DK3255062T3 - Anti-nkp46-antistof til diagnosticering af et ikke-kutant perifert t-cellelymfom (ptcl) - Google Patents

Anti-nkp46-antistof til diagnosticering af et ikke-kutant perifert t-cellelymfom (ptcl) Download PDF

Info

Publication number
DK3255062T3
DK3255062T3 DK17177583.6T DK17177583T DK3255062T3 DK 3255062 T3 DK3255062 T3 DK 3255062T3 DK 17177583 T DK17177583 T DK 17177583T DK 3255062 T3 DK3255062 T3 DK 3255062T3
Authority
DK
Denmark
Prior art keywords
cutant
diagnostication
ptcl
peripheral
cell lymphoma
Prior art date
Application number
DK17177583.6T
Other languages
English (en)
Inventor
Cecile Bonnafous
Hélène Sicard
Mathieu Blery
Renaud Buffet
Original Assignee
Innate Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innate Pharma filed Critical Innate Pharma
Application granted granted Critical
Publication of DK3255062T3 publication Critical patent/DK3255062T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK17177583.6T 2013-02-14 2014-02-13 Anti-nkp46-antistof til diagnosticering af et ikke-kutant perifert t-cellelymfom (ptcl) DK3255062T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361764639P 2013-02-14 2013-02-14
US201361831792P 2013-06-06 2013-06-06
EP14704576.9A EP2956482B1 (en) 2013-02-14 2014-02-13 Treatment of peripheral t cell lymphoma

Publications (1)

Publication Number Publication Date
DK3255062T3 true DK3255062T3 (da) 2019-10-07

Family

ID=50112904

Family Applications (2)

Application Number Title Priority Date Filing Date
DK14704576.9T DK2956482T3 (da) 2013-02-14 2014-02-13 Behandling af perifert t-cellelymfom
DK17177583.6T DK3255062T3 (da) 2013-02-14 2014-02-13 Anti-nkp46-antistof til diagnosticering af et ikke-kutant perifert t-cellelymfom (ptcl)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK14704576.9T DK2956482T3 (da) 2013-02-14 2014-02-13 Behandling af perifert t-cellelymfom

Country Status (5)

Country Link
US (3) US10344087B2 (da)
EP (2) EP2956482B1 (da)
DK (2) DK2956482T3 (da)
ES (2) ES2747920T3 (da)
WO (1) WO2014125041A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2956482B1 (en) * 2013-02-14 2017-06-28 Innate Pharma Treatment of peripheral t cell lymphoma
WO2016030488A1 (en) * 2014-08-27 2016-03-03 Innate Pharma Treatment of celiac disease
CN107850596B (zh) 2015-07-24 2020-12-04 先天制药公司 用于检测组织浸润nk细胞的方法
AU2016383475B2 (en) * 2015-12-28 2024-02-22 Innate Pharma Variable regions for NKp46 binding proteins
WO2018032088A2 (en) * 2016-08-17 2018-02-22 University Health Network Regulation of tumor-associated t cells
EP3510047A1 (en) * 2016-09-07 2019-07-17 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Anti-nkp46 antibodies and therapeutic use of same
CN109863175A (zh) 2016-10-21 2019-06-07 依奈特制药公司 用抗-kir3dl2药剂进行的治疗
WO2018138032A2 (en) * 2017-01-24 2018-08-02 Innate Pharma NKp46 BINDING AGENTS
JP7255896B2 (ja) * 2017-05-19 2023-04-11 ロイヤル・メルボルン・インスティテュート・オブ・テクノロジー シクロホスファミド療法に対する応答者の予測
WO2019226617A1 (en) 2018-05-21 2019-11-28 Compass Therapeutics Llc Compositions and methods for enhancing the killing of target cells by nk cells

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
ATE365562T1 (de) 1996-05-03 2007-07-15 Immunomedics Inc Zielgerichtete kombinations-immuntherapie für krebs
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
AU3657899A (en) 1998-04-20 1999-11-08 James E. Bailey Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
KR100940380B1 (ko) 1999-01-15 2010-02-02 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
PT1176195E (pt) 1999-04-09 2013-07-18 Kyowa Hakko Kirin Co Ltd Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico
KR100988949B1 (ko) 2001-10-25 2010-10-20 제넨테크, 인크. 당단백질 조성물
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US20040110704A1 (en) 2002-04-09 2004-06-10 Kyowa Hakko Kogyo Co., Ltd. Cells of which genome is modified
WO2004016750A2 (en) 2002-08-14 2004-02-26 Macrogenics, Inc. FcϜRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
US20060235208A1 (en) * 2002-09-27 2006-10-19 Xencor, Inc. Fc variants with optimized properties
US20050058661A1 (en) 2002-10-18 2005-03-17 Sykes Kathryn F. Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of the genus Borrelia
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
EP2368578A1 (en) 2003-01-09 2011-09-28 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
DE20308171U1 (de) 2003-05-21 2003-07-31 Aesculap AG & Co. KG, 78532 Tuttlingen Wirbelkörperersatzimplantat
EP2385069A3 (en) 2003-11-12 2012-05-30 Biogen Idec MA Inc. Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
SG173322A1 (en) 2004-04-16 2011-08-29 Macrogenics Inc Dw Us Fc gammad riib - specific antibodies and methods of use thereof
JP2007536932A (ja) 2004-05-10 2007-12-20 マクロジェニクス，インコーポレーテッド ヒト化ＦｃγＲＩＩＢ特異的抗体とその利用法
WO2007024249A2 (en) 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
WO2006133148A2 (en) 2005-06-03 2006-12-14 Genentech, Inc. Method of producing antibodies with modified fucosylation level
HUE029465T2 (en) 2005-08-10 2017-02-28 Macrogenics Inc Identification and engineering of antibodies with variant Fc regions and methods of using same
AU2012202895A1 (en) * 2005-10-14 2012-06-07 Innate Pharma Compositions and methods for treating proliferative disorders
CN101300272B (zh) * 2005-10-14 2013-09-18 依奈特制药公司 用于治疗增生性病症的组合物和方法
FR2894982A1 (fr) 2005-12-16 2007-06-22 Lab Francais Du Fractionnement Procede de preparation d'anticorps selectifs des recepteurs fc activateurs
ES2395842T3 (es) 2006-01-17 2013-02-15 Synthon Biopharmaceuticals B.V. Composiciones y métodos para la humanización y optimización de N-glicanos en plantas
EP1999470A4 (en) 2006-03-10 2009-08-19 Macrogenics Inc IDENTIFICATION AND GENETIC MODIFICATION OF ANTIBODIES WITH HEAVY CHAINS OF VARIANTS AND METHODS OF USE THEREOF
CA2660592C (en) 2006-05-26 2016-07-12 Macrogenics, Inc. Humanized fc.gamma.riib-specific antibodies and methods of use thereof
CA2656224C (en) 2006-06-26 2018-01-09 Macrogenics, Inc. Combination of fc.gamma.riib antibodies and cd20-specific antibodies and methods of use thereof
EP1878747A1 (en) 2006-07-11 2008-01-16 greenovation Biotech GmbH Glyco-engineered antibodies
EP1995309A1 (en) 2007-05-21 2008-11-26 Vivalis Recombinant protein production in avian EBx® cells
US20120288499A1 (en) * 2010-01-15 2012-11-15 Armand Bensussan Methods for diagnosis and treatment of cutaneous t cell lymphomas
PH12018501083A1 (en) 2010-03-04 2019-02-18 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
EP2723362A1 (en) 2011-06-21 2014-04-30 Innate Pharma NKp46-MEDIATED NK CELL TUNING
EP2956482B1 (en) * 2013-02-14 2017-06-28 Innate Pharma Treatment of peripheral t cell lymphoma

Also Published As

Publication number Publication date
EP3255062A1 (en) 2017-12-13
ES2747920T3 (es) 2020-03-12
EP2956482A1 (en) 2015-12-23
US20240425586A1 (en) 2024-12-26
DK2956482T3 (da) 2017-10-16
US11999784B2 (en) 2024-06-04
EP3255062B1 (en) 2019-07-03
US10344087B2 (en) 2019-07-09
EP2956482B1 (en) 2017-06-28
US20150376274A1 (en) 2015-12-31
ES2637151T3 (es) 2017-10-11
US20190315857A1 (en) 2019-10-17
WO2014125041A1 (en) 2014-08-21

Similar Documents

Publication Publication Date Title
IL245573B (en) Cell
IL242253A (en) Electro-chemical filter apparatus
DK3042411T3 (da) Metalunderstøttet fastoxidbrændselscelle
HUE043488T2 (hu) Aglikozilált Fc-t tartalmazó polipeptidek
DK3043816T3 (da) Anti-b7-h1-antistoffer til behandling af tumorer
DK3812453T3 (da) Metabolisk optimeret cellkultur
DK3336106T3 (da) Anti-fcrh5-antistoffer
DK3537097T3 (da) Indretning til udformning af riller i rørelementer
DK2992020T3 (da) Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller
DK3708583T3 (da) Ikke-fucosylerede anti-fgfr2iiib-antistoffer
EP2988346A4 (en) CELL HOUSING
DK3068800T3 (da) FcRn-specifikke antistoffer
IL240626A0 (en) Social context for applications
DK3680000T3 (da) Fremgangsmåder til oprensning af antistoffer
FI20135168L (fi) Tekniikoita matkaviestinsovellusten räätälöintiä varten
EP3066193C0 (en) CELL CULTURE PROCESS
KR20180084767A (ko) 휴대폰 하우징 적용을 위한 폴리카보네이트-폴리실록산 공중합체 조성물
HRP20190085T1 (hr) Anti-cd52 protutijela
DK2983680T3 (da) Forbedring af organer til transplantation
EP3067906A4 (en) ELECTROCHEMICAL DEVICE
DK3065774T3 (da) Anti-CCL17-antistoffer
FR3013901B1 (fr) Dispositif electrochimique autophotorechargeable
DK3042205T3 (da) Fremgangsmåde til forbedring af antistofstabilitet
EP3067936A4 (en) SOLAR CELL
DE112013007428A5 (de) Komponententräger