DK2755963T3 - Nye dihydroquinolin-2-on-derivater - Google Patents

Nye dihydroquinolin-2-on-derivater Download PDF

Info

Publication number: DK2755963T3
Authority: DK; Denmark
Prior art keywords: dihydroquinolin; derivatives; new; new dihydroquinolin
Prior art date: 2011-09-15

Application number

DK12756741.0T

Other languages

English (en)

Inventor

Johannes Aebi

Kurt Amrein

Benoit Hornsperger

Henner Knust

Bernd Kuhn

Yongfu Liu

Hans P Maerki

Peter Mohr

Xuefei Tan

Mingwei Zhou

Alexander V Mayweg

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-09-15

Filing date

2012-09-12

Publication date

2020-01-13

2012-09-12 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2020-01-13 Application granted granted Critical

2020-01-13 Publication of DK2755963T3 publication Critical patent/DK2755963T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK12756741.0T 2011-09-15 2012-09-12 Nye dihydroquinolin-2-on-derivater DK2755963T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CN2011079673		2011-09-15
PCT/EP2012/067744 WO2013037779A1 (en)	2011-09-15	2012-09-12	New dihydroquinoline-2-one derivatives

Publications (1)

Publication Number	Publication Date
DK2755963T3 true DK2755963T3 (da)	2020-01-13

Family

ID=46829775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK12756741.0T DK2755963T3 (da)	2011-09-15	2012-09-12	Nye dihydroquinolin-2-on-derivater

Country Status (33)

Country	Link
US (1)	US9260408B2 (da)
EP (2)	EP2755963B1 (da)
JP (1)	JP6012735B2 (da)
KR (1)	KR101785143B1 (da)
CN (1)	CN103814021B (da)
AR (1)	AR087901A1 (da)
AU (1)	AU2012307509B2 (da)
BR (1)	BR112014006283B1 (da)
CA (1)	CA2846785C (da)
CL (1)	CL2014000604A1 (da)
CO (1)	CO6890099A2 (da)
CR (1)	CR20140091A (da)
DK (1)	DK2755963T3 (da)
EA (1)	EA035757B1 (da)
EC (1)	ECSP14013245A (da)
ES (2)	ES2763332T3 (da)
HR (1)	HRP20192323T1 (da)
HU (1)	HUE047771T2 (da)
IL (1)	IL231229A0 (da)
LT (1)	LT2755963T (da)
MX (1)	MX358376B (da)
MY (1)	MY169043A (da)
PE (1)	PE20141372A1 (da)
PH (1)	PH12014500434A1 (da)
PL (1)	PL2755963T3 (da)
PT (1)	PT2755963T (da)
RS (1)	RS59737B1 (da)
SG (1)	SG11201400679WA (da)
SI (1)	SI2755963T1 (da)
TW (1)	TWI462914B (da)
UA (1)	UA111626C2 (da)
WO (1)	WO2013037779A1 (da)
ZA (1)	ZA201401884B (da)

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WO2014135561A1 (en) *	2013-03-08	2014-09-12	F. Hoffmann-La Roche Ag	New dihydroquinoline-2-one derivatives as aldosterone synthase (cyp1 1 b2 or cyp1 1 b1 ) inhibitors
RU2015138961A (ru) *	2013-03-14	2017-04-18	Ф. Хоффманн-Ля Рош Аг	Производные дигидрохинолин-2-она для применения в качестве ингибиторов альдостеронсинтазы
US9682983B2 (en)	2013-03-14	2017-06-20	The Brigham And Women's Hospital, Inc.	BMP inhibitors and methods of use thereof
CN105073732B (zh) *	2013-03-14	2017-07-21	豪夫迈·罗氏有限公司	用作醛固酮合酶抑制剂的二氢喹啉‑2‑酮衍生物
WO2014179186A1 (en) *	2013-04-30	2014-11-06	Boehringer Ingelheim International Gmbh	Aldosterone synthase inhibitors
SI3004076T1 (sl) *	2013-05-27	2020-02-28	F. Hoffmann-La Roche Ag	Novi spojini 3,4-dihidro-2H-izokinolin-1-on in 2,3-dihidro-izoindol-1-on
JP6581970B2 (ja) *	2013-05-27	2019-09-25	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	新規３，４−ジヒドロ−２ｈ−イソキノリン−１−オン及び２，３−ジヒドロ−イソインドール−１−オン化合物
CN105143205B (zh) *	2013-05-27	2018-02-02	豪夫迈·罗氏有限公司	新的3,4‑二氢‑2h‑异喹啉‑1‑酮和2,3‑二氢‑异吲哚‑1‑酮化合物
WO2014191338A1 (en) *	2013-05-27	2014-12-04	F. Hoffmann-La Roche Ag	New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds
WO2015125858A1 (ja) *	2014-02-24	2015-08-27	日本曹達株式会社	ヘテロアリール化合物およびその用途
WO2015148654A1 (en) *	2014-03-26	2015-10-01	The Brigham And Women's Hospital, Inc.	Compositions and methods for inhibiting bmp
MY176401A (en)	2014-04-24	2020-08-05	Mitsubishi Tanabe Pharma Corp	Novel disubstituted 1,2,4-triazine compound
WO2016011019A1 (en)	2014-07-15	2016-01-21	The Brigham And Women's Hospital, Inc.	Compositions and methods for inhibiting bmp
PE20171057A1 (es) *	2014-10-08	2017-07-21	Hoffmann La Roche	Derivados espirodiamina como inhibidores de la aldosterona sintasa
CN106660998B (zh) *	2014-10-31	2019-10-25	豪夫迈·罗氏有限公司	吡唑基-3,4-二氢喹啉-2-酮醛固酮合酶抑制剂
CN106604917B (zh) *	2014-10-31	2020-10-09	豪夫迈·罗氏有限公司	作为醛固酮合酶抑制剂的新型二氢喹啉吡唑基化合物
JP6622300B2 (ja) *	2014-10-31	2019-12-18	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	新規なジヒドロキノリンピラゾリル化合物
ES2799300T3 (es)	2015-08-31	2020-12-16	Dong A Socio Holdings Co Ltd	Compuestos heteroarilo y su uso como fármacos terapéuticos
JP6314196B2 (ja) *	2015-10-22	2018-04-18	田辺三菱製薬株式会社	医薬組成物
EP3381904B1 (en) *	2015-10-23	2021-07-28	Mitsubishi Tanabe Pharma Corporation	Novel nitrogen-containing aromatic heterocyclic compound
US10913730B2 (en)	2016-10-10	2021-02-09	Dong-A Socio Holdings Co., Ltd.	Heteroaryl compounds and their use as Mer inhibitors
BR112019006571A2 (pt) *	2016-12-08	2019-07-02	F. Hoffmann-La Roche Ag	derivados de éter de isoxazolila como gaba a alfa5 pam
JP7530384B2 (ja)	2019-05-01	2024-08-07	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	（ｒ）－（２－メチルオキシラン－２－イル）メチル４－ブロモベンゼンスルホネート
WO2023063851A1 (en) *	2021-10-13	2023-04-20	«Target Medicals» Limited Liability Company	Inhibitors of human aldosterone synthase (cyp11b2)
CA3236890A1 (en)	2021-12-14	2023-06-22	Boehringer Ingelheim International Gmbh	Aldosterone synthase inhibitors for treating chronic kidney disease
AU2023378302A1 (en) *	2022-11-10	2025-04-10	«Target Medicals» Limited Liability Company	Inhibitors of human aldosterone synthase (cyp11b2)
CN120187713A (zh) *	2022-11-23	2025-06-20	上海翰森生物医药科技有限公司	吡啶多环类化合物抑制剂、及其制备方法和应用
WO2024235165A1 (zh) *	2023-05-12	2024-11-21	南京明德新药研发有限公司	含氮杂环类化合物及其应用
TW202535378A (zh) *	2023-12-22	2025-09-16	大陸商上海翊石醫藥科技有限公司	一種芳雜環化合物及其製備方法和應用
CN121135736A (zh) *	2024-03-01	2025-12-16	浙江扬厉医药技术有限公司	吡喃并吡啶类化合物、其制备方法、药物组合物及应用

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GB8334282D0 (en) *	1983-12-22	1984-02-01	Pfizer Ltd	Quinolone inotropic agents
PT79699B (en) *	1983-12-22	1986-12-10	Pfizer	Process for preparing quinolone inotropic agents
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FR2580646A1 (fr) *	1985-04-19	1986-10-24	Synthelabo	Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique
WO2006113432A2 (en)	2005-04-14	2006-10-26	Smithkline Beecham Corporation	Compounds, compositions and methods
DE102008022221A1 (de) *	2008-05-06	2009-11-12	Universität des Saarlandes	Inhibitoren der humanen Aldosteronsynthase CYP11B2
WO2010130773A2 (en)	2009-05-15	2010-11-18	Novartis Ag	Benzoxazolone derivatives as aldosterone symthase inhibitors
HRP20140371T1 (hr)	2009-05-15	2014-05-23	Novartis Ag	Arilpiridini kao inhibitori sinteze aldosterona
US8541404B2 (en)	2009-11-09	2013-09-24	Elexopharm Gmbh	Inhibitors of the human aldosterone synthase CYP11B2

2012
- 2012-09-12 TW TW101133381A patent/TWI462914B/zh active
- 2012-09-12 PE PE2014000328A patent/PE20141372A1/es active IP Right Grant
- 2012-09-12 ES ES12756741T patent/ES2763332T3/es active Active
- 2012-09-12 KR KR1020147009761A patent/KR101785143B1/ko active Active
- 2012-09-12 BR BR112014006283-8A patent/BR112014006283B1/pt active IP Right Grant
- 2012-09-12 EA EA201490596A patent/EA035757B1/ru not_active IP Right Cessation
- 2012-09-12 AU AU2012307509A patent/AU2012307509B2/en active Active
- 2012-09-12 PL PL12756741T patent/PL2755963T3/pl unknown
- 2012-09-12 JP JP2014530184A patent/JP6012735B2/ja active Active
- 2012-09-12 LT LTEP12756741.0T patent/LT2755963T/lt unknown
- 2012-09-12 ES ES19204552T patent/ES3016782T3/es active Active
- 2012-09-12 RS RS20191655A patent/RS59737B1/sr unknown
- 2012-09-12 HU HUE12756741A patent/HUE047771T2/hu unknown
- 2012-09-12 HR HRP20192323TT patent/HRP20192323T1/hr unknown
- 2012-09-12 SG SG11201400679WA patent/SG11201400679WA/en unknown
- 2012-09-12 PT PT127567410T patent/PT2755963T/pt unknown
- 2012-09-12 MX MX2014002770A patent/MX358376B/es active IP Right Grant
- 2012-09-12 CA CA2846785A patent/CA2846785C/en active Active
- 2012-09-12 EP EP12756741.0A patent/EP2755963B1/en active Active
- 2012-09-12 MY MYPI2014700616A patent/MY169043A/en unknown
- 2012-09-12 DK DK12756741.0T patent/DK2755963T3/da active
- 2012-09-12 WO PCT/EP2012/067744 patent/WO2013037779A1/en not_active Ceased
- 2012-09-12 EP EP19204552.4A patent/EP3653618B1/en active Active
- 2012-09-12 PH PH1/2014/500434A patent/PH12014500434A1/en unknown
- 2012-09-12 CN CN201280045041.1A patent/CN103814021B/zh active Active
- 2012-09-12 SI SI201231713T patent/SI2755963T1/sl unknown
- 2012-09-13 US US13/612,956 patent/US9260408B2/en active Active
- 2012-09-17 AR ARP120103420A patent/AR087901A1/es active IP Right Grant
- 2012-12-09 UA UAA201404030A patent/UA111626C2/uk unknown
2014
- 2014-02-25 CR CR20140091A patent/CR20140091A/es unknown
- 2014-02-26 CO CO14040934A patent/CO6890099A2/es unknown
- 2014-02-27 IL IL231229A patent/IL231229A0/en active IP Right Grant
- 2014-03-13 CL CL2014000604A patent/CL2014000604A1/es unknown
- 2014-03-14 EC ECSP14013245 patent/ECSP14013245A/es unknown
- 2014-03-14 ZA ZA201401884A patent/ZA201401884B/en unknown

Also Published As

Publication number	Publication date
ES3016782T3 (en)	2025-05-09
RS59737B1 (sr)	2020-02-28
AR087901A1 (es)	2014-04-23
HUE047771T2 (hu)	2020-05-28
PE20141372A1 (es)	2014-10-13
CA2846785C (en)	2020-09-22
PH12014500434A1 (en)	2017-04-19
SG11201400679WA (en)	2014-04-28
EA035757B1 (ru)	2020-08-05
PL2755963T3 (pl)	2020-07-27
CO6890099A2 (es)	2014-03-10
AU2012307509A1 (en)	2014-03-13
CN103814021B (zh)	2016-12-21
HRP20192323T1 (hr)	2020-03-20
KR101785143B1 (ko)	2017-10-12
LT2755963T (lt)	2020-01-27
CA2846785A1 (en)	2013-03-21
TWI462914B (zh)	2014-12-01
ES2763332T3 (es)	2020-05-28
EP2755963A1 (en)	2014-07-23
EA201490596A1 (ru)	2014-07-30
KR20140067121A (ko)	2014-06-03
CL2014000604A1 (es)	2014-10-17
MX358376B (es)	2018-08-16
US20130072679A1 (en)	2013-03-21
JP2014527077A (ja)	2014-10-09
CN103814021A (zh)	2014-05-21
IL231229A0 (en)	2014-04-30
CR20140091A (es)	2014-06-03
EP3653618B1 (en)	2025-01-08
WO2013037779A1 (en)	2013-03-21
JP6012735B2 (ja)	2016-10-25
NZ621599A (en)	2016-07-29
ZA201401884B (en)	2019-11-27
EP2755963B1 (en)	2019-10-30
EP3653618A1 (en)	2020-05-20
UA111626C2 (uk)	2016-05-25
ECSP14013245A (es)	2014-07-31
MX2014002770A (es)	2014-06-05
BR112014006283A2 (pt)	2017-04-11
US9260408B2 (en)	2016-02-16
MY169043A (en)	2019-02-07
AU2012307509B2 (en)	2017-06-29
TW201315724A (zh)	2013-04-16
SI2755963T1 (sl)	2020-01-31
BR112014006283B1 (pt)	2021-11-03
PT2755963T (pt)	2020-01-10

Publication	Publication Date	Title
DK2755963T3 (da)	2020-01-13	Nye dihydroquinolin-2-on-derivater
DK2785695T3 (da)	2020-08-24	Nye bicykliske dihydroisoquinolin-1-on-derivater
DK2776436T3 (da)	2019-06-11	Nye forbindelser
PL2684880T3 (pl)	2018-07-31	Pochodna dispiropirolidyny
DK2744810T4 (da)	2023-11-20	Tenofovir-alafenamid-hemifumarat
HUE038773T2 (hu)	2018-11-28	Új biciklusos dihidrokinolin-2-on származékok
BR112013019509A2 (pt)	2017-03-28	derivados heterocíclicos
DK2769050T3 (da)	2021-05-17	Propsensor
DE102011100082A8 (de)	2013-01-10	Traygreifvorrichtung
DK2734499T3 (da)	2021-11-08	Merocyanine derivatives
IL231950B (en)	2018-02-28	Aryl-quinoline derivatives
BR112014000879A2 (pt)	2017-02-21	deflegmador
DK3272861T3 (da)	2020-03-23	Alpha-galactosidase-sammensætninger
EP2701512A4 (en)	2014-11-26	Aldosterone synthase inhibitors
CO6960543A2 (es)	2014-05-30	2-tiopirimidinonas
DK3141251T3 (da)	2021-02-01	Koloskopi - forberedelse
EP2708561A4 (en)	2014-09-24	BIO-PIN
CO6960557A2 (es)	2014-05-30	Derivados de 2-yodo-imidazol
EP2695208A4 (en)	2014-12-31	MICRO THERMOCOUPLE
DK2836494T3 (da)	2019-11-11	Nye alkyleringsmidler
PL2762466T3 (pl)	2017-09-29	Pochodna fenylu
DE112011104936A5 (de)	2013-11-28	Stanzstauchniet
DE112012000958A5 (de)	2013-11-28	Handsäge
CO6852074A2 (es)	2014-01-30	Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida
DK3106464T3 (da)	2020-03-23	Nye forbindelser