstilling af opskummede plaststoffer
DK192778A (da)	1978-11-06	Fremgangsmaade til fremstilling af bisamidiner
DK97877A (da)	1977-09-09	Fremgangsmade til fremstilling af urinstofderivater
DK502077A (da)	1978-05-13	Fremgangsmaade til fremstilling af gammapyroner
DK87977A (da)	1977-09-02	Fremgangsmade til fremstilling af benzylestere
DK216977A (da)	1977-11-22	Fremgangsmade til fremstilling af imidazobenzoxaziner
DK144277A (da)	1977-10-03	Fremgangsmade til fremstilling af acylcyanider
DK73977A (da)	1977-08-24	Fremgangsmade til fremstilling af d-homosteroider
DK551677A (da)	1978-06-19	Fremgangsmaade til fremstilling af prostaglandinanaloge
DK379277A (da)	1978-02-28	Fremgangsmaade til fremstilling af prostaglandinanaloge
DK140728B (da)	1979-11-05	Fremgangsmåde til fremstilling af pregnanderivater.
DK159878A (da)	1978-10-13	Fremgangsmaade til fremstilling af urokinase
DK98478A (da)	1978-09-06	Fremgangsmaade til fremstilling af antibiotika
DK562476A (da)	1977-07-08	Fremgangsmade til fremstilling af benzopyraner
DK148775C (da)	1986-03-03	Fremgangsmaade til fremstilling af oelurt