DK2956482T3 - Behandling af perifert t-cellelymfom - Google Patents

Behandling af perifert t-cellelymfom Download PDF

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Publication number
DK2956482T3
DK2956482T3 DK14704576.9T DK14704576T DK2956482T3 DK 2956482 T3 DK2956482 T3 DK 2956482T3 DK 14704576 T DK14704576 T DK 14704576T DK 2956482 T3 DK2956482 T3 DK 2956482T3
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Denmark
Prior art keywords
nkp46
antibody
ptcl
cells
antibodies
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DK14704576.9T
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English (en)
Inventor
Cécile Bonnafous
Hélène Sicard
Mathieu Blery
Renaud Buffet
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Innate Pharma
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Publication of DK2956482T3 publication Critical patent/DK2956482T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (14)

1. Antistof, der binder et NKp46-polypeptid og udtømmer NKp46-udtrykkende tumorceller, til anvendelse til behandling eller forebyggelse af et perifert T-cellelymfom (PTCL) hos en person.
2. Forbindelse til anvendelse ifølge krav 1, hvor personen har en orto-visceral ekstranodal PTCL.
3. Forbindelse til anvendelse ifølge krav 2, hvor den orto-viscerale ekstranodale sygdom er NK/T-lymfom.
4. Forbindelse til anvendelse ifølge krav 2, hvor den orto-viscerale ekstranodale sygdom er enteropatiforbundet T-cellelymfom (EATL).
5. Forbindelse ifølge krav 1, hvor personen har anaplastisk storcellet lymfom (ALCL).
6. Forbindelse til anvendelse ifølge krav 1, hvor PTCL er et NK/T-lymfom, nasal type, og hvor anvendelsen ikke kræver et trin med bestemmelse af NKp46-polypeptidstatus af maligne celler hos personen, der har et PTCL, før administration af et antistof, der binder et NKp46-polypeptid.
7. Forbindelse til anvendelse ifølge kravene 1 til 5, hvor behandlingen eller forebyggelsen af et PTCL hos en person omfatter: a) bestemmelse af NKp46-polypeptidstatus af maligne celler hos personen, der har et PTCL, og b) ved en bestemmelse af, at et NKp46-polypeptid udtrykkes på overfladen af et væsentligt antal af de maligne celler, administrering til personen af antistoffet, der binder et NKp4 6-polypeptid.
8. Forbindelse til anvendelse ifølge krav 7, hvor bestemmelse af NKp46-polypeptidstatus omfatter bestemmelse af, om et NKp46-polypeptid udtrykkes på overfladen af et væsentligt antal af de maligne celler.
9. Forbindelse til anvendelse ifølge krav 8, hvor bestemmelse af, om et NKp46-polypeptid udtrykkes på overfladen af de maligne celler, omfatter opnåelse fra personen af en biologisk prøve, der omfatter PTCL-celler, etablering af kontakt mellem cellerne og et antistof, der binder et NKp46-polypeptid, og påvisning af celler, der udtrykker NKp46.
10. Forbindelse til anvendelse ifølge krav 1, hvor antistoffet omfatter en konstant region af human IgGl eller IgG3.
11. Forbindelse til anvendelse ifølge krav 1 eller 10, hvor antistoffet omfatter en modificeret Fc-konstant region.
12. Forbindelse til anvendelse ifølge krav 1, 10 eller 11, hvor antistoffet omfatter en aminosyremodifikation, der øger binding til en human Fcy-receptor.
13. Forbindelse til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor antistoffet er koblet til et toksisk middel.
14. Forbindelse til anvendelse ifølge et hvilket som helst af ovennævnte krav, hvor anti-NKp46-antistoffet administreres som en farmaceutisk acceptabel sammensætning, der omfatter en terapeutisk effektiv mængde af anti-NKp46-antistoffet.
DK14704576.9T 2013-02-14 2014-02-13 Behandling af perifert t-cellelymfom DK2956482T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361764639P 2013-02-14 2013-02-14
US201361831792P 2013-06-06 2013-06-06
PCT/EP2014/052849 WO2014125041A1 (en) 2013-02-14 2014-02-13 Treatment of peripheral t cell lymphoma

Publications (1)

Publication Number Publication Date
DK2956482T3 true DK2956482T3 (da) 2017-10-16

Family

ID=50112904

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17177583.6T DK3255062T3 (da) 2013-02-14 2014-02-13 Anti-nkp46-antistof til diagnosticering af et ikke-kutant perifert t-cellelymfom (ptcl)
DK14704576.9T DK2956482T3 (da) 2013-02-14 2014-02-13 Behandling af perifert t-cellelymfom

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK17177583.6T DK3255062T3 (da) 2013-02-14 2014-02-13 Anti-nkp46-antistof til diagnosticering af et ikke-kutant perifert t-cellelymfom (ptcl)

Country Status (5)

Country Link
US (3) US10344087B2 (da)
EP (2) EP3255062B1 (da)
DK (2) DK3255062T3 (da)
ES (2) ES2747920T3 (da)
WO (1) WO2014125041A1 (da)

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ES2747920T3 (es) * 2013-02-14 2020-03-12 Innate Pharma Anticuerpo anti-NKP46 para diagnóstico de un linfoma de células T periféricas no cutáneo (PTCL)
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Also Published As

Publication number Publication date
EP2956482A1 (en) 2015-12-23
ES2637151T3 (es) 2017-10-11
EP2956482B1 (en) 2017-06-28
DK3255062T3 (da) 2019-10-07
US20150376274A1 (en) 2015-12-31
US11999784B2 (en) 2024-06-04
ES2747920T3 (es) 2020-03-12
EP3255062B1 (en) 2019-07-03
EP3255062A1 (en) 2017-12-13
US20240425586A1 (en) 2024-12-26
US10344087B2 (en) 2019-07-09
US20190315857A1 (en) 2019-10-17
WO2014125041A1 (en) 2014-08-21

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