DK2637646T3 - Farmaceutisk kombination indeholdende en ibat-inhibitor og et galdesyrebindemiddel - Google Patents

Farmaceutisk kombination indeholdende en ibat-inhibitor og et galdesyrebindemiddel Download PDF

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DK2637646T3
DK2637646T3 DK11840481.3T DK11840481T DK2637646T3 DK 2637646 T3 DK2637646 T3 DK 2637646T3 DK 11840481 T DK11840481 T DK 11840481T DK 2637646 T3 DK2637646 T3 DK 2637646T3
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phenyl
carbamoyl
methylthio
dibutyl
dioxo
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Per-Göran Gillberg
Hans Graffner
Ingemar Starke
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Albireo Ab
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Claims (16)

1. Kombination indeholdende en IBAT-inhibitor med formlen II
Formel II i hvilken Mer -CH2 eller NH; R1 er H eller OH; og R2 er H, -CH3, -CH2CH3, -CH2CH2CH3, -CH2CH2CH2CH3, -CH(CH3)2, -CH2CH(CH3)2, -CH(CH3)CH2CH3, -CH2OH, CH2OCH3, -CH(OH)CH3j -CH2SCH3 eller -CH2CH2-S-CH3; eller et farmaceutisk acceptabelt salt deraf, og et galdesyrebindemiddel, til samtidig, sekventiel eller særskilt indgivelse, hvor galdesyrebindemidlet er formuleret til frigivelse i colon, til anvendelse ved behandling afen leversygdom valgt fra gruppen bestående af primær biliær cirrhose (PBC); progressiv familiær intrahepatisk cholestase (PFIC); Alagilles syndrom (ALGS); primær skleroserende cholangitis (PSC); ikke-alkoholisk steatohepatitis (NASH); og pruritus ved cholestatisk leversygdom.
2. Kombination til anvendelse ifølge krav 1, hvor leversygdommen er primær biliær cirrhose (PBC).
3. Kombination til anvendelse ifølge krav 1, hvor leversygdommen er progressiv familiær intrahepatisk cholestase (PFIC).
4. Kombination til anvendelse ifølge krav 1, hvor leversygdommen er Alagilles syndrom (ALGS).
5. Kombination til anvendelse ifølge krav 1, hvor leversygdommen er primær skleroserende cholangitis (PSC).
6. Kombination til anvendelse ifølge krav 1, hvor leversygdommen er ikke-alkoholisk steatohepatitis (NASH).
7. Kombination til anvendelse ifølge krav 1, hvor leversygdommen er pruritus ved cholestatisk leversygdom.
8. Kombination til anvendelse ifølge ethvert af kravene 1 til 7, hvor kombinationen er udformet til afgivelse af IBAT-inhibitoren i tyndtarmen og galdesyrebindemidlet i colon.
9. Kombination til anvendelse ifølge ethvert af kravene 1 til 8, hvori forbindelsen med formlen (II) er valgt fra gruppen bestående af: 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-a-[N-(carboxymethyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-a-[N'-((S)-1-carboxyethyl) carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(A/-{(R)-a-[A/-((S)-1 -carboxypropyl) carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((R)-1-carboxy-2-methylthioethyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((R)-1-carboxy-2-methylthio-ethyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxy-2-methylpropyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxy-2-(R)-hydroxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/V-((S)-1 -carboxybutyl) carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(A/-{(R)-a-[A/-((S)-1 -carboxyethyl) carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8- (N-{(R)-a-[N'-((S)-1-carboxypropyl) carbamoyl]-4-hydroxybenzyl} carbamoylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxyethyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxy-2-methylpropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; og 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-1'-phenyl-1'-[N'-(carboxymethyl)carbamoyl]methyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepin, eller et farmaceutisk acceptabelt salt deraf.
10. Kombination til anvendelse ifølge krav 9, hvori forbindelsen med formlen (II) er 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1-carboxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin eller et farmaceutisk acceptabelt salt deraf.
11. Kombination til anvendelse ifølge ethvert af kravene 1 til 10, hvori galdesyrebindemidlet er cholestyramin, cholestipol eller colesevelam.
12. Farmaceutisk sammensætning indeholdende en IBAT-inhibitor med formlen II
Formel II i hvilken Mer -CH2 eller NH; R1 er Fl eller OFI; og R2 er H, -CH3, -CH2CH3, -CH2CH2CH3, -CH2CH2CH2CH3, -CH(CH3)2, -CH2CH(CH3)2, -CH(CH3)CH2CH3j -CH2OH, CH2OCH3j -CH(OH)CH3j -CFI2SCFI3 eller -CFI2CFI2-S-CFI3; eller et farmaceutisk acceptabelt salt deraf og et galdesyrebindemiddel, hvor galdesyrebindemidlet er i kernen og formuleret til frigivelse i colon, og hvor IBAT-inhibitoren er i et ydre lag formuleret til umiddelbar frigivelse eller til forsinket frigivelse i den distale jejunum eller den proximale ileum, til anvendelse ved behandling afen leversygdom valgt fra gruppen bestående af primær biliær cirrhose (PBC); progressiv familiær intrahepatisk cholestase (PFIC); Alagilles syndrom (ALGS); primær skleroserende cholangitis (PSC); ikke-alkoholisk steatohepatitis (NASFI); og pruritus ved cholestatisk leversygdom.
13. Formulering til anvendelse ifølge krav 12, indeholdende (i) en indre kerne indeholdende et galdesyrebindemiddel; (ii) et colonfrigivelseslag på kernen; (iii) et IBAT-inhibitorlag på colonfrigivelseslaget; og (iv) et ydre beskyttende overtræk.
14. Formulering til anvendelse ifølge krav 12 eller 13, hvori IBAT-inhibitorlaget indeholder en forbindelse valgt fra gruppen bestående af: 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-a-[N-(carboxymethyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-a-[N'-((S)-1-carboxyethyl) carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(A/-{(R)-a-[A/-((S)-1 -carboxypropyl) carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((R)-1-carboxy-2-methylthioethyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxypropyl) carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((R)-1-carboxy-2-methylthio-ethyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/V-((S)-1 -carboxy-2-methylpropyl)carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(A/-{(R)-a-[A/-((S)-1 -carboxy-2-(R)-hydroxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxybutyl) carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxyethyl) carbamoyl]benzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-a-[N'-((S)-1-carboxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/\/-((S)-1 -carboxyethyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; 1.1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[/V-((S)-1 -carboxy-2-methylpropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin; og 1.1- dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-1'-phenyl-1'-[N'-(carboxymethyl)carbamoyl]methyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepin, eller et farmaceutisk acceptabelt salt deraf.
15. Formulering til anvendelse ifølge krav 14, hvori IBAT-inhibitorlaget indeholder forbindelsen 1,1 -dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(/V-{(R)-a-[A/-((S)-1-carboxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepin eller et farmaceutisk acceptabelt salt deraf.
16. Formulering til anvendelse ifølge ethvert af kravene 12 til 15, hvori galdesyrebindemidlet er cholestyramin, cholestipol eller colesevelam.
DK11840481.3T 2010-11-08 2011-11-08 Farmaceutisk kombination indeholdende en ibat-inhibitor og et galdesyrebindemiddel DK2637646T3 (da)

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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062861A2 (en) 2008-11-26 2010-06-03 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
ES2552657T3 (es) 2010-05-26 2015-12-01 Satiogen Pharmaceuticals, Inc. Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias
ES2687027T3 (es) 2010-11-04 2018-10-23 Albireo Ab Inhibidores de ibat para el tratamiento de enfermedades hepáticas
DK2637646T3 (da) * 2010-11-08 2016-08-29 Albireo Ab Farmaceutisk kombination indeholdende en ibat-inhibitor og et galdesyrebindemiddel
WO2012064268A1 (en) * 2010-11-08 2012-05-18 Albireo Ab Ibat inhibitors for treatment of metabolic disorders and related conditions
AU2012328526B2 (en) 2011-10-28 2017-05-25 Shire Human Genetic Therapies, Inc. Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
US20130108573A1 (en) 2011-10-28 2013-05-02 Lumena Pharmaceuticals, Inc. Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
CA2952405A1 (en) * 2014-06-25 2015-12-30 Ea Pharma Co., Ltd. Solid formulation and method for stabilizing the same
CN106659726A (zh) 2014-06-25 2017-05-10 Ea制药株式会社 固体制剂及其着色防止或着色减少方法
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
CN105520919A (zh) * 2015-12-28 2016-04-27 青岛海之星生物科技有限公司 一种考来替泊缓释胶囊及制备方法
CN105456219A (zh) * 2015-12-28 2016-04-06 青岛海之星生物科技有限公司 一种考来替泊缓释片及制备方法
WO2017138878A1 (en) * 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
ES2874669T3 (es) * 2016-02-09 2021-11-05 Albireo Ab Formulación oral de colestiramina y uso de la misma
CN108601739B (zh) * 2016-02-09 2022-01-04 阿尔比里奥公司 考来烯胺丸剂及其制备方法
CN111032019B (zh) 2017-08-09 2022-07-05 阿尔比里奥公司 考来烯胺颗粒、口服考来烯胺制剂及其用途
EP3664782B1 (en) * 2017-08-09 2025-01-29 Albireo AB Cholestyramine pellets, oral cholestyramine formulations and medical use thereof
CN112449637B (zh) 2018-06-05 2024-03-19 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
PL3810581T3 (pl) * 2018-06-20 2025-04-28 Albireo Ab Modyfikacje kryształu odewiksibatu
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11524029B2 (en) 2018-08-13 2022-12-13 Viscera Labs, Inc. Therapeutic composition and methods
US11590161B2 (en) 2018-08-13 2023-02-28 Viscera Labs, Inc. Therapeutic composition and methods
TWI835997B (zh) 2019-02-06 2024-03-21 瑞典商艾爾比瑞歐公司 苯并噻氮呯化合物及其用作膽酸調節劑之用途
CN118852054A (zh) 2019-02-06 2024-10-29 阿尔比里奥公司 苯并硫杂二氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途
EP3923943B1 (en) * 2019-02-12 2024-07-31 Mirum Pharmaceuticals, Inc. Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency
JP2022544239A (ja) 2019-08-12 2022-10-17 マサチューセッツ インスティテュート オブ テクノロジー 治療薬の投与のための物品及び方法
EP4069247B1 (en) 2019-12-04 2025-03-26 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
JP7696898B2 (ja) 2019-12-04 2025-06-23 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CA3158175A1 (en) * 2019-12-04 2021-06-10 Per-Goran Gillberg Benzothiazepine compounds and their use as bile acid modulators
ES2973355T3 (es) 2019-12-04 2024-06-19 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
IL293379B2 (en) 2019-12-04 2026-04-01 Albireo Ab Benzothia(dia)azepine compounds and their use as bile acid modulators
EP4188541B1 (en) 2020-08-03 2024-12-25 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
CA3196488A1 (en) 2020-11-12 2022-05-19 Albireo Ab Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
BR112023010799A2 (pt) 2020-12-04 2023-10-03 Albireo Ab Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
WO2023039276A1 (en) * 2021-09-13 2023-03-16 Curtails Llc Use of ibat inhibitors and antimicrobials for the treatment of diseases
TW202535435A (zh) * 2024-02-01 2025-09-16 愛爾蘭商宇宙科技有限公司 用於治療膽汁酸吸收不良之組合物及方法
EP4595954A1 (en) * 2024-02-01 2025-08-06 Cosmo Technologies Ltd. Compositions and methods for treating bile acid malabsorption
TW202539708A (zh) * 2024-02-01 2025-10-16 愛爾蘭商宇宙科技有限公司 用於治療膽汁酸吸收不良之組合物及方法
EP4595955A1 (en) * 2024-02-01 2025-08-06 Cosmo Technologies Ltd. Compositions and methods for treating bile acid malabsorption

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE580490A (fr) 1958-07-15 1960-01-08 Merck & Co Inc Compositions et procédés pour abaisser la teneur en cholestérol du sang
US3308020A (en) 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3383281A (en) 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
NL7017227A (da) 1969-12-27 1971-06-29
GB1348642A (en) 1970-10-15 1974-03-20 Howard A N Hypocholesterolaemic compositions
US3769399A (en) 1971-03-05 1973-10-30 L Hagerman Intestinal bile acid binding process and compositions
US3974272A (en) 1972-09-01 1976-08-10 Merck & Co., Inc. Palatable cholestyramine coacervate compositions
US4252790A (en) 1974-10-23 1981-02-24 Interx Research Corporation Method for treating gastric ulcer-prone patients
GB1566609A (en) 1977-03-10 1980-05-08 Reckitt & Colmann Prod Ltd Pharmaceutical compositions containing cholestyramine and alginic acid
IT1106718B (it) 1978-12-21 1985-11-18 Alfa Farmaceutici Spa Composizioni a base di resine anioniche salificate farmacologicamente attive
CA1247547A (en) 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
GB8531071D0 (en) 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB2184122B (en) 1985-12-17 1989-10-18 Boots Co Plc N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate
US4895723A (en) 1986-09-08 1990-01-23 Amer And Company Cholestyramine compositions and method for preparation thereof
US4814354A (en) 1986-09-26 1989-03-21 Warner-Lambert Company Lipid regulating agents
GB8903564D0 (en) 1989-02-16 1989-04-05 Rashid Abdul Drug dispensing device
US4874744A (en) 1989-03-13 1989-10-17 University Of Cincinnati Method of using melanocyte stimulating hormone as dermatis treatment
US5250524A (en) 1990-12-06 1993-10-05 Hoechst Aktiengesellschaft Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals
EP0549967B1 (de) 1991-12-20 1996-03-13 Hoechst Aktiengesellschaft Polymere und Oligomere von Gallensäurederivaten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
GB9203347D0 (en) 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
IT1257793B (it) * 1992-05-18 1996-02-13 Composizione farmaceutica a base di acidi biliari in microgranuli a rilascio controllato
DK0573848T3 (da) 1992-06-12 1998-08-10 Hoechst Ag Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler
IL108634A0 (en) 1993-02-15 1994-05-30 Wellcome Found Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them
ZA941003B (en) 1993-02-15 1995-08-14 Wellcome Found Hypolipidaemic compounds
DE4314583A1 (de) 1993-04-29 1994-11-03 Astra Chem Gmbh Colestyramin enthaltende Zusammensetzung und Verfahren zu deren Herstellung
TW289757B (da) 1993-05-08 1996-11-01 Hoechst Ag
TW289020B (da) 1993-05-08 1996-10-21 Hoechst Sktiengesellschaft
EP0624593A3 (de) 1993-05-08 1995-06-07 Hoechst Ag Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel.
TW289021B (da) 1993-05-08 1996-10-21 Hoechst Ag
US5607669A (en) 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
ZA956647B (en) 1994-08-10 1997-02-10 Wellcome Found Hypolipidaemic compounds.
CN1084741C (zh) 1994-09-13 2002-05-15 孟山都公司 具有回肠胆汁酸转运和牛磺胆酸盐摄入抑制剂作用的新的苯并硫杂䓬
US5994391A (en) 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
GB9423172D0 (en) 1994-11-17 1995-01-04 Wellcom Foundation The Limited Hypolipidemic benzothiazepines
AU724620B2 (en) * 1996-01-16 2000-09-28 Sokol, Ronald J Dr. Use of antioxidant agents to treat cholestatic liver disease
HUP9903047A3 (en) 1996-03-11 2002-12-28 G D Searle & Co Chicago Novel benzothiazepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
AU3940897A (en) 1996-07-24 1998-02-10 Zumtobel Staff Gmbh Adapter for a retaining means used to secure a built-in lamp in a mounting hole,or retaining means or built-in lamp provided with such an adapter
DE19633268A1 (de) 1996-08-19 1998-02-26 Hoechst Ag Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
PL336415A1 (en) 1997-03-11 2000-06-19 Searle & Co Combined therapy employing ileic bile acid transport inhibiting benzothiepins as well as a hmg co-enzyme reductase inhibitors
DK0864582T3 (da) 1997-03-14 2003-09-29 Aventis Pharma Gmbh Hypolidemiske 1,4-benzothiazepin-1,1-dioxider
SE9702305D0 (sv) 1997-06-17 1997-06-17 Astra Ab New thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives
US6066336A (en) 1997-09-29 2000-05-23 Bristol-Myers Squibb Company Cholesterol-lowering tablets
ATE234829T1 (de) 1997-12-19 2003-04-15 Searle & Co Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxyden
GB9800428D0 (en) 1998-01-10 1998-03-04 Glaxo Group Ltd Chemical compounds
SE9801992D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
MA26634A1 (fr) 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
SE9801990D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl propionic acid derivatives and analogs
DE19825804C2 (de) 1998-06-10 2000-08-24 Aventis Pharma Gmbh 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
WO2000038727A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
KR20020002367A (ko) 1998-12-23 2002-01-09 윌리암스 로저 에이 심혈관 징후를 위한 조합물
JP2002533412A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するための回腸胆汁酸輸送阻害剤およびコレステリルエステル転送タンパク質阻害剤の組み合わせ
PT1140190E (pt) 1998-12-23 2003-02-28 Searle Llc Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares
JP2002533415A (ja) 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するための回腸胆汁酸輸送阻害剤およびニコチン酸誘導体の組み合わせ
JP2002536440A (ja) 1999-02-12 2002-10-29 ジー．ディー．サール エルエルシー 回腸胆汁酸輸送およびタウロコール酸塩取り込みの阻害剤としての活性を有する新規１，２−ベンゾチアゼピン
DE19916108C1 (de) 1999-04-09 2001-01-11 Aventis Pharma Gmbh Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung
SE9901387D0 (sv) * 1999-04-19 1999-04-19 Astra Ab New pharmaceutical foromaulations
GB9919413D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
GB9919411D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
TW574193B (en) 1999-12-03 2004-02-01 Astrazeneca Ab Novel phenalkyloxy-phenyl derivatives, pharmaceutical composition containing the same and their uses
SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
WO2001068096A2 (en) 2000-03-10 2001-09-20 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US6586434B2 (en) 2000-03-10 2003-07-01 G.D. Searle, Llc Method for the preparation of tetrahydrobenzothiepines
FR2812886B1 (fr) * 2000-08-08 2002-11-08 Assist Publ Hopitaux De Paris Depistage d'un nouveau syndrome hepatique et ses applications
SE0003766D0 (sv) * 2000-10-18 2000-10-18 Astrazeneca Ab Novel formulation
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
DE10131715B4 (de) 2001-06-29 2010-03-18 Sms Siemag Aktiengesellschaft Vorrichtung zum Stranggießen von flüssigen Metallen, insbesondere von Stahl, mit auf einem Schwingrahmen angeordneter Stranggießkokille
GB0121337D0 (en) 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
GB0121621D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
AU2002329387B2 (en) * 2001-09-08 2007-06-07 Albireo Ab Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (IBAT) inhibitory activity for the treatment hyperlipidaemia
AU2002332638A1 (en) 2001-09-12 2003-03-24 G.D. Searle Llc Method for the preparation of crystalline tetrahydrobenzothiepines
GB0201850D0 (en) * 2002-01-26 2002-03-13 Astrazeneca Ab Therapeutic treatment
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) * 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
GB0216321D0 (en) 2002-07-13 2002-08-21 Astrazeneca Ab Therapeutic treatment
CN100494185C (zh) * 2002-08-28 2009-06-03 旭化成制药株式会社 新型季铵化合物
US7312208B2 (en) * 2002-08-28 2007-12-25 Asahi Kasei Pharma Corporation Quaternary ammonium compounds
GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
US7670624B2 (en) * 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
US20090131395A1 (en) * 2005-05-05 2009-05-21 Microbia, Inc. Biphenylazetidinone cholesterol absorption inhibitors
DE102005033099A1 (de) 2005-07-15 2007-01-18 Sanofi-Aventis Deutschland Gmbh Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung
DE102005033100B3 (de) 2005-07-15 2007-01-25 Sanofi-Aventis Deutschland Gmbh Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, diese Verbindung enthaltene Arzneimittel und Verfahren zu deren Herstellung
WO2007050628A2 (en) 2005-10-24 2007-05-03 Andrew Young Biliary/pancreatic shunt device and method for treatment of metabolic and other diseases
DE102006053637B4 (de) 2006-11-14 2011-06-30 Sanofi-Aventis Deutschland GmbH, 65929 Neue mit Fluor substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
WO2008067219A2 (en) 2006-11-29 2008-06-05 Kalypsys, Inc. Quinazolinone modulators of tgr5
AU2008209566C1 (en) 2007-01-19 2013-02-14 Intercept Pharmaceuticals, Inc. 23-substituted bile acids as TGR5 modulators and methods of use thereof
US20080221161A1 (en) 2007-02-09 2008-09-11 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
WO2010062861A2 (en) * 2008-11-26 2010-06-03 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
ES2687027T3 (es) * 2010-11-04 2018-10-23 Albireo Ab Inhibidores de ibat para el tratamiento de enfermedades hepáticas
DK2637646T3 (da) * 2010-11-08 2016-08-29 Albireo Ab Farmaceutisk kombination indeholdende en ibat-inhibitor og et galdesyrebindemiddel
WO2012064268A1 (en) * 2010-11-08 2012-05-18 Albireo Ab Ibat inhibitors for treatment of metabolic disorders and related conditions
AU2019350487A1 (en) * 2018-09-27 2021-05-13 Albireo Energy, Llc System, apparatus and hybrid VAV device with multiple heating coils

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US20230330176A1 (en) 2023-10-19
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