LT2755963T - Nauji dihidrochinolin-2-ono dariniai - Google Patents
Nauji dihidrochinolin-2-ono dariniaiInfo
- Publication number
- LT2755963T LT2755963T LTEP12756741.0T LT12756741T LT2755963T LT 2755963 T LT2755963 T LT 2755963T LT 12756741 T LT12756741 T LT 12756741T LT 2755963 T LT2755963 T LT 2755963T
- Authority
- LT
- Lithuania
- Prior art keywords
- dihydrochinolin
- derivatives
- new
- new dihydrochinolin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011079673 | 2011-09-15 | ||
| PCT/EP2012/067744 WO2013037779A1 (en) | 2011-09-15 | 2012-09-12 | New dihydroquinoline-2-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2755963T true LT2755963T (lt) | 2020-01-27 |
Family
ID=46829775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP12756741.0T LT2755963T (lt) | 2011-09-15 | 2012-09-12 | Nauji dihidrochinolin-2-ono dariniai |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US9260408B2 (lt) |
| EP (2) | EP3653618B1 (lt) |
| JP (1) | JP6012735B2 (lt) |
| KR (1) | KR101785143B1 (lt) |
| CN (1) | CN103814021B (lt) |
| AR (1) | AR087901A1 (lt) |
| AU (1) | AU2012307509B2 (lt) |
| BR (1) | BR112014006283B1 (lt) |
| CA (1) | CA2846785C (lt) |
| CL (1) | CL2014000604A1 (lt) |
| CO (1) | CO6890099A2 (lt) |
| CR (1) | CR20140091A (lt) |
| DK (1) | DK2755963T3 (lt) |
| EA (1) | EA035757B1 (lt) |
| EC (1) | ECSP14013245A (lt) |
| ES (2) | ES2763332T3 (lt) |
| HR (1) | HRP20192323T1 (lt) |
| HU (1) | HUE047771T2 (lt) |
| IL (1) | IL231229A0 (lt) |
| LT (1) | LT2755963T (lt) |
| MX (1) | MX358376B (lt) |
| MY (1) | MY169043A (lt) |
| PE (1) | PE20141372A1 (lt) |
| PH (1) | PH12014500434A1 (lt) |
| PL (1) | PL2755963T3 (lt) |
| PT (1) | PT2755963T (lt) |
| RS (1) | RS59737B1 (lt) |
| SG (1) | SG11201400679WA (lt) |
| SI (1) | SI2755963T1 (lt) |
| TW (1) | TWI462914B (lt) |
| UA (1) | UA111626C2 (lt) |
| WO (1) | WO2013037779A1 (lt) |
| ZA (1) | ZA201401884B (lt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2015137972A (ru) * | 2013-03-08 | 2017-04-13 | Ф. Хоффманн-Ля Рош Аг | Новые производные дигидрохинолин-2-она в качестве ингибиторов альдостеронсинтазы (cyp1 1 b2 или cyp1 1 b1) |
| JP6542192B2 (ja) | 2013-03-14 | 2019-07-10 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | Ｂｍｐ阻害剤およびその使用方法 |
| CN105073732B (zh) * | 2013-03-14 | 2017-07-21 | 豪夫迈·罗氏有限公司 | 用作醛固酮合酶抑制剂的二氢喹啉‑2‑酮衍生物 |
| MX2015011005A (es) * | 2013-03-14 | 2015-10-22 | Hoffmann La Roche | Derivados de dihidorquinolin-2-ona para usarse como inhibidores de aldoesterona sintasa. |
| WO2014179186A1 (en) * | 2013-04-30 | 2014-11-06 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors |
| AR096423A1 (es) * | 2013-05-27 | 2015-12-30 | Hoffmann La Roche | Compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona |
| RU2693698C2 (ru) * | 2013-05-27 | 2019-07-04 | Ф. Хоффманн-Ля Рош Аг | Новые соединения 3,4-дигидро-2н-изохинолин-1-она и 2,3-дигидроизоиндол-1-она |
| WO2014191338A1 (en) * | 2013-05-27 | 2014-12-04 | F. Hoffmann-La Roche Ag | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
| WO2015125858A1 (ja) * | 2014-02-24 | 2015-08-27 | 日本曹達株式会社 | ヘテロアリール化合物およびその用途 |
| WO2015148654A1 (en) * | 2014-03-26 | 2015-10-01 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| MY176401A (en) * | 2014-04-24 | 2020-08-05 | Mitsubishi Tanabe Pharma Corp | Novel disubstituted 1,2,4-triazine compound |
| US10513521B2 (en) | 2014-07-15 | 2019-12-24 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting BMP |
| CR20170118A (es) * | 2014-10-08 | 2017-07-10 | Hoffmann La Roche | Derivados espirodiamina como inhibidores de la aldosterona sintasa |
| EP3212630B1 (en) * | 2014-10-31 | 2022-05-18 | F. Hoffmann-La Roche AG | New dihydroquinoline pyrazolyl compounds |
| CN106660998B (zh) * | 2014-10-31 | 2019-10-25 | 豪夫迈·罗氏有限公司 | 吡唑基-3,4-二氢喹啉-2-酮醛固酮合酶抑制剂 |
| WO2016066662A1 (en) * | 2014-10-31 | 2016-05-06 | F. Hoffmann-La Roche Ag | New dihydroquinoline pyrazolyl compounds as aldosterone synthase inhibitors |
| EP3344613B1 (en) | 2015-08-31 | 2020-03-04 | Dong-A Socio Holdings Co., Ltd. | Heteroaryl compounds and their use as therapeutic drugs |
| JP6314196B2 (ja) * | 2015-10-22 | 2018-04-18 | 田辺三菱製薬株式会社 | 医薬組成物 |
| JP6545275B2 (ja) | 2015-10-23 | 2019-07-17 | 田辺三菱製薬株式会社 | 新規含窒素芳香族複素環化合物 |
| US10913730B2 (en) | 2016-10-10 | 2021-02-09 | Dong-A Socio Holdings Co., Ltd. | Heteroaryl compounds and their use as Mer inhibitors |
| MA48594B1 (fr) * | 2016-12-08 | 2022-05-31 | Hoffmann La Roche | Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba a |
| CN113767095A (zh) | 2019-05-01 | 2021-12-07 | 勃林格殷格翰国际有限公司 | (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯 |
| EP4200281A4 (en) | 2020-08-18 | 2024-09-25 | Hutchison Medipharma Limited | PYRIMIDINONE COMPOUNDS AND THEIR USES |
| WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
| AU2022415313A1 (en) | 2021-12-14 | 2024-05-02 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors for treating chronic kidney disease |
| AU2023378302A1 (en) * | 2022-11-10 | 2025-04-10 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
| JP2025540715A (ja) * | 2022-11-23 | 2025-12-16 | 上▲海▼翰森生物医▲薬▼科技有限公司 | ピリジン多環系化合物阻害剤、及びその製造方法と使用 |
| KR20260009903A (ko) * | 2023-05-12 | 2026-01-20 | 장쑤 더위안 파머슈티컬 코.,엘티디. | 질소 함유 헤테로사이클릭 화합물 및 그의 용도 |
| TW202535378A (zh) * | 2023-12-22 | 2025-09-16 | 大陸商上海翊石醫藥科技有限公司 | 一種芳雜環化合物及其製備方法和應用 |
| CN120289471B (zh) * | 2024-03-01 | 2025-10-17 | 浙江扬厉医药技术有限公司 | 吡喃并吡啶类化合物、其制备方法、药物组合物及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8334282D0 (en) * | 1983-12-22 | 1984-02-01 | Pfizer Ltd | Quinolone inotropic agents |
| US4710507A (en) * | 1983-12-22 | 1987-12-01 | Pfizer Inc. | Quinolone inotropic agents |
| CN85100796A (zh) * | 1985-04-01 | 1986-10-01 | 辉瑞公司 | 喹啉酮衍生物的制备方法 |
| FR2580646A1 (fr) * | 1985-04-19 | 1986-10-24 | Synthelabo | Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique |
| WO2006113432A2 (en) | 2005-04-14 | 2006-10-26 | Smithkline Beecham Corporation | Compounds, compositions and methods |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| MX2011012199A (es) | 2009-05-15 | 2011-12-08 | Novartis Ag | Derivados de benzoxazolona como inhibidores de la sintasa de aldosterona. |
| ES2459468T3 (es) | 2009-05-15 | 2014-05-09 | Novartis Ag | Arilpiridinas como inhibidores de aldosterona sintasa |
| US8541404B2 (en) * | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
-
2012
- 2012-09-12 HR HRP20192323TT patent/HRP20192323T1/hr unknown
- 2012-09-12 PL PL12756741T patent/PL2755963T3/pl unknown
- 2012-09-12 RS RS20191655A patent/RS59737B1/sr unknown
- 2012-09-12 MY MYPI2014700616A patent/MY169043A/en unknown
- 2012-09-12 EA EA201490596A patent/EA035757B1/ru not_active IP Right Cessation
- 2012-09-12 CN CN201280045041.1A patent/CN103814021B/zh active Active
- 2012-09-12 MX MX2014002770A patent/MX358376B/es active IP Right Grant
- 2012-09-12 CA CA2846785A patent/CA2846785C/en active Active
- 2012-09-12 LT LTEP12756741.0T patent/LT2755963T/lt unknown
- 2012-09-12 WO PCT/EP2012/067744 patent/WO2013037779A1/en not_active Ceased
- 2012-09-12 PT PT127567410T patent/PT2755963T/pt unknown
- 2012-09-12 KR KR1020147009761A patent/KR101785143B1/ko active Active
- 2012-09-12 AU AU2012307509A patent/AU2012307509B2/en active Active
- 2012-09-12 TW TW101133381A patent/TWI462914B/zh active
- 2012-09-12 DK DK12756741.0T patent/DK2755963T3/da active
- 2012-09-12 ES ES12756741T patent/ES2763332T3/es active Active
- 2012-09-12 HU HUE12756741A patent/HUE047771T2/hu unknown
- 2012-09-12 JP JP2014530184A patent/JP6012735B2/ja active Active
- 2012-09-12 PE PE2014000328A patent/PE20141372A1/es active IP Right Grant
- 2012-09-12 SG SG11201400679WA patent/SG11201400679WA/en unknown
- 2012-09-12 EP EP19204552.4A patent/EP3653618B1/en active Active
- 2012-09-12 PH PH1/2014/500434A patent/PH12014500434A1/en unknown
- 2012-09-12 SI SI201231713T patent/SI2755963T1/sl unknown
- 2012-09-12 ES ES19204552T patent/ES3016782T3/es active Active
- 2012-09-12 BR BR112014006283-8A patent/BR112014006283B1/pt active IP Right Grant
- 2012-09-12 EP EP12756741.0A patent/EP2755963B1/en active Active
- 2012-09-13 US US13/612,956 patent/US9260408B2/en active Active
- 2012-09-17 AR ARP120103420A patent/AR087901A1/es active IP Right Grant
- 2012-12-09 UA UAA201404030A patent/UA111626C2/uk unknown
-
2014
- 2014-02-25 CR CR20140091A patent/CR20140091A/es unknown
- 2014-02-26 CO CO14040934A patent/CO6890099A2/es unknown
- 2014-02-27 IL IL231229A patent/IL231229A0/en active IP Right Grant
- 2014-03-13 CL CL2014000604A patent/CL2014000604A1/es unknown
- 2014-03-14 EC ECSP14013245 patent/ECSP14013245A/es unknown
- 2014-03-14 ZA ZA201401884A patent/ZA201401884B/en unknown
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