DK297483D0 - Fremgangsmade til fremstilling af derivater af 9-(2-hydroxyethoxymethyl) guanin - Google Patents

Fremgangsmade til fremstilling af derivater af 9-(2-hydroxyethoxymethyl) guanin

Info

Publication number: DK297483D0
Authority: DK; Denmark
Prior art keywords: sup; sub; hydroxyethoxymethyl; guanine; procedure
Prior art date: 1982-06-29

Application number

DK2974/83A

Other languages

English (en)

Other versions

DK159444B (da

DK159444C (da

DK297483A (da

Inventor

Erik Desire Alice De Clercq

Hubert Jean Henri Evari Haeghe

Roger Honore Cornelius Busson

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-06-29

Filing date

1983-06-28

Publication date

1983-06-28

1983-06-28 Application filed by Wellcome Found filed Critical Wellcome Found

1983-06-28 Publication of DK297483D0 publication Critical patent/DK297483D0/da

1983-12-30 Publication of DK297483A publication Critical patent/DK297483A/da

1990-10-15 Publication of DK159444B publication Critical patent/DK159444B/da

1991-03-18 Application granted granted Critical

1991-03-18 Publication of DK159444C publication Critical patent/DK159444C/da

Links

238000000034 method Methods 0.000 title abstract 2
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical class N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK297483A 1982-06-29 1983-06-28 Analogifremgangsmaade til fremstilling af derivater af 9-(2-hydroxyethoxymethyl)guanin DK159444C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8202626A NL8202626A (nl)	1982-06-29	1982-06-29	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
NL8202626		1985-06-29

Publications (4)

Publication Number	Publication Date
DK297483D0 true DK297483D0 (da)	1983-06-28
DK297483A DK297483A (da)	1983-12-30
DK159444B DK159444B (da)	1990-10-15
DK159444C DK159444C (da)	1991-03-18

Family

ID=19839947

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK297483A DK159444C (da)	1982-06-29	1983-06-28	Analogifremgangsmaade til fremstilling af derivater af 9-(2-hydroxyethoxymethyl)guanin

Country Status (13)

Country	Link
US (1)	US4548819A (da)
EP (1)	EP0099493B1 (da)
JP (1)	JPS5910587A (da)
AT (1)	ATE45580T1 (da)
CA (1)	CA1208637A (da)
DE (1)	DE3380410D1 (da)
DK (1)	DK159444C (da)
FI (1)	FI76087C (da)
GB (1)	GB2122618B (da)
HU (1)	HU189709B (da)
IL (1)	IL69095A (da)
MY (1)	MY102248A (da)
NL (1)	NL8202626A (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8513460D0 (en) *	1985-05-29	1985-07-03	Glaxo Group Ltd	Chemical compounds
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
GB8719367D0 (en) *	1987-08-15	1987-09-23	Wellcome Found	Therapeutic compounds
GB8725939D0 (en) *	1987-11-05	1987-12-09	Wellcome Found	Therapeutic compounds
US4943579A (en) *	1987-10-06	1990-07-24	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble prodrugs of camptothecin
IT1223604B (it) *	1987-12-24	1990-09-29	Co Pharma Corp Srl	Derivati purinici ad azione farmacologica
GB8800312D0 (en) *	1988-01-07	1988-02-10	Glaxo Group Ltd	Process
GB8829571D0 (en) *	1988-12-19	1989-02-08	Wellcome Found	Antiviral compounds
DE68922903T2 (de) *	1988-12-19	1995-11-23	Wellcome Found	Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
GB8904855D0 (en) *	1989-03-03	1989-04-12	Beecham Group Plc	Pharmaceutical treatment
US5451799A (en) *	1992-12-28	1995-09-19	Matsushita Electric Industrial Co., Ltd.	MOS transistor for protection against electrostatic discharge
DE69426880T2 (de) *	1993-06-10	2001-10-31	Rolabo S.L., Zaragoza	Verfahren zur herstellung von aminosäureester von nukleosid analogen
GB9320316D0 (en) *	1993-10-01	1993-11-17	Smithkline Beecham Plc	Pharmaceuticals
TW282470B (da) *	1993-11-18	1996-08-01	Ajinomoto Kk
DE69513313T2 (de) *	1994-02-01	2000-07-13	Ajinomoto Co., Inc.	Verfahren zur Herstellung von Nukleinsäurebasenderivaten
US5994361A (en) *	1994-06-22	1999-11-30	Biochem Pharma	Substituted purinyl derivatives with immunomodulating activity
US5543414A (en) *	1994-07-28	1996-08-06	Syntex (Usa) Inc.	Achiral amino acid acyl esters of ganciclovir and its derivatives
PE32296A1 (es) *	1994-07-28	1996-08-07	Hoffmann La Roche	Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5840891A (en) *	1994-07-28	1998-11-24	Syntex (U.S.A.) Inc.	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en)	1996-01-26	2000-03-21	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
DE69714971T3 (de) *	1996-01-26	2005-12-15	F. Hoffmann-La Roche Ag	Verfahren zur herstellung von purin-derivaten
US5869493A (en) *	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
ZA9810490B (en) *	1997-12-03	1999-05-20	Dainippon Pharmaceutical Co	2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
AU2002365234B2 (en)	2001-12-14	2009-01-29	Pharmasset Inc	N4-acylcytosine nucleosides for treatment of viral infections
US20070293517A1 (en) *	2004-06-09	2007-12-20	Ramot At Tel Aviv University Ltd.	Derivatives Of Chemotherapeutic Agents With A Formaldehyde Releasing Moiety
ATE546451T1 (de) *	2005-05-25	2012-03-15	Lilly Co Eli	Cyclopropancarbonsäureester von acyclovir
CN115745997A (zh) *	2022-11-30	2023-03-07	湖北省宏源药业科技股份有限公司	一种高纯度伐昔洛韦杂质h制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1523865A (en) *	1974-09-02	1978-09-06	Wellcome Found	Purine compunds and salts thereof
AU515553B2 (en) *	1976-03-01	1981-04-09	The Wellcome Foundation Limited	Purine derivatives
JPS52105195A (en) *	1976-03-01	1977-09-03	Wellcome Found	Substituted purine
US4060616A (en) *	1976-03-01	1977-11-29	Burroughs Wellcome Co.	Purine derivatives with repeating unit

1982
- 1982-06-29 NL NL8202626A patent/NL8202626A/nl not_active Application Discontinuation
1983
- 1983-06-23 US US06/507,712 patent/US4548819A/en not_active Expired - Lifetime
- 1983-06-28 DE DE8383106299T patent/DE3380410D1/de not_active Expired
- 1983-06-28 DK DK297483A patent/DK159444C/da not_active IP Right Cessation
- 1983-06-28 HU HU832337A patent/HU189709B/hu unknown
- 1983-06-28 IL IL69095A patent/IL69095A/xx not_active IP Right Cessation
- 1983-06-28 EP EP83106299A patent/EP0099493B1/en not_active Expired
- 1983-06-28 AT AT83106299T patent/ATE45580T1/de not_active IP Right Cessation
- 1983-06-28 JP JP58116807A patent/JPS5910587A/ja active Granted
- 1983-06-28 CA CA000431347A patent/CA1208637A/en not_active Expired
- 1983-06-28 FI FI832355A patent/FI76087C/fi not_active IP Right Cessation
- 1983-06-28 GB GB08317504A patent/GB2122618B/en not_active Expired
1987
- 1987-10-09 MY MYPI87002887A patent/MY102248A/en unknown

Also Published As

Publication number	Publication date
DE3380410D1 (en)	1989-09-21
EP0099493B1 (en)	1989-08-16
NL8202626A (nl)	1984-01-16
EP0099493A1 (en)	1984-02-01
ATE45580T1 (de)	1989-09-15
DK159444B (da)	1990-10-15
CA1208637A (en)	1986-07-29
GB8317504D0 (en)	1983-08-03
GB2122618B (en)	1985-11-13
DK159444C (da)	1991-03-18
MY102248A (en)	1992-05-15
FI832355L (fi)	1983-12-30
JPS5910587A (ja)	1984-01-20
GB2122618A (en)	1984-01-18
FI76087B (fi)	1988-05-31
HU189709B (en)	1986-07-28
FI76087C (fi)	1988-09-09
US4548819A (en)	1985-10-22
DK297483A (da)	1983-12-30
IL69095A0 (en)	1983-10-31
IL69095A (en)	1985-11-29
JPH04990B2 (da)	1992-01-09
FI832355A0 (fi)	1983-06-28

Legal Events

Date	Code	Title	Description
2003-07-14	PUP	Patent expired

Publication	Publication Date	Title
DK297483D0 (da)	1983-06-28	Fremgangsmade til fremstilling af derivater af 9-(2-hydroxyethoxymethyl) guanin
HUP0101999A2 (hu)	2001-11-28	4-Hidroxi-kinolin-3-karboxamid- és -hidrazid-származékok, ezeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása
HUT54144A (en)	1991-01-28	Process for producing 3-desmethylmevalonic acid derivatives and pharmaceutical compositions comprising same as active ingredient
DE2861729D1 (en)	1982-05-19	Aliphatic derivatives of phosphonoformic acid, pharmaceutical compositions and methods for combating virus infections
EP0786458A3 (en)	1999-10-13	Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents
DK359082A (da)	1983-02-12	Fremgangsmaade til fremstilling af antivirale purinderivater eller fysiologisk acceptable salte eller estere deraf
DE68901153D1 (de)	1992-05-14	Derivate von purin, verfahren zu ihrer herstellung und pharmazeutische zubereitung.
DK408083A (da)	1984-03-10	Isoquinolinderivater, deres fremstilling og anvendelse
ES528462A0 (es)	1985-10-01	Procedimiento de preparacion de nuevos derivados dialquilaminoalcoxibencilalcoholicos y de sus sales de adicion acidas y amonicas cuaternarias
DE3564684D1 (en)	1988-10-06	Tetrahydrothienopyridines, process for their preparation and their pharmaceutical application
IT1197516B (it)	1988-11-30	Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
DK212387D0 (da)	1987-04-27	Benzhydrylpiperazinderivater eller farmaceutisk acceptable syreadditonssalte og kvaternaere ammoni-umsalte deraf, deres fremstilling og anvendelse
ES8802612A1 (es)	1988-09-01	Procedimiento para preparar derivados de benzisoselenazolilo
NO167981C (no)	1992-01-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno(3,4-d)imidazoler.
SE8504708D0 (sv)	1985-10-11	Novel nucleoside derivatives having antiherpetic properties, pharmaceutical compositions comprising same and process for the preparation of the active ingredients
GEP19970666B (en)	1997-01-04	Process for the preparation of purine derivatives