DK2801355T3 - Farmaceutisk sammensætning med reguleret frigivelse omfattende en fumarsyreester. - Google Patents

Farmaceutisk sammensætning med reguleret frigivelse omfattende en fumarsyreester. Download PDF

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Publication number
DK2801355T3
DK2801355T3 DK14172398.1T DK14172398T DK2801355T3 DK 2801355 T3 DK2801355 T3 DK 2801355T3 DK 14172398 T DK14172398 T DK 14172398T DK 2801355 T3 DK2801355 T3 DK 2801355T3
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fumaric acid
composition
acid ester
hours
test
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DK14172398.1T
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Henrik Nilsson
Florian Schönharting
Bernd W Müller
Joseph R Robinson
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Forward Pharma As
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    • A—HUMAN NECESSITIES
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
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Claims (10)

1. Farmaceutisk sammensætning med pH kontrolleret frigivelse til oral anvendelse, hvilken består af dimethylfumarate, som det aktive stof, hvor sammensætningen er tilvejebragt med en enterisk coating, hvor den daglige dosering er fra 480 til 720 mg aktiv stof givet i en til tre doser til anvendelse i behandling af psoriasisarthrit, neurodermatitis, inflammatorisk tarmsygdom, eller en autoimmun sygdom.
2. Sammensætning til anvendelse ifølge krav 1, hvilken er en multi-partikelformet sammensætning og enkelte enheder er tilvejebragt med en enterisk coating.
3. Sammensætning til anvendelse ifølge krav 1, hvor den daglige dosering er fra 480 til 600 mg aktiv stof.
4. Sammensætning til anvendelse ifølge krav 1, hvor den daglige dosering er fra 600 til 720 mg aktiv stof.
5. Sammensætning til anvendelse ifølge krav 1, hvor den daglige dosering er 480 mg aktiv stof.
6. Sammensætning til anvendelse ifølge krav 1, hvor the doseringsformen indeholder 120, 180 eller 240 mg aktiv stof.
7. Sammensætning til anvendelse ifølge krav 1, hvor den autoimmune sygdom er valgt blandt: i. polyarthritis ii. multipel sklerose (MS) iii. juvenil-onset diabetes mellitus iv. Hashimoto's thyroiditis v. Graves sygdom vi. SLE (systemisk lupus erythematosus) vii. Sjogren's syndrome viii. perniciøs anæmi ix. kronisk aktiv (lupoid) hepatitis x. rheumatoid arthrit (RA) xi. optisk neuritis.
8. Sammensætning til anvendelse ifølge krav 7, hvor den autoimmun sygdom er multipel sklerose.
9. Farmaceutisk sammensætning med pH kontrolleret frigivelse til oral anvendelse i behandling af psoriasisarthrit, neurodermatitis, inflammatorisk tarmsygdom, eller en autoimmun sygdom, hvilken består af dimethylfumarate, som det aktive stof, tilvejebragt med en enterisk coating, hvor den daglige dosering er fra 480 mg aktiv stof givet i en til tre doser.
10. Sammensætning til anvendelse ifølge krav 9 i behandling af multipel sklerose.
DK14172398.1T 2004-10-08 2005-10-07 Farmaceutisk sammensætning med reguleret frigivelse omfattende en fumarsyreester. DK2801355T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DKPA200401546 2004-10-08
DKPA200401736 2004-11-10
DKPA200500211 2005-02-11
DKPA200500419 2005-03-23
US69151305P 2005-06-16 2005-06-16
EP05789026.1A EP1799196B1 (en) 2004-10-08 2005-10-07 Controlled release pharmaceutical compositions comprising a fumaric acid ester

Publications (1)

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DK2801355T3 true DK2801355T3 (da) 2015-07-06

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